Found in tissue tissue inhibitor of metalloproteinases. Medical search. Frequent questions

Remodeling of atrial extracellular matrix (ECM) in atrial fibrillation (AF) involves changes in the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs). (unboundmedicine.com)
The underlying mechanisms of matrix destruction in TB remain poorly understood but consideration of the lung extracellular matrix predicts that matrix metalloproteinases (MMPs) will play a central role, owing to their unique ability to degrade fibrillar collagens and other matrix components. (ersjournals.com)
Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. (biomedcentral.com)
It might have an important polymorphic association at the promoter regions of several MMPs such as MMP-1 (-1607 1G/2G), MMP-2 (-1306 C/T), MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T) and TIMP-2 (-418 G/C or C/C). Tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring inhibitors of MMPs, which inhibit the activity of MMPs and control the breakdown of ECM. (biomedcentral.com)
Tissue inhibitors of matrix metallo-proteinases (TIMPs) are known to have the ability to inhibit the catalytic activity of MMPs. (biomedcentral.com)
Turpeenniemi-Hujanen et al suggested that the expressions of matrix expression of MMPs as well as their tissue inhibitors the TIMPs are associated with the clinical behaviour in head and neck malignancy [ 12 ]. (biomedcentral.com)
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases. (molvis.org)
A reduction of MMPs in aqueous humor can alter the balance between MMPs and the tissue inhibitors of metalloproteinases (TIMPs). (molvis.org)
Human orthopedic studies of failed hip implant sites have identified increased mRNA expression of several collagen-degrading matrix metalloproteinases (MMPs), while in vitro experiments have shown increases in MMP secretion after exposure to inflammatory mediators. (allenpress.com)
Proteolytic activity and collagenolytic degradation of extracellular matrix at the bone-implant interface have been reported in conjunction with increased mRNA expression of metalloproteinases (MMPs) in otherwise healthy tissues. (allenpress.com)
MMPs play an important role in skeletal connective tissue degradation and remodeling. (allenpress.com)
Levels of MMPs are determined by a balance between their expression and inhibition in tissues by specific proteins, known as tissue inhibitors of metalloproteinases. (allenpress.com)
The pathology of ankylosing spondylitis (AS) suggests that certain cytokines and matrix metalloproteinases (MMPs) might provide useful markers of disease activity. (bath.ac.uk)
Serum levels of some cytokines and MMPs have been found to be elevated in active disease, but there is a general lack of information about biomarker profiles in AS and how these are related to disease activity and function. (bath.ac.uk)
Measurement of 30 cytokines, five MMPs and four tissue inhibitors of metalloproteinases was carried out using Luminex® technology on a well-characterised population of AS patients (n = 157). (bath.ac.uk)
The aim of the study was to explore whether the serum level of interleukin 6 (IL-6) is correlated with matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), and with clinical markers of the disease activity in rheumatoid arthritis (RA). (termedia.pl)
Aims Matrix metalloproteinases (MMPs) play a significant function in wound recovery: they are able to degrade all the different parts of the extracellular matrix. (researchensemble.com)
We excluded gentle tissue infections, because bacteria may secrete MMPs. (researchensemble.com)

The most notorious endogenous metalloproteinases are tissue inhibitors of metalloproteinases (TIMPs). (wikipedia.org)
The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). (embl.de)
It is suggested that the hemopexin domain facilitates binding to a variety of molecules and proteins, for example the HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs). (embl.de)

These enzymes constitute a family of zinc-dependent endopeptidases, expressed at low levels in normal adult tissues, which regulate the turnover of the extracellular matrix in connective tissues. (allenpress.com)
Transcriptional profiling and functional validation studies demonstrate that these include effects dependent on increased expression of tissue inhibitor of metalloproteinase-sensitive proteases, enzymes more commonly associated with extracellular matrix remodelling. (gla.ac.uk)
A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. (lookformedical.com)
This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (lookformedical.com)
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. (lookformedical.com)
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. (lookformedical.com)
Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an important regulator of extracellular matrix turnover that has been traditionally regarded as a potential tumor suppressor owing to its inhibitory effects of matrix metal-loproteinases. (ibecbarcelona.eu)

Matrix metalloproteinase are a family of zinc dependent endopeptidases that are capable of degrading most components of the extra cellular matrix (ECM) [ 7 - 9 ]. (biomedcentral.com)

Proteomic approaches have proven powerful at identifying large numbers of proteins, but there are fewer reports of functional characterization of proteins in biological tissues. (hindawi.com)
ECM consists of proteins and polysaccharides distributed in many different tissues of the body. (biomedcentral.com)
Overall, 477 proteins were found interacting with at least one of four distinct sGAGs. (degruyter.com)
MECs were found to express numerous proteinase inhibitors, anti-angiogenic factors, and tumour suppressors proteins. (biomedcentral.com)
10 High expression of miR-21 in melanoma cells inhibits mRNA expression of crucial tumor suppressor proteins such as the tissue inhibitor of metalloproteinases 3 (TIMP3). (dovepress.com)
3 ] This dynamic process can also involve remodeling and regression of the fibrous tissue via breakdown of the matrix proteins by the protease enzymes matrix metalloproteinases (MMP). (uw.edu)

There are also cartilage-derived angiogenesis inhibitors. (wikipedia.org)
Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. (embl.de)
Endogenous inhibitors of angiogenesis include thrombospondin 1 (TSP-1) and a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1), and their aberrant expression may contribute to the diabetes-related dysregulation of retinal vascular homeostasis and vasculopathies ( 7 , 8 ). (spandidos-publications.com)

MiR-21 promoted invasion of fibroblasts by down-regulation of tissue inhibitor of metalloproteinase 3 (TIMP3) expression and increasing of matrix metalloprotein (MMP) expression in fibroblast cells via melanoma-derived exosomes in a time-dependent manner. (dovepress.com)

Oral submucous fibrosis is a chronic debilitating disease of the oral cavity characterized by inflammation and progressive fibrosis of the submucosal tissues (lamina propria and deeper connective tissues). (medscape.com)
[ 16 ] In one study, arecoline was found to elevate the mRNA and protein expression of cystatin C, a nonglycosylated basic protein consistently up-regulated in a variety of fibrotic diseases, in a dose-dependent manner in persons with oral submucous fibrosis. (medscape.com)
The pathologic hallmark of scleroderma is progressive fibrosis of tissues. (medscape.com)
Ratas con fibrosis hepática inducida por tioacetamida fueron agrupadas en: grupo I control que no recibió tioacetamida ni células madre, grupo II recibió tioacetamida y suero fisiológico i.v., grupo III recibió tioacetamida y células madre adiposas 1 x 106/kg i.v. vía vena de la cola. (bvsalud.org)
En conclusión la infusión intravenosa de CMAd-h en ratas disminuye el daño funcional y estructural de la fibrosis hepática con escasa persistencia de CMAd-h en el parénquima hepático. (bvsalud.org)

The inhibitory activities of glycosylated TIMP-1 and TIMP-3, but not TIMP-2, in AF tissues were markedly elevated and also localized in the atrial interstitium. (unboundmedicine.com)
TIMP-1 was found to be mostly colocalized with gelatinase activity over the AF tissues, implying the coexistence of gelatinase activity and TIMP-1, but TIMP-3 appeared only partially colocalized and discontinued the gelatinase activity surrounding the cardiomyocytes. (unboundmedicine.com)
INTRODUCTION: This study was designed to investigate the levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and their respective tissue inhibitors, tissue matrix metalloproteinase inhibitor-1 (TIMP-1) and tissue matrix metalloproteinase inhibitor-2 (TIMP-2), in eclamptic and preeclamptic pregnant women. (eastjmed.org)
When the three groups were examined in terms of the ratio of MMP-2 to TIMP-2, no significant difference was found (p=0.788). (eastjmed.org)
We found that TIMP-1 is aberrantly overexpressed in tumor-associated fibroblasts (TAFs) in ADC compared to SCC. (ibecbarcelona.eu)
Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2. (embl.de)
The binding properties of the newly described tissue inhibitor of metalloproteinases-4 (TIMP-4) to progelatinase A and to the COOH-terminal hemopexin-like domain (C domain) of the enzyme were examined. (embl.de)
2 , 4 ] Balance of the remodeling process occurs with inhibition of the remodeling by tissue inhibitors of metalloproteinases (TIMP). (uw.edu)
Moderate positive MMP2 structures and variable - mainly moderate to numerous positive TIMP structures - were found in vein wall. (utlib.ee)
A number of VEGF, MMP and TIMP positive cells found in saphenous vein wall indicates a presence of tissue remodelling and ischemia, while low number of HGF positive cells shows its lesser involvement in homeostasis regulation. (utlib.ee)
The supplementary objective was to find any relationship between adjustments in TIMP and MMP amounts and wound curing, and discover feasible predictors of curing. (researchensemble.com)
To determine the expression of tissue inhibitors of metalloproteinases (TIMP-2) in oral squamous cell carcinoma (OSCC) and the difference in its expression level between positive and negative HPV-16 (human papilloma virus- 16) OSCC patients. (bvsalud.org)
TIMP-2 was found to be highly expressed in OSCC sections, and the presence of HPV was not related to its overexpression. (bvsalud.org)

The slides were processed for histological routine and immunohistochemical staining with following markers: endothelin (ET), metallomembranoproteinase 2 (MMP2), tissue inhibitor of metalloproteinase 2 (TIMP2), transforming growth factor beta (TGF β), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), protein gene product 9.5 (PGP9.5), vascular cell adhesion molecule (VCAM), intercellular adhesion molecule (ICAM). (utlib.ee)
Such treatment was associated with upregulation of invasion- and inflammation-promoting soluble factors, such as matrix metalloproteinase 2 (MMP2), its activator MMP14, tissue inhibitors of matrix metalloproteinase 2 (TIMP2), chemokine ligand 2 (CCL2), and urokinase-type plasminogen activator (uPA), the latter two being linked to the recruitment of the monocytic cells. (biomedcentral.com)

The strongest association with the BASDAI was found with a component consisting of MMP-8, MMP-9, hepatocyte growth factor and CXCL8, and was independent of C-reactive protein levels. (bath.ac.uk)
Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)

This study suggests that the regulation of metalloproteinases at both the mRNA and protein level are important in the response of bone to mechanical stress. (allenpress.com)

Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
Excessive accumulation of adipose tissue in cultured fish is an outstanding problem in aquaculture. (biomedcentral.com)
Despite of the relevance of this issue, very little is known about the factors regulating the development of adipose tissue in fish, and the possible health alterations associated to an increased fat deposition. (biomedcentral.com)
In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
Therefore, growth of adipose tissue includes the hypertrophy of already existing adipocytes and the proliferation and differentiation of new ones from MSCs. (biomedcentral.com)
We have previously shown that fish primary preadipocytes differentiate into mature adipocytes in vitro and that these cells represent a very helpful model system to study adipose tissue development in fish [ 5 , 6 ]. (biomedcentral.com)
Dual-energy x-ray absorptiometry was used to determine fat mass and visceral adipose tissue, and fasting venous blood samples were collected for analysis of glucose, insulin and C-peptide and for targeted proteomics, measuring a total of 184. (lu.se)
In contrast, most of the associations between IGFBP2 and insulin dynamics, except for insulin secretion, were mediated by either fat mass index or visceral adipose tissue in men and women. (lu.se)

Using a mouse model of MWCNT exposure, we found that the tissue inhibitor of metalloproteinase 1 (Timp1) gene was rapidly and highly induced in the lungs by MWCNTs in a time- and dose-dependent manner. (cdc.gov)
We also found that high TIMP1 and CD63 mRNA levels combined define a stronger prognostic biomarker than TIMP1 alone. (ibecbarcelona.eu)

Matrix metalloproteinases are pivotal enzymes in connective tissue remodeling. (stanford.edu)
Toxins with hemorrhagic and myonecrotic activity are generally found in the venoms of the Viperidae family due to synergic action of proteolytic enzymes, such as metalloproteinases and serine proteinases 4 . (nature.com)

A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics. (lookformedical.com)
In fact, matrix metalloproteinase 2 (MMP-2) and integrin alphavbeta3 are functionally associated on the surface of angiogenic blood vessels. (embl.de)
Levels of PEX in these vascularized tissues suggest that it interacts with endothelial cell alphavbeta3 where it serves as a natural inhibitor of MMP-2 activity, thereby regulating the invasive behavior of new blood vessels. (embl.de)
Moderate positive endothelin containing endothelial cells and moderate to numerous positive VEGF cells were found on small blood vessels. (utlib.ee)

If harmful stimuli cannot be removed in time, increasing numbers of immune cells are recruited to the pulp tissue[5] and the immune-inflammatory balance is disrupted. (researchsquare.com)
We investigated the effect of HA on the expression of matrix metalloproteinases (MMP-2 and MMP-9) in cultured trabecular meshwork cells. (molvis.org)
Trabecular meshwork cells were cultured from trabecular tissues obtained from the POAG patients aged 23 to 45. (molvis.org)
Also, following transplantation and migration to target tissue, they encounter a harsh milieu accompanied by death signals because of the lack of proper tensegrity structure between the cells and matrix. (biomedcentral.com)
However, natural MSCs in vivo survival and their biological effects on tissue recovery decrease with long-term cultivation called aging and also injected cells demonstrate poor targeted migration [ 21 ]. (biomedcentral.com)
In this study, a dual-luciferase assay-based screening of 537 compounds for STAT-3 inhibitors of hepatocellular carcinoma (HCC) cells was conducted, leading to the identification of genipin. (biomedcentral.com)
Biochemical assays indicated that SVEVs are functionally active, showing high metalloproteinase and fibrinogenolytic activity besides being cytotoxic against HUVEC cells. (nature.com)
During the new blood vessel formation process, capillaries are formed when endothelial cells are stimulated to migrate, proliferate and invade the surrounding tissues ( 5 ). (spandidos-publications.com)
Abundance of VCAM and ICAM positive endothelial cells was also found. (utlib.ee)
Recruitment of CD11b + CD11c + myelomonocytic cells to the metastatic site was also found after whole thorax irradiation at a dose of 15 Gy of mice that significantly enhanced seeding and metastatic growth of intravenously injected cancer cells. (biomedcentral.com)
Tissues and Cells. (lu.se)

11 This results in increased matrix metalloproteinase activity, playing a pivotal role in the process of invasion and metastasis. (dovepress.com)

Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)

Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)

P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)

A total of 470 DEGs comprising 394 upregulated and 76 downregulated genes were found in pulpitis tissue. (researchsquare.com)
At the transcriptomics level, we found that several classes of genes were affected by mMSC treatment. (thno.org)

3 Because this bone cell culture model demonstrates a capacity to respond to mechanical changes, we hypothesize that this model may also show differences in expression of metalloproteinases in response to cyclic mechanical stretch that can be used to model changes at the bone-implant interface. (allenpress.com)
Further, we found that FGF9 induces expression of Ccl2 and Ccl7, two pro-inflammatory chemokines that contribute to recruitment of microglia and macrophages into multiple sclerosis lesions. (gla.ac.uk)
We also perform microarray transcriptomics experiments to characterize the gene expression states of the MSC-treated is- chemic tissues, and compare the results with those of non-ischemic tissues, as well as ischemic tissues from a saline-treated control group. (thno.org)
There are, in addition, other cals that are able to provoke an immune response such that characteristics, such as the ability to increase matrix allergic sensitization of the respiratory tract will be metalloproteinase expression or to cause perturbation of acquired. (cdc.gov)

Nonetheless, MECs were also found to exhibit cancer-promoting effects and provoke tumour invasion and dissemination by displaying distinct cancer chemokines. (biomedcentral.com)
CONCLUSIONS: Using data representing over 99% of U.S. population, we found that incidence rates of distant-stage prostate cancer significantly increased during 2010-2014 among men in certain ages, in white, and with non-Hispanic ethnicity. (cdc.gov)
Taking proanthocyanidin, a chemical found in grape seed extract, does not reduce breast tissue hardness, pain, or tenderness in people treated with radiation therapy for breast cancer. (medlineplus.gov)

Skin atrophy and soft tissue necrosis were observed 8 weeks after the completion of therapy. (biomedcentral.com)
We didn't exclude osteomyelitis because chronic osteomyelitis specifically may not necessarily be connected with soft-tissue infection. (researchensemble.com)

In the 1970s, Morphine was isolated from the poppy and found to bind to opiate receptors in the brain. (greenmedinfo.com)

Advances in tissue engineering technology have led to the production of novel human skin equivalents and organoids that reproduce cell-cell interactions with tissue-scale tensional homeostasis, and enable us to evaluate skin tissue morphology, functionality, drug response and wound healing. (mdpi.com)
Compromised wound healing in irradiated tissues is a common and challenging clinical problem. (biomedcentral.com)
In this review, the current state of research regarding the pathomechanisms of compromised wound healing in irradiated tissues is presented. (biomedcentral.com)

Historically, idiopathic lesions of anetoderma were classified clinically as either inflammatory (Jadassohn-Pellizzari type) or non-inflammatory (Schweninger-Buzzi type), although both types of lesions may be found in the same patient. (jcadonline.com)

Three primary pathologic features are found in scleroderma and include increased collagen deposition, perivascular mononuclear cell infiltration, and vascular abnormalities. (medscape.com)

A family of structurally related collagens that form the characteristic collagen fibril bundles seen in CONNECTIVE TISSUE. (lookformedical.com)
A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. (lookformedical.com)
They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. (lookformedical.com)
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. (lookformedical.com)
A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. (lookformedical.com)
A fibrillar collagen found primarily in interstitial CARTILAGE. (lookformedical.com)
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. (lookformedical.com)

ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)

This suggests that dextrose affects patellar tendinopathy at a tissue level. (regenerativehealth.co.za)

INTERVENTION(S): Oral administration of the aromatase inhibitor anastrozole with the addition of 200-mg oral progesterone (P) capsules once daily, hs, and calcitriol 0.5 microg oral capsules twice daily. (endometriosi.it)

Injection of solutions that block breakdown of tissue may also help healing. (regenerativehealth.co.za)

ECM environment provides appropriate conditions for cell growth, cell differentiation and survival of tissues. (biomedcentral.com)
1 It has been found that exosomes can mediate local and systemic cell communication with transmitting signals from one cell to another on the molecular level. (dovepress.com)
Pathologic changes seen on autopsy lack major cell and tissue injury but include signs of pleural effusion, pulmonary edema, ascites, and gastrointestinal mucosa bleeding ( 5 , 6 ), all indications of systemic vascular leakage. (cdc.gov)

OBJECTIVE: To determine matrix metalloproteinase 2 (MMP-2) levels in sera and peritoneal fluids of women with or without endometriosis-associated infertility and to determine whether MMP-2 had correlation with 17beta-E(2) and P in the sera and peritoneal fluids of the patients with endometriosis. (endometriosi.it)

In lung tissue, lipid peroxidation, reactive oxygen species, superoxide dismutase activity and reduced glutathione were all increased by WPS exposure. (who.int)

The proliferative phase is characterized by granulation tissue formation, re-epitheliaziation and neovascularization. (biomedcentral.com)

In this post, we discuss some commonly used active ingredients found in skincare products and their benefits for your skin, plus some hot tips for creating your own skincare products at home. (aromantic.co.uk)

Traditional methods of evaluating the status of dental pulp tissue in clinical practice have limitations. (researchsquare.com)
Objectives: The aim of the work was to find biomarkers identifying patients at high risk of adverse clinical outcomes after TAVI and SAVR in addition to currently used predictive model (EuroSCORE). (muni.cz)

An improved hypoechoic appearance of the tendon was associated with decreased pain scores, suggesting that dextrose injections may modify patellar tendinopathy at the tissue level and that fibrillar changes may play a role in tendon nociception. (regenerativehealth.co.za)

A matrix metalloproteinase inhibitor (MMPI, INN stem -mastat) inhibits matrix metalloproteinases. (wikipedia.org)

Examples include: Batimastat Cipemastat Ilomastat Marimastat MMI270 Prinomastat Rebimastat Ro 28-2653 Tanomastat Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae, and bacteria. (wikipedia.org)

Thus, tissues collected from cases diagnosed as irreversible pulpitis may not present severe inflammation in pathologic examination[11]. (researchsquare.com)

Anatomy3

Diseases1

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Disciplines and Occupations1

MMPs18

TIMPs3

Extracellular7

Family of zinc dependent endopeptidases1

Proteins6

Angiogenesis3

TIMP31

Fibrosis5

TIMP13

TIMP22

Hepatocyte Growth2

MRNA and protein1

Adipose8

Timp12

Enzymes2

BLOOD VESSELS4

Cells11

Pivotal1

Vitro1

Intracellular1

Endothelial1

Genes2

Expression4

Cancer3

Soft tissue2

Bind1

Wound3

Lesions1

Perivascular1

Collagen7

Compounds1

Suggests1

Oral1

Breakdown1

Cell3

Levels1

Lipid1

Neovascularization1

Commonly1

Clinical2

Fibrillar1

Stem1

Bacteria1

Pathologic1