EpitopesPeptidesMelanomaBinding an antigen derivedUntreated HLA-A2 positiveImmunotherapyAllelesHumansReceptorsChimeric antigen receptorCorresponding antigen-specificCytotoxicCellsProteinAllogeneicHumanTransplantationEpitopeTumorsHistocompatibilityActivationVitroRecognitionMultimersRepertoireTCRsRecombinantAntibodiesCTLsViralLigandsPathogensDonorsAdoptiveVaccineDetectableVivoPatient'sPatientsCancerDonorLeukemiaImmune systemTargetsMolecularNSCLCVector
Epitopes10
- In this study, we comprehensively screened HLA-A2 restricted MAGE-A3 tumor epitopes and characterized the corresponding TCRs using in vitro artificial antigen presentation cells (APC) system, single-cell transcriptome and TCR V(D)J sequencing, and machine-learning. (thno.org)
- We identified the HLA-A2 restricted T cell epitopes from MAGE-A3 that could effectively induce the activation and cytotoxicity of CD8+ T cells using artificial APC in vitro . (thno.org)
- A cohort of HLA-A2+ NSCLC donors demonstrated that the number of epitope specific CD8+ T cells increased in NSCLC than healthy controls when measured with tetramer derived from the candidate MAGE-A3 epitopes, especially epitope Mp4 (MAGE-A3: 160-169, LVFGIELMEV). (thno.org)
- Importantly, we show for three different epitopes that MCC specific T cells are capable of killing target cells expressing Large T antigen, including HLA-matched MCC cell lines, indicating that these T cells could provide functional activity upon in vivo transfer, and thus be employed in adoptive T cell therapy for MCC. (biomedcentral.com)
- T cell epitopes from Large T antigen of MCPyV display a large sequence variation with other polyomaviruses, but are highly conserved among different strains of MCPyV. (biomedcentral.com)
- We have identified directly ex vivo and in bulk T cell cultures HLA-A2-restricted cross-reactive CD8 T cell responses that recognize both EBV BMLF-1 and influenza A M1 HLA-A2 restricted epitopes. (umassmed.edu)
- because it targeted 9 epitopes from 5 antigens plus an additional epitope. (targetedonc.com)
- Recently, the first set of naturally presented human leukocyte antigen Class I (HLA-I) epitopes of MuV was identified by us. (mdpi.com)
- Here we explored the feasibility of using recombinant HLA-A2 monomers containing single peptide epitopes as immunogens to generate peptide-specific CTLs from allogeneic donors. (ox.ac.uk)
- Tedopi is composed of synthetic tumoral neo-epitopes (peptide fragments) that target five tumoral antigens, permitting the activation of tumor-specific T-lymphocytes for patients who are HLA-A2 positive. (medscape.com)
Peptides6
- Also, at least for MHC I presentation, there has been evidence of antigenic peptide splicing, which can combine peptides from different proteins, vastly increasing antigen diversity. (wikipedia.org)
- For immunization with such antigens, proteins should be less suitable than peptides, which do not require proteasome digestion in dendritic cells. (ox.ac.uk)
- MHC class II genes are mainly expressed on specialized antigen-presenting cells of the immune system, which monitor the extracellular environment and use MHC receptors to present peptides of extracellular pathogens to the T-cells. (biomedcentral.com)
- H-2-deficient mice transgenic for either A2, A24, B7, DR2, DR3, or DR4 HLA alleles were immunized with overlapping peptides of the WNV proteome, and peptide-specific T-cell activation was measured by gamma interferon (IFN-γ) enzyme-linked immunosorbent spot (ELISpot) assays. (ox.ac.uk)
- Approximately 30% (137) of the WNV proteome peptides were identified as HLA-restricted T-cell ligands. (ox.ac.uk)
- Although HLA-mismatched donors can mount high-avidity CTLs against HLA-A2-presented peptides of WT1, a dominant anti-alloimmune response usually obscures detection of peptide-specific CTLs. (ox.ac.uk)
Melanoma12
- Adoptive cell therapy using engineered T-cell receptors (TCRs) targeting cancer-testis antigens, such as Melanoma-associated antigen 3 (MAGE-A3), is a potential approach for the treatment of NSCLC. (thno.org)
- Here, we took advantage of an in vitro system to generate antigen-specific human T cells and show that melanoma-associated antigens, MART-1 and gp100, can be recognized by γδ T cells in an MHC-restricted fashion. (rcsb.org)
- The identification of proteins and carbohydrates associated with melanoma led to development of defined antigen vaccines. (northwestern.edu)
- A phase III trial indicated a survival benefit for Melacine® in the subset of melanoma patients who express the HLA class I antigens A2 and/or HLA-C3. (northwestern.edu)
- Melanoma cell lines HLA-A2+/MART-1+ (624.38) and HLA-A2? (biotechpatents.org)
- SK-MEL23 is normally a HLA-A2+ melanoma cell series (CVCL_6027). (biotechpatents.org)
- A375 (CVCL_0132) melanoma is normally HLA-A2+/MART-1? (biotechpatents.org)
- This phase II trial studies the side effects and how well white blood cells taken from person's own (autologous) cluster of differentiation (CD)8+ antigen-specific T cells, cyclophosphamide, aldesleukin, and ipilimumab work in treating patients with melanoma that has spread to another place in the body. (survivornet.com)
- Autologous CD8+ antigen-specific T cells are white blood cells that are designed in the laboratory to find melanoma cells and may kill them. (survivornet.com)
- Giving autologous CD8+ antigen-specific T cells with cyclophosphamide, aldesleukin, and ipilimumab may be an effective treatment for patients with metastatic melanoma. (survivornet.com)
- Lack of cleavage by the immunoproteasome was also observed for melanoma differentiation antigen Melan-A26-35/HLA-A2, currently used for antitumoral vaccination. (ox.ac.uk)
- Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune checkpoint receptors such as programmed death-1 (PD-1), programmed death ligand 1 (PD-L1) or cytotoxic T lymphocyte antigen-4 (CTLA-4). (biomedcentral.com)
Binding an antigen derived1
- Later studies revealed that tissue rejection due to incompatibility is only a facet of the full function of MHC molecules: binding an antigen derived from self-proteins, or from pathogens, and bringing the antigen presentation to the cell surface for recognition by the appropriate T-cells. (wikipedia.org)
Untreated HLA-A2 positive1
- METHODS AND FINDINGS:We undertook a detailed investigation of longitudinal CTL responses and HIV-1 evolution beginning with primary infection in 11 untreated HLA-A2 positive individuals. (jenner.ac.uk)
Immunotherapy4
- Novel immunotherapy strategy and therapeutic target has become a recent research focus in the effort of finding cures for NSCLC. (thno.org)
- In the first part we talk about immunotherapy and in particular about vaccines, personalized vaccines with dendritic cells, tumor-associated antigen vaccines and the famous vaccine targeted at CytoMegaloVirus (CMV). (glioblastomamultiforme.it)
- Numerous T cell responses were detected against MCPyV in both healthy donors and MCC patients, with a striking observation that T cell responses against Large and Small T antigens were found exclusively in MCC patients, suggesting that these oncoproteins are only presented to the immune system in the tumor-bearing host and represent highly specific targets for cancer immunotherapy of MCC. (biomedcentral.com)
- The immunotherapeutic vaccine OSE-2101 (Tedopi) improved survival by antigen-specific cytotoxic T lymphocytes (CTL) responses in patients with HLA-A2 positive advanced non small cell lung cancer (NSCLC), according to results from a phase II study presented in a poster at the 34th Society for Immunotherapy of Cancer (SITC) Annual Meeting. (targetedonc.com)
Alleles2
- Circulating T cells reactive against NY-ESO-1, MART-1, gp100 and TYRP-1, were found in 12/23 pts expressing at least one of the HLA-A1, A2, -A3 or A24 alleles with induction or augmentation of TAA reactivity in the course of treatment. (bmj.com)
- There is a fairly strong genetic background to pemphigus vulgaris with linkage to HLA class II alleles. (bvsalud.org)
Humans3
- Later Jean Dausset demonstrated the existence of MHC genes in humans and described the first human leucocyte antigen, the protein which we call now HLA-A2. (wikipedia.org)
- In order to better understand how cross-reactive CD8 T cells may be modulating disease outcome by enhancing viral clearance or inducing immunopathology, such as that seen in IM, we continue to characterize the cross-reactive TCR, both functionally and structurally, and examine how cross-reactivity influences the evolution of antigen-specific TCR repertoire development and disease outcome in both mice and humans during viral infections. (umassmed.edu)
- We show that the monocyte:macrophage balance is disrupted in colon inflammation to favour recruitment of CD14 + HLA-DR Int cells in humans, and Ly6C Hi monocytes in mice. (frontiersin.org)
Receptors3
- Antigen recognition by T cells bearing αβ T cell receptors (TCRs) is restricted by major histocompatibility complex (MHC). (rcsb.org)
- Modification with chimeric antigen receptors (CARs) endows T cells with tumor specific cytotoxicity and thus induce anti-tumor immunity against malignancies. (ijbs.com)
- These include the T cell immunoglobulin and mucin-domain containing-3 (TIM-3), lymphocyte-activation gene-3 (LAG-3), TIGIT, and B-and T-lymphocyte-associated protein (BTLA) receptors associated with T cell exhaustion and V-domain immunoglobulin suppressor of T cell activation (VISTA), a receptor found on tumor-infiltrating myeloid cells. (biomedcentral.com)
Chimeric antigen receptor3
- Chimeric antigen receptor (CAR) T cells have successfully induced remission in patients with relapsed or refractory B cell malignancies, but a substantial portion of patients eventually relapse. (acir.org)
- Therapies in which T cells are engineered to express a chimeric antigen receptor (CAR) have proven to be incredibly effective against certain hematological malignancies. (acir.org)
- Advances in our understanding on the interaction between the immune system and tumor cells have contributed to the rapid development of novel therapeutic strategies based on chimeric antigen receptor (CAR) or T cell receptor (TCR) modified T cells. (ijbs.com)
Corresponding antigen-specific1
- However, systematic analysis of T cell immune responses to MAGE-A3 antigen and corresponding antigen-specific TCR is still lacking. (thno.org)
Cytotoxic3
- Here we show the features of repertoire diversity and the gene expression profile of HLA-A24 cytomegalovirus-specific cytotoxic T-cells in actual recipients according to the cytomegalovirus reactivation pattern. (nature.com)
- Recent studies have detected Wilms tumor antigen (WT1)-specific cytotoxic T lymphocytes (CTLs) in patients with acute myelogenous leukemia (AML) and chronic myelogenous leukemia (CML) and demonstrated that most of these CTLs were low avidity. (ox.ac.uk)
- Furthermore, sorted A2/WT1 tetramer-positive CTLs display strong cytotoxic activity against leukemia cells expressing WT1 endogenously but not against WT1(-) human tumor cells. (ox.ac.uk)
Cells30
- The presented self-antigens prevent an organism's immune system from targeting its own cells. (wikipedia.org)
- Some years later Baruj Benacerraf showed that polymorphic MHC genes not only determine an individual's unique constitution of antigens but also regulate the interaction among the various cells of the immunological system. (wikipedia.org)
- However, how antigens are recognized by T cells bearing γδ TCRs remains unclear. (rcsb.org)
- Although γδ T cells can recognize nonclassical MHC, it is generally thought that recognition of antigens is not MHC restricted. (rcsb.org)
- Our work shows that antigen-specific and MHC-restricted γδ T cells can be generated in vitro and that MART-1-specific γδ T cells can also be found and cloned from the naïve repertoire. (rcsb.org)
- Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
- Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
- CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
- There was no off-target toxicity: cells which did not express the target antigen PRAME, including a panel of normal healthy tissues (such as lung, bone, heart and kidney among others), were not killed. (1440dev.com)
- Furthermore, no toxicity was observed against HLA-A2 negative cells. (1440dev.com)
- Thus, the local immunological milieu in tissue compartments forms the nature and magnitude of the host responses, i.e., frequencies of regulatory T cells (Tregs) vs. T-helper 17 (Th17) cells, amount of pro-inflammatory cytokines vs. anti-inflammatory cytokines, extent of neutrophilia and antigen-presenting-cell (APC) activation, among others. (frontiersin.org)
- However, targeting solid tumors is more challenging than targeting B-cell malignancies with CAR-T cells because of the histopathological structure features, specific antigens shortage and strong immunosuppressive environment of solid tumors. (ijbs.com)
- These cross-reactive T cells were found to participate in acute infectious mononucleosis (IM). (umassmed.edu)
- Five of 8 young adult HLA-A2+ patients experiencing IM had an increased number of influenza virus (FLU)-M1 58-66 specific CD8+ T cells in their peripheral blood as compared to healthy donors. (umassmed.edu)
- We know that at least 1 of these antigens is expressed by the lung cancer cells. (targetedonc.com)
- In order to determine whether or not a patient already has any specific HLA antibodies, a lab specialist will test a patient's blood (serum) against lymphocytes (white blood cells) obtained from a panel of about 100 blood donors. (hrsa.gov)
- HLA antigens are substances, usually a protein, found on the surface of our cells that stimulate the production of antibodies. (hrsa.gov)
- Due to their HLA-independent mode of action, allogeneic Vγ9Vδ2 T cells can be considered for clinical application. (nature.com)
- We found that the expanded cells possessed significantly improved immune effector functions, including proliferation, differentiation, and cancer cell killing, both in vitro and in the humanized mouse model. (nature.com)
- γδ T cells, specifically the Vγ9Vδ2 subset, which is the dominate subset among γδ T cells in human peripheral blood, recognize target cells in a human leukocyte antigen (HLA)-independent manner. (nature.com)
- Here, we analyzed V and CDR3 TCR regions of single circulating naive T cells specifically detected ex vivo and isolated with HLA-A2/melan-A peptide multimers. (elsevierpure.com)
- Similarly to what was previously observed for melan-A-specific Ag-experienced T cells, we found a relatively wide Vβ usage, but a preferential Vα 2.1 usage. (elsevierpure.com)
- Scholars@Duke publication: Peptide/MHC tetramer-based sorting of CD8⁺ T cells to a leukemia antigen yields clonotypes drawn nonspecifically from an underlying restricted repertoire. (duke.edu)
- Evaluate the influence of anti-CTLA4 on the induction of T cells to non-targeted tumor-associated antigens (antigen-spreading) following adoptive transfer antigen-specific CTL, and the correlation of these responses with clinical outcome. (survivornet.com)
- CAR T cell therapy for hematological cancers can be highly effective, but is currently limited to antigens that are only expressed by tumor cells or by lineages that are non-essential. (acir.org)
- Targeting antigens expressed by all tumor cells is often associated with on-target/off-tumor toxicities to normal hematopoietic cells. (acir.org)
- Previous studies have shown the accumulation of human CD14 Hi or CD14 + HLA-DR Int cells in the GI tract lamina propria (LP) during inflammation ( 2 , 6 , 11 - 14 ). (frontiersin.org)
- Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells. (ox.ac.uk)
- We show that dendritic cells also carry immunoproteasomes and fail to present this antigen. (ox.ac.uk)
- After 3 to 5 rounds of stimulation a population of CD8(+) T cells binding A2/peptide tetramers is easily detectable by fluorescence-activated cell sorting analysis. (ox.ac.uk)
Protein6
- Cross-reactivity between a streptococcal 60- to 65-kd heat shock protein (hsp) and the oral mucosa has been demonstrated, and significantly elevated levels of serum antibodies to hsp are found in patients with RAS. (medscape.com)
- We investigated the T cell recognition of both the oncogenic proteins, Large and Small T antigen and the capsid protein VP1 that is profoundly expressed also in the non-symptomatic MCPyV infected healthy individuals. (biomedcentral.com)
- The binding of the adenovirus (Ad) protein E3-19K with the human leukocyte antigen (HLA) plays an. (chemaxon.com)
- By stimulating human lymphocytes with an autologous renal carcinoma, we obtained CTL recognizing an antigen derived from a novel, ubiquitous protein. (ox.ac.uk)
- En archaeology and les andthemes de Twitter, human coin protein Utilisation des things. (whmoodie.com)
- Use of B cell-bound HLA-A2 class I monomers to generate high-avidity, allo-restricted CTLs against the leukemia-associated protein Wilms tumor antigen. (ox.ac.uk)
Allogeneic2
- This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
- We identified UNC-CDK4-1/HLA-A*02:01 tetramer⁺ populations in 3 of 6 patients with acute myeloid leukemia who had undergone allogeneic stem cell transplantation. (duke.edu)
Human4
- The human MHC is also called the HLA (human leukocyte antigen) complex (often just the HLA). (wikipedia.org)
- HLA stands for Human Leukocyte Antigen. (hrsa.gov)
- This study focused on the identification of human leukocyte antigen (HLA)-restricted West Nile virus (WNV) T-cell ligands and characterization of their distribution in reported sequence data of WNV and other flaviviruses. (ox.ac.uk)
- The technology uses the human leukocyte antigen (HLA) system, one of the keys for presenting antigens to T-lymphocytes. (medscape.com)
Transplantation3
- Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
- 2001) archaeology of smart dendritic rheumatoid vitro lupus Example mature such price Tregs expanded by the HLA-A2 transplantation lung motivation. (whmoodie.com)
- Thus, HLA/peptide monomers may be useful to isolate peptide-specific donor lymphocytes for treatment of patients with leukemia after HLA-mismatched transplantation. (ox.ac.uk)
Epitope1
Tumors3
- Clarence Little transplanted tumors across different strains and found rejection of transplanted tumors according to strains of host versus donor. (wikipedia.org)
- Nevertheless, targeting solid tumors is more challenging than targeting hematological malignancies because of tumor histopathological characteristics, shortage of specific antigens and local strong immunosuppressive microenvironment [ 4 ]. (ijbs.com)
- In 95% of cases, tumors express at least one of these five antigens. (medscape.com)
Histocompatibility1
- We have mapped the T cell recognition of MCPyV by use of a novel technology platform for T-cell enrichment and combinatorial encoding of histocompatibility antigen (HLA) class I multimers. (biomedcentral.com)
Activation1
- manual researchers Was found by the likely drink activation of 1832. (whmoodie.com)
Vitro1
- TIGIT-28 improving capacity was also showed in an primary in vitro style of T-cell of hypofunction induction upon recurring antigen publicity. (biotechpatents.org)
Recognition4
- Cloning and transferring of MART-1-specific γδ TCRs restored the specific recognition of the initial antigen MHC/peptide reactivity and conferred antigen-specific functional responses. (rcsb.org)
- We investigated the T cell recognition of 398 in silico predicted HLA-ligands from Large T, Small T and VP1 and identified T-cell responses restricted to HLA-A1, A2, A3, A11 and B7. (biomedcentral.com)
- Our studies with viruses in murine systems have focused on virus-specific memory T cell populations, which demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. (umassmed.edu)
- On one hand, positive selection signals are expected in the ABS as they may evolve to bind novel antigens carried by pathogens, which in turn may evolve to escape recognition. (biomedcentral.com)
Multimers1
- Thus, interaction of the pMHC complex with selected Vα-chains contributes to set the broad Ag specificity, as underlined by preferential binding of A2/melan-A multimers to Vα 2.1-bearing TCRs, whereas functional outcomes result from the sum of these with other interactions between pMHC complex and TCR. (elsevierpure.com)
Repertoire1
- In parallel, we measured the patient's TCRβ repertoire and found it to be highly restricted/oligoclonal. (duke.edu)
TCRs2
- This work identified candidate TCRs potentially suitable for TCR-T design targeting HLA-A2 restricted MAGE-A3 tumor antigen. (thno.org)
- A crystal structure of a MART-1-specific γδ TCR, together with MHC/peptide, revealed distinctive but similar docking properties to those previously reported for αβ TCRs, recognizing MART-1 on HLA-A*0201. (rcsb.org)
Recombinant1
- We use several virus systems, but focus on lymphocytic chorimeningitis (LCMV) and Pichinde (PV) viruses, distantly related arenaviruses whose T cell responses are well defined, and on the poxvirus vaccinia (VV), which is used as a vaccine for smallpox and as a recombinant vaccine and vector for many antigens. (umassmed.edu)
Antibodies4
- For example, a patient could develop antibodies to A2 and A24. (hrsa.gov)
- In the case of an organ transplant, the body will recognize the HLA antigens on the transplanted organ as not being the same as its own, and form specific antibodies against those particular HLA antigens. (hrsa.gov)
- Second, because of previous medical events, some patients have already developed antibodies to specific HLA antigens. (hrsa.gov)
- Finally, at baseline, antibodies against NY-ESO-1, MAGE-A3, SSX-2, HMW-MAA, TYRP-1 and MSLN were found in sera of 9-15-8-7-7-6 of 40 investigated MM pts, respectively. (bmj.com)
CTLs3
- Thus, we conducted immune- and RNA-sequencing of HLA-A24-restricted CMVpp65-specific CTLs to better understand the immune reconstitution of CMV-CTLs after allo-HCT. (nature.com)
- To the best of our knowledge, this is the first report on the features of TCRβ-CDR3, diversity, and GEP of HLA-A24 CMV-CTLs according to the CMV-reactivation pattern among recipients after allo-HCT. (nature.com)
- We demonstrate that the coating of HLA-A2(-) B lymphocytes with A2/peptide monomers provides a strong stimulus for autologous peptide-specific CTLs. (ox.ac.uk)
Viral2
- BACKGROUND:Antigen-specific CTL responses are thought to play a central role in containment of HIV-1 infection, but no consistent correlation has been found between the magnitude and/or breadth of response and viral load changes during disease progression. (jenner.ac.uk)
- Our results also demonstrate that CTL pressures help to maintain certain elements of consensus viral sequence, which likely represent viral escape from common HLA-restricted CTL responses. (jenner.ac.uk)
Ligands1
- Peripheral blood lymphocytes (PBMC) and sera were collected at baseline, wk12, and wk24 to perform phenotypic and functional T cell assays, and to investigate humoral responses against a panel of tumor-associated antigens (TAAs) and soluble NKG2D ligands (sNKG2DL). (bmj.com)
Pathogens1
- The MHC encodes cell surface glycoproteins that bind antigens derived from pathogens or parasites and present them to T-lymphocytes, triggering the adaptive immune response. (biomedcentral.com)
Donors5
- These 100 donors represent the potential HLA makeup for a donor from that area. (hrsa.gov)
- Entering unacceptable antigens for candidates increases the efficiency of organ allocation by screening off incompatible donors. (hrsa.gov)
- To determine the CPRA value, the computer system will use an established formula and HLA frequencies derived from the HLA types found in more than 12,000 donors. (hrsa.gov)
- Methods Individual PBMCs and cell lines Every one of the PBMCs found in this research had been from healthful donors extracted from the Israeli Bloodstream Bank (Sheba INFIRMARY, Tel-Hashomer, Israel). (biotechpatents.org)
- These results are representative of ten self-employed experiments with at least eight different donors and the difference between the populace transduced and the non-transduced populace was found statistically significant (combined t-test). (biotechpatents.org)
Adoptive1
- I. Evaluate the influence of anti-CTLA4 on the duration of in vivo persistence and anti-tumor efficacy achieved following adoptive transfer of antigen-specific CTL. (survivornet.com)
Vaccine4
- The ability of HIV to evolve to escape CTL responses restricted by a common HLA type highlights the challenges posed to development of an effective CTL-based vaccine. (jenner.ac.uk)
- OSE-2102 is now being studied in the phase III ATALANTE trial, in which the vaccine is being compared with the standard of care in HLA-A2-positive advanced NSCLC. (targetedonc.com)
- The vaccine is effective for patients who express the HLA-A2 gene, which is present in around half of the population. (medscape.com)
- They had an HLA-A2 phenotype, as determined by a blood draw to determine whether their immune system could respond to the vaccine. (medscape.com)
Detectable1
- Occult hepatitis B virus infection is a well-recognized clinical entity characterized by the detection of hepatitis B virus DNA in serum and/or liver in the absence of detectable hepatitis B virus surface antigen, with or without any serological markers of a past infection. (omjournal.org)
Vivo2
- Testing of T cell-based cancer therapeutics often involves measuring cancer antigen-specific T-cell populations with the assumption that they arise from in vivo clonal expansion. (duke.edu)
- Mapping recurrent TCRβ clonotype sequences onto TCRβ repertoires can help confirm or refute antigen-specific T-cell expansion in vivo. (duke.edu)
Patient's1
Patients6
- CD8 + CTL clones recognizing minor H antigens were isolated from five patients studied. (aacrjournals.org)
- It's given subcutaneously to the subpopulation of patients that are HLA-A2 positive. (targetedonc.com)
- Additionally, at the 2019 SITC Meeting, we presented a poster (P339) which showed that patients who develop at least 2 immune responses against antigens have a survival that will be double compared to the other patients. (targetedonc.com)
- Methods Patients with a PS 0-1, HLA-A2+ and CEA-expressing, previously-treated PC were randomized to receive 10 μg (arm A), 100 μg (arm B) or 1000 μg (arm C) of CEA peptide emulsified in Montanide and GM-CSF, given every 2 weeks until disease progression. (bmj.com)
- Similar patterns are found in other European countries, with different therapeutic options offered to patients. (mdmsignaling.com)
- The HLA-A2 biomarker, detected via a blood test, can identify appropriate patients. (medscape.com)
Cancer2
- Methods to improve the detection of tumor antigens are now the subject of intense research for various types of cancer. (glioblastomamultiforme.it)
- TCR-4 which specifically targets the PRAME cancer antigen in the context of HLA-A2 was combined with Medigene's lead functional T cell enhancer, the PD1-41BB switch receptor, and evaluated pre-clinically against a set of key performance hurdles to determine safety and efficacy. (1440dev.com)
Donor2
Leukemia1
Immune system2
- The second problem is that the immune system is not an efficient detector of tumor antigens. (glioblastomamultiforme.it)
- The nature of the molecule, that interacts both with the antigens (i.e., the Antigen Binding Sites, onwards ABS) and the cellular and immune system components, makes it subject to different types of natural selection. (biomedcentral.com)
Targets1
- Tedopi was developed in NSCLC because this therapy targets 5 antigens. (targetedonc.com)
Molecular1
- In a previous study we introduced the concept of molecular groups of carcinoids: A1, A2, and B, which, importantly, contained a mixture of the two histological types. (who.int)
NSCLC1
- What was the rationale for the phase III ATALANTE-1 trial of Tedopi versus standard of care in HLA-A2 positive advanced NSCLC? (targetedonc.com)
Vector1
- which is normally Compact disc19 bad) was constructed expressing the Compact disc19 antigen pursuing retroviral transduction using a Compact disc19 encoding vector. (biotechpatents.org)