Fosfomycin resistance protein. Medical search. Frequent questions

they do not create new genes, new proteins, or enzymes. (creation.com)
Bacteria - including the ones carrying antimicrobial resistance genes - also enter the wastewater system. (elifesciences.org)
identified 29 different major types of antimicrobial resistance genes. (elifesciences.org)
Overall, antimicrobial genes that provide protection against multiple drugs, and those that provide resistance against two common types of antibiotics (aminoglycosides and beta lactams) were both abundant and highly expressed. (elifesciences.org)
Interestingly, the most highly expressed genes were related to resistance against antimicrobial peptides, which are part of the innate immune system in multicellular organisms. (elifesciences.org)
next focused on two relevant types of mobile genetic elements that convey antimicrobial resistance genes: plasmids (small, circular DNA molecules) and bacteriophages (viruses that infect bacteria). (elifesciences.org)
April 2022 release - new H. pylori resistance genes, added disinfecting agents and antiseptics and their resistance genes, new Erm proteins, added sal-type ABC-F proteins. (mcmaster.ca)
This study aimed to assay the prevalence of common β-lactam resistance genes including bla TEM , bla SHV , bla CTX-M and bla CMY and phenotypic resistance to commonly used β-lactam and fluoroquinolone antibiotics in UTIs. (biomedcentral.com)
Real-time PCR was applied to detect β-lactam resistance genes and conventional PCR was used to determine the phylotypes. (biomedcentral.com)
The prevalence of resistance genes were 89.6% for bla TEM , 44.3% for bla CTX-M , 6.6% for bla SHV and 0.9% for bla CMY . (biomedcentral.com)
Infant gut commensals risk transferring multidrug-resistant antibiotic resistance genes (ARGs) to pathogenic bacteria. (biomedcentral.com)
all infants harboured these antibiotic resistance genes at some point in the first year of life. (biomedcentral.com)
In this longitudinal cohort study of infants living in a region with high endemic antibacterial resistance, we demonstrate that majority of the infants harboured several antibiotic resistance genes in their gut and showed that the infant gut resistome is diverse and dynamic over the first year of life. (biomedcentral.com)
However, the gut microbiota is a reservoir for antibiotic resistance genes (ARGs). (biomedcentral.com)
Screening for genes which are required for growth when new cell wall synthesis is reduced by the antibiotic Fosfomycin, they found that a transporter belonging to the ATP-binding cassette, ABC, family seemed to be become essential for the bacteria to survive. (sciencemission.com)
The detection of fosfomycin resistance genes in Enterobacteriaceae from pets and their owners. (cdc.gov)
Some serovars of non-typhoidal Salmonella (NTS) have been associated with bloodstream infections and gastroenteritis, especially in children in Sub-Saharan Africa with circulating S. enterica serovars with drug resistance and virulence genes. (biomedcentral.com)
Virulence and antimicrobial resistance genes, sequence type, and cluster analysis were investigated using WGS data. (biomedcentral.com)
Antimicrobial susceptibility design and recognition of genes coding for MDR efflux pumps and external membrane porins As dependant on disk diffusion antimicrobial susceptibility examining method, a share 77.7% (28/36) of isolates showed multidrug level of resistance (MDR) patterns, but each one of these MDR isolates were sensitive to colisitin (10?g). (irjs.info)
Strikingly, K-2157 displayed a resistome composed of ß-lactam resistance genes (blaSHV-190, blaTEM-1, blaOXA-9, and blaKPC-2), the fosfomycin resistance gene fosA, and the fluoroquinolones resistance genes oqxA and oqxB. (bvsalud.org)
In addition, K-2157 harbored two plasmids: one of 113,644 bp (KPC+) and another of 230,602 bp, containing virulence genes, in addition to an integrative and conjugative element (ICE) embedded on its chromosome, revealing that the presence of these mobile genetic elements mediates the convergence between virulence and antibiotic resistance. (bvsalud.org)
A number of resistance mechanisms are responsible for the emergence and prevalence of antimicrobial resistance, and such mechanisms have been divided into genetic mutation occurred at a low frequency and acquisition of various genes mediated resistance to their host microorganisms. (biomedcentral.com)

Despite its name (ending in -omycin) Fosfomycin is not a macrolide, but a member of a novel class of phosphonic antibiotics. (wikipedia.org)
However, the development of resistance to antibiotics threatens this success. (creation.com)
Antimicrobial resistance - the ability of bacteria to evolve resistance to drug treatments, including antibiotics - poses a major threat to health interventions ( McEwen and Collignon, 2018 ). (elifesciences.org)
Although antimicrobial resistance occurs naturally, the widespread and often uncontrolled use of antibiotics in both humans and livestock have exacerbated this ability. (elifesciences.org)
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the major classes of antibiotics, together with their modes of action and mechanisms of resistance. (cshlpress.com)
The authors also explore the environmental origins of antibiotic resistance and provide guidance on the rational development and therapeutic application of new antibiotics. (cshlpress.com)
Several antibiotics are considered for treatment of cystitis and pyelonephritis, including oral β-lactams (amoxicillin-clavulanic acid or third-generation cephalosporin), fluoroquinolones (ciprofloxacin or levofloxacin), nitrofurantoin, fosfomycin or trimethoprim-sulfamethoxazole [ 5 ]. (biomedcentral.com)
Many multidrug resistant organisms retain susceptibility to two old antibiotics, nitrofurantoin and fosfomycin. (tg.org.au)
7-10 Nitrofurantoin and fosfomycin are old antibiotics. (tg.org.au)
These antibiotics bind to the 30S ribosome, thereby inhibiting bacterial protein synthesis. (msdmanuals.com)
The cell wall is essential for bacteria since it determines their shape and allows them to protect themselves, and many of our best antibiotics target the proteins that build and remodel this structure. (sciencemission.com)
When the researchers tested the resistance of the transporter mutant to β-lactam antibiotics such as ampicillin, they found that it became extremely sensitive. (sciencemission.com)
Although there are already antibiotics available that can treat bacterial pneumonia, there are serious concerns about the rise of antibiotic resistance . (labiotech.eu)
"Xenleta has a mechanism of action that is different than that of other approved antibiotics, resulting in a low propensity for the development of resistance," explained Ted Schroeder, CEO of Nabriva Therapeutics, in a statement this week. (labiotech.eu)
Enterococci impart resistance to antibiotics in a variety of ways. (uspharmacist.com)
Normally, these MDR infections are hard-to-treat with limited available choices of antibiotics such as tigecycline, colistin, fosfomycin, and aminoglycosides22,23. (irjs.info)
All MDR isolates had been resistant to beta lactam antibiotics and 64.28%, 82.15%, and 85.7% showed level of resistance to carbapenem, quinolone, and aminoglycosides, respectively. (irjs.info)
Due to differences in the molecular epidemiology of resistance and availability of specific antibiotics internationally, treatment recommendations are geared toward antimicrobial resistant infections in the United States. (idsociety.org)
This pathogen is characterized by its notorious resistance to last-line antibiotics, such as carbapenems. (bvsalud.org)
As recently indiscriminate abuse of existing antibiotics in both clinical and veterinary treatment leads to proliferation of antibiotic resistance in microbes and poses a dilemma for the future treatment of such bacterial infection, antimicrobial resistance has been considered to be one of the currently leading concerns in global public health, and reported to widely spread and extended to a large variety of microorganisms. (biomedcentral.com)
and B. licheniformis recorded high sensitivity (71%) against most antibiotics, in addition, B. subtilis showed resistance to Aztreonam only. (modernjmicrobiol.com)
Resistance to antibiotics occurs because of the changing nature of bacteria that no longer can be killed. (modernjmicrobiol.com)

Nitrofurantoin and fosfomycin are often effective against vancomycin -resistant enterococcal urinary tract infection. (msdmanuals.com)

Intravenous fosfomycin is being increasingly used for treating infections caused by multidrug-resistant bacteria, mostly as a partner drug in order to avoid the occurrence of resistances and to take advantage of its synergistic activity with several other antimicrobials. (wikipedia.org)
Mutations that inactivate the nonessential glycerophosphate transporter render bacteria resistant to fosfomycin. (wikipedia.org)
While acquired resistance has received considerable attention, relatively little is known of intrinsic resistance that allows bacteria to naturally withstand antimicrobials. (frontiersin.org)
Besides the ability of bacteria to acquire antimicrobial resistance via horizontal gene transfer or spontaneous mutations, they can also be intrinsically resistant to antimicrobials ( Cox and Wright, 2013 ). (frontiersin.org)
An example is fosfomycin, which kills bacteria by blocking them from making a crucial component of the cell wall. (creation.com)
While many bacteria have intrinsic, chromosomally encoded ARDs and the capability of increasing resistance through mutation, they can also enrich their resistance capabilities through the acquisition of exogenous ARDs located on mobile genetic elements (MGEs) such as plasmids, transposons or phages. (nature.com)
One of these was a gene called YojI, which encodes resistance to microcin, a common toxin that is widely produced by bacteria and other prokaryotic species. (elifesciences.org)
The production of extended spectrum β-lactamases (ESBLs) is a primary β-lactam resistance mechanism in Gram-negative bacteria. (biomedcentral.com)
A Novel Fosfomycin-Trimethoprim-Sulfamethoxazole Combination Exhibits Marked In Vitro Antibacterial Synergy Against Bacteria Causative of Urinary Tract Infections. (asm.org)
We expected to see a drop in antibiotic resistance due to lower β-lactamase expression, but how sick the bacteria became when deleted the transporter was very surprising," says the author. (sciencemission.com)
The active ingredient works by stopping protein production in bacteria by binding to a component of the cell known as a ribosome. (labiotech.eu)
Furthermore, the iron chelator siderophore enables bacteria to consider up protein-bound iron from the web host cellular material7. (irjs.info)
Bacteria are able to compete effectively for iron bound to host proteins because of the secretion of high-affinity, low molecular weight iron chelators known as siderophores. (medscape.com)
In order to deprive bacteria of iron, the host also secretes iron-binding proteins. (medscape.com)
It was found high effect on inhibiting the growth of pathogenic bacteria using 5 μl of crude enzyme with specific enzyme activity 73, 76, and 92 (units/ml)/(mg protein/ml) for B. subtilis , B. licheniformis , and B. cereus , respectively. (modernjmicrobiol.com)
Among the causes of cUTI is Enterobacteriaceae, which is a multi-drug resistance (MDR) strain of Gram-negative bacteria. (chronicleshealth.com)

Glyoxalase/fosfomycin resistance/dioxygenase domain [Interproscan]. (ntu.edu.sg)

Intrinsic resistance to antimicrobials has traditionally been attributed to reduced permeability of the cell envelope, presence of inactivating enzymes or efflux pumps that can extrude the antimicrobial agents ( Cox and Wright, 2013 ). (frontiersin.org)
Resistance against β-lactam agents can occur via (i) mutation or expression of alternative penicillin-binding proteins (PBPs) as the drug target, (ii) downregulation of porins to reduce the bacterial permeability against β-lactams, (iii) over-expression of efflux systems which are membrane transport proteins to export drug substrates and (iv) production of β-lactamases that hydrolyze the β-lactam amide [ 6 ]. (biomedcentral.com)
This, subsequently, resulted in the emergence of particular medication and multidrug level of resistance among different strains of microorganisms which includes you need to include AcrAB and mdtK systems, These participate in the Level of resistance Nodulation Division (RND) and Multi Antimicrobial Extrusion (MATE) family members efflux pumps, respectively. (irjs.info)

In addition, this enhanced dose would deal with the relative resistance of enterococcal isolates that have been previously exposed to vancomycin. (medscape.com)
This study's results confirmed an explosion of antibiotic resistance amongst E. coli isolates from UTI against β-lactams and fluoroquinolones. (biomedcentral.com)
4 , 5 One large national survey of urinary isolates from 2015 found resistance rates in Escherichia coli of 43% for ampicillin, 9% for amoxicillin with clavulanic acid, 16% for cefazolin, 22% for trimethoprim, and 7% for ciprofloxacin. (tg.org.au)
In-vitro Antibacterial Activity of a Fosfomycin-Trimethoprim-Sulfamethoxazole Combination Against a Bacterial Collection of Multidrug-Resistant Clinical Isolates. (asm.org)
Establishment of Loop Mediated Isothermal Amplification Assay for the Surveillance of Multi-drug Resistance Markers in P.vivax Clinical Isolates and Chloroquine Transporter Markers in P.falciparum Clinical Isolates. (asm.org)
Alarmingly, isolates displaying a convergence phenotype of carbapenem resistance and hypervirulence have been detected in several countries, representing a serious threat to public health. (bvsalud.org)
In summary, we demonstrated that P. aeuginosa clinical isolates with novel epigenetic markers could form excessive biofilm, which might enhance its antibiotic resistance and in vivo colonization in COVID-19 patients. (frontiersin.org)
The containment of the phenomenon of resistance towards antimicrobials is a priority, especially in preserving molecules acting against Gram-negative pathogens, which represent the isolates more frequently found in the fragile population of patients admitted to Intensive Care Units. (mdpi.com)

January 2023 release - additional MCR phosphoethanolamine transferases, quinolone resistance proteins, and fosfomycin thiol transferases. (mcmaster.ca)

The Comprehensive Antibiotic Resistance Database gratefully acknowledges recent funding from the Genome Canada & Canadian Institutes of Health Research's Bioinformatics & Computational Biology program, allowing integration of the Antibiotic Resistance Ontology (ARO) with the Genomic Epidemiology Ontology, IRIDA platform, and OBO Foundry (see Genome Canada press release ). (mcmaster.ca)
2023. CARD 2023: Expanded Curation, Support for Machine Learning, and Resistome Prediction at the Comprehensive Antibiotic Resistance Database. (mcmaster.ca)

Fosfomycin, sold under the brand name Monurol among others, is an antibiotic primarily used to treat lower urinary tract infections. (wikipedia.org)

Three related fosfomycin resistance enzymes (named FosA, FosB, and FosX) are members of the glyoxalase superfamily. (wikipedia.org)

Carbapenem resistance among Enterobacteriaceae has also increased. (ceufast.com)
Contepo (fosfomycin) for injection is a novel, potentially first-in-class in the United States, intravenous investigational antibiotic with a broad spectrum of Gram-negative and Gram-positive activity, including activity against most contemporary multi-drug resistant (MDR) strains such as extended spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. (chronicleshealth.com)

Any way you look at it, the mutations involved are breaking an existing function rather than creating a new mechanism involving new enzymes or proteins. (creation.com)
New use of the participates_in and has_part relationships in place of formerly incorrect usage of the part_of relationship for association of resistance determinants with their mechanism of action. (mcmaster.ca)
Although QACs may play an important role in the propagation of antibiotic resistance gene (ARGs), the potential contribution and mechanism remains unclear. (bvsalud.org)

The fosfomycin molecule has an epoxide or oxirane ring, which is highly strained and thus very reactive. (wikipedia.org)
These enzymes function by nucleophilic attack on carbon 1 of fosfomycin, which opens the epoxide ring and renders the drug ineffective. (wikipedia.org)
The use of different nucleophilic molecules by enzymes can break up the epoxide ring of fosfomycin and render the molecule ineffective. (mcmaster.ca)
Nabriva Therapeutics is also developing CONTEPO (fosfomycin) for injection, a potential first-in-class epoxide antibiotic for complicated urinary tract infections (cUTIs), including acute pyelonephritis. (chronicleshealth.com)

KEGG) database, Cluster of Orthologous Groups of proteins (COG), Gene Ontology (GO), and protein families (Pfam). (cdc.gov)
Gene products that confer intrinsic resistance to antimicrobial agents may be explored for alternative antimicrobial therapies, by potentiating the efficacy of existing antimicrobials. (frontiersin.org)
We screened the Nebraska Transposon Mutant Library of 1920 single-gene inactivations in S. aureus strain JE2, for increased susceptibility to the anti-staphylococcal antimicrobials (ciprofloxacin, oxacillin, linezolid, fosfomycin, daptomycin, mupirocin, vancomycin, and gentamicin). (frontiersin.org)
Our results demonstrate that many gene products contribute to the intrinsic antimicrobial resistance of S. aureus . (frontiersin.org)
The Antibiotic Resistance Ontology (ARO), draft Mobilome Ontology (MOBIO), draft Virulence Ontology (VIRO), and Resistance Gene Identifier (RGI) are also available at GitHub . (mcmaster.ca)
This is the first study in the region describing changes in the total antibiotic resistance gene (ARG) profile (also known as the resistome) of healthy infants over time. (biomedcentral.com)
Gene cassettes and cassette arrays in mobile resistance integrons. (edu.au)
Partridge SR, Tsafnat G, Coiera E, Iredell JR. Gene cassettes and cassette arrays in mobile resistance integrons. (edu.au)
Plasmid-mediated gene complexes confer high-level resistance to vancomycin and are often used as targets for molecular detection of VRE. (uspharmacist.com)

Vancomycin should be used in patients with a penicillin allergy or infections with strains that have high-level penicillin resistance due to altered PBPs. (medscape.com)
Although some species are inherently resistant to vancomycin, they are far less common than species that acquire resistance through transfer of genetic material. (uspharmacist.com)

Administer orally as fosfomycin tromethamine. (drugs.com)

Virulence, Antimicrobial Resistance Properties and Phylogenetic Background of Non-H7 Enteropathogenic Escherichia coli O157. (cdc.gov)
ERIC genotyping considerably correlated with level of resistance patterns and virulence determinants. (irjs.info)

Its second most advanced drug is Contepo (fosfomycin), a new antibiotic for treating complex urinary tract and kidney infections. (labiotech.eu)

This pump is in charge of level of resistance to quinolones, tetracyclines, and chloramphenicol in a variety of MDR isolates14. (irjs.info)

Such cells are resistant to fosfomycin. (creation.com)
Fosfomycin is a potential treatment option for patients with uncomplicated urinary tract infection due to resistant organisms. (tg.org.au)
As antimicrobial resistance continues to rise globally, multidrug-resistant (MDR) organisms have posed a significant challenge for clinicians, owing to the dearth of effective therapeutic options to combat them. (uspharmacist.com)
In the United States, antimicrobial resistant pathogens caused more than 2.8 million infections and over 35,000 deaths annually from 2012 through 2017, according to the Centers for Disease Control and Prevention (CDC) Antibiotic Resistance Threats in the United States Report[2]. (idsociety.org)
In the present document, guidance is provided on the treatment of infections caused by extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E), AmpC β-lactamase-producing Enterobacterales (AmpC-E), carbapenem-resistant Enterobacterales (CRE), Pseudomonas aeruginosa with difficult-to-treat resistance (DTR-P. aeruginosa), carbapenem-resistant Acinetobacter baumannii species (CRAB), and Stenotrophomonas maltophilia. (idsociety.org)

The contributors describe the mechanisms by which the agents disrupt cell wall assembly and maintenance, membrane synthesis and integrity, DNA and RNA metabolism, protein synthesis, and the folate cycle. (cshlpress.com)

Enzymes conferring resistance to fosfomycin have also been identified and are encoded both chromosomally and on plasmids. (wikipedia.org)

These conditions provide ample opportunities for the evolution and/or transmission of antimicrobial resistance. (elifesciences.org)
During the pandemic of COVID-19, the amounts of quaternary ammonium compounds (QACs) used to inactivate the virus in public facilities, hospitals and households increased, which raised concerns about the evolution and transmission of antimicrobial resistance (AMR). (bvsalud.org)

Fosfomycin is used to treat bladder infections, where it is usually given as a single dose by mouth. (wikipedia.org)

citation needed] Development of bacterial resistance under therapy is a frequent occurrence and makes fosfomycin unsuitable for sustained therapy of severe infections. (wikipedia.org)
The emergence of antimicrobial resistance severely threatens our ability to treat bacterial infections. (frontiersin.org)
Considered a good choice for such infections since incidence of fosfomycin resistance among uropathogens (e.g. (drugs.com)
However, treatment failures also reported and further study needed to evaluate efficacy and safety of oral fosfomycin for treatment of chronic prostatitis and to identify optimal dosage and duration of fosfomycin treatment for such infections. (drugs.com)
Antimicrobial resistance is increasing worldwide, resulting in infections that are more difficult to treat and associated with higher mortality, morbidity and cost. (tg.org.au)
Limited Australian data are available for antimicrobial resistance rates in community-onset urinary tract infections. (tg.org.au)
IV fosfomycin has been approved for a number of indications and utilized for over 45 years outside the U.S. to treat a variety of infections, including cUTIs and other serious bacterial infections. (chronicleshealth.com)

citation needed] Fosfomycin has broad antibacterial activity against both Gram-positive and Gram-negative pathogens, with useful activity against E. faecalis, E. coli, and various Gram-negatives such as Citrobacter and Proteus. (wikipedia.org)

Phenotypic resistance against β-lactams (ceftazidime, cefotaxime, aztreonam and ceftriaxone) and fluoroquinolones (ciprofloxacin) were identified by the disc diffusion technique. (biomedcentral.com)

Knowledge of these intrinsic resistance determinants provides alternative targets for compounds that may potentiate the efficacy of existing antimicrobial agents against this important pathogen. (frontiersin.org)
The intestinal microbiota is considered to be a major reservoir of antibiotic resistance determinants (ARDs) that could potentially be transferred to bacterial pathogens via mobile genetic elements. (nature.com)
The intestinal microbiota plays a pivotal role in this phenomenon as it harbours a vast diversity of bacterial species, some of them possessing antibiotic resistance determinants (ARDs) that may enable their survival under antibiotic exposure. (nature.com)

Findings explain the necessity of deep changes in quantity and quality of drug resistance diagnosis and antibiotic therapy strategies. (biomedcentral.com)
Consider factors for drug resistance, including previous antimicrobial use, and results of recent urine cultures. (ceufast.com)
When starting empiric antimicrobial therapy, make sure to consider factors for drug resistance, including previous antimicrobial use, and results of recent urine cultures. (ceufast.com)
The Antimicrobial Pharmacodynamics and Therapeutics (APT) Group has five research themes that cover different therapeutic areas and patient groups, all centred around drug resistance and dose optimisation. (liverpool.ac.uk)
Complicated cystitis manifests with the same symptoms as uncomplicated cystitis, but additional characteristics include urinary obstruction, male gender, diabetes, history of drug resistance, recurrent cystitis, or pregnancy. (myamericannurse.com)

They share some important properties including high concentrations in the urinary tract, a minimal impact on gastrointestinal flora and a low propensity for resistance ( Table ). (tg.org.au)

Given a greater activity in a low-pH milieu, and predominant excretion in active form into the urine, fosfomycin has found use for the prophylaxis and treatment of UTIs caused by these uropathogens. (wikipedia.org)
Increasing rates of resistance in uropathogens have been reported globally. (ceufast.com)

Fosfomycin was discovered in 1969 and approved for medical use in the United States in 1996[globalize]. (wikipedia.org)

Protein kinase A anchor protein, nuclear localisation signal domain [Interproscan]. (ntu.edu.sg)

However, studies of the biochemical mechanisms that underlie resistance show that the development of resistance gives no support to such 'big picture' evolutionary changes. (creation.com)
Microbial communities in wastewater treatment plants provide insights into the development and mechanisms of antimicrobial resistance. (elifesciences.org)
To better understand the mechanisms underlying antimicrobial resistance within microbial communities in wastewater, de Nies et al. (elifesciences.org)
Although brief descriptions of notable clinical trials, resistance mechanisms, and antimicrobial susceptibility testing (AST) methods are included, the document does not provide a comprehensive review of these topics. (idsociety.org)
This capsule encases the entire cell surface, accounts for the large appearance of the organism on gram stain, and provides resistance against many host defense mechanisms. (medscape.com)

protein_coding" "Cz01g39090.t1","No alias","Chromochloris zofingiensis","Protein N-terminal asparagine amidohydrolase [Interproscan]. (ntu.edu.sg)
protein_coding" "Cz03g09200.t1","No alias","Chromochloris zofingiensis","UV radiation resistance protein/autophagy-related protein 14 [Interproscan]. (ntu.edu.sg)
protein_coding" "Cz03g33270.t1","No alias","Chromochloris zofingiensis","Domain of unknown function DUF155 [Interproscan]. (ntu.edu.sg)
protein_coding" "Cz10g28290.t1","No alias","Chromochloris zofingiensis","Chorismate pyruvate-lyase Rv2949c-like [Interproscan]. (ntu.edu.sg)
Protein N-terminal asparagine amidohydrolase [Interproscan]. (ntu.edu.sg)
Protein of unknown function DUF5068 [Interproscan]. (ntu.edu.sg)
Enoyl-(Acyl carrier protein) reductase [Interproscan]. (ntu.edu.sg)
protein_coding" "Cz02g30180.t1","No alias","Chromochloris zofingiensis","N-(5'phosphoribosyl) anthranilate isomerase (PRAI) [Interproscan]. (ntu.edu.sg)
protein_coding" "Cz03g27200.t1","No alias","Chromochloris zofingiensis","CRAL-TRIO lipid binding domain [Interproscan]. (ntu.edu.sg)
protein_coding" "Cz04g10270.t1","No alias","Chromochloris zofingiensis","Ribosomal protein L1/ribosomal biogenesis protein [Interproscan]. (ntu.edu.sg)

In the past several decades, resistance to multiple antimicrobials has increased rapidly, especially among E. faecium . (msdmanuals.com)

FosC uses ATP and adds a phosphate group to fosfomycin, thus altering its properties and making the drug ineffective. (wikipedia.org)

Fosfomycin can be used as an efficacious treatment for both UTIs and complicated UTIs including acute pyelonephritis. (wikipedia.org)
The standard regimen for complicated UTIs is an oral 3 g dose administered once every 48 or 72 hours for a total of 3 doses or a 6 g dose every 8 hours for 7-14 days when fosfomycin is given in IV form. (wikipedia.org)

Once Enterococcus species colonize the GI tract, the development of antibiotic resistance increases, as does the risk of transmission between patients and providers. (uspharmacist.com)

It can confer resistance to novomycin. (gu.se)

Development of a Rabbit Model of Nosocomial Pneumonia to Combat Emergence of Resistance. (asm.org)

Oral fosfomycin (single 3-g dose) is one of several preferred anti-infectives for empiric treatment of uncomplicated cystitis in women. (drugs.com)

Fosfomycin is bactericidal and inhibits bacterial cell wall biogenesis by inactivating the enzyme UDP-N-acetylglucosamine-3-enolpyruvyltransferase, also known as MurA. (wikipedia.org)

Organisms1

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes4

Information Science1

Genes22

Antibiotics22

Nitrofurantoin1

Bacteria16

Dioxygenase domain1

Efflux3

Isolates8

Quinolone resistance1

Comprehensive Antibiotic Resistance Database2

Monurol1

Glyoxalase1

Enterobacteriaceae2

Mechanism3

Epoxide4

Gene9

Vancomycin2

Tromethamine1

Virulence2

Contepo1

Chloramphenicol1

Resistant5

Synthesis1

EnZYmes1

Transmission of antimicrobial resistance2

Bladder infections1

Infections7

Antibacterial1

Ciprofloxacin1

Determinants3

Drug resistance5

Urinary1

Uropathogens2

19691

Kinase1

Mechanisms5

Interproscan10

Antimicrobials1

Ineffective1

UTIs2

Enterococcus1

Confer resistance1

Emergence1

Cystitis1

Inhibits1