• Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene. (wikipedia.org)
  • We now provide evidence that two growth-regulated, nucleus- and cytoplasm-localized protein kinases, 90-kDa ribosomal S6 kinase (RSK) and mitogen-activated protein kinase (MAP kinase), contribute to the serum-induced phosphorylation of c-Fos. (nih.gov)
  • Although the pattern of corticosterone release was similar between the genotypes, neuronal activation in response to stress, quantified by the expression of the immediate early genes activity regulated cytoskeleton associated protein ( Arc ) and Fos Proto-Oncogene ( cFos ), was blunted in both sexes of animals lacking brain serotonin. (frontiersin.org)
  • Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. (nih.gov)
  • Here we co-inject RB protein with c-myc, EJ-ras, c-fos or c-jun protein. (wdv.com)
  • Are there multiple proteolytic pathways contributing to c-Fos, c-Jun and p53 protein degradation in vivo? (cnrs.fr)
  • The c-Fos and c-Jun oncoproteins and the p53 tumor suppressor protein are short-lived transcription factors. (cnrs.fr)
  • The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. (avivasysbio.com)
  • This antibody also gave a positive signal against the Full length Recombinant FOS protein (Tagged). (abcam.cn)
  • Ben-Yosef T, Yanuka O, Benvenisty N. ECA39 is regulated by c-Myc in human and by a Jun/Fos homolog, Gcn4, in yeast. (bdbiosciences.com)
  • The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. (avivasysbio.com)
  • As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. (wikipedia.org)
  • Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. (nih.gov)
  • c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. (avivasysbio.com)
  • The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. (wikipedia.org)
  • Erratum: Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors (Proc. (tmu.edu.tw)
  • A targeting vector was designed to insert a cre/ERT2-SV40 polyA cassette followed by an FRT5-flanked pSV40-NeoR-pA cassette into the translational start site of the FBJ osteosarcoma oncogene gene (Fos). (jax.org)
  • Mayr D, Hirschmann A, Marlow S, Horvath C, Diebold J. Analysis of selected oncogenes (AKT1, FOS, BCL2L2, TGFbeta) on chromosome 14 in granulosa cell tumors (GCTs): a comprehensive study on 30 GCTs combining comparative genomic hybridization (CGH) and fluorescence-in situ-hybridization (FISH). (cancercentrum.se)
  • Products of myc oncogenes are transcription factors that bind to the DNA sequence, CACGTG, and regulate the expression of multiple target genes. (bdbiosciences.com)
  • Proteína homeótica y factor de transcripción que se localiza en el núcleo celular donde activa la expresión de genes tiroideos específicos como el de la TIROGLOBULINA y el RECEPTOR DE TIROTROPINA. (bvsalud.org)
  • Artificial rearing causes changes in maternal behavior and c-fos expression in juvenile female rats. (mcmaster.ca)
  • As in the case of the tumor cells, treating the non-transformed cells with the various modulators prior to their exposure to CdCl2 resulted in inhibition in the expression of the proto-oncogenes. (cdc.gov)
  • Phosphorylation of the C terminus of c-Fos has been implicated in serum response element-mediated repression of c-fos transcription after its induction by serum growth factors. (nih.gov)
  • Overexpression of the proto-oncogenes in these cells was blocked by superoxide dismutase, catalase and BAPTA/AM confirming that the overexpression of the proto-oncogenes in the tumor cells required elevated levels of ROS and Ca. Inhibitors specific for transcription, PKC and MAP kinase also blocked the overexpression of the proto-oncogenes in the tumor cells. (cdc.gov)
  • nc886's tumor suppressive role is corroborated by the induction of well-known oncogenes such as FOS, NF-κB, and MYC upon its knockdown. (oncotarget.com)
  • Product Description google Sheep anti-Cellular oncogene fos (c-Fos) Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen. (biosensis.com)
  • Cadmium -induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species. (cdc.gov)
  • we conclude that the Cd-induced overexpression of cellular proto-oncogenes is mediated by the elevation of intracellular levels of superoxide anion, hydrogen peroxide and Ca. Further, the Cd-induced overexpression of the proto-oncogenes is dependent on transcriptional activation as well as on pathways involving PKC and MAP kinase. (cdc.gov)
  • The major phosphopeptides derived from biosynthetically labeled c-Fos correspond to phosphopeptides generated after phosphorylation of c-Fos in vitro with both RSK and MAP kinase. (nih.gov)
  • Intended Use Human c Fos ELISA Kit allows for the in vitro quantitative determination of c Fos , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids. (biobool.com)
  • Inquiry About Human c Fos ELISA Kit If you hope to order it or contact us directly, please contact us via [email protected]. (biobool.com)
  • Synthetic peptide corresponding to Human c-Fos aa 200-300 (phospho T232) conjugated to keyhole limpet haemocyanin. (abcam.cn)
  • Component of the SMAD3/SMAD4/JUN/FOS complex required for synergistic TGF-beta-mediated transcription at the AP1 promoter site. (icr.ac.uk)
  • On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. (icr.ac.uk)
  • Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway. (nih.gov)
  • Co-injection of c-myc, but not EJ-ras, c-fos or c-jun, inhibits the ability of Rb to arrest the cell cycle. (wdv.com)
  • The proto-oncogenes c-fos, c-jun, and c-myc were overexpressed in the cell lines. (cdc.gov)
  • This study suggests a role for nuclear RSK and MAP kinase in modulating newly synthesized c-Fos phosphorylation and downstream signaling. (nih.gov)
  • In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. (icr.ac.uk)
  • Products of the fos and jun proto-oncogenes bind cooperatively to the AP1 DNA recognition sequence. (nih.gov)
  • Possible involvement of proto-oncogenes c-jun and c-fos. (nih.gov)
  • Cadmium -induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species. (cdc.gov)
  • The proto-oncogenes c-fos, c-jun, and c-myc were overexpressed in the cell lines. (cdc.gov)
  • Overexpression of the proto-oncogenes in these cells was blocked by superoxide dismutase, catalase and BAPTA/AM confirming that the overexpression of the proto-oncogenes in the tumor cells required elevated levels of ROS and Ca. Inhibitors specific for transcription, PKC and MAP kinase also blocked the overexpression of the proto-oncogenes in the tumor cells. (cdc.gov)
  • As in the case of the tumor cells, treating the non-transformed cells with the various modulators prior to their exposure to CdCl2 resulted in inhibition in the expression of the proto-oncogenes. (cdc.gov)
  • we conclude that the Cd-induced overexpression of cellular proto-oncogenes is mediated by the elevation of intracellular levels of superoxide anion, hydrogen peroxide and Ca. Further, the Cd-induced overexpression of the proto-oncogenes is dependent on transcriptional activation as well as on pathways involving PKC and MAP kinase. (cdc.gov)
  • Osteoblastoma is a rare benign tumor of the bones in which recurrent rearrangements of FOS have been found. (nih.gov)
  • The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. (wikipedia.org)
  • some of these long-term effects include: increased neuron growth , increased neurological activity (e.g., c-Fos and BDNF signaling), improved stress coping, enhanced cognitive control of behavior , improved declarative , spatial , and working memory, and structural and functional improvements in brain structures and pathways associated with cognitive control and memory. (wikipedia.org)
  • Dijke, P. ten & Dam, H. van (2020), TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness, Oncogene 39(22): 4436-4449. (universiteitleiden.nl)
  • This study was undertaken to confirm a previous work (see publication 3649 ) where CDMA and FDMA irradiation caused small but statistically significant increases in Fos levels as cells entered plateau phase during exposure . (emf-portal.org)
  • Absence of 60-Hz, 0.1-mT magnetic field-induced changes in oncogene transcription rates or levels in CEM-CM3 cells. (nih.gov)
  • Our objective was to assess the reproducibility of the 60-Hz magnetic field-induced, time-dependent transcription changes of c-fos, c-jun and c-myc oncogenes in CEM-CM3 cells reported by Phillips et al. (nih.gov)
  • To test this hypothesis in vivo , we generated mice with a nervous system-specific c- fos knock-out using the Cre-loxP system. (jneurosci.org)
  • Adult mice lacking c-Fos in the CNS (c- fos ΔCNS ) showed normal general and emotional behavior but were specifically impaired in hippocampus-dependent spatial and associative learning tasks. (jneurosci.org)
  • Two such gene products, CD44 and ezrin, are both upregulated in fibroblasts transformed by v- fos and are commonly implicated in cell motility and invasion. (silverchair.com)
  • Transcript levels of the oncogenes were measured by Northern analysis and normalized as above. (nih.gov)
  • The use of the system is illustrated by application to rats given subconvulsive doses of picrotoxin to induce a seizure-prone state analogous to epilepsy: levels of the neuronal activity marker c-Fos in the frontal and piriform cortex of picrotoxin-treated rats exposed to 900 MHz GSM radiation were twice as high as those of unexposed animals. (jpier.org)
  • To download a certificate of analysis for pfos-1 [p.fos-1] ( 41040 ), enter the lot number exactly as it appears on your product label or packing slip. (atcc.org)
  • The certificate of analysis for that lot of pfos-1 [p.fos-1] ( 41040 ) is not currently available online. (atcc.org)
  • Estas proteínas se han encontrado en el virus del sarcoma murino Finkel-Biskis-Jinkins (FBJ-MSV) y Finkel-Biskis-Reilly (FBR-MSV), que induce los sarcomas osteogénicos en ratones. (bvsalud.org)