• He is known for discovery of the "Forssman antigen", defined as a glycolipid heterophile antigen found on tissue cells of many animal species. (wikipedia.org)
  • A new histo-blood group system was discovered, based on the identification of Forssman glycolipid antigen on human red blood cells. (ashpublications.org)
  • The unexpected Fs antigen was confirmed in structural, serologic, and flow-cytometric studies. (ashpublications.org)
  • A newly described polymorphism in the GBGT1 gene activates the encoded enzyme to synthesize Forssman antigen. (ashpublications.org)
  • Anti-A(EC) has no ability to release the cellfixed anti-Forssman haemolysin and the cell-fixed blood group A-decomposing enzyme. (karger.com)
  • An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. (lookformedical.com)
  • Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
  • Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (lookformedical.com)
  • Rat anaphylatoxin was found to cause vascular localization and symptoms of anaphylaxis identical with that brought about by antigen-antibody anaphylaxis. (silverchair.com)
  • Nevertheless, Yamamoto discovered that reversion of two inactivating missense mutations in the individual gene (c.688G>A [p.Gly230Ser] and c.887A>G [p.Gln296Arg]) fully restored glycosyltransferase activity allowing the formation of Fs antigen genes in Fs-positive types8. (neighborhoodhousecharterschool.org)
  • However, primates including humans lack Fs synthase activity and have naturally occurring Fs antibodies in plasma. (ashpublications.org)
  • The number of anti-Forssman antibodies in plasma is normally higher in females than in men. (neighborhoodhousecharterschool.org)
  • To be able to determine the prevalence from the anti-Fs antibody, cross-reactions should be performed between RBC containing the Fs plasma and saccharide examples. (neighborhoodhousecharterschool.org)
  • The purpose of this scholarly research was to look for the prevalence of anti-Fs antibodies in plasma examples from human beings, thereby adding data to fortify the classification from the FORS bloodstream group as a fresh histo-blood group. (neighborhoodhousecharterschool.org)
  • Plasma from a person was utilized as a poor control and anti-Fs antibody (M1/22.25.8HL cell line supernatant) was utilized as the positive control. (neighborhoodhousecharterschool.org)
  • Clinical manifestation coincides with the employment of humoral immune mechanisms, enrolling plasma cell recruitment, deposition of myelin-bound IgG and antibody-dependent macrophageal myelin-stripping. (biomedcentral.com)
  • positive family demonstrated uncommon lectin and antibody response patterns, with a solid a reaction to lectin, a vulnerable a reaction to some polyclonal anti-A antibodies and, strangely, no a reaction to monoclonal anti-A antibody, resulting in some controversy5 hence,6. (neighborhoodhousecharterschool.org)
  • The reticulocyte count is usually low during an acute episode, representing an ineffective marrow response either to viral hematopoietic suppression or preferential destruction of RBCs by the D-L antibody. (medscape.com)
  • The Fs antigen exists in several types of individual cancer tumor, including gastric, digestive tract, and lung malignancies9,10. (neighborhoodhousecharterschool.org)
  • Antibodies from an individual that react with ISOANTIGENS of another individual of the same species. (lookformedical.com)
  • Antigens that exist in alternative (allelic) forms in a single species. (lookformedical.com)
  • Using chemical substance and immunological ways of detection it had Oxolamine citrate been confirmed which the Fs antigen is normally absent from healthful tissues of people with Fs-positive tumours, causeing this to be antigen a fascinating applicant for targeted cancers therapy10. (neighborhoodhousecharterschool.org)
  • The type of antibody can be identified with the use of monospecific antibodies to immunoglobulin G (IgG) and complement 3d (C3d). (medscape.com)
  • Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS). (lookformedical.com)
  • Titers greater than 1:64 are likely due to a cold hemagglutinin disease (CHD) antibody, although hemolysis rarely occurs at titers less than 1000. (medscape.com)
  • In some cases (direct antiglobulin test negativity, IgM warm antibodies, cold antibodies with low titers, or Donath-Landsteiner [D-L] antibodies), diagnosis may be difficult, and the expertise of an immune-hematologic laboratory is required. (medscape.com)
  • A study{ 4 } of 6-month-old and 15-month-old infants born to vaccine-immunized mothers demonstrated that, following vaccination with ATTENUVAX, 74% of the 6-month-old infants developed detectable neutralizing antibody (NT) titers while 100% of the 15-month-old infants developed NT. (nih.gov)
  • Recently, however, modifications have been introduced by which quantitative absolute methods for the estimation of antibody nitrogen (3, 4) were made applicable to amounts as small as a few micrograms (5,6). (nih.gov)
  • We tested LGALS4, CEACAM6, TSPAN8, and COL1A2, referred to as the CELTiC panel, using quantitative reverse transcription polymerase chain reaction, on subjects with positive fecal immunochemical test (FIT) results and undergoing colonoscopy. (cancerindex.org)
  • When the red cells are coated with C3d only, the antibody is often but not always a cold antibody. (medscape.com)
  • Antibodies produced by a single clone of cells. (lookformedical.com)
  • On closer scrutiny it developed that the sample of Type VII polysaccharide used con- tained roughly one-third of its weight of the C substance of pneumococcus (8) and that the greater portion of the precipitates obtained with the crude material was due to the reaction of the C substance with anti-C present in almost all of the sera. (nih.gov)
  • The Donath-Landsteiner antibody test, direct antiglobulin test (DAT), and indirect antiglobulin test are all useful in confirming the clinical diagnosis of paroxysmal cold hemoglobinuria. (medscape.com)
  • If the Donath-Landsteiner test results are negative or equivocal and a cold-reacting antibody is still suspected, perform a cold agglutinin titer. (medscape.com)
  • Essential changes were the use of a more sensitive method for measuring antibody protein, allowance of sufficient time for small quantities of specific precipitates to separate from the viscous serum medium, and use of relatively much serum (about 4 ml. per determination) when necessary. (nih.gov)
  • 303 304 ANTIBODY FORMATION TO PNEUMOCOCCI AND POLYSACCHARIDES Owing to the widespread occurrence of antibodies reactive with C substance in normal sera it became necessary to remove these prior to estimation of the type-specific response due to vaccination, since almost all samples of type-specific polysaccharides contain C substance as an impurity and analytical results would otherwise tend tobe too high. (nih.gov)