FAMPYRA 10 mg tablets is a prolonged-release (sustained release) tablet formulation of the drug fampridine (4-aminopyridine or 4-AP). (biogen.com)
BACKGROUND: Gait imbalance is one of the frequent complications in subjects with multiple sclerosis (MS). Fampridine (4-aminopyridine) is a potassium-channel blocker that is administered for gait imbalance in MS. Different studies showed the effects of fampridine on gait status based on various tests in subjects with MS. Some showed significant improvement after treatment, and others did not. (bvsalud.org)
Prolonged-release formulation was developed2
This prolonged-release formulation was developed and is being commercialized in the U.S. by Acorda Therapeutics, Inc. It has been approved in the U.S. under the trade name AMPYRA (dalfampridine) Extended Release Tablets, 10 mg. (biogen.com)
Pelanserin is a weakly basic experimental drug with a short half-life and a prolonged release formulation was developed using hydroxypropyl methylcellulose (HPMC) and citric acid to set up a system bringing about gradual release of this drug. (unboundmedicine.com)
Dalfampridine3
Dalfampridine (4-aminopyridine), a voltage-dependent potassium channel blocker, has been shown to improve walking in patients with MS, as demonstrated by an increase in walking speed. (qxmd.com)
Such improvements were observed in approximately one third of patients treated with an extended-release formulation of dalfampridine in clinical trials. (qxmd.com)
The extended-release formulation of dalfampridine has been shown in clinical trials to improve walking speed in approximately one third of MS patients with ambulatory impairment. (qxmd.com)
Blocker1
A treatment option for downbeat nystagmus (DBN), a common form of acquired fixation nystagmus that often occurs with cerebellar degeneration, is low doses of the potassium channel blocker 4-aminopyridine (4-AP). (herts.ac.uk)
Drug2
Solubility in water at 20 °C (68 °F) is 25 g/L. The drug formulation amifampridine phosphate contains the phosphate salt, more specifically 4-aminopyridine-3-ylammonium dihydrogen phosphate. (wikipedia.org)
Regulatory authorities mandate manufacturers to make efforts to minimize these heterogeneities during process and formulation development, so as to ensure that the safety of patients is not jeopardized and that the drug efficacy stays intact. (chromatographyonline.com)
Product2
Because of the high vulnerability of sunflower, much of the effort was concentrated in this crop, despite the 1976 federal registration of a 4-aminopyridine product, Avitrol® FC Corn Chops-99S, in 14 midwestern states. (escholarship.org)
5) Dry formulations, packaged in containers of 50 pounds or less, of a product that contains 10 percent or less dicamba and is labeled to be used without further dilution. (ca.gov)
Studies2
In 1976 and 1977, studies to improve the use of 4-aminopyridine (4-AP), a chemical frightening agent for protecting crops from blackbird damage, were conducted in sunflower in North Dakota, corn in Ohio, grain sorghum in Kansas, and sprouting rice in Arkansas and Texas. (escholarship.org)
Acute toxicity studies revealed a ca. 150 times lower toxicity of the new compounds as compared to 4-aminopyridine that may be ascribed to their peptide fragment. (bvsalud.org)
Method1
SCOPEThe method is used for the determination of (i) impurities in water-soluble technicalpesticides or (ii) insoluble materials in water-soluble formulations which could causeblockage of sieves or jets in spray machinery. (drugstodaypdf.com)