Formation vesicular transport proteins. Medical search. Frequent questions

They play a role in the intracellular transport of molecules contained within membrane vesicles. (online-medical-dictionary.org)
The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
Due to the spatial segregation of intracellular organelles of eukaryotic cells a sophisticated system of vesicular transport is required to ensure the communication between different compartments. (scilifelab.se)
Rab GTPases function as key regulators of intracellular vesicular transport. (scilifelab.se)
Disrupting any component in this pathway led to disrupted SD on the cell surface and intracellular accumulation of mislocalized SD proteins. (sdbonline.org)
Formation of intraluminal vesicles of MVBs and targeting of transmembrane proteins to these vesicles involve a complex intracellular sorting network, including the endosomal sorting complex required for transport (ESCRT) machinery [2], [15]. (technuc.com)
Although 271 genes linked to hereditary retinal diseases have already been identified, these genes encode diverse functions, including phototransduction, retinol metabolism, and intracellular protein transport. (oist.jp)

One especially interesting aspect of COPII is that it can form typical spherical vesicles and tubules to transport large molecules like collagen precursors, which cannot fit inside typical spherical vesicles. (wikipedia.org)
A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES . (online-medical-dictionary.org)
The outer surface of these vesicles is covered with a lattice-like network of the protein CLATHRIN. (lookformedical.com)
Shortly after formation, however, the clathrin coat is removed and the vesicles are referred to as ENDOSOMES. (lookformedical.com)
An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE. (lookformedical.com)
A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. (lookformedical.com)
The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS. (lookformedical.com)
The ↑[Ca 2+ ] i activates a signaling cascade that involves, sequentially, calcium-calmodulin, nitric oxide synthase, guanylyl cyclase, and protein kinase G. This signal transduction pathway enables Cl − to pass through vesicular channels and act as a counterion for the transport of H + , so that the vesicles of secretogogue-stimulated cells become acidic. (jneurosci.org)
Early to late endosome transport may be mediated by small vesicular intermediates, or may be a maturation process whereby early endosomes lose components through recycling pathways and gain components through fusion with vesicles derived from the secretory pathway. (wormbook.org)
Clathrin and cargo molecules are assembled into clathrin-coated pits on the plasma membrane together with an adaptor complex called AP-2 that links clathrin with transmembrane receptors, concluding in the formation of mature clathrin-coated vesicles (CCVs). (wormbook.org)
As they leave the Endoplasmic Reticulum (ER), properly folded and assembled proteins are selectively packaged into vesicles. (jove.com)
These vesicles are transported by microtubule-based motor proteins and fuse together to form vesicular tubular clusters, subsequently arriving at the Golgi apparatus, a eukaryotic endomembrane organelle that often has a distinctive ribbon-like appearance. (jove.com)
[1] Part of the endomembrane system in the cytoplasm , it packages proteins into membrane-bound vesicle s inside the cell before the vesicles are sent to their destination. (explained.today)
The CGN is the first cisternal structure, and the TGN is the final, from which protein s are packaged into vesicle s destined to lysosome s, secretory vesicles, or the cell surface. (explained.today)
These vesicles mediate the secretion of a wide variety of proteins, lipids, mRNAs, and microRNAs (miRNAs), interact with neighboring cells, and thereby traffic molecules from the cytoplasm and membranes of one cell to other cells or extracellular spaces [1], [2]. (technuc.com)
Exosomes represent a specific subtype of secreted membrane vesicles that are around 30C100 nm in size, formed inside the secreting cells in endosomal compartments called multi-vesicular bodies (MVBs) [2]. (technuc.com)
The Rab family of small GTP-binding proteins has long been implicated in the docking and fusion of transport vesicles with their target membranes. (embl.de)
Vesicular Transport: Large molecules, such as proteins, are transported through the capillary walls via vesicles. (labtestsguide.com)
Vesicles store, transport, or digest cellular products and waste. (wikidoc.org)
Vesicles are a basic tool of the cell for organizing metabolism , transport, enzyme storage, as well as being chemical reaction chambers. (wikidoc.org)
Transport vesicles can move molecules between locations inside the cell, e.g., proteins from the rough endoplasmic reticulum to the Golgi apparatus . (wikidoc.org)
Thus, matrix vesicles convey to the extracellular matrix calcium, phosphate, lipids and the annexins which act to nucleate mineral formation. (wikidoc.org)
COPI coated vesicles are responsible for retrograde transport from the Golgi to the ER, while COPII coated vesicles are responsible for anterograde transport from the ER to the Golgi. (wikidoc.org)

A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane. (lookformedical.com)
It is becoming evident that while the bulk lipid transport occurs via vesicular transport, a major portion of lipids are trafficked by lipid transfer proteins (LTPs). (helsinki.fi)
Endocytosis is the vesicle-mediated process used by all cells to internalize extracellular macromolecules, plasma membrane lipids, and plasma membrane proteins ( Figure 1 ). (wormbook.org)
One important model for mechanistic studies of endocytosis in C. elegans focuses on oocytes, which internalize huge quantities of yolk proteins and their associated lipids by clathrin-mediated endocytosis ( Grant and Hirsh, 1999 ). (wormbook.org)
We found that the FERM domain in the tail region, which is known to bind to lipids as well as other proteins, is essential for both nuclear and chloroplast positioning, whereas the proximal MyTH4 domain plays a supporting role in chloroplast transport. (go.jp)
Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)
Due to the lack of detergent solubilization and reconstitution steps, the nSLBs created using this approach contain essentially all of the native lipids, as well as the membrane-associated proteins and carbohydrates from the donor membrane. (lu.se)

Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules from one subcellular location to another. (wikipedia.org)
While some of the details of how these adaptor proteins achieve their trafficking specificity has been worked out, there is still much to be learned. (wikipedia.org)
Most of the adaptor proteins are heterotetramers. (wikipedia.org)
GGAs (Golgi-localising, Gamma-adaptin ear domain homology, ARF-binding proteins) are a group of related proteins (three in humans) that act as monomeric clathrin adaptor proteins in various important membrane vesicle traffickings, but are not similar to any of the AP complexes and will not be discussed in detail in this article. (wikipedia.org)
Epsin and AP180 in the ANTH domain are other adaptor proteins that have been reviewed. (wikipedia.org)
An almost universal feature of coat assembly is the recruitment of the various adaptor complexes to the "donor" membrane by the protein Arf1. (wikipedia.org)
The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found. (lookformedical.com)
They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2. (lookformedical.com)
A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK. (lookformedical.com)
An adaptor protein complex found primarily on perinuclear compartments. (lookformedical.com)
Many receptors and their associated ligands cluster into clathrin-coated pits by association with clathrin adaptor proteins such as the four-subunit complex AP2. (wormbook.org)
Four-phosphate adaptor proteins 2 (FAPP2) after that transports GluCer towards the biosynthesis. (moonphase2018.com)
TLRs recognize discrete pathogen-associated molecular patterns and activate a set of adaptor proteins (e.g. (technuc.com)

The formation of a COPII vesicle at the endoplasmic reticulum and its transport to the Golgi body. (wikipedia.org)
It is believed to be a novel Rab protein involved in regulating Golgi-associated vesicular transport during cellular endocytosis. (umbc.edu)
Cer is normally shipped by ceramide transportation proteins (CERT) or vesicular transportation towards the Golgi for synthesis of ceramide-1-phosphate (C1P) (by ceramide kinase, CERK), sphingomyelin (SM), and glucosylceramide (GluCer). (moonphase2018.com)
To achieve this goal he wanted me to reconstitute the transfer of a newly synthesized protein destined for the plasma membrane from the ER to the Golgi complex in a cell homogenate. (uu.se)
For instance, how can cells control the diverse patterns of glycosylation of various secretory proteins in the endoplasmic reticulum and Golgi in an orderly manner with high accuracy? (go.jp)

Ceramide sets off many pathways that creates endothelial cell loss of life, including activation of caspases, or PP2A2 or PP1,55, and raising mitochondrial permeability by developing ceramide-enriched platforms with the capacity of translocating protein. (moonphase2018.com)
The regulatory pathways of autophagy and the formation of autophagosome remain the most important questions for understanding autophagy. (scilifelab.se)
The PI3K/Akt/mTOR signaling pathway is a key regulator of diverse physiological functions such as proliferation, global protein, and lipid synthesis as well as many metabolic pathways interacting to increase secretory capabilities. (go.jp)
In eukaryotic cells, protein transport through the secretory and endocytic pathways is mediated by vesicular intermediates. (embl.de)
This effect was found to depend on the Ca 2+ increase mediated by the phospholipase C-β (PLC-β) and protein kinase C (PKC) pathways, as well as by the reverse activity of the Na + /Ca 2+ exchanger. (molvis.org)

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)
The aim of this unit is to examine the molecular mechanisms of protein sorting in eukaryotes, and will review recent data demonstrating that some of these processes are fundamental to all living cells. (manchester.ac.uk)
Rothman wanted to elucidate the molecular mechanisms underlying the vesicular transport of proteins from the endoplasmic reticulum (ER) to the cell surface. (uu.se)
The diversity of processes leading to trapping of topoisomerases suggested that cells might have specific mechanisms to repair the protein/DNA covalent complexes. (prolekarniky.cz)
Although the GTPase switch of Rab proteins is highly conserved, functional mechanisms may be highly diversified among members of the Rab family. (embl.de)

It executes a key step in many cellular events, including cytokinesis and multi-vesicular body formation. (cornell.edu)
Exosomes are membranous nanovesicles released by most cell types from multi-vesicular endosomes. (technuc.com)

Protein targeting to the endoplasmic reticulum. (manchester.ac.uk)
cisterna , also called "dictyosomes"), originating from vesicular clusters that bud off the endoplasmic reticulum . (explained.today)

New insights into protein secretion: TANGO1 runs rings around the COPII coat. (uchicago.edu)
We tested the hypothesis that protein kinase C (PKC) participates in stimulus-secretion coupling. (jneurosci.org)
In November 1980 I returned to Uppsala to work on protein secretion with Prof Per Peterson at the Department of Cell Research. (uu.se)
It is of particular importance in processing protein s for secretion , containing a set of glycosylation enzyme s that attach various sugar monomers to proteins as the proteins move through the apparatus. (explained.today)
Several Rab family proteins, including Rab11 and Rab27b, are key regulators of the exosome secretion pathway and are involved in MVB docking at the plasma membrane [17]. (technuc.com)

Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS , which move molecules across membranes, by the mode in which the molecules are transported. (online-medical-dictionary.org)
My project concerned the release of proteins from membranes by detergentmolecules. (uu.se)
The endosomal sorting complex required for transport (ESCRT) is a conserved protein complex that facilitates budding and fission of membranes. (cornell.edu)
Moss KCBP is postulated to transport the nucleus and chloroplast via direct binding to their membranes, since it binds to and transports liposomes composed of phospholipids in vitro . (go.jp)
Prof. Sima Lev' team showed that the three Nir proteins interact with VAP-B, but each interaction affects the structural integrity of the ER membranes differently. (simalev.net)
Whereas the Nir2-VAP-B interaction induces the formation of stacked ER membrane arrays as demonstrated by electron microscopy analysis, the Nir3-VAP-B interaction leads to a gross remodeling of the ER and the bundling of thick microtubules along the altered ER membranes. (simalev.net)
Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. (lu.se)

They preferentially bind and release hydrophobic peptides by an ATP-dependent process and are involved in post-translational PROTEIN TRANSLOCATION. (lookformedical.com)

This compartmental organisation demands that newly synthesised proteins are accurately and efficiently targeted to their appropriate sub-cellular locations. (manchester.ac.uk)
The LYPxL motif interacts with the cellular protein Alix (ALG2-interacting protein-1, or AIP1), which is associated with the Endosomal Sorting Complex Required for Transport (ESCRT). (eu.org)
LYPxL and PTAP are among the many short linear motifs that were first identified in viral proteins and only later in the regular cellular context. (eu.org)
During normal calcification , a major influx of calcium and phosphate ions into the cells accompanies cellular apoptosis (genetically determined self-destruction) and matrix vesicle formation. (wikidoc.org)

Trafficking of yolk and yolk receptors also depends critically upon the activities of the endocytic Rab proteins RAB-5 , RAB-7 , and RAB-11 , known modulators of endocytosis in all eukaryotes ( Grant and Hirsh, 1999 ). (wormbook.org)
SD proteins are known to undergo endocytosis and recycling to maintain the integrity of the filtration structure. (sdbonline.org)
Using the Drosophila nephrocyte as a genetic screen platform, most genes involved in endocytosis and cell trafficking were screened, and the key components were identified of the cell trafficking pathway required for SD protein endocytosis and recycling. (sdbonline.org)
The SD protein endocytosis and recycling pathway was found to contain clathrin , dynamin , AP-2 complex, like-AP180 (Lap) , auxilin and Hsc70-4 (the endocytosis part) followed by Rab11 and the exocyst complex (the recycling part). (sdbonline.org)
All genes in this SD protein endocytosis and recycling pathway, as well as SD proteins themselves, are highly conserved from flies to humans. (sdbonline.org)
Thus, these results suggest that the SD proteins in human kidney undergo the same endocytosis and recycling pathway to maintain the filtration structure, and mutations in any genes in this pathway could lead to abnormal SD and renal diseases. (sdbonline.org)

The individual proteins of the COPII complex are called SEC proteins, because they are encoded by genes identified in secretory mutants of yeast. (wikipedia.org)
This domain occurred 99 times on human genes ( 182 proteins). (umbc.edu)
The cytoHubba plug-in were used to identify hub genes from the protein-protein interaction network. (biomedcentral.com)

Sorting of proteins to specific compartments within mitochondria. (manchester.ac.uk)

This new approach has been shown to preserve mobility and enzymatic activity of transmembrane proteins in the resulting nSLB. (lu.se)

GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. (umbc.edu)

The cDNAs were derived from a gene, designated ypt1, which codes for a protein of 205 amino acids with 71% homology to the yeast YPT1 gene product. (embl.de)

YP170-GFP, like endogenous yolk, is a cholesterol binding/transport protein related to human ApoB-100, the major protein component of serum low-density lipoprotein (LDL). (wormbook.org)

In this way the vesicle coat clusters selected membrane cargo proteins into nascent vesicle buds. (wikidoc.org)

ORP2 was also found to facilitate cholesterol transport between the late endosomes/lysosomes (LE/LY) and plasma membrane (PM) and to interact with the related LE/LY cholesterol transporter ORP1L. (helsinki.fi)
This study provides the first in vivo evidence of trapped SD proteins in clathrin-coated pits at the plasma membrane when this pathway is disrupted. (sdbonline.org)
calcium:phosphate complexes in the plasma membrane mediated in part by a protein called annexins. (wikidoc.org)

Protein translocation into and across the ER membrane. (manchester.ac.uk)

Alix is associated with the ESCRT system, which is involved in endosomal sorting of membrane proteins. (eu.org)

Immunohistochemistry and immunofluorescence was used to evaluate relative proteins expression. (biomedcentral.com)
Multiplex fluorescence immunohistochemistry was performed to detect the protein level of Rab37 and CHI3L1, and localization of the tumor-infiltrating immune cells in allografts from mice or tumor specimens from cancer patients. (thno.org)

The two smaller proteins are a medium subunit named μ (mu ~50 kD) and a small subunit σ (sigma ~20 kD), and named 1 through 5 corresponding to the 5 AP complexes. (wikipedia.org)

While many studies have been focused on the membrane structure, the dynamics of such systems are crucial for the function of the membrane including membrane bound proteins. (lu.se)

This in-depth analysis will include functional characterization using intestinal organoids where we will assess barrier formation, active ion and water transport, and vesicular trafficking/protein sorting. (grantome.com)
Labeling proteins with synthetic probes, such as fluorophores, affinity tags, and other functional labels is enormously useful for characterizing protein function in vitro, in live cells, or in whole organisms. (scilifelab.se)

Background: The basolateral potassium channels play an important role in maintaining the membrane transport in the renal proximal tubules (PT) and adenosine receptors have been shown to regulate the trans-epithelial Na+ absorption in the PT. (bvsalud.org)

Neuroinflammation and oxidative stress, mitochondrial dysfunction, dysregulation of the expression of histone deacetylases, and aggregation of pathogenic forms of proteins are among the most common and significant pathological features of neurodegenerative diseases. (actanaturae.ru)

Recent evidence, however, suggests that some Rabs may play an additional role in transport vesicle formation. (embl.de)

Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. (umbc.edu)
Disulfiram is highly lipid soluble (accumulates in adipose tissue, crosses blood-brain barrier), highly protein-bound, and has 80% bioavailability after an oral dose of 350 mg. (medscape.com)

A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. (lookformedical.com)

Here, we characterize its functions in carbohydrate and TG metabolism in hepatocytes (HCs), examine its involvement on subcellular transport of cholesterol in endothelial cells (ECs) and assess the role of ORP2 in key cell signaling processes in both HCs and ECs. (helsinki.fi)
Initial, a lot of the regulatory enzymes and proteins involved with sphingolipid metabolism as well as the receptors for S1P have already been cloned. (moonphase2018.com)

Moreover, the effect of adenosine on the 50 pS K+ channel was blocked in the PT pretreated with U-73122 or Calphostin C, suggesting that adenosine-induced stimulation of the 50 pS K+ channels of the PT was due to the activation of phospholipase C (PLC) and protein kinase C (PKC) pathway. (bvsalud.org)
In contrast, the inhibition of phospholipase A2 (PLA2) with AACOCF3 or inhibition of protein kinase A (PKA) with H8 failed to block the adenosine-induced stimulation of the 50 pS K+ channel of the PT. (bvsalud.org)
The canonical TGFβ signalling pathway involves ligand-dependent assembly of a heteromeric receptor complex, receptor-kinase activation and subsequent phosphorylation and activation of SMAD proteins, which are transcriptional regulators that consequently accumulate in the nucleus. (nature.com)

The LYPxL motif binds to the V-domain of eukaryotic Alix protein. (eu.org)
Vesicular transport: how many Ypt/Rab-GTPases make a eukaryotic cell? (embl.de)
The ras-related ypt protein is an ubiquitous eukaryotic protein: isolation and sequence analysis of mouse cDNA clones highly homologous to the yeast YPT1 gene. (embl.de)

A key finding from the original identification of Tdp2 was that the protein was more active in processing 5′ phosphotyrosyl-linked oligonucleotides, and that siRNA knockdown of Tdp2 in mammalian cells resulted in sensitivity to etoposide, a drug targeting topoisomerase II, but not camptothecin, a drug that targets topoisomerase I. Recent work has greatly enhanced our understanding of the biochemistry and structural biology of Tdp2. (prolekarniky.cz)
Mammalian host protein Syntenin has the LYPxL motif. (eu.org)

Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. (uchicago.edu)
It undergoes tyrosine phosphorylation by C-SRC PROTEIN PP60 and plays a regulatory role in CAVEOLAE formation. (bvsalud.org)

Many ligands do not recycle but instead are transported from early to late endosomes and eventually to lysosomes for degradation. (wormbook.org)
Some cargos are further transported to lysosomes through late endosomes. (wormbook.org)
CCVs are then actively uncoated and transported to early/sorting endosomes. (wormbook.org)

Current works are investigating the cooperation of BMP with actors of non-vesicular transport (i.e., proteins including ORPs) or vesicular transport (i.e. exosomes) of cholesterol and oxysterols. (oxysterols.net)

In the AP complexes, there are two large proteins (~100 kD) and two smaller proteins. (wikipedia.org)
The other large protein has different designations in the different complexes. (wikipedia.org)
Parts of the AP complexes have evolved into parts of the GGA and stonin proteins. (wikipedia.org)

Parafollicular (PF) cells secrete 5-HT in response to stimulation of a G-protein-coupled Ca 2+ receptor (CaR) by increased extracellular Ca 2+ (↑[Ca 2+ ] e ). (jneurosci.org)
One of the proteins I studied was the chondroitin-sulphate containing protein bikunin, which, in a complicated way, is involved in the formation of the extracellular matrix. (uu.se)

Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. (umbc.edu)
Individual transport steps are regulated by Ras-like guanine nucleotide-binding proteins, termed Ypt in yeast or Rab in mammals. (embl.de)
The YPT1 gene of the yeast Saccharomyces cerevisiae codes for a guanine nucleotide-binding protein which is essential for cell viability. (embl.de)
Amino acid sequences typical for guanine nucleotide-binding proteins and characteristic for ypt proteins are perfectly conserved in the mouse ypt1 protein. (embl.de)

The ESCRT system is involved in the selective trafficking of membrane proteins to the lysosome by incorporating the membrane proteins into multivesicular bodies (MVBs). (eu.org)
The final step in the biogenesis of MVBs is the ESCRT-mediated abscission of the cargo-containing vesicular membrane from the perimeter membrane (reviewed in Raiborg,2009 ). (eu.org)

They also trap various transmembrane receptor proteins, called cargo receptors, which in turn trap the cargo molecules. (wikidoc.org)

The yeast YPxL motif binds to a hydrophobic groove in the central V-domain of yeast proteins Bro1 and Rim20 (Alix_V domain-containing proteins), which are implicated in vacuolar transport and the pH response respectively. (eu.org)

There is some redundancy among the 11 Ypt proteins, and only those involved in the biosynthetic pathway are essential for cell viability. (embl.de)

[10] Within individual stacks are assortments of enzyme s responsible for selectively modifying protein cargo. (explained.today)

Oxysterol binding protein-related protein 2 (ORP2) belongs to a ubiquitously expressed and conserved family of LTPs, the oxysterol binding protein (OSBP)-relate proteins. (helsinki.fi)
Bis(monoacylglycero)phosphate reduces oxysterol formation and apoptosis in macrophages exposed to oxidized LDL. (oxysterols.net)

The ESCRT-III protein Shrub in flies, or its homologs in yeast (Snf7) or humans (CHMP4B), is a critical polymerizing component of ESCRT-III needed to effect membrane fission. (cornell.edu)
A monoclonal antibody specifically recognizing the 23.5-kd yeast YPT1 protein cross-reacted with a protein of identical size on protein blots of mouse, rat, pig, bovine and human cell lines. (embl.de)
A yeast gene encoding a protein homologous to the human c-has/bas proto-oncogene product. (embl.de)

We focus on zebrafish mutants, in which photoreceptor degeneration is caused by defects in protein synthesis in ER, protein transport from ER to the apical photoreceptive membrane region, and phototransduction. (oist.jp)

AP-5 is associated with 2 proteins, SPG11 and SPG15, which have some structural similarity to clathrin, and may form the coat around the AP-5 complex, but the ultrastructure of that coat is not known. (wikipedia.org)
The vesicle coat serves to sculpt the curvature of a donor membrane, and to select specific proteins as cargo. (wikidoc.org)
The clathrin coat is thought to assemble in response to regulatory G protein . (wikidoc.org)
A coatomer coat assembles and disassembles due to an ARF protein. (wikidoc.org)

Here I continued my work on proteins secreted by hepatocytes, in particular how these proteins are modified during their transport to the cell surface. (uu.se)

Our goal was to identify novel mutations, proteins, and mRNA transcripts that are dysregulated in LGSOC, particularly in short-term survivors. (biomedcentral.com)
The etiopathogenesis of the zinc deficiency occurs as a result of loss-of-function mutations of the zinc-ligand binding protein ZIP4 encoded by the SLC39A4 ( solute carrier 39A) gene located on band 8q24.3. (medscape.com)

W. using the condensation of palmitoyl coenzyme A (CoA) and serine by serine palmitoyltransferase (SPT), an enzyme that's negatively governed by ORM1-like proteins 3 (ORMDL3). (moonphase2018.com)

Clathrin also interacts with cytoskeletal proteins. (lookformedical.com)

Regulatory Rab proteins are thought to inspect the joining of the SNAREs. (wikidoc.org)
Rab protein is a regulatory GTP-binding protein, and controls the binding of these complementary SNAREs for a long enough time for the Rab protein to hydrolyse its bound GTP and lock the vesicle onto the membrane. (wikidoc.org)

Anatomy42

Organisms11

Diseases1

Chemicals and Drugs133

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes48

Disciplines and Occupations1

Information Science3

Health Care1

Intracellular7

Vesicles23

Lipids7

Adaptor13

Golgi5

Pathways5

Mechanisms5

Multi-vesicular2

Endoplasmic2

Secretion5

Membranes7

Peptides1

Cellular4

Endocytosis6

Genes3

Compartments1

Transmembrane proteins1

GTPase1

Amino Acids1

Endogenous1

Clusters1

Plasma membrane3

Translocation1

Endosomal1

Immunohistochemistry2

Medium subunit1

Membrane-bound1

Functional2

Maintaining the membrane1

Mitochondrial1

Vesicle formation1

Lipid2

Molecular1

Metabolism2

Kinase3

Eukaryotic3

Mammalian2

Phosphorylation2

ENDOSOMES3

Exosomes1

Complexes3

Extracellular2

Guanine4

MVBs2

Molecules1

Vacuolar1

Redundancy1

Selectively1

Oxysterol2

Yeast3

Synthesis1

Coat4

Hepatocytes1

Mutations2

Enzyme1

Interacts1

Regulatory2