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  • known as a blastema
  • These stem cells then created a bud (known as a blastema) that developed into a new, fully functional head within two days, allowing the animals to capture prey. (elifesciences.org)
  • Now new research by a British team published on Thursday shows that a protein called nAG, secreted by nerve and skin cells, plays a central role in producing a clump of immature cells, known as a blastema, which regrows the missing part. (yahoo.com)
  • populations
  • Full limb regenerative capacity of failed stumps was restored by reamputation once endogenous macrophage populations had been replenished. (pnas.org)
  • The results are discussed in terms of the control of pattern regulation in localized populations of limb blastema cells. (cloudfront.net)
  • Using viral vectors, we have found that progenitor populations for many different cell types within the blastema are present at all stages of limb regeneration, although their relative proportions change with time. (biologists.org)
  • mammals
  • Anoop Kumar and colleagues from University College London (UCL), writing in the journal Science, said the finding 'may hold promise for future efforts to promote limb regeneration in mammals. (yahoo.com)
  • But unlike mammals which form a scar, the newt forms a blastema . (viewzone.com)
  • induces
  • Because of the restricted expression of Shh to the posterior margin, it remains unclear, however, whether Shh induces the limb polarity directly or through a secondary signal. (biomedcentral.com)
  • spinal cord
  • Continued growth of the blastema is matched by the initiation of angiogenesis, followed by the re-development of peripheral axons and the ependymal tube of the spinal cord. (biomedcentral.com)
  • digits
  • The proposed studies address one of the most pressing needs of the wounded soldier population: the replacement of lost digits and limbs. (pitt.edu)
  • Overexpression of BMP-2 in regenerating limbs caused a loss of digits. (biomedcentral.com)
  • Overexpression of Noggin ( BMP inhibitor) in regenerating limbs also resulted in a loss of digits. (biomedcentral.com)
  • Overexpression of BMP-2 did not cause the formation of extra digits, which is consistent with the hypothesis that it is not the secondary signal of sonic hedgehog. (biomedcentral.com)
  • flatworms
  • For example, salamanders, newts and flatworms are the stars of regeneration science, but more because it's convenient to work with them than because they're the most relevant creatures for our own biology. (discovermagazine.com)
  • proliferation
  • Studying the hydrozoan Hydractinia echinata we show that a burst of stem cell proliferation occurs following decapitation, forming a blastema at the oral pole within 24 hr. (elifesciences.org)
  • However, this remarkable turnover does not result in a high incidence of tumor formation [ 3 ], suggesting that a tight control system is in place that prevents uncontrolled cell proliferation and therefore cancer. (jcancer.org)
  • Inhibition
  • Inhibition and axial deviation of limb regeneration in the newt by means of a digit implanted into the amputated limb Supported by grants from the Damon Runyan Foundation and the Muscular Dystrophy Association. (umich.edu)
  • The inhibition of sonic hedgehog signaling with cyclopamine caused hypomorphic limbs (during development and regeneration) but did not affect the expression of BMP-2 and SOX-9 . (biomedcentral.com)
  • regenerates
  • The regenerates that did form were strongly deviated (45-90°) radially from the longitudinal axis of the limb. (umich.edu)