We are interested in achieving a dynamic description with structural resolution of the full-fibrillation pathway of the enzyme superoxide dismutase 1. (lu.se)
Aggregation of mutant superoxide dismutase 1 (SOD1) is a pathological hallmark of a subset of familial ALS patients. (nature.com)
This process, known as Mehler reaction, results in formation of H 2 O 2 which is generated by the superoxide dismutase (SOD) and converted into water and oxygen by ascorbate peroxidase 9 . (nature.com)
Superoxide dismutase (SOD) is an important antioxidant enzyme present in all oxygen-metabolizing cells. (scirp.org)
The effect of different wavelengths on superoxide dismutase (SOD) has been reported previously which has shown to have a remarkable effect on immune system. (scirp.org)
Trichoderma reesei superoxide dismutase (TrSOD) is a well characterized enzyme being stable between 30 and 90°C for 1 h with activity at pH between 2.6 and 9.0. (pimac.org)
Better combination of kojic acid and other agents (such as superoxide dismutase (SOD), placenta extract, amino acids, sunscreen agents and various kinds of plant extracts, etc. (lookchem.com)
Superoxide Dismutase can clean the excessive superoxide anion radical which Generated by metabolic, can play the role of slowing down the aging body. (soddismutase.com)
Superoxide Dismutase can significantly improve and enhance the human body immune function against the Diseases arising from superoxide anion radical , include tumor, inflammation, emphysema, cataract, and so on. (soddismutase.com)
Superoxide Dismutase also can significantly improve and enhance the human body immune function against the superoxide anion radical-induced factors such as smog, radiation,Toxic chemicals and medicine. (soddismutase.com)
Acrylonitrile (ACN), one of the top 50 chemicals produced in the world, is a very powerful pro-oxidant compound whose metabolism leads to a profound glutathione (GSH) depletion and to a production of cyanide (CN) which, in turn, can inhibit superoxide dismutase (SOD). (cdc.gov)
300 nm) KN photoreduces oxygen to superoxide radical (in DMSO) and nitromethane (CH3NO2) to a nitromethane radical anion (CH3NO2. (nih.gov)
Low concentrations of LPS can be used to "prime" neutrophils toward enhanced function, such as formation of stimulated superoxide anion. (nih.gov)
Previously, we showed that diabetic monocytes produce increased superoxide anion (O 2 − ), and α-tocopherol (AT) supplementation decreases this. (diabetesjournals.org)
Monocytes from type 2 diabetic patients secrete increased superoxide anion (O 2 − ) compared with control subjects ( 2 ). (diabetesjournals.org)
Addition of opsonized zymosan to the granulocyte preparation stimulated production of superoxide anion and hydrogen-peroxide. (cdc.gov)
Antioxidants prevent free radicals induced tissue damage by preventing the formation of radicals, scavenging them, or by promoting their disintegration. (scirp.org)
Subcutaneous injection of sodium selenite led to severe oxidative damage in the lenticular tissues, shown by increased formation of formazan crystals, elevated generation of superoxide, hydroxyl, and nitric oxide radicals, and elevated inducible nitric oxide synthase gene and protein expression that possibly contributed to the opacification of the lens and thus cataract formation. (molvis.org)
Therefore, preventing ROS production or scavenging of free radicals may be an effective strategy for preventing or delaying cataract formation or progression. (molvis.org)
All of the above mentioned conditions can disturb the oxidant-antioxidant balance of the organism and can trigger the formation of free radicals. (bvsalud.org)
Hydroxyl4
Wang, Y. (2023) Evaluation of the role of superoxide radical as chain carrier for the formation of hydroxyl radical during ozonation , Water Research , 242, 120158 (10 pp. (eawag.ch)
The lack of formation of superoxide and hydrogen-peroxide following treatment with unopsonized zymosan indicated that the granulocyte preparation was relatively uncontaminated by monocytes. (cdc.gov)
Reactive oxygen1
The safe compartmentalisation of iron is critical, and should decompartmentalisation occur the Haber-Weiss and Fenton type reactions provide a mechanism for the formation of reactive oxygen species capable of reacting with and causing severe damage to cellular components. (bmj.com)
Inhibit1
NAD+ and NADH inhibit the succinate-supported superoxide generation. (scienceopen.com)
Metabolism1
For this purpose, two different drugs were used: (1) Sodium thiosulfate (STS), a CN antidote commonly used in humans in case of CN poisoning and (2) 4-methylpyrazole (4MP) which blocks ACN metabolism through the oxidative pathway, preventing CN formation. (cdc.gov)
Oxygen6
Burning caesium in excess oxygen will produce caesium superoxide. (wikipedia.org)
But when oxygen is not available in adequate amounts to accept electrons (hydrogen atoms) from NADH, the excess electrons form superoxide from the residual oxygen. (benbest.com)
The microbes lose their cell walls, become trapped in plant cells, and are hit with reactive oxygen (superoxide). (rutgers.edu)
The rate of superoxide formation during Deltamu(H(+))-controlled respiration with succinate depends linearly on oxygen concentration and contributes approximately 0.4% of the overall oxidase activity at saturating (0.25 mM) oxygen. (scienceopen.com)
In preclinical studies, CIT enhanced the L-arginine/asymmetrical dimethylarginine ratio, boosted Nitric Oxide (NO) levels, protected endothelial function by lowering superoxide generation, and the accompanying ELK- 1 and p-CREB, two oxygen-sensitive proteins[ 3 - 5 ]. (ijpsonline.com)
With intact cells, the to radiation killing compared with well formation of oxygen reactive intermediates oxygenated healthy cells [ 2,3,7-9 ]. (who.int)
Oxidative stress1
Ab-TrSOD, when compared to TrSOD, promoted a decrease in the formation of ROS of 19 and 14% at the concentrations of 1 and 6 μmol/L, respectively, indicating that this joplinks Recombinant Human Regulator of G-protein form was more effective in reducing oxidative stress compared to SOD without the cell penetrating peptide (CPP). (pimac.org)
NADH5
Oxidation of cysteine, NADH, and EDTA was accompanied by superoxide radical formation. (nih.gov)
Generation of superoxide-radical by the NADH:ubiquinone oxidoreductase of heart mitochondria. (scienceopen.com)
In contrast to NADH oxidase, the rate-substrate concentration dependence for the superoxide production shows a maximum at low (approximately 50 microM) concentrations of NADH. (scienceopen.com)
Deactivation of Complex I results in almost complete loss of its NADH-ubiquinone reductase activity and in increase in NADH-dependent superoxide generation. (scienceopen.com)
One site (F) serves as an entry for the NADH oxidation and the other one (R) serves as an exit during either the succinate-supported NAD+ reduction or superoxide generation or NADH-ferricyanide reductase reaction. (scienceopen.com)
Significantly1
Furthermore, inhibition of NADPH oxidase or scavenging of superoxide significantly reduced the rotenone-induced neurotoxicity. (jneurosci.org)
Enzyme1
Tyrosinase is a key enzyme in melanin formation. (lookchem.com)
Cataract1
this has been identified as one of the major triggering factors for human senile cataract formation. (molvis.org)
Protein1
Our research is focused on a quantitative description of protein amyloid formation. (lu.se)
Production1
It is well established that the formation of normal numbers of Sertoli cells is a key factor in determining testis size, germ cell numbers per testis, and sperm production rate in adulthood in a range of mammals, including humans [ 17 ]. (hindawi.com)
Electron1
We have employed electron paramagnetic resonance (EPR) spectroscopy to study free radical formation and electron partitioning in TROL-depleted chloroplasts. (nature.com)
Generation1
In this paper the superoxide generation by Complex I in tightly coupled bovine heart submitochondrial particles is quantitatively characterized. (scienceopen.com)
Reduction1
OTHER PROPERTIES Solutions of paraquat become intensely purple on reduction, due to the formation of a water soluble, relatively stable free radical, which absorbs at 400 nm. (inchem.org)
Collagen1
Moreover, pearl can improve the formation and regular deposition of collagen, and enhance the skin angiogenesis. (selfgrowth.com)
Free radical formation1
Our studies 1-3 support the hypothesis of Golden 4 that increased free radical formation and a deficiency of micronutrients essential for protective antioxidant function exists in malnourished children. (bmj.com)
Substantially1
formation is substantially smaller than that with succinate as the substrate. (scienceopen.com)
Inclusions1
reported that chronic administration of a common herbicide, rotenone, resulted in a selective destruction of the nigrostriatal dopaminergic system, formation of cytoplasmic inclusions in nigral neurons, and induction of hypokinesia and rigidity in rats, reproducing the key features of human PD. (jneurosci.org)
Release1
Mechanistically, rotenone stimulated the release of superoxide from microglia that was attenuated by inhibitors of NADPH oxidase. (jneurosci.org)
We hypothesized that, in retina, angiotensin II (Ang II) downregulates GLO-I, which leads to an increase in methylglyoxal-AGE formation. (diabetesjournals.org)
Standard1
The standard enthalpy of formation ΔHf0 of caesium superoxide is −295 kJ/mol. (wikipedia.org)