Formation of new vessels angiogenesis modulating agents. Medical search. Frequent questions

This review article focuses on the role of honey in modulating the development and progression of tumors or cancers. (mdpi.com)
Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment? (nature.com)
Curcumin can slow the growth of these tumors by inhibiting angiogenesis. (beatcancer.org)
We describe areas where major inroads were initially achieved by targeting angiogenesis and by unraveling pathways in the heterogeneous tumors of mesenchymal origin-spurred by the identification of c-Kit-activating mutations in GIST and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec). (cancernetwork.com)
Here, in Part I, we describe areas where major inroads were initially achieved by targeting angiogenesis (central to the biology of renal cell carcinoma and hepatocellular cancer) and by unraveling pathways in the heterogeneous tumors of mesenchymal origin-spurred by the identification of c-Kit-activating mutations in gastrointestinal stromal tumors (GIST) and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec). (cancernetwork.com)
At present, and for some years to come, the treatment of most solid tumors will continue to rely on a patchwork of empirically derived and newly introduced molecularly targeted agents. (cancernetwork.com)
Passive targeting occurs due to poorly differentiated vasculature of solid tumors by a process called angiogenesis. (trialx.com)

We now know that VEGF not only plays a major role in controlling blood vessel formation, but also modulates tumor-induced immunosuppression. (nih.gov)
Folkman, J. Tumor angiogenesis: therapeutic implications. (nature.com)
Kerbel, R. S. Tumor angiogenesis. (nature.com)
Weis, S. M. & Cheresh, D. A. Tumor angiogenesis: molecular pathways and therapeutic targets. (nature.com)
Overall, these findings highlight the potential of HNK as an immunotherapeutic agent for mBCSCs by modulating the tumor immune environment. (hindawi.com)
In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
Angiogenesis is essential in the process of carcinogenesis to facilitate tumor progression and metastasis. (spandidos-publications.com)
The vascular endothelial growth factor (VEGF) is a well characterized angiogenic factor known to stimulate angiogenesis within a tumor ( 1 ). (spandidos-publications.com)
Targeted suppression of AFAP1L1 specifically in endothelial cells in vivo proves effective in inhibiting tumor formation and ocular pathological neovascularization. (biomedcentral.com)
Our recent studies demonstrated D2R agonists, including FDA approved cabergoline, inhibit lung cancer growth in in vivo models by reducing angiogenesis and tumor infiltrating immune suppressor cells. (umn.edu)
Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma. (rochester.edu)

Vascular endothelial growth factor (VEGF) and its receptors are among the most widely validated signaling pathways involved in angiogenesis. (arvojournals.org)
BPC 157 stimulates the formation of new blood vessels by activating certain growth factors and signaling pathways involved in angiogenesis. (marketingoutsourcing.es)

However, clinical experience with anti-angiogenic agents has shown that this is not always the case. (nature.com)
In 1996, we formally recognized and described non-angiogenic tumours in lungs where the only blood vessels present were those originating from normal lung tissue. (nature.com)
The in-growth of new blood vessels is mediated by the upregulation of angiogenic cytokines. (aao.org)
Heparin modulates the expression of anti-angiogenic and pro-angiogenic factors. (aao.org)
Using α v β 3 -integrin-targeted perfluorocarbon nanocarriers to deliver Fum-PD specifically to angiogenic vessels, we effectively suppressed clinical disease in an experimental model of rheumatoid arthritis (RA). (wustl.edu)
Studies show many of the ingredients in the Mediterranean diet are natural anti-angiogenic agents. (patrioticpost.com)
Among the angiogenic mediators, vascular endothelial growth factor (VEGF) is considered to be the main stimulating factor, which acts via promoting the migration and proliferation of vascular endothelial cells, and thereby stimulates the generation of new blood vessels ( 6 ). (spandidos-publications.com)
Recently, several novel agents targeting growth factor receptors, angiogenic pathways, adhesion molecules and mediators of intracellular signal transduction have been clinically explored. (docksci.com)

Moreover, Dicer effects in vivo angiogenesis, a process which is unaffected by Drosha. (uni-frankfurt.de)
It also affects the in vitro and in vivo formation of new vessels [8]. (deepdyve.com)
In vivo, NO-induced AMPK activation inhibits mammalian target of rapamycin (mTOR) activity and enhances autophagic flux, as evidenced by p62 depletion and increased autolysosome formation. (wustl.edu)

These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)
We found that VEGFR-2 is a requirement for endothelial Dll4 upregulation and filopodia formation following Notch inhibition, both independently of VEGFR-3. (helsinki.fi)
The principal mechanism of angiogenesis inhibition entails the regulation of tip cell behavior through the YAP-DLL4-NOTCH axis. (biomedcentral.com)
Inhibiting AFAP1L1 results in the inhibition of angiogenesis by suppressing the germination of endothelial tip cells through the YAP-DLL4-NOTCH axis. (biomedcentral.com)
In the tracheobronchial (airway) vasculature, these include the inhibition of inflammatory hyperperfusion, microvascular hyperpermeability, mucosal oedema formation, and the formation of new blood vessels (angiogenesis). (ersjournals.com)
Integrin α5β1 inhibition by ATN-161 may be a promising alternative therapy for CNV-related angiogenesis. (arvojournals.org)

Near infrared light therapy has been found to alleviate inflammation by modulating the activity of inflammatory cells and reducing the release of pro-inflammatory molecules. (tier1tc.com)
According to research published in Clinics in Dermatology , they can be used in the dermatology and skin care industries to improve skin issues, such as inflammation, pigmentation, cell proliferation and migration, and changes in angiogenesis (making new blood vessels). (draxe.com)
Immature new blood vessels may lead to lipid exudation, persistent inflammation, and scarring, thus threatening corneal transparency and visual acuity. (aao.org)
The degree of inflammation has a direct impact on the ultimate scar formation. (medscape.com)
We herein present evidence that Fum-PD nanotherapy indirectly suppresses inflammation in experimental RA through the local production of endothelial nitric oxide (NO). Fum-PD-induced NO activates AMP-activated protein kinase (AMPK), which subsequently modulates macrophage inflammatory response. (wustl.edu)
Genomic actions involve the regulation of target genes, and suppress most of the vascular elements of inflammation and angiogenesis in the airway. (ersjournals.com)

Curcumin is a multi-targeted agent which can modulate several oncogenic signaling cascades and can be effective for multiple human cancers. (beatcancer.org)
Oleuropein, a natural compound found in olive oil, can modulate several oncogenic signaling pathways and is used in the prevention and treatment of cancer. (patrioticpost.com)

But recent advances in our understanding of neovascularization have made angiogenesis a prime target for therapeutic manipulation in wound healing. (docksci.com)
Corneal neovascularization (NV) is a pathologic condition of the cornea, characterized by the formation and extension of new vascular capillaries within and into the previously avascular corneal regions, extending from the limbus into the superficial or deep areas of the cornea. (aao.org)
Topical treatments for corneal neovascularization include steroids and anti-VEGF agents are currently the mainstay initial treatment for corneal neovascularization. (aao.org)
have also pointed out that SNAI2 downregulation is related with reduced angiogenesis of mice with retinal neovascularization [ 14 ]. (hindawi.com)
This study demonstrated that overexpression of miR-203 suppressed the angiogenesis in mice with pathological retinal neovascularization disease via the inactivation of GSK-3 β / β -catenin pathway by inhibiting SNAI2. (hindawi.com)

When the VEGF-A-targeting monoclonal antibody bevacizumab (Avastin®) entered clinical practice more than 15 years ago, it was one of the first targeted therapies and the first approved angiogenesis inhibitor. (nih.gov)
VEGF paves the way for new blood vessel formation by upregulating matrix metalloproteinases production by endothelial cells in the limbal vascular plexus. (aao.org)
i.p) or vehicle administered 24 hours after permanent middle cerebral artery occlusion (pMCAO) on behavior, angiogenesis, ultra-structural integrity of brain capillary endothelial cells, and expression of EPO and VEGF were assessed. (researchgate.net)
Repeated treatments with Catalpol reduced neurological deficits and significantly improved angiogenesis, while significantly increasing brain levels of EPO and VEGF without worsening BBB edema. (researchgate.net)
These results suggested that catalpol might contribute to infarcted-brain angiogenesis and ameliorate the edema of brain capillary endothelial cells (BCECs) by upregulating VEGF and EPO coordinately. (researchgate.net)
Vascular endothelial growth factor (VEGF) is required for blood vessel formation and promotes permeability in veins. (umn.edu)
Dopamine (DA) and dopamine D2 receptor (D2R) agonists inhibit VEGF-mediated blood vessel development (angiogenesis) and vascular permeability by inhibiting VEGF binding, VEGF receptor phosphorylation and subsequent downstream signaling. (umn.edu)
ATN-161 inhibited VEGF-induced migration and capillary tube formation in hCECs, but did not inhibit proliferation. (arvojournals.org)
A study has demonstrated that activation of the peroxisome proliferator-activated receptor g coactivator 1-α (PGC-1α)/ERRα pathway increases VEGF expression and angiogenesis in endothelial cells, which suggests that ERRα may be involved in the pathogenesis of DR ( 10 ). (spandidos-publications.com)

The molecular mechanism by which vascular endothelial receptors (VEGFRs) control vessel growth and function in physiological and pathological settings is under intensive study, but questions remain. (helsinki.fi)
Pathological angiogenesis has a causal role in these eye diseases. (deepdyve.com)
These results suggest that RSV may be and Ewa Piatkowska ˛ useful in the prevention or treatment of pathological angiogenesis in eye disorders. (deepdyve.com)

Inhibit Angiogenesis - Curcumin slows new blood vessel growth by blocking vascular growth factors. (beatcancer.org)
[4] The main therapeutic aim of these treatments is to initiate anti-angiogenesis and inhibit the neoangiogenesis at early stages, whereas the other treatment modality aims to achieve angio-regression by inducing reversion of immature vessels. (aao.org)
Currently, we are focused on understanding how a signaling molecule downstream of the dopamine D2 receptor, called DARPP-32 (dopamine and cyclic-AMP-regulated phosphoprotein), can be modulated to inhibit lung cancer growth. (umn.edu)
The antiangiogenic efficacy of resveratrol can inhibit the metastasis of glioma cancer cells and angiogenesis in melanoma and can decrease microvessel density in lung carcinomas. (patrioticpost.com)
The results showed that miR-429 was significantly upregulated in the serums of the patients, and overexpressed miR-429 could extremely inhibit the viability, migration, and tube formation of OGD-induced HBMECs. (hindawi.com)

Regardless of this, the capacity of miR-92a to target various downstream effectors might be an advantage of miRNA-based therapeutic strategies and may overcome the limited therapeutic capacity of single growth factor or single gene therapies in ischemic diseases, since the highly organized process of vessel growth, maturation and functional maintenance is well known to require the fine-tuned regulation of a set of genes. (uni-frankfurt.de)
Elucidation of this mechanism is essential for the therapeutic manipulation of these pathologies, and in the future, more than 500 million people worldwide may benefit from pro- or anti-angiogenesis treatment. (helsinki.fi)
Due to their small size, nanoparticles can also penetrate the blood-brain barrier which is impervious to most therapeutic and imaging agents. (trialx.com)
As a substitute of injecting some therapeutic agent or prompting supranormal physiological responses, PEMF enhances your physique's skill to do what it will ideally do naturally: preserve homeostasis, heal from harm, combat off overseas invaders, and eradicate dysfunctional cells (together with cancerous ones). (purehealthy.co)
Therefore, improving the angiogenesis of patients has been increasingly recognized as a promising therapeutic strategy for the treatment of ischemic stroke. (hindawi.com)
One of the key mechanisms through which BPC 157 exerts its therapeutic effects is by promoting angiogenesis, which is the formation of new blood vessels. (marketingoutsourcing.es)

Endogenous inhibitors of angiogenesis include thrombospondin 1 (TSP-1) and a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1), and their aberrant expression may contribute to the diabetes-related dysregulation of retinal vascular homeostasis and vasculopathies ( 7 , 8 ). (spandidos-publications.com)

HBOT stimulates the formation of new blood vessels, enhancing blood flow to the injured areas of the brain. (tier1tc.com)
Near infrared light stimulates the production of nitric oxide, a molecule that dilates blood vessels and improves blood flow. (tier1tc.com)
Solid tumours need a blood supply, and a large body of evidence has previously suggested that they can grow only if they induce the development of new blood vessels, a process known as tumour angiogenesis. (nature.com)
Figure 2: Patterns of tumour growth in relation to blood vessels. (nature.com)
According to a 2016 article in Life Extension , "a rapidly growing and poorly differentiated (higher grade) cancer can be distinguished by its high rate of new blood vessel formation (angiogenesis). (beatcancer.org)
Blood and lymphatic vessels form extensive networks, which deliver oxygen and nutrients to the tissues and remove extravasated fluid. (helsinki.fi)
Advanced stages, in which ingrown blood vessels reach the visual axis, can become permanently vision-threatening and, in patients with corneal grafts, may contribute to rejection. (aao.org)
The diagnosis is made by clinical examination at the slit lamp, in which blood vessels cross the corneal limbus. (aao.org)
[9] The use of steroids (such as cortisone) in conjunction with heparin and cyclodextrins causes a greater antiangiogenic effect, leading to the development of 'angiostatic steroids', which are thought to modulate collagen metabolism that can completely disintegrate the basement membrane of the blood vessels. (aao.org)
Angiogenesis is the intricate process of generating fresh blood vessels from pre-existing ones. (biomedcentral.com)
The major structural and functional changes related to the airway circulation include the proliferation of blood vessels (angiogenesis) 2 - 4 , increased blood flow 5 , 6 , increased microvascular permeability 7 , 8 , and oedema formation in the airway wall 9 . (ersjournals.com)
and 3) the interactions of corticosteroids and airway blood vessels by which inflammatory changes of the airway vasculature can be reversed in patients with asthma. (ersjournals.com)
Angiogenesis is a process involving growth of formation of new blood vessels from old pre-existing ones. (trialx.com)
Cancer cells enter the circulatory system via these new blood vessels to disseminate. (patrioticpost.com)
They can successfully prevent and even control cancer by suppressing angiogenesis in the human body and reducing the imbalance of blood vessel formation. (patrioticpost.com)
Stroke is an acute cerebrovascular disease induced by the sudden rupture of blood vessels or vascular obstruction, which seriously threaten the health of millions of people all over the world in each year [ 1 , 2 ]. (hindawi.com)
For restoring the blood supply, the progression of the angiogenesis will undergo when the body suffered insufficient blood supply [ 4 ]. (hindawi.com)
Patients with higher blood vessel density showed better functional recovery after ischemic stroke impact. (hindawi.com)
Blood Vessel Patterning on Retinal Astrocytes Requires Endothelial Flt-1 (VEGFR-1). (vt.edu)
This results in improved blood flow to the heart's own coronary blood vessels. (olives101.com)
Although they utilize different mechanisms of action (oleuropein acts as a natural calcium channel blocker and captopril is a well-known ACE-inhibitor), both oleuropein and captopril function inside the vasculature to decrease the tension in the walls of blood vessels and promote widening of the vessels (vasodilation), ultimately lowering blood pressure. (olives101.com)
they also regulate the distribution of smooth muscle cells and sustain an even flow of blood through vessels. (olives101.com)
They increase the production of nitric oxide, a signaling molecule that helps relax blood vessels. (olives101.com)
The early clinical signs of DR include microaneurysms and hemorrhages, while the later signs are narrowed, tortuous and irregular retinal blood vessels, due to the formation of abnormal new blood vessels at the back of the eye in proliferative DR ( 4 ). (spandidos-publications.com)
During the new blood vessel formation process, capillaries are formed when endothelial cells are stimulated to migrate, proliferate and invade the surrounding tissues ( 5 ). (spandidos-publications.com)
It promotes the healing process by increasing collagen production and blood vessel formation. (marketingoutsourcing.es)
This promotes the formation of new connective tissue, blood vessels, and other components necessary for tissue regeneration. (marketingoutsourcing.es)

BPC 157 works by promoting angiogenesis, increasing collagen production, and modulating the immune response in the body. (marketingoutsourcing.es)

IL-1 stimulates the proliferation of inflammatory cells and promotes angiogenesis through endothelial cell replication. (medscape.com)

The researchers observed that because available anti-cancer drugs exhibit limited efficacy, are associated with severe side effects , and are also expensive, identification of pharmacological agents without these disadvantages is necessary. (beatcancer.org)
A review published in Frontiers in Cellular and Infection Microbiology indicates that antimicrobial peptides are used as pharmacological agents to modulate the immune response, promote wound healing and prevent post-surgical adhesions. (draxe.com)

The antiangiogenic potential of ATN-161 was evaluated in VEFG-stimulated hCECs by MTS proliferation assays, migration assays, and synthetic matrix capillary tube formation assays. (arvojournals.org)
In addition, HREC proliferation, migration and cell sprouting were determined using Cell Counting kit‑8, wound scratch and tube formation assays, respectively. (spandidos-publications.com)
Compared with 5 mM normal glucose treatment, high (30 mM) glucose significantly promoted the proliferation, migration and tube formation of HRECs, which was antagonized by 10 and 30 µM kaempferol in a dose‑dependent manner. (spandidos-publications.com)

The relationship between Vit D and PE development may explain its impact on implantation, angiogenesis, and endothelial status, regulation of the immune response, effect on RAAS, and calcium metabolism. (encyclopedia.pub)
How does BPC 157 modulate the immune response? (marketingoutsourcing.es)

In conclusion, this study suggests that miR-429 inhibits the angiogenesis of HBMECs through SNAI2-mediated GSK-3 β / β -catenin pathway. (hindawi.com)

Regulation of angiogenesis in repair 2.4.1. (docksci.com)
Regulation of repair by angiogenesis 2.6. (docksci.com)

While previous studies found the truncation of amyloid A (AA) and amyloid transthyretin (ATTR) occurs in C- and N-terminal, respectively, the detailed mechanism of the fibril formation remains unclear. (bvsalud.org)
Overall, the mechanism of action of BPC 157 involves a complex interplay of cellular and molecular events that promote tissue repair, angiogenesis, and anti-inflammatory responses. (marketingoutsourcing.es)

It is well established that angiogenesis is strongly associated with improvement of neurological deficits after stroke [ 3 , 4 ]. (hindawi.com)

In sum, these results provide new insights into the treatment of angiogenesis-related diseases, such as cancer. (helsinki.fi)
These unexpected results uncover an activity of Fum-PD nanotherapy that may be further explored in the treatment of angiogenesis-dependent diseases. (wustl.edu)
19 published his findings on cortisone causing dramatic improvements in patients with rheumatoid arthritis, corticosteroids have become established as the most potent anti-inflammatory agents in the pharmacotherapy of various chronic inflammatory diseases, including asthma 20 . (ersjournals.com)
In recent decade, increasing evidences have been confirmed that dysfunctions of miRNAs involve in the formation and development of many disease ranging from cancers to neurological diseases [ 8 , 9 ]. (hindawi.com)

Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)

Biology of Vessel Growth in Wounds 2.1. (docksci.com)
ANGIOGENESIS The 'sprouting' model of angiogenesis (Ausprunk, 1979) originates from studies in various transparent, essentially two-dimensional, experimental wounds, from frog's webs (Wharton-Jones, 1850) to the rabbit ear chamber (Clark and Clark, 1939). (docksci.com)

Vessel growth is controlled by the local actions of chemical mediators, the extracellular matrix, metabolic gradients, and physical forces. (docksci.com)
Practical stratagems to modulate vessel growth have been exploited, consciously and otherwise, by surgeons since the ancient Hindu invention of flap repairs (Prakash, 1978). (docksci.com)
BPC 157 has been shown to stimulate the production of growth factors and cytokines that promote angiogenesis, thereby enhancing the body's natural healing processes. (marketingoutsourcing.es)

Wound healing cannot occur without angiogenesis, The vasculature comprises up to 60% of repair tissue (Dyson et aI. (docksci.com)
1991), and the original name for the temporary organ of repair, 'granulation tissue' (Hunter, 1787), is derived from the prominence of its vessels. (docksci.com)
Reduce Production of Adhesion Molecules - Curcumin keeps malignant tissue from sticking to vessel walls and reduces cancer cells' ability to form distant metastases. (beatcancer.org)
The newly formed vessels after stroke not only improved tissue perfusion but also closely linked with neurovascular remodeling, axonal sprouting, and remyelination [ 1 - 4 ]. (hindawi.com)

Angiogenesis in wound healing. (docksci.com)
Department of Cell and Structural Biology, University of Manchester M I3 9PL, U.K. t Department of ,tmmunology, University of Liverpool, P.O. Box 147, L69 3BX, U.K. Abstraet--Angiogenesis is an essential component of wound healing. (docksci.com)
How do wound vessels grow and what are the signals which control them? (docksci.com)
In addition, angiogenesis, epithelization, and the production of new glycosaminoglycans (GAGs) and proteoglycans are vital to the wound healing milieu. (medscape.com)
The qRT-PCR was used to measure the expression levels of the miR-429 in the serums of the patients or cells, and CCK-8, wound healing assay, and tube formation assay were used to observe the effects of miR-429 on the phenotype of HBMECs. (hindawi.com)
Eicosanoids mediate activity influencing platelet plug formation, vascular permeability, and cellular chemotaxis to influence wound healing. (medscape.com)

HBOT has been shown to modulate the inflammatory response, reducing the release of pro-inflammatory substances and promoting the production of anti-inflammatory agents. (tier1tc.com)
This study brought the first indications that, in contrast to its starting substances thiotepa (a well known cytostatic agent) and greater celandine alkaloids, NSC631570 is in fact only toxic against cancer cells and not against normal cells. (ukrin.com)

Despite administration of front-line chemotherapeutic agents with molecular targeted systemic therapies, the survival rate of NSCLC patients remains dismal due to the large number of individuals diagnosed with advanced stage disease and the primary and secondary resistance to current therapies. (umn.edu)

SNAI2, an angiogenesis-related factor, was highly expressed under the high glucose condition and also led to viability and migration of human brain microvascular endothelial cells (HBMECs) [ 13 ]. (hindawi.com)
The results of this study suggest that kaempferol targets ERRα and suppresses the angiogenesis of HRECs under high glucose conditions. (spandidos-publications.com)

According to this 'central dogma', angiogenesis is thought to initiate predominantly from venules. (docksci.com)

These findings demonstrated that key TF related to lipid metabolism could be modulated by dietary inclusion of soybean oil. (nature.com)

Our first study showed that VEGFR-2 could to sustain angiogenesis to some extent and that postnatal angiogenesis requires VEGFR-2 signaling also in the absence of VEGFR-3. (helsinki.fi)

Immunonutrition refers to circumstances where feeding specific nutrients present a potential to modulate the activity of the immune system. (nature.com)

Then the survival cells were collected to investigate their potential of colony formation, attachment, invasion, and migration. (scielo.br)

Angiogenesis is a complicated and sequential process, which occurs in the ischemic penumbra within hours after stroke and lasts for weeks. (hindawi.com)

Overall, bevacizumab is expected to remain a key agent in cancer therapy, both due to its established efficacy in approved indications and its promise as a partner in novel targeted combination treatments. (nih.gov)
These data indicate that AST may be an effective chemotherapeutic agent in colon cancer treatment, and may also be used as an adjuvant in combination with other orthodox chemotherapeutic drugs to reduce the side-effects of the latter compounds. (spandidos-publications.com)
A patient referred for keloid formation after excision of facial cancer and reconstruction. (medscape.com)

BCSCs are mostly dormant and therefore activating dormant cells, and modulating the cell cycle is important for achieving successful BCSCs therapy [ 7 ]. (hindawi.com)
By actively targeting nanoscale drug delivery systems it is possible to minimize the uptake of anticancer agent by normal cells thus minimizing the side effects of therapy. (trialx.com)
At lower NSC631570 concentrations malignant cells die as a result of apoptosis, at higher concentrations the formation of microtubules is prevented und polyploidy occurs (62). (ukrin.com)

Fumagillin, a mycotoxin produced by Aspergillus fumigatus that binds methionine aminopeptidase 2 (MetAP-2), is a potent antiangiogenic agent. (wustl.edu)

Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)

This study is aimed at revealing the role of miR-429 in the angiogenesis of HBMECs. (hindawi.com)
The study has indicated that the angiogenesis play an important role in the repair of cerebral ischemia, which may prevent the patients away from stroke [ 5 ]. (hindawi.com)

Triclosan (TCS), a chlorinated aromatic compound containing phenol and ether functional groups, is an antimicrobial and antibacterial agent in many consumer products, notably hand sanitizers and aerosol sprays. (scirp.org)

Studies have shown that the expanded use of antimicrobial agents causes them to be found and remain suspended in the ecosystem, most notably the soil and watersheds. (scirp.org)
Our study concluded that increased use of products containing the antimicrobial agent TCS contributes to higher levels of total organochlorine contaminant, trichloromethane, leading to an increase in TTHM levels recorded annually on water quality reports. (scirp.org)

Consequently, this review (which is being presented in two parts) consists of a perspective on current opportunities and the "work in progress" and is not a compendium of clinical trials with novel targeted agents still seeking an indication. (cancernetwork.com)

This discrepancy might be partially due to the involvement of Dicer in other cellular processes like heterochromatin formation and to the fact that Dicer and Drosha target mainly different subsets of microRNAs. (uni-frankfurt.de)
Thus, carcinogens nogenic are polycyclic aromatic hy- to induce DNA damage, it can be may act not only by producing DNA drocarbons and benzene, which by cal ed a genotoxicant or a genotox- damage directly but also by altering themselves are relatively inert chem- in, and if it is shown that the agent the processes that control normal ical y. (who.int)

Anatomy49

Organisms14

Diseases27

Chemicals and Drugs89

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes37

Disciplines and Occupations1

Information Science2

Health Care1

Tumors7

Tumor12

Pathways involved in angiogenesis2

Angiogenic8

Vivo3

Inhibition6

Inflammation6

Several oncogenic2

Neovascularization5

VEGF9

Pathological3

Inhibit5

Therapeutic6

Inhibitors1

Blood27

Collagen1

Endothelial cell1

Pharmacological agents2

Proliferation3

Immune response2

Inhibits1

Regulation2

Mechanism2

Neurological deficits1

Diseases4

Metastasis1

Wounds2

Growth3

Tissue4

Wound6

Substances2

Molecular1

High glucose2

Initiate1

Lipid1

Sustain1

Nutrients1

Migration1

Process1

Cancer3

Cells3

Antiangiogenic1

Receptors1

Role2

Functional1

Antimicrobial2

Novel targeted1

Processes2