• The ascorbate-dependent lipid peroxidation in the microsomal fraction of at term placentas and fetal membranes were studied. (karger.com)
  • Lipid peroxidation was significantly higher in the chorion and amnion compared to the placenta. (karger.com)
  • The results indicate that the ascorbate-dependent lipid peroxidation in the fetal membranes is specific for prostaglandin synthetase activity and that these tissues are a major site of prostaglandin synthesis. (karger.com)
  • Therefore, trans-4,5-epoxy-2(E)-decenal, a primary product of lipid peroxidation, is a precursor to the formation of 1,N(6)-etheno-2'-deoxyadenosine and 1,N(2)-etheno-2'-deoxyguanosine. (nih.gov)
  • These findings provide an important link between a primary product of lipid peroxidation and a mutagenic DNA lesion that has been detected in human tissues. (nih.gov)
  • Free radicals are known to cause oxidative damage by increasing polymorphonuclear leukocytes and by inducing lipid peroxidation [ 2 , 3 ]. (hindawi.com)
  • These conditions lead to the damage of mitochondria [ 20 ], and cigarette smoke may even induce liver injury via lipid peroxidation and corresponding inflammation [ 21 , 22 ]. (hindawi.com)
  • Epidemiological studies indicate that fruits and vegetables may reduce free radical-induced oxidative damage and lipid peroxidation in cigarette smokers [ 23 ]. (hindawi.com)
  • The generation of ROS is known to play a role in lipid peroxidation. (cdc.gov)
  • Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum. (harvard.edu)
  • Seipin forms a flexible cage at lipid droplet formation sites. (harvard.edu)
  • Figure 1A shows that lipid droplet formation in Dictyostelium has some qualities also observed in mammalian cells (34). (acthreceptor.com)
  • Spreading of small unilamellar vesicles on solid surfaces is one of the most common ways to obtain supported lipid bilayers. (unige.ch)
  • We believe that the results presented in this work may provide some new insights into the area of research related to supported lipid bilayers. (unige.ch)
  • We identify mitoguardin-2, a mitochondrial protein at contacts with the ER and/or lipid droplets (LDs), as a lipid transporter. (rupress.org)
  • The Farese-Walther laboratory studies cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets. (harvard.edu)
  • The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets. (harvard.edu)
  • Identification of two pathways mediating protein targeting from ER to lipid droplets. (harvard.edu)
  • In the case of cells stimulated with 2,3-diGGA, neutrophils were not detected, but the formation of lipid droplets was induced. (elsevierpure.com)
  • In the latter case, when the cells were cultured in the co-presence of a caspase-3 inhibitor (Ac-DMQD-CHO), the lipid droplets formation was observed in the cells. (elsevierpure.com)
  • New lipid droplets kind rapidly, rising initially more than 10-fold in number (Fig. 1B) then up to 2-fold in size (Fig. 1C), with a higher cellto-cell variation at six or 8 h just after feeding. (acthreceptor.com)
  • At late time points, the lipid droplets also are likely to form aggregates (Fig. 1A, 8 h). (acthreceptor.com)
  • Purification of lipid droplets and proteomic evaluation. (acthreceptor.com)
  • About ten years ago, Miura and coworkers had fused the sequence from the Dictyostelium homologue of perilipin (Plin) to GFP and expressed the construct in mammalian CHO cells, exactly where it localized to lipid droplets (35). (acthreceptor.com)
  • In order to receive a Aurora B Inhibitor Species marker for biochemical preparation of lipid droplets, we constructed a GFP-Plin fusion for the expression in Dictyostelium cells. (acthreceptor.com)
  • Insect eggs store many lipid droplets as an energy source for embryonic development. (bioone.org)
  • We previously reported that lipid droplets are incorporated into embryos in three steps in the silkworm, Bombyx mori . (bioone.org)
  • At the beginning of the first step (blastoderm formation stage), some lipid droplets were observed in each cell of the embryonic tissues. (bioone.org)
  • Lipid droplets were seen to be derived from the oocyte peripheral cytoplasm by superficial cleavage. (bioone.org)
  • At the end of the first step (late appendage formation stage), some lipid droplets were attached to the elongated rough endoplasmic reticulum (rER). (bioone.org)
  • It seemed that formation of the lipid droplets occurred in embryonic cells at the end of the first step, because the rER is the site of biogenesis of lipid droplets. (bioone.org)
  • The incorporation of lipid droplets in the first step may be subdivided into two stages: the blastoderm formation stage and the subsequent stage before blastokinesis. (bioone.org)
  • Our data suggests that TMEM106B is one of a growing list of major dementia risk genes that affect glial lipid metabolism. (biomedcentral.com)
  • Dr. Farese has made important contributions to our understanding of lipid metabolism. (harvard.edu)
  • His laboratory discovered genes that encode enzymes critical for neutral lipid metabolism, including the DGAT enzymes which mediate triglyceride (TG) synthesis. (harvard.edu)
  • Since 2007, Dr. Farese's laboratory has studied the role of lipid metabolism in the central nervous system, particularly in neurodegenerative disorders such as Frontotemporal Dementia (FTD). (harvard.edu)
  • Genetic alterations of CAV1N1 and CAV1 modify lipid metabolism and underpin lipodystrophy syndromes. (aacrjournals.org)
  • Lipids contribute to tumorigenesis by providing fuel to cancer metabolism and supporting growth and signaling. (aacrjournals.org)
  • Such alterations are likely to lead to imbalances in lipid metabolism. (hindawi.com)
  • Vesicles are spherical membrane structures composed of a lipid bilayer enclosing aqueous material. (biomedcentral.com)
  • They inserted a photosensitive protein into nanodiscs -- circular fragments of cell membrane composed of a lipid bilayer -- and enhanced the resultant structure with particles of titanium dioxide, a photocatalyst. (nanowerk.com)
  • Biochemistry Essential fatty acid Lipid raft PIP2 domain Lipid signaling Saturated and unsaturated compounds Biomembranes, Molecular structure and function, by Robert B. Gennis, p. 164, Springer-Verlag, New York, 1989. (wikipedia.org)
  • Some possible effects on lipid biochemistry of differences in the distribution on glycerol of long-chain n-3 fatty acids in the fats of marine fish and marine mammals. (springer.com)
  • The left column lists the lipids known as phospholipids. (springer.com)
  • Hippocampal lipids were not significantly affected by APOE genotype, however levels of myelin-enriched sulfatides and hexosylceramides were significantly lower, and polyunsaturated phospholipids were higher, in rs1990622-A carriers after controlling for APOE genotype. (biomedcentral.com)
  • MlaA represents a lipid transport protein that selectively removes outer leaflet phospholipids to help maintain the essential barrier function of the bacterial OM. (nature.com)
  • Among such media available to scientists are nanodiscs -- membrane fragments made up of phospholipids and encircled by two protein molecules in a double belt formation. (nanowerk.com)
  • Lipids are a group of hydrophobic molecules that include triglycerides, which are used to store energy, and phospholipids, which are the major structural components of cell membranes. (jove.com)
  • Another type of lipid, phospholipids, is an important structural feature of biological membranes. (jove.com)
  • However, these lipids can be transported throughout the bloodstream as lipoproteins when packaged with phospholipids and proteins (apoproteins). (medscape.com)
  • Liposomes (lipid vesicles) are formed when thin lipid films or lipid cakes are hydrated and stacks of liquid crystalline bilayers become fluid and swell. (sigmaaldrich.com)
  • The hydrated lipid sheets detach during agitation and self-close to form large, multilamellar vesicles (LMV) which prevents interaction of water with the hydrocarbon core of the bilayer at the edges. (sigmaaldrich.com)
  • Properties of lipid formulations can vary depending on the composition (cationic, anionic, neutral lipid species), however, the same preparation method can be used for all lipid vesicles regardless of composition. (sigmaaldrich.com)
  • The general elements of the procedure involve preparation of the lipid for hydration, hydration with agitation, and sizing to a homogeneous distribution of vesicles. (sigmaaldrich.com)
  • The hydration medium is generally determined by the application of the lipid vesicles. (sigmaaldrich.com)
  • Co-expression of P9 and P12 in a Pseudomonas host results in the formation of intracellular vesicles that are potential intermediates in the phi6 virion assembly pathway. (biomedcentral.com)
  • This study evaluated the minimum requirements for the formation of phi6-specific vesicles and the possibility to localize P9-tagged heterologous proteins into such structures in Escherichia coli . (biomedcentral.com)
  • The possibility to locate heterologous proteins into the P9-lipid vesicles facilitates the production of vesicular structures with novel properties. (biomedcentral.com)
  • Furthermore, production of intracellular membrane vesicles in Escherichia coli can be triggered by expression of Acholeplasma laidlawii lipid glycosyltransferases [ 5 ]. (biomedcentral.com)
  • We present an experimental protocol to form a supported lipid bilayer on solid substrates without using lipid vesicles. (jove.com)
  • Mechanism of Lipid Vesicles Spreading and Bilayer Formation on a Au(111) Surface. (unige.ch)
  • In this work, we have employed scanning probe microscopy techniques to evaluate the details of lipid vesicles spreading and formation of the lipid bilayer on a Au(111) surface in a phosphate-buffered saline solution. (unige.ch)
  • Initially, the vesicles accumulate on a gold surface and release lipid molecules that adsorb on a Au(111) surface, giving rise to the appearance of highly ordered stripelike domains. (unige.ch)
  • Here, cryo-EM is used to examine the protein-lipid architecture of this membrane in tubular vesicles obtained from the (muscle-derived) electric organ of the Torpedo ray. (iucr.org)
  • As reported earlier, the helical arrangement of the protein component of the vesicles facilitates image averaging and enables us to determine how cholesterol and phospho-lipid molecules are distributed in the surrounding matrix, using headgroup size as a means to discriminate between the two kinds of lipid. (iucr.org)
  • Here, we analyse by cryo-EM the architecture of this membrane in vesicles isolated from the (muscle-derived) electric organ of the Torpedo ray, with view to defining the protein-lipid interplay required to achieve an optimal neurotransmitter response. (iucr.org)
  • An x-ray structure shows that the C-terminal domain of mitoguardin-2 has a hydrophobic cavity that binds lipids. (rupress.org)
  • Lipids are hydrophobic metabolites connected with tea flavor quality formation. (bvsalud.org)
  • Bile salts aid in forming lipid micelles, which create a hydrophilic surface with a hydrophobic core of lipid molecules, including FFA. (medscape.com)
  • Lipid transport proteins at membrane contacts, where organelles are closely apposed, are critical in redistributing lipids from the endoplasmic reticulum (ER), where they are made, to other cellular membranes. (rupress.org)
  • Lipid bilayer membranes are among the most ubiquitous structures in the living world, with intricate structural features and a multitude of biological functions. (nature.com)
  • The lipid bilayer of cell membranes is impermeable to large and polar molecules but permeable to water molecules and other small uncharged molecules like O 2 and CO 2 . (wikibooks.org)
  • We demonstrate a one-step method to form a lipid bilayer on silicon dioxide and gold as well as supported membranes with cholesterol-enriched domain for various biological applications. (jove.com)
  • When preparing liposomes with mixed lipid composition, the lipids must first be dissolved and mixed in an organic solvent to assure a homogeneous mixture of lipids. (sigmaaldrich.com)
  • Writing ( Fig. 1a-b ), Dynamic control of composition ( Fig. 1c-d ), Erasing ( Fig. 1e ) and Localized lipid film modification and decoration ( Fig. 1f-g ). 2D-networks are directly written by providing liposomes through the pipette, while simultaneously translating the substrate by means of a motorized stage. (nature.com)
  • Diffusively continuous fluidic networks can be produced in this way, where the topology is defined by the x, y scanning sequence and the composition depends on the lipids supplied by the pipette. (nature.com)
  • In this study, the direct correlation between the composition of the lipids from three types of mammalian milk, three brands of infant formulas (IFs), and soy milk and the liquid crystalline structures that form during their digestion was investigated to link the material properties to the composition. (monash.edu)
  • Lipid composition was determined during in vitro digestion using ex situ liquid chromatography-mass spectrometry. (monash.edu)
  • Triglycerides are lipid compounds composed of a glycerol esterified to 3 fatty acid chains of varying length and composition. (medscape.com)
  • Furthermore, its protein-lipid composition, organization and size are subject to modification by physiological events, making it an important mediator of neuronal plasticity. (iucr.org)
  • Herein, we emphasize that the lipids composition in preharvest tea leaves is crucial for materials quality and hence tea flavor. (bvsalud.org)
  • Throughout this time, three cell divisions took location, explaining the gradual consumption of storage fat and its conversion into membrane lipids or metabolic power. (acthreceptor.com)
  • Applied to a small library of 960 known bioactive compounds, we are able to report identification of 37 compounds of which 36 were not previously reported as active toward IAPP fiber formation. (nyu.edu)
  • Bile salts are released in the duodenum in response to cholecystokinin release occurring in the presence of lipid compounds within the ingesta. (medscape.com)
  • Absorption of lipid compounds into the enterocyte for biochemical usage occurs through diffusion across the cellular membrane and also through lipid transporters that are located on the luminal side of the enterocyte. (medscape.com)
  • Hydration of the dry lipid film/cake is accomplished simply by adding an aqueous medium to the container of dry lipid and agitating. (sigmaaldrich.com)
  • fluorescence analyses were undergone on the aqueous and organic (lipids) phases resulting from the lipid extraction. (csic.es)
  • Fatty acid-binding proteins (FABPs) bind and internalize long-chain fatty acids, controlling lipid dynamics. (elsevierpure.com)
  • Professor Vladimir Chupin, who holds a ScD in chemistry and heads the Laboratory of the Chemistry and Physics of Lipids at MIPT's Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, notes: "Our laboratories working with membrane proteins, in particular with nanodiscs, are mostly focused on biophysical and medical issues. (nanowerk.com)
  • This enzyme helps break down certain proteins, fats (lipids), and cholesterol. (medlineplus.gov)
  • A lack of AdoCbl impairs the function of methylmalonyl CoA mutase, which results in the incomplete breakdown of certain proteins and lipids. (medlineplus.gov)
  • Both hexavalent and trivalent chromium were used in increasing concentrations ranging from 0.1mM to 1.2mM to oxidize proteins under physiological conditions resulting in protein carbonyl formation. (cdc.gov)
  • [ 4 ] If pancreatitis is likely or potentially threatening and levels of triglycerides are found to be 1000 mg/dL or greater, immediate institution of lipid lowering therapy should begin. (medscape.com)
  • A full lipid profile shows the actual levels of each type of fat in the blood, such as LDL, HDL, triglycerides and total cholesterol. (choc.org)
  • Aging is not recommended for high transition lipids as lipid hydrolysis increases with elevated temperatures. (sigmaaldrich.com)
  • Quality measures of lipid hydrolysis (free fatty acids content, FFA) and oxidation (conjugated diene formation and thiobarbituric acid, TBA, test) were also carried out. (csic.es)
  • Often, the methods suggest regions with different lipid fluidity, as would be expected of coexisting gel and liquid crystalline phases within the biomembrane. (wikipedia.org)
  • The device allows multiplexing between several different lipid (e.g. (nature.com)
  • By reviewing each patient's personal and family medical history and current lifestyle, they will try to determine whether the lipid imbalance is caused by genetics (family history) or lifestyle. (choc.org)
  • In this animated object, learners examine the formation of ester bonds in the synthesis of lipids using triglyceride biosynthesis as an example. (wisc-online.com)
  • The two major forms of circulating lipid in the body, triglyceride (TG) and cholesterol, are insoluble in plasma. (medscape.com)
  • Triglyceride is the most abundant dietary lipid compound found throughout the diet and is the method with which energy is stored in the body. (medscape.com)
  • Older overweight patients with polyps, accompanied by abnormal lipid levels, are at high risk for cholesterol polyps. (biomedcentral.com)
  • If a child has dyslipidemia, he or she has abnormal lipid levels. (choc.org)
  • Up to 99% of the lipids in plant and animal material consist of such esters, known as fats and oils. (springer.com)
  • Lipids are the fats found in blood. (choc.org)
  • A lipid screening consists of a blood test that provides a child's health care team with an overall look at the fats in the blood. (choc.org)
  • In this work, it is show that two unrelated domains, a VSD from voltage dependent ion channels and a lipid PD homologous to protein tyrosine phosphatases evolved a tight mechanism of allosteric regulation that transduces fluctuations in membrane potential into changes in the enzyme selectivity of a novel lipid phosphatase. (escholarship.org)
  • The MMAB gene provides instructions for making an enzyme that is involved in the formation of a compound called adenosylcobalamin (AdoCbl). (medlineplus.gov)
  • RÉSUMÉ L'objectif de la présente étude était d'évaluer l'efficacité d'un programme d'exercice sur tapis roulant électronique sur le malondialdéhyde, en tant que marqueur de la peroxydation lipidique et sur une enzyme antioxydante, le glutathion peroxydase, chez des adolescents atteints du Syndrome de Down. (who.int)
  • In addition, the Mla system was recently shown to regulate outer membrane vesicle formation 16 . (nature.com)
  • The characterization of lipids in preharvest tea leaves provides a reference to obtain better tea quality. (bvsalud.org)
  • Particularly controversial is the mechanism of bilayer formation on metallic surfaces like gold. (unige.ch)
  • 2006. Investigation of the lipid domains and apolipoprotein orientation in reconstituted high-density lipoproteins by fluorescence and IR methods. (wikipedia.org)
  • Resolution of inflammation is an active process timely controlled by endogenous specialized pro-resolving lipid mediators (SPMs) produced locally in inflammatory loci to restrain this innate response, prevent further damages to the host, and permit return to homeostasis. (frontiersin.org)
  • As fat-containing chyme enters the small intestine, it causes the formation of anorexic lipid mediators, such as oleoylethanolamide, which promote satiety. (jci.org)
  • Chemical structures and molecular targets of lipid-derived mediators involved in the monitoring of dietary fat. (jci.org)
  • Using a multidisciplinary approach that includes an exercise educator, dietitian and cardiologist, we work with more than 150 patients each year to provide ongoing medical monitoring every three to six months, as well exercise and lifestyle recommendations with expert meal planning based on each patient's specific lipid imbalances and, in some cases, drug therapy when indicated. (choc.org)
  • The Lipid Clinic is the only multidisciplinary clinic in the region that is dedicated to the treatment of lipid imbalances in children. (choc.org)
  • Lipids in mammalian milks such as bovine milk and human breast milk have been shown to self-assemble into various liquid crystalline materials during digestion. (monash.edu)
  • For example, monoglycerides of the short-chain fatty acids are undoubtedly lipids, but they would not fit the definition on the basis of solubility because they are more soluble in water than in organic solvents. (springer.com)
  • The basic components of lipids are listed in the central column with the fatty acids occupying the prominent position. (springer.com)
  • They are composed of three fatty acids linked to glycerol through ester linkages between the hydroxyl ends of glycerol and the carboxyl ends of the fatty acids resulting in the formation of a nonpolar molecule. (jove.com)
  • To characterize the lipid solutions that happen to be formed upon fatty acid addition, extracts had been analyzed by thin-layer chromatography (TLC) (Fig. 1D). (acthreceptor.com)
  • In the mouth, dietary fat constituents such as mono- and diunsaturated fatty acids give rise to taste signals that stimulate food intake, in part by enhancing the production of lipid-derived endocannabinoid messengers in the gut. (jci.org)
  • These include increased release of reactive oxygen species from phagocytes, such as superoxide from peripheral blood neutrophils, oxidized low density lipoprotein cholesterol (LDL), increased lipid hydroperoxides and malondialdehyde, and decreased plasma antioxidant capacity [ 4 - 11 ]. (hindawi.com)
  • The purpose of this study was to assess the risk factors for cholesterol polyp formation in the gallbladder. (biomedcentral.com)
  • The risk factors for cholesterol polyp formation were analyzed by comparing the two groups. (biomedcentral.com)
  • Exploring the risk factors for cholesterol polyp formation, actively controlling the risk factors to reduce the incidence of cholesterol polyps, and decreasing the number of patients undergoing cholecystectomy due to cholesterol polyps are desirable to reduce the surgical trauma and economic costs caused by unnecessary surgery. (biomedcentral.com)
  • As differences exist in the formation and pathological process between cholesterol GBP and non-cholesterol GBP, a predictor of cholesterol GBP based on pathological classification is more accurate and reliable. (biomedcentral.com)
  • Therefore, this study recruited patients with cholesterol GBP, the dominant type of GBP, according to postoperative pathology from the four-year databases of three high-volume centers, to investigate specific risk factors for cholesterol GBP formation, and to provide a basis for its prevention and treatment. (biomedcentral.com)
  • It is shown that cholesterol segregates preferentially around the receptors in both leaflets of the lipid bilayer, interacting robustly with specific transmembrane sites and creating a network of bridging microdomains. (iucr.org)
  • Cholesterol interactions with the receptor are apparently essential for stabilizing and maintaining its physiological architecture, since the transmembrane structure contracts, involving displacements of the helices at the outer membrane surface by ∼2 Å (1-3 Å), when this lipid is extracted. (iucr.org)
  • If a child is overweight or obese, has high cholesterol or has a high body mass index (BMI), they may be referred to one of CHOC healthy lifestyle programs prior to visiting the Lipid Clinic. (choc.org)
  • There is no need for an additional oxidation step such as would be required if trans,trans-2,4-decadienal or 4-hydroxy-2-nonenal were the lipid hydroperoxide decomposition products that initiated the formation of unsubstituted etheno adducts. (nih.gov)
  • In this study, we focused on how lipids were incorporated into the embryo in the first step, compared with the mechanisms used in the second step, by means of transmission electron microscopy using the high-pressure freezing and freeze substitution method. (bioone.org)
  • Remarkably, they increase lipid uptake and M2 inflammatory macrophage infiltration in the primary tumors and metastasis to distant sites. (aacrjournals.org)
  • This study showed that stromal CAVIN1 suppresses prostate cancer metastasis by modulating tumor microenvironment, lipid content, and inflammatory response. (aacrjournals.org)
  • [ 2 ] The purpose of this article is to discuss the basic biology of lipoproteins, the pathophysiology of dyslipidemias, the interpretation of lipid levels in pediatric patients, dyslipidemia screening, and the management of pediatric lipid abnormalities. (medscape.com)
  • People with dyslipidemia have lipid levels that are either too high or two low. (choc.org)
  • If the dyslipidemia does not improve or becomes worse, he or she may then refer the patient to the Lipid Clinic. (choc.org)
  • Before treating the dyslipidemia, Lipid Clinic staff work to evaluate the cause of the imbalance. (choc.org)
  • These processes have been correlated with solution biophysical observations of lipid bilayer catalyzed acceleration of amyloid formation. (nyu.edu)
  • Although the relationship between amyloid formation and toxicity is poorly understood, the fact that conditions promoting one also favor the other suggests related membrane active structural states. (nyu.edu)
  • Our data here suggest that a screening protocol based on lipid-catalyzed assembly will find mechanistically informative small molecule hits in this subclass of amyloid diseases. (nyu.edu)
  • More broadly, the lab investigates the mechanisms by which cells regulate the abundance of lipids, how they store lipids to buffer fluctuations in their availability, and how these processes function in membrane biology and cell physiology. (harvard.edu)
  • Hydration time may differ slightly among lipid species and structure, however, a hydration time of 1 hour with vigorousshaking, mixing, or stirring is highly recommended. (sigmaaldrich.com)
  • Lipid domains are not readily isolated and examined as unique species, in contrast to the examples of lateral heterogeneity. (wikipedia.org)
  • While the total number of lipid species in biology may not exceed the number of metabolites, they can be modified chemically and biochemically leading to an enormous diversity of derivatives, many of which retain the lipophilic properties of lipids and thus expand the lipidome greatly. (aston.ac.uk)
  • Candida species, including the novel opportunistic cans many virulence factors, such as germ tube formation, pathogen Candida dubliniensis , are now emerging as exoenzyme production, and phenotypic switching (10). (cdc.gov)
  • Chromium is known to catalyze the formation of reactive oxygen species that may have a role in disease, aging, and oxidative stress. (cdc.gov)
  • Our study demonstrates that TMEM106B protein abundance is increased with brain ageing in humans, establishes that dementia risk allele rs1990622-A predisposes to TMEM106B fibril formation in the hippocampus, and provides the first evidence that rs1990622-A affects brain lipid homeostasis, particularly myelin lipids. (biomedcentral.com)
  • Taken together, these data suggest that FABP7 protects astrocytes from ROS toxicity through LD formation, providing new insights linking FABP7, lipid homeostasis, and neuropsychiatric/neurodegenerative disorders, including Alzheimer's disease and schizophrenia. (elsevierpure.com)
  • [ 6 ] ABCA12 encodes a transmembrane protein that mediates lipid transport. (medscape.com)
  • Lipid microdomains are formed when lipids undergo lateral phase separations yielding stable coexisting lamellar domains. (wikipedia.org)
  • The question of whether such lipid microdomains observed in model lipid systems also exist in biomembranes had motivated considerable research efforts. (wikipedia.org)
  • Typically lipid solutions are prepared at 10-20mg lipid/ml organic solvent, although higher concentrations may be used if the lipid solubility and mixing are acceptable. (sigmaaldrich.com)
  • The modified lipids typically contain more oxygens in the form of hydroxyl, epoxide, carbonyl and carboxylic acid groups, and nitration, nitrosylation, halogenation or sulfation can also occur. (aston.ac.uk)
  • These data suggest that, at least under conditions of marked hypercholesterolemia, hyperglycemia and enhanced AGE formation do not contribute significantly to atherogenesis in LDL -1- L mice. (elsevierpure.com)
  • The placebo, which was devoid of iridoid glycosides, did not significantly influence blood lipid profiles or hs-CRP. (hindawi.com)
  • These results also indicate that intravenously administered tocotrienols were significantly better than tocopherols in inhibiting cyclic flow reductions (CFRs), a measure of the acute platelet-mediated thrombus formation. (biomedcentral.com)
  • Ester bond formation is described as a dehydration synthesis reaction. (wisc-online.com)
  • Bob Farese Jr. is an expert in how lipid synthesis and storage may lead to disease-and an accomplished amateur photographer. (harvard.edu)
  • One such protein, the voltage sensing phosphatase (VSP), developed a sophisticated mechanism of inter-domain coupling, which enabled cells to integrate changes in membrane potential into chemical changes in a class of secondary signaling lipids called phosphatidylinositol-phosphates (PIPs). (escholarship.org)
  • Phosphoinositol phosphate signaling lipids (PIPs) are important second messengers that regulate ion channels, transporters, cell motility and endo/exocytosis. (escholarship.org)
  • Once the lipids are thoroughly mixed in the organic solvent, the solvent is removed to yield a lipid film. (sigmaaldrich.com)
  • For larger volumes, the organic solvent should be removed by rotary evaporation yielding a thin lipid film on the sides of a round bottom flask. (sigmaaldrich.com)
  • The lipid film is thoroughly dried to remove residual organic solvent by placing the vial or flask on a vacuum pump overnight. (sigmaaldrich.com)
  • The first event in acute inflammation is edema formation, followed by infiltration of PMN, and then monocyte and macrophages that clear PMN leading to resolution, which is essential for ensuring host protection and sparing from tissue damage. (frontiersin.org)
  • We show that depletion of CAVIN1 in prostate stromal cells markedly reduces their lipid droplet accumulation and increases inflammation. (aacrjournals.org)
  • Our data support the concept that stromal cells contribute to prostate cancer aggressiveness by modulating lipid content and inflammation in the tumor microenvironment. (aacrjournals.org)
  • Here, we show that stromal CAVIN1 regulates lipid abundance in the prostate cancer microenvironment and suppresses metastasis. (aacrjournals.org)
  • If the use of chloroform is objectionable, an alternative is to dissolve the lipid(s) in tertiary butanol or cyclohexane. (sigmaaldrich.com)
  • Our results demonstrate that the phi6 major envelope protein P9 can trigger formation of cytoplasmic membrane structures in E. coli in the absence of any other viral protein. (biomedcentral.com)
  • Lipid uptake occurs through caveolae, plasma membrane invaginations formed by caveolins (CAV) and caveolae-associated protein 1 (CAVIN1). (aacrjournals.org)