Formation of focal focal adhesions. Medical search. Frequent questions

PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. (wikipedia.org)
PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to each other and their surroundings) and spreading processes (how cells move around). (wikipedia.org)
The PTK2 gene encodes a cytosolic protein tyrosine kinase that is found concentrated in the focal adhesions that form among cells attaching to extracellular matrix constituents. (wikipedia.org)
Focal adhesion kinase has four defined regions, or tertiary structure domains. (wikipedia.org)
We also demonstrate that, while paxillin is phosphorylated by Pyk2, complex formation between Pyk2 and paxillin does not depend on Pyk2 tyrosine kinase activity. (rcsb.org)
These complexes, which are associated with lamellipodia and filopodia, contain vinculin, paxillin, and focal adhesion kinase, but are distinct from and formed independently of rho-induced focal adhesions. (nih.gov)
Podosomes are structurally divided into a core, which mainly contains proteins involved in actin polymerization (such as WASP, the Arp2/3 complex and cortactin ), and a surrounding ring populated by integrin receptors and adhesion proteins (for example, paxillin and focal adhesion kinase (FAK/Pyk2) ) [15] . (cellmigration.org)
Integrin-linked kinase (ILK) is a major structural adaptor protein governing signaling complex formation and cytoskeletal dynamics. (jneurosci.org)
Tenascin-C modulates matrix contraction via focal adhesion kinase- and Rho-mediated signaling pathways. (ox.ac.uk)
Using a synthetic model of the provisional matrix, we have found that tenascin-C regulates cell responses to a fibrin-FN matrix through modulation of focal adhesion kinase (FAK) and RhoA activation. (ox.ac.uk)
In the present study, we used a knockout murine model to analyze the contribution of the Ca2+-dependent focal adhesion kinase Pyk2 in platelet activation and thrombus formation in vivo. (edu.au)
The Rho kinase inhibitor Y27632 completely blocks acid-induced stress fiber formation and the increases in apical membrane NHE3 abundance and activity, but it has no effect on acid-induced tyrosine phosphorylation of p125 FAK or paxillin. (elsevierpure.com)
These studies demonstrate that Rho kinase mediates acid-induced stress fiber formation, which is required for NHE3 exocytosis, and increases in NHE3 activity. (elsevierpure.com)
Acid-induced tyrosine phosphorylation of the focal adhesion proteins p125 FAK and paxillin is not Rho kinase dependent. (elsevierpure.com)
Moreover, Wnt-5a is known to inhibit migration of breast epithelial cells in culture and expression of Wnt-5a potentiates activation of the receptor tyrosine kinase DDR1, a collagen receptor implicated in cell adhesion and migration. (lu.se)
Finally, we found that phospho-DARPP-32 inhibited the activity of the focal adhesion kinase (FAK) in MCF-7 breast cancer cells, and that MCF-7 cells expressing phospho-DARPP-32 displayed less filopodia formation. (lu.se)

Tensin is a gene family with four members (tensin1, tensin2, tensin3, and cten), and their encoding proteins are localized to the cytoplasmic side of focal adhesions. (rupress.org)
Release of this auto-inhibitory interaction has been shown to occur within focal adhesions-but not in the cytoplasm-and therefore is thought to require interaction with focal adhesion proteins, potentially as a result of mechanical forces transmitted through the focal adhesion. (wikipedia.org)
Although focal adhesions are similar, in terms of molecular composition, to nascent adhesions and focal complexes, several adhesion proteins appear to change as focal adhesions evolve in response to tension, e.g., zyxin and vinculin . (cellmigration.org)
Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. (antibodies-online.com)
Focal adhesions are large specialized proteins that are located in the area where a cell membrane meets the extracellular matrix (ECM), a collection of molecules surrounding the cells that provide support and regulate micromechanical signals to the cells. (rdworldonline.com)
Typically people look at focal adhesions with fluorescent tags or proteins," Zhuo said. (rdworldonline.com)
But fluorescent imaging is an invasive imaging method that may change the conformations or block the binding sites of the proteins in the focal adhesion area. (rdworldonline.com)
Business and dynamics of focal adhesion proteins have been well characterized in cells grown on two-dimensional (2D) cell culture surfaces. (technologybooksindustrialprojectreports.com)
Using sFCS we found higher percentage of slow diffusing proteins at these focal spots suggesting assembling/disassembling processes. (technologybooksindustrialprojectreports.com)
Formation of stress fibers is associated with acid-induced tyrosine phosphorylation and increases in protein abundance of two focal adhesion proteins, p125 FAK and paxillin. (elsevierpure.com)
These properties will act mediating the action of cell adhesion proteins, regulating cell behavior and causing tissue regeneration. (bvsalud.org)
To occur the adhesion of CAMs to the biomaterial, it is necessary their interaction with some components of extracellular matrix, such as proteoglycans, collagen and proteins 23 . (bvsalud.org)

Thus, by linking extracellular matrix sensing and signaling, focal adhesion maturation, and actomyosin activation EPB41L5 ensures the mechanical stability required for podocytes at the kidney filtration barrier. (elsevierpure.com)
FAK is typically located at structures known as focal adhesions, which are multi-protein structures that link the extracellular matrix (ECM) to the cytoplasmic cytoskeleton. (wikipedia.org)
Cell adhesion (the physical interaction of a cell with another cell or with the extracellular matrix (ECM)) is essential for cell migration and tissue integrity. (cellmigration.org)
During normal cell migration, cells use focal adhesions to facilitate cycles of cell adhesion to, and release from, the extracellular matrix (ECM). (ubc.ca)
2001). The extracellular region has an adhesion-related function (Hägg et al. (reactome.org)
Functional analyses indicated that some of the genes induced by dragonfly larvae caused an increase in laminins necessary for cell adhesion in the extracellular matrix. (biomedcentral.com)
Focal adhesions connect extracellular matrix (ECM) and F-actin cytoskeleton through transmembrane protein integrins [3]-[6]. (technologybooksindustrialprojectreports.com)
These cell adhesion molecules (CAM) will mediate the contact between two cells or between cells and the extracellular matrix, an essential process to the success of the implant. (bvsalud.org)
The main reported mechanisms involve cell adhesion molecules (CAMs) and extracellular matrix components. (bvsalud.org)
Some of these molecules are glycoproteins expressed on the cell surface, socalled cell adhesion molecules (CAM), which mediate either the contact between two cells or the contact among cells and the extracellular matrix, being therefore of fundamental importance for adhesion 3 . (bvsalud.org)

Although previous studies have identified different chemotropic and adhesion molecules that influence axonal development, the molecular mechanism by which these signals control the cytoskeleton remains poorly understood. (biologists.com)
Focal adhesions are integrin-mediated cell matrix junctions connecting the ECM to the actin cytoskeleton. (rupress.org)
ILK forms an obligate heterotrimeric complex with particularly interesting Cys-His-rich protein (PINCH) and parvin, which together lend stability to the actin cytoskeleton at focal adhesions ( Brakebusch and Fässler, 2003 ). (jneurosci.org)
The work provides new insight into the cooperation among receptors, the actin cytoskeleton, and myosin motors that is required for the formation of a B cell immune synapse. (sciety.org)
Whether the actin cytoskeleton plays a specific role in integrin-dependent IS formation is unknown. (sciety.org)
Feedback interactions from mechanical and biochemical signals within focal adhesion and the F-actin cytoskeleton coordinate the behavior of the protrusive and contractile lamella by promoting and sustaining the proper spatial and temporal control in the cell [3]. (technologybooksindustrialprojectreports.com)

In panel 2, some adhesions attach to stress fibers and grow in size while some disassemble (yellow with dotted outline) at the lamellipodium-lamellum boundary. (mechanobio.info)
In addition to stress fibers, rho controls the assembly of focal adhesion complexes. (nih.gov)
In addition, immunofluorescence showed the formation of stress fibers and vinculin foci in cells without AGR2 and in response to TGF-ß treatment, with synergistic effects observed. (muni.cz)
In addition, we also demonstrated that NDRG1 reduced cell locomotion by inhibiting the formation of F-actin stress fibers and focal adhesions, via its ability to suppress the Src and ROCK/pMLC2 pathways. (edu.au)
Small transient integrin-associated nascent adhesions form first followed by the formation of larger more stable fibrillar adhesion with actin stress fibers which facilitate cell distributing and migration [7]. (technologybooksindustrialprojectreports.com)

From left: Panel 1 shows formation of nascent adhesions at the cell periphery. (mechanobio.info)
Nascent adhesions are the first observable adhesive structures, emerging within the lamellipodium. (cellmigration.org)
Nascent adhesions are small and highly transient - either maturing or disassembling ('turning over') - and are therefore not easily observed in every cell type [6] , [7] . (cellmigration.org)
They are larger than nascent adhesions, depend on myosin II for their formation and maintenance, and reside at the boundary of the lamellum and lamellipodium [10] , [11] . (cellmigration.org)
Like nascent adhesions, they also tend to either disassemble (turnover) or grow and elongate into focal adhesions. (cellmigration.org)

The protrusions of the cell edge are shown as green arrows corresponding to points of adhesion maturation (panels 3 and 4). (mechanobio.info)
Remarkably, by binding and recruiting the RhoGEF ARGHEF18 to the leading edge, EPB41L5 directly controls actomyosin contractility and subsequent maturation of focal adhesions, cell spreading, and migration. (elsevierpure.com)
Scheme depicts the process of adhesion maturation. (cellmigration.org)
Focal complexes are adhesions in the early stages of maturation. (cellmigration.org)
Fibrillar adhesions represent an extreme in the maturation of adhesions and are not generally seen in migrating cells. (cellmigration.org)

The four panels represent roughly the different steps in the formation and disassembly of focal adhesions. (mechanobio.info)
At the front edge of cells, PAK1 promotes focal adhesion formation by phosphorylating PIX, while at the back edge, it directs focal adhesion disassembly. (rndsystems.com)
and microtubule targeting, which may contribute to adhesion disassembly. (cellmigration.org)
Our findings demonstrate that by multiplexing these techniques we have the ability to spatially and temporally quantify focal adhesion assembly and disassembly in 3D space and allow the understanding tumor cell invasion in a more complex relevant environment. (technologybooksindustrialprojectreports.com)

Furthermore, we revealed enhanced focal adhesion formation and osteogenic differentiation of MSCs cultured on positively charged protein fibers. (nature.com)
In addition the N&B analysis shows paxillin aggregated predominantly at these focal contacts which are next to collagen fibers. (technologybooksindustrialprojectreports.com)

Focal adhesion targeting (FAT) domains target the non-receptor tyrosine kinases FAK and Pyk2 to cellular focal adhesion areas, where the signaling molecule paxillin is also located. (rcsb.org)
Herbimycin A completely blocks acid-induced tyrosine phosphorylation of p125 FAK and paxillin but only partially blocks stress fiber formation and NHE3 activation. (elsevierpure.com)

Cell-cell adhesion maintains epithelial tissues, supports functional contacts between specialized cells, and can facilitate directed migration (for example, radial glia can guide neuronal progenitor cells to specific layers of the brain). (cellmigration.org)
Cell-matrix adhesion is the best-studied form of adhesion that mediates cell migration, and is the focus of this outline. (cellmigration.org)
Receptor-type protein tyrosine phosphatase alpha (PTPα is a widely expressed transmembrane-bound protein that has been implicated in integrin signaling, focal adhesion formation, and normal cell migration. (ubc.ca)
These findings imply that both AGR2 downregulation and TGF-ß have a role in focal adhesion formation and cancer cell migration and invasion. (muni.cz)
The Focal Adhesion Assembly Pathway has been researched in relation to Cell Adhesion, Cell Migration, Cell Motility, Localization, Integrin Activation. (novusbio.com)
Since so many biological processes are mediated through attachment of cells to surfaces, PROM provides a unique view of migration, chemotaxis, chemotoxicity, differentiation, biofilm formation, and division. (rdworldonline.com)
Introduction The study of focal adhesions in the two-dimensional (2D) environment has led to an in depth understanding of their protein composition [1] structure [2] and their role in cell migration as well as mechanical sensing. (technologybooksindustrialprojectreports.com)
In addition when cells are in the 3D environment there is a continuum of migration modes that are determined by both matrix substrate and intrinsic contractility of the cell [7] and focal adhesions may not be needed for migration. (technologybooksindustrialprojectreports.com)
These studies have served to highlight the role of AND-34/BCAR3 and p130Cas in cell adhesion and migration signaling pathways. (molvis.org)
In order to be effective and integrated to the receiving area, the bone graft is required to allow a strong cell adhesion, interacting with several molecules to induce migration, differentiation, and thus the mineralization of the new bone on the graft. (bvsalud.org)

Integrin receptors are heterodimeric transmembrane glycoproteins that cluster upon ECM engagement, leading to FAK phosphorylation and recruitment to focal adhesions. (wikipedia.org)
It undergoes tyrosine phosphorylation by C-SRC PROTEIN PP60 and plays a regulatory role in CAVEOLAE formation. (bvsalud.org)

Evidence for integrin activation (focal adhesion formation) at the conceptus-maternal interface of pregnant sheep. (tamu.edu)

Cell adhesion, proliferation, and colonization were enhanced on those scaffolds functionalized with RGD-ELR, while differentiation was promoted on those with SNA15-ELR. (ibecbarcelona.eu)
The combination of both RGD and SNA15 into the same ELR stimulated cell adhesion, proliferation, and differentiation, although at lower levels than those for every single moiety. (ibecbarcelona.eu)
Further investigation on the amount and distribution of RGD and SNA15 moieties in ELRs could improve cell adhesion, proliferation, and differentiation compared to the present study. (ibecbarcelona.eu)
Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)

A gain of function screen for genes that enable proliferation independently of matrix anchorage identified a cell adhesion molecule PVRL4 (poliovirus-receptor-like 4), also known as Nectin-4. (elifesciences.org)

Focal adhesions act as molecular clutches that provide grip to the substrate for the lamellipodium to protrude forward during motility. (mechanobio.info)
FAK is a protein of 125 kD recruited as a participant in focal adhesion dynamics between cells, and has a role in motility and cell survival. (wikipedia.org)
It is responsible for regulating focal adhesions during motility. (rndsystems.com)
These adhesions are usually physically linked to large, readily visualized actomyosin bundles [13] , and their appearance correlates inversely with motility, such that they are conspicuously absent in cells migrating within a three-dimensional (3D) substrate. (cellmigration.org)
VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. (antibodies-online.com)

Rho activation is thought to generate focal adhesions and actin bundling due to increased myosin II activity. (cellmigration.org)
This phenomenon, termed fouling, is then followed by a series of undesired reactions involving activation of complement or the coagulation cascade and adhesion of leukocytes and platelets leading to thrombus formation. (ibecbarcelona.eu)
B-cell activation and immune synapse (IS) formation with membrane-bound antigens are actin-dependent processes that scale positively with the strength of antigen-induced signals. (sciety.org)
Together, these results argue that a contractile actomyosin arc network plays a key role in the mechanism by which LFA-1 co-stimulation promotes B-cell activation and IS formation. (sciety.org)

BackgroundWe have previously shown the presence of a TRAF4/p47phox/Hic5/Pyk2 complex associated with the platelet collagen receptor, GPVI, consistent with a potential role of this complex in GPVI-dependent ROS formation. (edu.au)

Their paper, "Quantitative Analysis of Focal Adhesion Dynamics Using Photonic Resonator Outcoupler Microscopy (PROM)" details how the new live cell imaging technique can observe the formation and evolution of cell membrane focal adhesions. (rdworldonline.com)

Under conditions where integrin is required for synapse formation, inhibiting myosin impairs synapse formation, as evidenced by reduced antigen centralization, diminished BCR signaling, and defective signaling protein distribution at the synapse. (sciety.org)
It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. (nih.gov)
AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. (molvis.org)

They also demonstrate that myosin IIa contractility is required for the formation of the actomyosin arcs and promotes the exertion of strong traction forces on the antigen- and ICAM-1-presenting substrate. (sciety.org)

It was found that the nanoscale gratings and pillars could facilitate focal adhesion elongation by providing anchoring sites, and the nanogratings could orient focal adhesions and nuclei along the nanograting direction, depending on not only the feature size but also the spacing of the nanogratings. (cdc.gov)

However, it is not well-understood how fascin-1 induces actin binding/bundling and where fascin-1 localizes along the actin filaments, thus facilitating actin bundle formation. (bvsalud.org)

In persons who develop TBM, bacilli seed to the meninges or brain parenchyma, resulting in the formation of small subpial or subependymal foci of metastatic caseous lesions, termed Rich foci. (medscape.com)

Whereas the formation of focal adhesions requires actomyosin-mediated contractile force mediated by RhoA , podosome formation is stimulated by a local loss of contractility and the recruitment of negative regulators of RhoA, such as p190RhoGAP [16] . (cellmigration.org)
Here we show using super-resolution imaging of mouse primary B cells that LFA-1: ICAM-1 interactions promote the formation of an actomyosin network that dominates the B-cell IS. (sciety.org)
They find that LFA-1:ICAM-1 ligation promotes the formation of actomyosin arcs that regulate various activities in the B cell synapse including BCR signalling, BCR:antigen microcluster transport, and the centralisation of antigen. (sciety.org)

Changes in transcripts associated with the focal adhesion pathway were validated by RT-qPCR of COL4A1, COL4A2, FLNA, VAV3, VEGFA, and VINC mRNAs. (muni.cz)
Disease and disorder research has been conducted in relation to the Focal Adhesion Assembly Pathway and Tissue Adhesions, Malignant Neoplasms, Neoplasms, Cell Invasion, Carcinoma. (novusbio.com)
The study of the Focal Adhesion Assembly Pathway has been mentioned in research publications which can be found using our bioinformatics tool below. (novusbio.com)
The Focal Adhesion Assembly Pathway complements our catalog of research reagents including antibodies and ELISA kits against PTK2, PXN, VCL, FN1, PXDN. (novusbio.com)
We have 2524 products for the study of the Focal Adhesion Assembly Pathway that can be applied to Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits. (novusbio.com)

We now show that rac and cdc42 also stimulate the assembly of multimolecular focal complexes at the plasma membrane. (nih.gov)

These adhesions generate signals that activate Rac, promoting actin polymerization and preventing myosin II engagement in the lamellipodium. (cellmigration.org)
These signals are also required for the dissolution of some adhesions (turnover) as the cell advances. (cellmigration.org)

Researchers at the Beckman Institute for Advanced Science and Technology and the Micro and Nanotechnology Laboratory at the University of Illinois have developed a new form of microscopy that allows them to observe the formation and evolution of cell membrane focal adhesions. (rdworldonline.com)
investigate the role of LFA-1:ICAM-1 ligation in B cell synapse formation using live-cell super-resolution fluorescence microscopy in both primary B cells and the A20 B cell line. (sciety.org)

At the lamellipodium-lamellum interface, unstable adhesions disappear and stable ones start to elongate in a centripetal fashion along the direction of actin retrograde flow. (mechanobio.info)

Second high cytoplasmic fluorescence background may give low signal-to-background ratio that hinders the detection of focal adhesions [10]-[12]. (technologybooksindustrialprojectreports.com)

Podosomes are ring-shaped adhesions often found in fast-moving cells, such as macrophages. (cellmigration.org)
Focal adhesion structures bear resemblance to invadopodia, which are dynamic actin-based protrusions that form on the plasma membrane of cancer cells. (ubc.ca)
in cultured cells it is localized in focal adhesions (Hägg et al. (reactome.org)
used genetic techniques to silence PVRL4 in cells from breast tumors, they found that it reduced the formation of clusters by the cancer cells and also reduced their ability to grow in the absence of attachment. (elifesciences.org)
Cells on fibrin-FN+tenascin-C redistribute their actin to the cell cortex, downregulate focal adhesion formation, and do not assemble a FN matrix. (ox.ac.uk)
Obtaining focal adhesion sites in live cells embedded in 3D matrices has been challenging. (technologybooksindustrialprojectreports.com)
Recent literature has discussed several other issues regarding focal adhesion studies of live cells in 3D. (technologybooksindustrialprojectreports.com)
First the focal adhesions detected may be from your cells that experience the stiff glass surface due to the proximity to the imaging dish ('edge effect') which is not a true 3D environment. (technologybooksindustrialprojectreports.com)
These results demonstrate the loss of AND-34 dysregulates focal adhesion complex signaling in lens epithelial cells and suggest that AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens. (molvis.org)

Although their molecular composition is very similar to that of focal adhesions, their spatial distribution is radial, forming dot-like structures similar to 'suction cups' [14] . (cellmigration.org)
Compared to 2D imaging standard confocal microscopes have an axial resolution that is about three times lower than lateral resolution which makes it hard to discern very small structures such as focal adhesions. (technologybooksindustrialprojectreports.com)
When the shoal approaches the trap structures, at the same time as the dolphins' attack, it scatters from its initial formation and splits, which aids the dolphins in their capture (Landeau & Terborgh, 1986). (bvsalud.org)

Mutations on DLC-1 perturb the interaction with cten and disrupt the focal adhesion localization of DLC-1. (rupress.org)
These results provide a novel mechanism whereby the SH2 domain of cten-mediated focal adhesion localization of DLC-1 plays an essential role in its tumor suppression activity. (rupress.org)

The resistance to fouling is quantified and thrombus formation and deposition of blood cellular components on the coatings are analyzed. (ibecbarcelona.eu)
The discrepancy of cellular migratory behavior when focal adhesion-related components in 2D and 3D are altered could indicate that focal adhesions in 3D if they exist may carry out different functions [12]-[14]. (technologybooksindustrialprojectreports.com)

The tensin family member cten (C-terminal tensin like) is an Src homology 2 (SH2) and phosphotyrosine binding domain-containing focal adhesion molecule that may function as a tumor suppressor. (rupress.org)

Compared with an unmodified glass surface, the grafting of polymer brushes minimizes the adhesion of platelets and leukocytes and prevents the thrombus formation. (ibecbarcelona.eu)

Solid tumors frequently have copy number gains of the PVRL4 locus and some have focal amplifications. (elifesciences.org)

Importantly, ligating the B-cell integrin, LFA-1, with ICAM-1 promotes IS formation when antigen is limiting. (sciety.org)
Promotes targeting of RAC1 to focal adhesions (By similarity). (nih.gov)
Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. (nih.gov)

Compared with continuous nanogratings, discrete nanopillars tended to disrupt the formation and growth of focal adhesions and thus had less profound effects on nuclear deformation. (cdc.gov)

5 μm (fibrillar adhesion) with slower turnover rates [3] [8]. (technologybooksindustrialprojectreports.com)

This paper is a systematic review of the literature on the mechanisms of cell adhesion to bone grafts associated to nanotechnology, describing the importance and the role of those molecules in the adhesion and thus in tissue regeneration. (bvsalud.org)
Several molecules are involved in the process of cell adhesion to bone grafts, highlighting the role of integrins, the focal adhesion mechanism, the influence of the collagen matrix, and the activity of alkaline phosphatase in bone matrix formation. (bvsalud.org)

Although nanotopography has been shown to be a potent modulator of cell behavior, it is unclear how the nanotopographical cue, through focal adhesions, affects the nucleus, eventually influencing cell phenotype and function. (cdc.gov)

Throughout apoptosis, FAK is an important contributor to cell rounding, loss of focal contacts and apoptotic membrane formations such as blebbing, which involves contracting the cortical actin ring and is followed by chromatin condensation and nuclear fragmentation. (wikipedia.org)

Owing to their highly localized nature, cell-matrix adhesions were initially called focal adhesions. (cellmigration.org)

However, little is known about the regulation of podocyte adhesion in vivo. (elsevierpure.com)

Our study delineated the relationships between focal adhesions, nucleus and cell function and highlighted that the nanotopography could regulate cell phenotype and function by modulating nuclear deformation. (cdc.gov)

The present studies demonstrate that acid-induced stress fiber formation is required for stimulation of NHE3 activity. (elsevierpure.com)

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After the use of search strategies, 18 articles that describe processes of cell adhesion to bone grafts were selected. (bvsalud.org)

Anatomy39

Organisms5

Diseases11

Chemicals and Drugs128

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes48

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science4

Kinase16

Proteins12

Extracellular10

Cytoskeleton6

Stress fibers5

Nascent adhesions5

Maturation5

Disassembly4

Fibers2

Paxillin2

Migration10

Phosphorylation2

Integrin activation1

Differentiation4

Proliferation1

Motility5

Activation4

Pyk21

Dynamics1

Protein3

Substrate1

Elongation1

Actin filaments1

Metastatic1

Actomyosin3

Pathway5

Complexes1

Signals2

Microscopy2

Elongate1

Cytoplasmic1

Cells9

Structures3

Localization2

Cellular2

Molecule1

Thrombus formation1

Tumors1

Promotes3

Disrupt1

Turnover1

Molecules2

Behavior1

Membrane1

Initially1

Vivo1

Regulate1

Demonstrate1

Assembly3

Processes1