• Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
  • Proteins that incorporate vWF domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signal transduction), involving interaction with a large array of ligands. (embl-heidelberg.de)
  • The presence of this region in a number of other complex-forming proteins points to the possible involvment of the VWFC domain in complex formation. (embl-heidelberg.de)
  • The formation of necrosome, a multiprotein complex that stimulates necroptosis, is tightly regulated by proteins downstream of the receptor and can be the deciding factor in inducing necroptosis. (news-medical.net)
  • Microdomains or lipid rafts greatly affect the distribution of proteins and peptides in the membrane and play a vital role in the formation and activation of receptor/protein complexes. (frontiersin.org)
  • Second Mouse monoclonal to GATA1 it provides interaction sites for bromo-domain containing proteins to build large multi-protein complexes required for transcription initiation Idarubicin HCl and elongation. (biodiversityhotspot.org)
  • The resultant 2 encoded von Hippel-Lindau protein (pVHL) products, a 30-kD full-length form (p30) and a 19-kD form (p19), shuttle between the nucleus and the cytoplasm, where they form complexes with other proteins. (medscape.com)
  • Small angle neutron scattering (SANS) provides unique insight into biomacromolecular complexes by combining solvent contrast variation (H2O:D2O exchange) with either natural contrast between different classes of biomolecules (proteins, RNA/DNA, lipids/detergents) and/or by applying artificial contrast, i.e. deuteration of specific biomolecules. (lu.se)
  • This process begins with recognition of intracellular and extracellular danger signals, which leads to formation of a large, multi-protein complex known as the inflammasome. (immunochemistry.com)
  • 2008 An underlying molecular mechanism of both cocaine-induced neuroplasticity associated with habit (with HDAC4 or HDAC5 in multi-protein transcriptional repressor complexes (Lahm et al. (healthandwellnesssource.org)
  • In a first couple of examples, I will show how distance and shape restraints from SANS have helped to improve the uniqueness of structural models for two multi-protein-RNA complexes, in combination with NMR restraints and building blocks from crystallography [1, 2]. (lu.se)
  • Our findings establish Sox17 as a tissue -specific modifier of Wnt responses and point to a novel paradigm where genomic specificity of Wnt/β-catenin transcription is determined through functional interactions between lineage-specific Sox TFs and β-catenin/Tcf transcriptional complexes. (xenbase.org)
  • Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors. (ox.ac.uk)
  • Here we have addressed the transcriptional hierarchy responsible for HSC formation by characterizing an SCL 3' enhancer that targets expression to HSCs and endothelium and their bipotential precursors, the haemangioblast. (ox.ac.uk)
  • Our results suggest that these transcription factors are key components of an enhanceosome responsible for activating SCL transcription and establishing the transcriptional programme required for HSC formation. (ox.ac.uk)
  • In the Pol IV mutant, both siRNA formation and DNA methylation are decreased at heterochromatic regions, Herr and colleagues found. (biomedcentral.com)
  • In addition, Sec6 interacts with the plasma membrane t-SNARE Sec9, suggesting that the Sec6-Sec9 interaction is a critical intermediate in the assembly of SNARE complexes (8). (bio2009.org)
  • Several studies have also suggested that the protein Sec1 interacts with Sec6 to regulate SNARE complex assembly (9, 10). (bio2009.org)
  • It is thought that Sec6 interacts with the exocyst after Sec6 releases Sec9, and Sec1 is recruited simultaneously for coordinated SNARE complex formation and membrane fusion (10). (bio2009.org)
  • Part of the AS1 repressor complex to regulate the KNOX expression in leaf development (PubMed:23271976). (ac.be)
  • De novo formation of an adherens junction (AJ) between single epithelial cells requires coordinated, spatial actin dynamics, but the mechanisms steering nascent actin polymerization for cell-cell adhesion initiation are not well understood. (rupress.org)
  • The yeast exocyst is a multiprotein complex comprised of eight subunits (Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84) which orchestrates trafficking of exocytic vesicles to specific docking sites on the plasma membrane during polarized secretion. (bio2009.org)
  • Complement activation generates membrane attack complex (MAC). (biomedcentral.com)
  • MAC causes channel formation to the cell membrane of pathogen, leading to death of microorganisms. (biomedcentral.com)
  • The surface of the living cells is decorated by a complex layer of glycosylated molecules that store relevant biological information. (nature.com)
  • The signalling molecules are delivered directly to the receiving cells by a direct-contact model and parameters such as cytoneme length or speed of filopodia formation dictate local Wnt concentration. (exeter.ac.uk)
  • We consider that in a healthy cell there is an equilibrium between the concentrations of the molecules Bid, Bax, Bcl-2, and the complexes Bcl2:tBid and Bcl2:Bax. (parathyroid-hormone1-34.com)
  • Because FGF1 plays an important role in tumor formation, it is clear that preventing the formation of the multiprotein complex would be an effective strategy to inhibit a wide range of cancers. (rcsb.org)
  • Angiogenesis - the formation of new blood vessels - occurs during tissue growth and development, but also during wound healing and cancer [1] , [2] . (plos.org)
  • RNA silencing occurs through the multiprotein RNA-induced silencing complex that cleaves double stranded RNA, producing short interfering RNAs (siRNA), which then amplify the cycle. (biomedcentral.com)
  • In the host, MAC also may induce channel formation to innocent bystander endothelial cells (ECs) and ECs cannot be protected. (biomedcentral.com)
  • In a second example, the stoichiometry and internal topology of a highly symmetric, hetero-dodecameric aminopeptidase enzyme complex is revealed by SANS, and conclusions on the assembling process can be drawn in combination with EM data [3]. (lu.se)
  • This study provides a proof of concept for the application of this method on large complexes. (cnrs.fr)
  • 2013). Finally chromatin remodeling involves large multi-subunit complexes that can alter nucleosome positioning and the wrapping of DNA (reviewed in Hargreaves et al. (biodiversityhotspot.org)
  • FGFs are essential for early embryonic development, organ formation, and angiogenesis. (rcsb.org)
  • Both responses require the Myddosome, a multiprotein complex. (bvsalud.org)
  • To cope with Pi limitations, plants have evolved complex adaptive responses that include morphological and physiological modifications to improve Pi acquisition or remobilization via the differential expression of various Pi transporter genes [ 10 , 11 ]. (biomedcentral.com)
  • 2006 It is hypothesized that related molecular mechanisms responsible for long-term memory space formation also participate in the formation of Pyroxamide (NSC 696085) long-term cocaine-context connected remembrances (Nestler 2002 Hyman 2005 Everitt et al. (healthandwellnesssource.org)
  • In the next section of this review we will first discuss the ways in which these epigenetic mechanisms are involved in the formation of long-term memory and then approach the question of persistence. (biodiversityhotspot.org)
  • As it is very difficult to determine the specific impact of individual parameters in a complex biological system by a purely experimental approach, we interact with mathematicians using computational modelling. (exeter.ac.uk)
  • Recently, we showed that Wnt8a is transported on short, actin-based filopodia known as cytonemes to contact responding cells and activate signalling during neural plate formation in zebrafish (1).Wnt/ Ror2 signalling regulates the formation of these Wnt cytonemes (5). (exeter.ac.uk)
  • These data uncover FMNL2 as a driver for human epithelial AJ formation downstream of Rac1. (rupress.org)
  • Overall, these data identify a critical functional role for ATF7IP in heterochromatin formation by regulating SETDB1 abundance in the nucleus. (nih.gov)
  • The role of HDACs as repressors of gene expression leads to the prediction that inhibition of HDACs during the transcription-dependent consolidation phase of memory formation would Idarubicin HCl result in enhancement of long-term memory. (biodiversityhotspot.org)
  • A wide variety of inflammatory mediators such as pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) trigger the formation and activation of the NLRP3 inflammasome. (nature.com)
  • E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection. (umassmed.edu)
  • Mitochondrial reactive oxygen species (mtROS) driven by gefitinib stimulated the formation of the NLRP3 (NACHT, LRR and PYD-containing protein 3) inflammasome, leading to mature-IL-1β release. (nature.com)
  • It does so by forming a multiprotein signaling complex, the NLRP3 inflammasome, with apoptosis-associated speck-like protein containing CARD (ASC) and caspase-1 1 . (nature.com)
  • FGF1 is exported through a non-classical release pathway involving the formation of a specific multiprotein complex. (rcsb.org)
  • Our results suggest that pathway specific targeting and sorting mechanism are required to significantly narrow down the receptor/raft ratio and to enable the formation of the LRP6 signalosome, hence signaling. (frontiersin.org)
  • Pharmacological inhibition of the IL-1R1 does not consistently protect the kidney from injury, suggesting there may be complex, cell-specific effects of IL-1R1 stimulation in AKI. (bvsalud.org)
  • Might remove acetyl residues only from specific targets, such as rDNA repeats or complex transgenes. (ac.be)
  • To understand the molecular events in the FGF1 release pathway, we studied the FGF1-S100A13 tetrameric and FGF1-S100A13-C2A hexameric complex structures, which are both complexes possibly formed during the non-classical pathway of FGF1 release. (rcsb.org)
  • Inflammasomes are cytosolic multiprotein complexes, whose formation is triggered by sensors of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs). (invivogen.com)
  • Haematopoietic stem cells (HSCs) represent the best-characterized example of this phenomenon, but the molecular mechanisms responsible for their formation remain obscure. (ox.ac.uk)
  • The mitochondrial contact site and cristae organization system (MICOS) is a multiprotein complex responsible for cristae formation. (jcu.cz)
  • The subsequent release of Cytochrome C inside the citoplasm of the cells induces the formation of a multiprotein complex, called apoptosome, that activates the caspase cascade through caspase-9 (C9) leading to Apoptosis. (parathyroid-hormone1-34.com)
  • Here we investigated real-time actin assembly during daughter cell-cell adhesion formation in human breast epithelial cells in 3D environments. (rupress.org)
  • We identify formin-like 2 (FMNL2) as being specifically required for actin assembly and turnover at newly formed cell-cell contacts as well as for human epithelial lumen formation. (rupress.org)
  • There are lots of similar mechanisms underlying diabetic and common AS, the former is more complex. (wjgnet.com)
  • A key question that is explored in this review from a learning and memory perspective is whether stress-dependent signaling drives the formation and persistence of long-term memory via HDAC-dependent mechanisms. (biodiversityhotspot.org)
  • A second area if interest is how initial satellite cell number is determined during skeletal muscle formation (myogenesis). (missouri.edu)
  • Soluble Pi in the soil also forms complexes with cations like calcium, magnesium, aluminum or iron, which are not readily absorbed by plants. (biomedcentral.com)
  • In particular, Bax forms the pore, while Bcl-2 inhibits its formation. (parathyroid-hormone1-34.com)
  • Enhanced formation of cytonemes increases the effective signalling range of Wnt by facilitating spreading. (exeter.ac.uk)
  • The HDAC inhibitors valproic acid (VPA) trichostatin A (TSA) and sodium butyrate (NaB) have been shown to enhance LTP memory formation and the extinction of memory (Guan et al. (biodiversityhotspot.org)
  • The protein constituents of this complex include FGF1, S100A13, and the p40 form of synaptotagmin 1 (Syt1). (rcsb.org)
  • As a result, ATF7IP is critical for repression that requires H3K9 trimethylation by SETDB1, including transgene silencing by the HUSH complex. (nih.gov)
  • 2001). Multiprotein complex formation at the beta myosin heavy chain distal muscle CAT element correlates with slow muscle expression but not mechanical overload responsiveness. (missouri.edu)