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  • mammalian
  • The folding pattern for this structure closely resembles that found in some tandem-repeat mammalian lipid-binding and bactericidal permeability-increasing proteins, with a similar organisation of the major cavity and a disulfide bond linking the long helix and the beta-sheet. (wikipedia.org)
  • encode
  • A precursor messenger RNA (mRNA) from the complete gene first is transcribed and then spliced to encode the full receptor protein. (wikipedia.org)
  • Mutations
  • Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. (abnova.com)
  • These mutations show a lower kcat and an increase in the rate of decay of the peroxo intermediate, providing evidence of stabilization of the intermediate. (wisconsin.edu)
  • Type I patients showed only deletions, insertions, and nonsense mutations were identified, most leading to shortened polypeptides. (wikipedia.org)
  • Most type II patients show missense mutations in D-BP hydratase unit as well as some in-frame deletions. (wikipedia.org)
  • Type III individuals commonly show missense mutations in the coding region of the dehydrogenase domain. (wikipedia.org)
  • interactions
  • 2 The α- and β-tubulin isoforms contribute to the functional diversity of microtubules either through their differential polymerization, or by virtue of unique interactions with distinct microtubule-associated proteins (MAPs). (bloodjournal.org)
  • acetyl
  • 2. Oxidation: In order to form an acetyl group, the hydroxyethyl group which is attached to TTP is oxidized. (wikibooks.org)
  • 3. Formation of Acetyl CoA: Formation of Acetyl CoA: In this step, acetyl CoA is formed when acetyl group is transferred from acetyllipoamide. (wikibooks.org)
  • The figure shows the possible cyclizations of tetraacetic acid assumed to be formed by condensation of four acetyl units. (els.net)
  • cytoplasm
  • Oleic acid is formed from this reaction is transported to either the thylakoid or cytoplasm to complete desaturation. (wikipedia.org)
  • distinct
  • Each of the different forms of FAD have distinct absorbance spectra, making for easy observation of changes in oxidation state. (wikipedia.org)
  • Oxidation
  • Next a still unidentified protein catalyzes the selective oxidation of the benzene (as shown in Fig. 2). (wikipedia.org)
  • Upon oxidation this intermediate will spontaneously lactonize to form the aromatic ring B and lose NovH in the process. (wikipedia.org)
  • D-Bifunctional protein deficiency (officially called 17β-hydroxysteroid dehydrogenase IV deficiency) is an autosomal recessive peroxisomal fatty acid oxidation disorder. (wikipedia.org)
  • cells
  • Transfection of green fluorescent protein (GFP)-tagged Q43P β1-tubulin in megakaryocytic MEG01 cells resulted in a disturbed tubulin organization. (bloodjournal.org)
  • Water stays put in the cells because it's absorbed onto the protein surfaces. (outofthisworld1150.com)
  • Structured water adheres to the proteins of the cells. (outofthisworld1150.com)
  • Expression of IRE-BP in cultured cells has revealed that the protein functions either as an active aconitase, when cells are iron-replete, or as an active RNA-binding protein, when cells are iron-depleted. (wikipedia.org)
  • ADP/ATP translocase 1 is the major AAC in human cells and the archetypal protein of this family. (wikipedia.org)
  • The mechanism below describes the process in which auxin is trapped in the cell by the so-called acid trap and how it can then leave the cell only by activity of specific carriers, which control the directionality of the flow from cells and generally the direction of auxin transport through the whole plant body. (wikipedia.org)
  • enzymes
  • However, it is also used in other cellular processes, most notably a substrate of enzymes that add or remove chemical groups from proteins, in posttranslational modifications. (wikipedia.org)
  • carboxyl
  • 5 The amino acid differences between β1-tubulin and other β-tubulins are scattered throughout the protein but are mainly concentrated in the carboxyl terminal region, which is located on the outer surface of the microtubules and interacts with MAPs. (bloodjournal.org)
  • fold
  • Of these, 15 showed significant changes in expression levels (log 2 fold values ≥ 1) during seed development. (biomedcentral.com)
  • The crystal structure of the JHBP from Galleria mellonella (greater wax moth) shows an unusual fold consisting of a long alpha-helix wrapped in a much curved antiparallel beta-sheet. (wikipedia.org)
  • substrates
  • Shows preference for long-chain fatty acyl thioester substrates, and can also use 2-trans-enoyl-CoAs as alternative substrates. (uniprot.org)
  • precursor
  • The mycobacterial FAS-II system utilizes the products of the FAS-I system as primers to extend fatty acyl chain lengths up to C56, forming the meromycolate chain that serves as the precursor for final mycolic acids. (uniprot.org)