• Morphea is a form of localized scleroderma characterized by waxy patches on the skin of varying sizes, shapes and color. (scleroderma.org)
  • Linear scleroderma and morphea can coexist in the same patient. (medscape.com)
  • There are two main forms of localized scleroderma: morphea and linear scleroderma. (mountsinai.org)
  • In morphea scleroderma, patches of hard skin form and can last for years. (mountsinai.org)
  • Localized scleroderma (also called morphea) -- Often affects only the skin on the chest, abdomen, or limb but not usually on the hands and face. (medlineplus.gov)
  • Morphea, also known as localized scleroderma, is characterized by predominant skin involvement, with occasional involvement of subjacent muscles and usually sparing the internal organs. (biomedcentral.com)
  • The proposed study will investigate the esophageal involvement in the two forms of scleroderma (systemic and localized), compare the same and address any need of upper gastrointestinal evaluation in morphea (localized scleroderma) patients. (biomedcentral.com)
  • Morphea, also called as localized scleroderma, predominantly involves the skin and occasionally involves subjacent muscles. (biomedcentral.com)
  • The present study was designed to investigate the esophageal involvement in the systemic (SSc) and localized (morphea) forms of scleroderma and to compare the same. (biomedcentral.com)
  • Children who get morphea, the most common form of Scleroderma, are more likely to have a close relative with the disease. (e-sportsmag.com)
  • Morphea en plaque is more common in adults. (medscape.com)
  • Raised, waxy skin accumulations known as morphea are a hallmark of localized scleroderma. (facty.com)
  • Morphea is a form of localized scleroderma. (surgpath4u.com)
  • This form of the disease is called localized scleroderma or morphea. (arthritisdaily.net)
  • Some drugs, such as rituximab (Rituxan), mycophenolate mofetil (CellCept), and imatinib mesylate (Gleevac), used to treat certain autoimmune diseases and cancers may play a role in treating scleroderma. (mountsinai.org)
  • Widespread scleroderma can occur with other autoimmune diseases, including systemic lupus erythematosus and polymyositis . (medlineplus.gov)
  • If you would like to add to this blog with similar articles for other varieties of scleroderma or even for other autoimmune diseases or chronic conditions please drop me a line using my contact form . (marieperry.com)
  • Autoimmune diseases can be difficult to diagnose due to the variety of symptoms, and scleroderma is no exception. (mountain-ice.com)
  • Complicated, accelerated, and acute silicosis are frequently accompanied by mycobacterial infections and autoimmune diseases such as scleroderma and rheumatoid arthritis. (cdc.gov)
  • Silica exposure and/or silicosis has also been associated with autoimmune diseases such as lupus erythematosus, rheumatoid arthritis, scleroderma, and with glomerulonephritis. (cdc.gov)
  • However, persons with limited scleroderma, and occasionally those with diffuse scleroderma, can develop pulmonary hypertension, a condition in which the lung's blood vessels become narrow, leading to impaired blood flow through the lungs resulting in shortness of breath. (scleroderma.org)
  • Scleroderma - causes scar tissue to form in the skin, internal organs, and small blood vessels. (upmc.com)
  • Scleroderma can cause small blood vessels in the kidneys to become narrowed. (medlineplus.gov)
  • While Scleroderma affects only the skin, in many cases, it can go beyond the skin, damaging structures such as internal organs, blood vessels, and the digestive tract. (prlog.org)
  • Scleroderma can damage your blood vessels, digestive tract, and internal organs, especially when it is left untreated. (stemaidinstitute.com)
  • Symptoms range from mild to life-threatening, and in severe cases, scleroderma can damage the blood vessels and organs. (facty.com)
  • Despite the name, limited scleroderma may narrow the blood vessels of the lungs and lead to lung scarring, which can cause shortness of breath. (facty.com)
  • In other forms, however, the problem goes much deeper, and may severely affect blood vessels and internal organs such as the heart, lungs, and kidneys. (skinpatientalliance.ca)
  • Ashton Kutcher said he is "lucky to be alive" after dealing with a rare form of vasculitis, which involves inflammation of the blood vessels. (hppr.org)
  • There are several types of vasculitis, and while it's not clear which affected Kutcher, all forms involve swelling in the walls of blood vessels and can result in a variety of conditions. (hppr.org)
  • The systemic sclerosis overlap syndrome is characterized by features of one of the scleroderma subsets with those of another autoimmune disease (eg, lupus erythematosus , dermatomyositis , Sjögren syndrome , and/or rheumatoid arthritis ). (logicalimages.com)
  • If your doctor suspects that you have an autoimmune disorder such as systemic lupus erythematosus (SLE), rheumatoid arthritis or scleroderma, he may arrange to have you take an antinuclear antibody (ANA) test. (healthy.net)
  • People with other autoimmune disorders, including lupus, rheumatoid arthritis and scleroderma, may also develop vasculitis. (hppr.org)
  • Scleroderma is commonly misdiagnosed and confusing to patients and medical doctor since the symptoms can extend beyond other auto immune diseases such as Lupus, Rheumatoid Arthritis and Multiple Sclerosis. (herbal-care-products.com)
  • This means that age-associated B-cells develop more frequently, such as with rheumatoid arthritis (RA), scleroderma, and systemic lupus erythematosus . (medscape.com)
  • This form of scleroderma can also cause complications like pulmonary arterial hypertension. (home-remedies-for-you.com)
  • Systemic sclerosis is a generalized form of scleroderma which affects multiple organs at a time and if not treated timely can cause various complications. (selfgrowth.com)
  • The present clinical case is that of a man with the renal complications of scleroderma and the difficulties of the treatment even in the developed countries like France. (scirp.org)
  • What are possible complications of scleroderma in a child? (uhhospitals.org)
  • Complications of scleroderma vary depending on the type of the disease and how severe it is. (uhhospitals.org)
  • and scleroderma renal crisis are the major complications. (msdmanuals.com)
  • However, other patients with scleroderma do develop internal complications relatively soon after the onset of skin problems. (arthritisdaily.net)
  • The aim of Natural Treatment for Scleroderma will be to relieve the symptoms such as, hardness of skin, joint pain, dry cough, shortness of breath, Diarrhea and difficulty swallowing to stop the condition from worsening, or however slow it down, to detect and treat complications as soon as possible, and to minimize disabilities. (herbal-care-products.com)
  • Renal and cardiovascular complications were the leading causes of death.Conclusion: Diffuse systemic sclerosis is a more serious disease than the limited form. (bvsalud.org)
  • The internal organs are usually not affected, and persons with localized scleroderma rarely develop systemic scleroderma. (scleroderma.org)
  • In addition, people with diffuse scleroderma have a higher risk of developing "sclerosis" or fibrous hardening of the internal organs. (scleroderma.org)
  • Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. (wikipedia.org)
  • There are two more versions - morpha and linear scleroderma - which affect the skin and may afflict the internal organs. (home-remedies-for-you.com)
  • Scleroderma can lead to scarring of the skin, joints, and internal organs. (uhhospitals.org)
  • Systemic sclerosis is a form of scleroderma that can not only affect the skin and underlying tissue, but also the internal organs. (23andme.com)
  • Scleroderma, or progressive systemic sclerosis, is an autoimmune connective tissue disease that involves sclerotic changes of the skin and may involve internal organs. (logicalimages.com)
  • The systemic form scleroderma involves the sclerosis (hardening) of internal organs. (drwilderman.com)
  • Systemic Scleroderma, or systemic sclerosis, can have a sudden or progressive onset and damage internal organs and the skin. (e-sportsmag.com)
  • Scleroderma is an aspect of systemic sclerosis , a systemic connective tissue disease that also involves subcutaneous tissue, muscles, and internal organs. (medscape.com)
  • Like lupus, patients having scleroderma skin changes have a variable risk for having associated damage to internal organs, especially the kidneys and lungs. (arthritisdaily.net)
  • Some patients develop a form of scleroderma that never goes on to cause damage to internal organs. (arthritisdaily.net)
  • Typically only affecting the skin, localized scleroderma can spread to muscles, bones, and joints, but not to the internal organs. (mountain-ice.com)
  • Scleroderma involving the internal organs may be treated with herbal supplements offered by Herbal Care Products that improve blood flow, promote esophagus and bowel function, keep the kidneys functioning, and control high blood pressure. (herbal-care-products.com)
  • The severity of these symptoms varies greatly among patients: Some having scleroderma of only a limited area of the skin (such as the fingers) and little involvement of the underlying tissue, while others have progressive skin involvement. (wikipedia.org)
  • Musculoskeletal The first joint symptoms that patients with scleroderma have are typically nonspecific joint pains, which can lead to arthritis, or cause discomfort in tendons or muscles. (wikipedia.org)
  • Lungs Some impairment in lung function is almost universally seen in patients with diffuse scleroderma on pulmonary function testing, but it does not necessarily cause symptoms, such as shortness of breath. (wikipedia.org)
  • We describe the progression of bullous scleroderma in a 67-year-old patient since the first symptoms. (cdlib.org)
  • No drugs have been cured the symptoms of Scleroderma in modern medicine, but Ayurveda has an answer for this rare disease too. (selfgrowth.com)
  • What are the symptoms of scleroderma in a child? (uhhospitals.org)
  • Keep reading to learn about the similarities, differences, and relationship between lupus and scleroderma, including their symptoms, treatments, and prognosis for people with both conditions. (medicalnewstoday.com)
  • This form of the disease overlaps with lupus in terms of symptoms. (medicalnewstoday.com)
  • You may have no symptoms if you have a mild form of guttate scleroderma, lichen sclerosus type. (illness.com)
  • Regarding Scleroderma, the symptoms might vary widely from person to person according to which body systems are being impacted. (e-sportsmag.com)
  • However, several treatments available to those living with scleroderma help alleviate symptoms, boost the quality of life and slow the disease progression. (e-sportsmag.com)
  • Scleroderma symptoms are highly distinctive and depend on a person's type of Scleroderma. (e-sportsmag.com)
  • If you have symptoms of scleroderma or you have been diagnosed with this skin disorder, you should seek medical attention. (stemaidinstitute.com)
  • Your symptoms will vary based on the type of scleroderma you have, but there are a few vital signs you should look out for that may indicate you have the disease. (stemaidinstitute.com)
  • However, if you're suffering from scleroderma, you don't have to turn to heavy medications to relieve your symptoms. (stemaidinstitute.com)
  • The symptoms of Scleroderma vary from person to person. (drdubow.com)
  • Scleroderma can't be cured, but the symptoms impacting the skin can be treated. (drdubow.com)
  • Although there is no cure for scleroderma, medications can reduce symptoms and help individuals lead active lives. (facty.com)
  • Scleroderma symptoms can be intermittent or progressive depending on the form. (facty.com)
  • Scleroderma is difficult to diagnose because it causes many common autoimmune symptoms. (facty.com)
  • After this initial warning sign, individuals may notice other scleroderma symptoms appear or worsen. (facty.com)
  • Neurologic symptoms (e.g. seizures/epilepsy, headaches/migraines, stroke) and/or ophthalmology conditions such as uveitis may occur in LoS of the head or face (en coup de sabre subtype, progressive hemifacial atrophy) [ 3 ]. (biomedcentral.com)
  • In the case of scleroderma, this rheumatic autoimmune disease tends to involve the thickening or tightening of the skin and the connective tissue under it, but many other symptoms may be present. (mountain-ice.com)
  • As we've said, diagnosing scleroderma can be difficult because some of the symptoms are shared with other autoimmune and rheumatic disorders. (mountain-ice.com)
  • Started Herbal Treatment for Scleroderma with herbal supplement such as "CLEMICAL" its work on the immune system and can help diminish Symptoms of Scleroderma completely and effectively. (herbal-care-products.com)
  • Linear scleroderma is a form of localized scleroderma which frequently starts as a streak or line of hardened, waxy skin on an arm or leg or on the forehead. (scleroderma.org)
  • Linear scleroderma tends to involve deeper layers of the skin as well as the surface layers, and sometimes affects the motion of the joints, which lie underneath. (scleroderma.org)
  • Linear scleroderma usually develops in childhood. (scleroderma.org)
  • Linear scleroderma causes bands of hard skin across the face or on a single arm or leg. (mountsinai.org)
  • Linear scleroderma may also involve muscle or bone. (mountsinai.org)
  • Linear scleroderma tends to affect children and adolescents. (medscape.com)
  • Linear scleroderma is typically diagnosed in childhood and has the potential to affect limb development, so responsive treatment is important. (facty.com)
  • linear scleroderma on the face or forehead. (mountain-ice.com)
  • Background: There is much evidence that T cells are strongly involved in the pathogenesis of localized and systemic forms of scleroderma (SSc). (uni-wuerzburg.de)
  • There are two types of the disease, localized and systemic scleroderma. (mountain-ice.com)
  • We always thought that oestrogen played a role, but we needed additional research to identify associations between elevated oestrogen levels and clinical aspects of scleroderma. (hospitalhealthcare.com)
  • They then used a variety of statistical approaches and the careful clinical annotations accompanying each sample to determine whether estradiol levels were linked to any of the clinical traits of scleroderma. (hospitalhealthcare.com)
  • A recent exciting clinical trial finding funded by the National Institutes of Health revealed that stem cell therapy can improve the survival rate and quality of life for those with severe scleroderma. (stemaidinstitute.com)
  • Systemic sclerosis is a complex and heterogeneous disease with clinical forms ranging from limited skin involvement (limited cutaneous systemic sclerosis) to forms with diffuse skin sclerosis and severe and often progressive internal organ involvement (diffuse cutaneous systemic sclerosis), and occasionally a fulminant course (fulminant systemic sclerosis). (medscape.com)
  • Maureen Mayes, M.D., is the founder and director of the Scleroderma Clinical and Research Program at the University of. (medlineplus.gov)
  • This form of the disease is classified as diffuse cutaneous systemic sclerosis (dcSSc). (medlineplus.gov)
  • The team tested oestradiol and scleroderma autoantibody levels in banked samples from 83 men aged 50 years and older with diffuse cutaneous systemic sclerosis, a type of scleroderma. (hospitalhealthcare.com)
  • As I mentioned earlier, I have the limited cutaneous systemic sclerosis variant of scleroderma so that is my focus here. (marieperry.com)
  • Though the exact cause of scleroderma is yet to be determined, the disease itself involves the overproduction of collagen, a protein that binds skin and connective tissue. (drwilderman.com)
  • The main reason why Scleroderma forms in the body are because of the overproduction of collagen. (drdubow.com)
  • It is known that scleroderma involves an overproduction of collagen. (skinpatientalliance.ca)
  • There is no medical treatment for scleroderma that controls or stops the underlying problem - the overproduction of collagen - in all forms of scleroderma. (herbal-care-products.com)
  • Endostatin, an anti-angiogenic C-terminal fragment of collagen XVIII, has been recently reported to play a role in scleroderma pathogenesis, but collagen XVIII immunohistochemistry in scleroderma skin has still not been performed. (cdlib.org)
  • Conversely, both fibronectin and collagen XVIII are increased in scleroderma skin, suggesting their involvement in the pathogenesis of bullous scleroderma. (cdlib.org)
  • The apparently normal skin from the patient with scleroderma shows histological signs of the disease, with thick collagen fibers and lymphatic ectasia. (cdlib.org)
  • In Scleroderma, immunity plays an important role in collagen production. (selfgrowth.com)
  • In scleroderma, the immune system attacks the skin, which causes inflammation and the production of excessive amounts of collagen . (medicalnewstoday.com)
  • It is an excessive quantity of collagen production in the body that can lead to Scleroderma. (e-sportsmag.com)
  • Collagen accumulates in the tissues of people with Scleroderma because their bodies produce too much protein. (e-sportsmag.com)
  • However, when your body starts producing collagen in excess and this collagen accumulates in your body, scleroderma results. (stemaidinstitute.com)
  • In some forms of scleroderma, hard, tight skin is the extent of this irregular collagen over-production process. (skinpatientalliance.ca)
  • The limited form affects areas below, but not above, the elbows and knees with or without involvement of the face. (wikipedia.org)
  • Prognosis is determined by the form of the disease and the extent of visceral involvement. (wikipedia.org)
  • As scleroderma progresses, esophageal involvement from abnormalities in decreased motility may worsen due to progressive fibrosis (scarring). (wikipedia.org)
  • Systemic sclerosis sine scleroderma - Raynaud phenomenon and systemic involvement without skin sclerosis. (logicalimages.com)
  • The team also found that men with scleroderma and higher levels of estradiol had more severe disease and heart involvement. (hospitalhealthcare.com)
  • Internal involvement in localized scleroderma. (medscape.com)
  • It is characterized by similar skin lesions as seen in scleroderma (thickening of dermis and subcutaneous tissues), however, unlike scleroderma, there is no systemic involvement. (surgpath4u.com)
  • Other forms or sub classifications, each with its own characteristics and prognosis, may be identified through future research. (scleroderma.org)
  • Patients with limited systemic sclerosis have a better prognosis than those with the diffuse form. (wikipedia.org)
  • Systemic scleroderma is a serious condition, while localized scleroderma carries a good prognosis and normal lifespan. (mountsinai.org)
  • The aim is to coordinate and focus research activities, in order to improve treatment, quality of life and prognosis of patients with scleroderma. (eustar.org)
  • Systemic scleroderma, or sclerosis -- May affect large areas of skin and organs such as the heart, lungs, or kidneys. (medlineplus.gov)
  • The type of scleroderma you have will be categorized based on the severity of skin thickening and the damage to your lungs, heart, and other vital body systems. (stemaidinstitute.com)
  • Although most patients have mild to moderate scleroderma, severe forms can injure the lungs, kidneys, and heart. (facty.com)
  • localized scleroderma and systemic sclerosis (SSc). (scleroderma.org)
  • Systemic scleroderma (systemic sclerosis) may affect the connective tissue in many parts of the body. (scleroderma.org)
  • There is the limited systemic sclerosis or scleroderma which affects the hands, arms and face. (home-remedies-for-you.com)
  • The next type is diffuse systemic sclerosis or scleroderma. (home-remedies-for-you.com)
  • Systemic scleroderma is also called systemic sclerosis . (mountsinai.org)
  • Hyperkeratosis, epidermal atrophy, vacuolization of basal cells, dermal edema and sclerosis, perivascular lymphohistiocytic infiltrate, multifocal vesiculation and dermo-epidermal fends are seen in the scleroderma skin. (cdlib.org)
  • Systemic sclerosis is known as scleroderma or progressive systemic sclerosis, or CREST syndrome. (selfgrowth.com)
  • It is characterized by microcirculation abnormalities and scleroderma and/or visceral sclerosis. (scirp.org)
  • Scleroderma is primarily a skin disease, but when it affects other systems in the body, doctors call it systemic scleroderma, or systemic sclerosis. (medicalnewstoday.com)
  • Yes, a person can have lupus and scleroderma, or systemic sclerosis, at the same time. (medicalnewstoday.com)
  • Scleroderma, also known as systemic sclerosis, is a chronic connective tissue disease characterized by the hardening of skin and connective tissue. (drwilderman.com)
  • The most common form of scleroderma-systemic sclerosis-entails the patient will have a relatively normal life expectancy. (stemaidinstitute.com)
  • Scleroderma is also known as systemic sclerosis, a collection of rare diseases that make skin harden and tighten. (drdubow.com)
  • Scleroderma, also called systemic sclerosis, is an autoimmune disease that produces scars and patches of thick, rough, or scaly skin. (facty.com)
  • In systemic sclerosis sine scleroderma, patients have systemic sclerosis-related antibodies and visceral manifestations of the disease but no skin tightening. (msdmanuals.com)
  • Localized scleroderma (LoS) is an autoimmune disorder characterised by inflammation and sclerosis of the skin and less commonly subcutaneous fat, in some cases only affecting the fasciae, muscles and bones. (biomedcentral.com)
  • The European Scleroderma Trials and Research group (EUSTAR) aims to foster the awareness, understanding and research on systemic sclerosis and its management throughout Europe and the rest of the world. (eustar.org)
  • Some laboratory abnormalities commonly seen in systemic scleroderma are frequently absent in the localized form. (scleroderma.org)
  • Although internal problems occur, they are less frequent and tend to be less severe than in diffuse scleroderma and are usually delayed in onset for several years. (scleroderma.org)
  • Rarely, if this type of scleroderma affects children or young adults, it may interfere with growth and cause severe deformities in the arms and legs. (mountsinai.org)
  • Second, a severe form of degenerative shoulder arthritis with BCP deposits has the name Milwaukee shoulder . (nethealthbook.com)
  • Severe fatigue is associated with scleroderma and many other chronic illnesses. (facty.com)
  • This type of scleroderma affects large portions of the skin and can spread to other organs too. (home-remedies-for-you.com)
  • X-rays may show changes in bone, soft tissues, and organs caused by scleroderma. (uhhospitals.org)
  • When Scleroderma is localized, it can cause damage to the underlying tissues and organs. (e-sportsmag.com)
  • The name scleroderma means 'hard skin'-a simple description of a complex disease that causes thick, hard scar tissue to form. (medlineplus.gov)
  • Diagnosis of scleroderma is based on physical examination, skin assessment tests, blood tests, and biopsies. (drwilderman.com)
  • Because this symptom is so common, it is not enough to form an accurate diagnosis on its own. (facty.com)
  • An estimated 300,000 Americans have scleroderma, although the difficulty of diagnosis makes this number hard to pin down. (mountain-ice.com)
  • All the patients with the diagnosis of scleroderma were included. (bvsalud.org)
  • Localized scleroderma usually affects only the skin on the hands and face. (mountsinai.org)
  • In limited scleroderma, skin thickening is less widespread, typically confined to the fingers, hands and face, and develops slowly over years. (scleroderma.org)
  • Though scleroderma typically affects the skin, and literally means 'hard skin', it can extend to other parts of your body and may have a significant negative impact on your lifespan. (stemaidinstitute.com)
  • Genetics typically factor in whether somebody will be at high risk for getting Scleroderma. (drdubow.com)
  • Limited scleroderma is sometimes called CREST syndrome. (scleroderma.org)
  • CREST syndrome (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias) refers to a subset of patients with limited scleroderma. (logicalimages.com)
  • Scleroderma is a chronic hardening and contraction of the skin and connective tissue, either locally or throughout the body. (skinpatientalliance.ca)
  • Localized Scleroderma (LoS) is an autoimmune connective tissue disease that affects skin and less commonly subcutaneous tissues. (biomedcentral.com)
  • Male patients with diffuse cutaneous scleroderma had significantly higher levels of estradiol (average, 30.6pg/ml) than both healthy men (average, 12.9pg/ml) and postmenopausal women with the disease (24.2pg/ml). (hospitalhealthcare.com)
  • Contact us today for more information on our effective scleroderma treatments. (stemaidinstitute.com)
  • Scleroderma is usually treated with herbal treatments such as herbal supplements or herbal moisturizers. (herbal-care-products.com)
  • There may not be a cure yet, but many scleroderma experts are optimistic about ongoing research into new treatments. (medlineplus.gov)
  • Pulmonary arterial hypertension related to scleroderma (PAH-Scl) is associated with high morbidity and mortality as well as poorer response to therapy and worse outcomes compared with the idiopathic form of PAH (IPAH). (nih.gov)
  • Scleroderma is an autoimmune disease that can affect left and right heart function directly through inflammation and fibrosis and indirectly through systemic and pulmonary hypertension. (nih.gov)
  • How to Treat Scleroderma? (stemaidinstitute.com)
  • Due to this, research on the disease is limited and needs increased attention in order for doctors to better treat scleroderma. (mountain-ice.com)
  • Sometimes it forms a long crease on the head or neck, referred to as en coup de sabre because it resembles a saber or sword wound. (scleroderma.org)
  • People with scleroderma may develop either a localized or a systemic (body-wide) form of the disease. (mountsinai.org)
  • Some people with scleroderma have a history of being around silica dust and polyvinyl chloride, but most do not. (medlineplus.gov)
  • It is thought that the inflammation that accompanies the development of scleroderma initiates a keloidal response in those who are predisposed to keloid formation. (logicalimages.com)
  • The MUSC team's recent findings provide some of the first evidence to confirm a link between high oestrogen levels and the development of scleroderma. (hospitalhealthcare.com)
  • Systemic scleroderma is a rare disease in which visceral manifestations occur, particularly peripheral vascular, digestive, cardiopulmonary and renal. (scirp.org)
  • Scleroderma can affect different parts of your body, including your esophagus. (stemaidinstitute.com)
  • In diffuse scleroderma , skin thickening occurs more rapidly and involves more skin areas than in limited disease. (scleroderma.org)
  • Scleroderma is an uncommon, complex, autoimmune disease. (mountsinai.org)
  • There are two major forms of the disease. (mountsinai.org)
  • In children, localized scleroderma is three times more common than the systemic form of the disease. (mountsinai.org)
  • Histological and immunohistochemical aspects of skin biopsies are compared to normal skin from a patient without scleroderma and are correlated with the pathogenesis of the disease. (cdlib.org)
  • Scleroderma is thought to be an autoimmune disease. (uhhospitals.org)
  • Scleroderma is a disease that involves the buildup of fibrous tissue in the skin and elsewhere in the body. (medlineplus.gov)
  • Since then, many synonyms have been in use, notably 'Kraurosis vulvae,' 'vulvar dystrophy,' 'white spot disease,' and 'lichen sclerosus et atrophicus' or 'guttate scleroderma. (illness.com)
  • Most reports point to a sclerodermalike disease rather than true systemic scleroderma. (logicalimages.com)
  • Having a parent with Scleroderma does not enhance a child's likelihood of developing the disease, but having any affected family raises that risk significantly. (e-sportsmag.com)
  • It is surprising, then, that a Medical University of South Carolina (MUSC) study found that a type of oestrogen, oestradiol, was more abundant in older men with scleroderma than in postmenopausal women with the disease. (hospitalhealthcare.com)
  • Many patients who have scleroderma have a weak lower esophageal sphincter, and this significantly increases their chances of developing gastroesophageal reflux disease (GERD). (stemaidinstitute.com)
  • The term scleroderma is derived from the Greek words skleros (hard or indurated) and derma (skin) and it is used to describe a disease characterized by progressive skin hardening and induration. (medscape.com)
  • In this common form, the disease is unlikely to spread or cause organ damage. (facty.com)
  • This mild, restricted form of the disease produces minimal skin thickening that is limited to the face and hands. (facty.com)
  • About one-third of these patients have systemic scleroderma, the most serious form of the disease. (mountain-ice.com)
  • Living with scleroderma is difficult, as there is no drug that has been shown to stop or reverse the hardening and thickening of skin, the major symptom of the disease. (mountain-ice.com)
  • There are two forms of the disease: nodular silicosis and silicoproteinosis (acute silicosis). (cdc.gov)
  • Digestive tract Diffuse scleroderma can affect any part of the gastrointestinal tract. (wikipedia.org)
  • Scleroderma can decrease motility anywhere in the gastrointestinal tract. (wikipedia.org)
  • The name scleroderma comes from the Greek words skleros , which means hard, and derma , which means skin. (mountsinai.org)
  • The presence of anti-topoisomerase I, which is a specific type of antinuclear antibody, may indicate scleroderma. (medicalnewstoday.com)
  • Localized scleroderma occurs most commonly in children, while systemic scleroderma is more common in adults. (drwilderman.com)
  • Scleroderma affects women more often than men and most commonly occurs between the ages of 30 and 50. (skinpatientalliance.ca)
  • This summary discusses scleroderma in adults. (logicalimages.com)
  • Children are more likely than adults to develop localized forms of scleroderma. (medscape.com)
  • There is also the possibility that the individual's environment can trigger the onset of Scleroderma. (e-sportsmag.com)
  • Scleroderma can affect persons of all races and ethnic groups. (e-sportsmag.com)
  • A person's genetic makeup can affect the form of Scleroderma they create. (e-sportsmag.com)
  • For some people, scleroderma will only affect the skin, but for others, it goes a lot deeper than that. (stemaidinstitute.com)
  • Hereditary factors and ethnicity also affect the chances of scleroderma developing. (facty.com)
  • Diseases that affect GI motility such as scleroderma. (who.int)
  • There is some evidence that a subset of cases (less than 5%) may progress to scleroderma (Nyugen). (surgpath4u.com)
  • However, some forms of partial lipodystrophy in children do not seem to fit the diagnostic criteria for any of the established lipodystrophy subset. (medscape.com)