Form laminin proteins. Medical search. Frequent questions

Substrate-bound factor(s) from central nervous system-conditioned media also had a synergistic effect with laminin, suggesting a possible cooperation between humoral proteins and nervous system extracellular matrix. (nature.com)
Laminins are a family of glycoproteins of the extracellular matrix of all animals. (wikipedia.org)
The trimeric proteins intersect, composing a cruciform structure that is able to bind to other molecules of the extracellular matrix and cell membrane. (wikipedia.org)
Laminins are found in an intricate lattice of proteins and other molecules that forms in the spaces between cells (the extracellular matrix). (medlineplus.gov)
The laminins attach (bind) to other proteins in the extracellular matrix and in the membrane of muscle cells, which helps maintain the stability of muscle fibers. (medlineplus.gov)
There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). (urosario.edu.co)
Laminin 5 (Ln5) is an extracellular matrix protein that plays an important role in cell migration and tumor invasion. (spandidos-publications.com)
Laminin is a protein that produces merosin for the extracellular matrix. (cmdir.org)
Laminins plays a major role in binding itself and other proteins together not only in the extracellular matrix but also to the muscle cell membrane. (cmdir.org)
Typically less than 1% cross reactivity against other extracellular matrix proteins was detected by ELISA against purified standards. (covalab.com)
Non-specific cross reaction of anti-Laminin antibodies with other human serum proteins or non-Laminin extracellular matrix proteins is negligible. (covalab.com)
A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. (lookformedical.com)
Laminins are extracellular matrix proteins that reside in the basement membrane and provide structural support in addition to promoting cellular adhesion and migration. (bvsalud.org)
To occur the adhesion of CAMs to the biomaterial, it is necessary their interaction with some components of extracellular matrix, such as proteoglycans, collagen and proteins 23 . (bvsalud.org)

Laminins form independent networks and are associated with type IV collagen networks via entactin, fibronectin, and perlecan. (wikipedia.org)
TBD cells embedded in collagen gel formed three-dimensional clusters, which had an internal cavity equipped with a tight junction-like structure, a microvilluslike structure, and a laminin-positive layer surrounding the cluster. (bioone.org)
TBD cells formed a monolayer on collagen gel when they were co-cultured with TMD cells. (bioone.org)
BMs are specialized structures that underlie epithelia and surround organs and mainly comprise collagen IV, laminins, and heparan sulfate proteoglycans (HSPG). (nature.com)
The major components of the ECM are interstitial collagens (types I and III), membrane collagen (type IV), and non-collagenous glycoproteins, such as laminin and fibronectin. (vin.com)
ECM was prepared to a protein concentration of 8-12 mg/mL (in DMEM), containing laminin as a major component, collagen type IV, heparin sulfate proteoglycan, entactin, and other minor components. (sigmaaldrich.com)
This form of the disease is the result of abnormalities in collagen (a type of connective tissue) and laminin (a protein found in the basement membrane which helps to hold cells and tissues together). (entclinic.com.au)
It constitutes fibrous proteins such as collagen and elastin, elongated glycoproteins such as fibronectin and laminin, which provide cell matrix adhesion. (biomedcentral.com)
Due to its human origin and minimal processing, HumaMatrix retains the native matrix proteins and growth factors found in healthy human tissue including collagen, elastin, laminin, glycosaminoglycans and many other matrix proteins. (azbio.org)
It boosts production of basal membrane proteins, including collagen and laminins. (rituel-beaute.ca)
The most common form of fibrillar collagen. (lookformedical.com)
A family of structurally related collagens that form the characteristic collagen fibril bundles seen in CONNECTIVE TISSUE. (lookformedical.com)
Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. (lookformedical.com)
The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers. (lookformedical.com)
Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer. (lookformedical.com)
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. (lookformedical.com)
As an example of protein therapy, a completed phase I/II trial associated recombinant human collagen with wound healing and pain reduction in RDEB. (medscape.com)

They are major constituents of the basement membrane, namely the basal lamina (the protein network foundation for most cells and organs). (wikipedia.org)
Abnormal laminin-332, which is essential for epithelial cell adhesion to the basement membrane, leads to a condition called junctional epidermolysis bullosa, characterized by generalized blisters, exuberant granulation tissue of skin and mucosa, and pitted teeth. (wikipedia.org)
Based on a better understanding of the basement membrane zone (BMZ) and the genes responsible for its components, newer treatments (eg, gene or protein therapy) may provide solutions to the skin fragility found in patients with epidermolysis bullosa. (medscape.com)
LAMB3 / Laminin Beta 3 is a laminin that belongs to a family of basement membrane proteins. (lsbio.com)
In addition, Sive lab researchers demonstrated that this process requires the protein laminin, which is a crucial part of the basement membrane that lines the outside of the neural tube. (news-medical.net)
The ECM gel will undergo thermally activated polymerization when brought to 20-40°C, forming a reconstituted basement membrane. (sigmaaldrich.com)

For example, growth cones are repelled by netrin when grown on laminin-111 but are attracted to netrin when grown on fibronectin. (wikipedia.org)

network-forming non fibrillar collagens (type IV), that composed a non-fibril network. (premiumbeautynews.com)

7 Briefly, APAC consists of mast cell-derived heparin proteoglycans in the form of a semisynthetic conjugate of unfractionated heparin and a protein core. (lww.com)

This combination increased outgrowth and branching relative to either laminin or hemolymph alone. (nature.com)
In addition, many laminins had common names before either laminin nomenclature was in place. (wikipedia.org)

This gene provides instructions for making a part (subunit) of certain members of a protein family called laminins. (medlineplus.gov)
There are several forms of each subunit, and each form is produced from instructions carried by a different gene. (medlineplus.gov)
Most LAMA2 gene mutations that cause the severe, early-onset form of LAMA2 -related muscular dystrophy result in the absence of functional laminin alpha-2 subunit. (medlineplus.gov)
Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. (lsbio.com)
The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. (nih.gov)
Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
A CMD Subtype that results from gene defects in the laminin-alpha2 gene affecting the production of merosin protein in the muscle cell. (cmdir.org)
Our laboratory focuses on discovery, cloning, sequencing, and creating gene therapy approaches for patients with hereditary forms of epidermolysis bullosa, a serious (potentially lethal) skin disease. (stanford.edu)
Functional similarities, such as conservation of genes encoding for laminin binding and phenolic glycolipid 1 adhesin systems involved in Schwann cell invasion, outweigh differences, such as the presence of the hemN gene only in M. lepromatosis ( 3 , 4 ). (cdc.gov)
In addition to cell therapies and gene therapies, Mellerio discussed progress in three additional areas: gene editing, protein therapy, and drug repurposing. (medscape.com)
Perhaps less advanced but still promising, protein therapy, gene editing, and repurposing of existing therapies are all approaches that are moving forward. (medscape.com)

Laminins are heterotrimeric proteins with a high molecular mass (~400 to ~900 kDa) and possess three different chains (α, β and γ) encoded by five, four, and three paralogous genes in humans, respectively. (wikipedia.org)
The proteins produced from the affected genes form part of NADPH oxidase. (bartleby.com)
Clostridium difficile is a gram positive, spore forming anaerobic bacillus, which may or may not carry the genes for toxin A-B production (Nipa, 2010). (bartleby.com)
In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
Analyses indicated a most recent common ancestor ≈13.9 million years ago and a 9% overall difference in nucleotide sequence identity (7% in protein-coding genes, 18% in pseudogenes), differentiating M. lepromatosis as a separate species from M. leprae ( 3 , 4 ). (cdc.gov)
Laminin 411 markedly induced the expression of the genes Foxa2 and Sox17 , markers for pancreatic precursor cells, efficiently induced IPC differentiation from MSCs, and up-regulated insulin expression at both mRNA and protein levels. (biomedcentral.com)
Furthermore, the expression of the genes known to govern insulin expression including Pdx1 and Ngn3 was markedly induced by laminin 411, which suggests that Pdx 1 and Ngn 3 signaling pathways are involved in laminin 411 induced-insulin expression machinery. (biomedcentral.com)
Differentially expressed candidate genes for ageing previously identified in the human blood transcriptome up-regulated in PP cows were mainly associated with T-cell function ( CCR7 , CD27 , IL7R , CAMK4 , CD28 ), mitochondrial ribosomal proteins ( MRPS27 , MRPS9 , MRPS31 ), and DNA replication and repair ( WRN ). (biomedcentral.com)

We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)
In metabolic tissues such as the pancreas, adipose, muscle, and liver, laminin isoforms are expressed in discrete temporal and spatial patterns suggesting that certain isoforms may support the development and function of particular metabolic cell types. (bvsalud.org)
This review focuses on the research to date detailing the expression of laminin isoforms, their potential function, as well as known pathways involved in laminin signaling in metabolic tissues. (bvsalud.org)

Laminin subunit beta 1 (LAMB1) is involved in attachment, migration, and organization during development, and its elevated expression has been associated with several cancers. (bvsalud.org)

The aim of the present study was to functionalize Ti scaffolds with genetically modified elastin-like recombinamers (ELRs), synthetic polymeric proteins containing the elastin epitopes responsible for their mechanical properties and for promoting mesenchymal stem cell (MSC) recruitment, proliferation, and differentiation to ultimately increase scaffold osseointegration. (ibecbarcelona.eu)

Lamins, also known as nuclear lamins are fibrous proteins in type V intermediate filaments, providing structural function and transcriptional regulation in the cell nucleus. (cmdir.org)

citation needed] This effect of laminin-111 probably occurs through a lowering of intracellular cyclic AMP. (wikipedia.org)
The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. (nih.gov)
These result in imbalances in the connectivity of neuronal circuitry, and also negatively impact the intracellular connectivity of neuronal proteins and protein pathways, contributing to cognitive decline associated with AD 6 . (nature.com)
Through interactions with cell surface receptors, laminins stimulate intracellular signaling cascades which direct specific survival and differentiation outcomes. (bvsalud.org)

This makes laminin a critical means of holding tissues and organs together. (gotquestions.org)
ECM consists of proteins and polysaccharides distributed in many different tissues of the body. (biomedcentral.com)
The body will divert energy and protein from other tissues to the wound bed causing dysregulation and further slowing the healing process. (zennutrients.com)
We will also discuss the current biomedical therapies involving laminins in these tissues in addition to prospective applications, with the goal being to encourage future investigation of laminins in the context of metabolic disease. (bvsalud.org)

Mutations that cause the milder, later-onset form usually result in a reduction (deficiency) of functional laminin alpha-2 subunit. (medlineplus.gov)
PMID: 25486376 Mutations in Biosynthetic Enzymes for the Protein Linker Region of Chondroitin/Dermatan/Heparan Sulfate Cause Skeletal and Skin Dysplasias . (symptoma.com)
I am particularly interested in the effects of mutations and polymorphisms on protein function since these studies can identify underlying pathologies and potential therapies. (cardiff.ac.uk)
Mellerio described efforts to use an aminoglycoside to circumvent nonsense mutations that produce messenger RNA decay and impaired production of the proteins that prevent EB. (medscape.com)

The laminin molecules are named according to their chain composition, e.g. laminin-511 contains α5, β1, and γ1 chains. (wikipedia.org)
The three short arms have an affinity for binding to other laminin molecules, conducing sheet formation. (wikipedia.org)
The proteins also bind to cell membranes through integrins and other plasma membrane molecules, such as the dystroglycan glycoprotein complex and Lutheran blood group glycoprotein. (wikipedia.org)
Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)

Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. (mdpi.com)
This is very important in forming tubes, which are found in essentially all organs, and constrictions, which bend many organs in characteristic ways. (news-medical.net)
Prolonged overexpression of TGF-β1 suppresses cell proliferation, is pro-apoptotic, and induces a deposition of ECM proteins, resulting in fibrosis in major organs such as the liver. (vin.com)

Cross reacts with most mammalian proteins. (covalab.com)
A polypeptide substance comprising about one third of the total protein in mammalian organisms. (lookformedical.com)

The most important property of laminins is their ability to easily bind to each other and to other proteins. (gotquestions.org)
These proteins have several short arms that bind easily to other laminins and a single long arm that binds easily to other cell structures and membranes. (gotquestions.org)
We found that the proteins bind to NWs, forming coronas with thicknesses close to the proteins' hydrodynamic diameters. (lu.se)

For example, the peptide sequence [GTFALRGDNGDNGQ], which is located on the alpha-chain of laminin, promotes the adhesion of endothelial cells. (wikipedia.org)
MAX8 is an amphiphilic beta-hairpin peptide that forms a hydrogel at physiological conditions. (udel.edu)

Through these interactions, laminins critically contribute to cell attachment and differentiation, cell shape and movement, maintenance of tissue phenotype, and promotion of tissue survival. (wikipedia.org)
This is accomplished by increasing both the interaction strength and number of interactions among participant proteins, which is not necessarily accompanied by a change in expression levels. (nature.com)
2. The laminins forms networks that remain in close association with cells through interactions with cell surface receptors. (premiumbeautynews.com)

Important biological events associated with plasma membranes, such as signal transduction, cell adhesion, and protein trafficking, are mediated through the membrane microdomains. (mdpi.com)
Sive lab investigators looked at the midbrain-hindbrain boundary constriction in the living zebrafish brain, after labeling the membrane of each cell in the constriction with a green fluorescent protein. (news-medical.net)
The major observation considered to be involved in the pathogenesis of retinal lesions is abnormalities in the internal limiting membrane formed by Müller cells, which is corresponding to the glia limitans formed by astrocytes in the brain. (intechopen.com)
Nuclear lamins interact with inner nuclear membrane proteins to form the nuclear lamina on the interior of the nuclear envelope. (cmdir.org)

The ECM composed of hundred proteins is a dynamic network controlling the proliferation, adhesion, migration, polarity, differentiation, and apoptosis of the cells. (premiumbeautynews.com)
These properties will act mediating the action of cell adhesion proteins, regulating cell behavior and causing tissue regeneration. (bvsalud.org)
In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (medscape.com)
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)

Dysfunctional structure of one particular laminin, laminin-211, is the cause of one form of congenital muscular dystrophy. (wikipedia.org)
These structures provide the backbone upon which proteome-wide connectivity, and in turn, protein networks become disturbed and ultimately dysfunctional. (nature.com)
All stem from dysfunctional N -glycosylation of proteins. (medscape.com)

Laminin proteins are made of three different subunits called alpha, beta, and gamma. (medlineplus.gov)
The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer. (lookformedical.com)

Laminins are integral to the structural scaffolding of almost every tissue of an organism-secreted and incorporated into cell-associated extracellular matrices. (wikipedia.org)
This review critically focuses on opportunities to employ protein-graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. (mdpi.com)
This extensive imaging methodology simultaneously reveals structural, chemical and morphological details of individual nanowires and the adsorbed proteins. (lu.se)
This type of the condition is caused by genetic defects in keratin, a protein which is an important structural component of the skin. (entclinic.com.au)
SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
Laminin is often referred to as an integral part of the structural scaffolding which keeps the body together. (petrachurch.net)

We have imaged GaP nanowires (NWs) incubated with human laminin, serum albumin (HSA), and blood plasma using both cryo-transmission electron microscopy and synchrotron based X-ray photoemission electron microscopy. (lu.se)

Notably, the addition of hemolymph to laminin substrates accelerated growth cone migration rate over ten-fold. (nature.com)
The presence of laminin-1 can influence how the growth cone responds to other cues. (wikipedia.org)

defective laminins can cause muscles to form improperly, leading to a form of muscular dystrophy, lethal skin blistering disease (junctional epidermolysis bullosa), and/or defects of the kidney filter (nephrotic syndrome). (wikipedia.org)
Esophageal strictures associated with junctional epidermolysis bullosa, dystrophic epidermolysis bullosa, or the pyloric atresia associated with a rare form of junctional epidermolysis bullosa can be visualized best by an upper GI series or endoscopy. (medscape.com)
In epidermolysis bullosa, blisters form on the skin following minor skin trauma, such as bumping into objects, sitting on hard surfaces and walking. (entclinic.com.au)
this form of epidermolysis bullosa affects predominantly the hands and feet. (entclinic.com.au)
This is the most severe form of junctional epidermolysis bullosa. (entclinic.com.au)

Laminin 2 and laminin 4 play a particularly important role in the skeletal muscles. (medlineplus.gov)

Clinical evidence is limited, but Mellerio suggested that the theoretical potential for eliminating the source of abnormal transcription is the restoration of functional proteins essential for reversing skin fragility. (medscape.com)

More importantly, administration of laminin 411-induced IPCs rapidly and significantly down-regulated fasting blood glucose levels, significantly reduced the HbA1c concentration and markedly improved the symptoms and survival of T1DM rats. (biomedcentral.com)
Moreover, transfusion of laminin 411 induced-IPCs more efficiently improves symptoms and survival of T1DM rats. (biomedcentral.com)
This protein is vital for the health and survival of the core tissue. (petrachurch.net)

We followed single cells over time to see what happens during brain development, and found that a distinct group of cells at the midbrain-hindbrain boundary constrict basally to form the sharp bend," says Gutzman, co-lead author on the paper. (news-medical.net)
Blisters are mainly found on the palms of the hands and the sole of the foot, and in most instances were caused by some form of trauma to the area. (entclinic.com.au)

Increased mRNA expression of a laminin-binding protein in human colon carcinoma: complete sequence of a full-length cDNA encoding the protein. (joplink.net)

The laminins are combinations of different alpha-, beta-, and gamma-chains. (wikipedia.org)
Laminin-211 is composed of an α2, β1 and γ1 chains. (wikipedia.org)
The coiled-coil structure of the long arm is formed by three chains (α3, β3 and γ2) covalently linked via interchain disulfide bonds ( 8 ). (spandidos-publications.com)
Compared to ECs, pancreatic pericytes produce significantly higher levels of α2 and α4 laminin chains, which constitute the peri-islet and vascular BM. (nature.com)

The sympathetic nervous system regulates this function through β-adrenergic stimulation of brown mature adipocytes' dissipation of energy in the form of heat mediated by mitochondrial uncoupling protein-1 (UCP-1) activation. (springer.com)

Synthetic peptides from the regions of adherence on human laminin. (covalab.com)

The ability to directly visualize proteins on nanostructures in situ holds great promise for assessing the conformation and thickness of the protein corona, which is key to understanding and predicting the properties of engineered nanomaterials in a biological environment. (lu.se)

Our results indicate that the active factor is either a high molecular weight protein or protein complex and is not the respiratory protein hemocyanin. (nature.com)
We analyzed liver fibrosis using several molecular and biochemical techniques (Q-PCR, Western blotting, and semi-quantitative immunohistochemistry on ECM proteins). (vin.com)
I use a range of molecular biology techniques to determine the cellular function of proteins involved in the aforementioned disorders. (cardiff.ac.uk)

One side of the cell sheet is called 'apical', the other 'basal', and each contains distinct proteins. (news-medical.net)
We noticed that this bend formed in an unusual way, with the basal sides of the cell sheet constricted. (news-medical.net)
Also functions as a cell surface receptor for laminin. (joplink.net)
Early steps in myelination in the central nervous system (CNS) include a specialized and extreme form of cell spreading in which oligodendrocytes extend large lamellae that spiral around axons to form myelin. (rupress.org)

Deficiency or absence of the laminin alpha-2 subunit results in a corresponding lack of laminin 2 and laminin 4, reducing the strength and stability of muscle tissue and leading to the signs and symptoms of LAMA2 -related muscular dystrophy. (medlineplus.gov)

Laminin is the name used for a family of proteins that serve many useful functions in biology. (gotquestions.org)

Reacts with human Laminin. (covalab.com)
The molecule, Laminin is the protein that holds human beings together. (pinterest.co.kr)
however, little is known about a role of laminin 411 in the regulation of IPC differentiation from human MSCs. (biomedcentral.com)

Some of these biological functions of laminin have been associated with specific amino-acid sequences or fragments of laminin. (wikipedia.org)

The protein expression of Ln5, PTEN, p-EGFR and p-Akt was assessed by immunohistochemical analysis, and their relationships to prognosis were analyzed. (spandidos-publications.com)
Protein expression of Ln5, p-EGFR and p-Akt was detected in 61.2 (60/98), 60.2 (59/98) and 45.3% (43/95) of patients with NSCLC, respectively. (spandidos-publications.com)
The events in signal transduction that govern MMP expression and activity and expression of inhibitory proteins are crucial for understanding wound healing, tumorigenesis, and certain genetic diseases. (stanford.edu)
HSP90 inhibition may also enhance synaptic protein expression via activation of heat shock factor 1 (HSF-1) transcriptional regulation 16 . (nature.com)

Or, could one claim laminin looks like a pitchfork and use that correlation as a biological proof of our inherited sin nature? (gotquestions.org)

One crucial part of this organization is to bend sheets of connected cells ("epithelia") so that they form a structure that is an integral part of the functional organ. (news-medical.net)
Isn't it amazing that God would think so far in the future, and make the very thing that makes us think of Jesus, make up and play a crucial role in how we are formed? (pinterest.co.kr)

Current technical limitations curb our ability to explore global changes in protein level connectivity, restricting how to translate key network changes into AD therapies. (nature.com)

In the natural body, this adhesive substance is called "laminin. (petrachurch.net)

Anatomy7

Chemicals and Drugs23

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes4

Disciplines and Occupations1

Information Science2

Extracellular matrix14

Collagen17

Basement membrane6

Fibronectin1

Collagens1

Proteoglycans1

Either laminin2

Gene11

Genes8

Isoforms3

Subunit beta1

Elastin1

Fibrous proteins1

Intracellular4

Tissues4

Mutations4

Molecules4

Organs3

Mammalian2

Bind3

Peptide2

Interactions3

Membrane4

Adhesion5

Dysfunctional3

Subunits2

Structural6

Serum1

Growth cone2

Epidermolysis bullosa5

Skeletal1

Abnormal1

Survival3

Found2

MRNA1

Chains4

Mitochondrial1

Peptides1

Nanostructures1

Molecular3

Cell4

Deficiency1

Family1

Human3

Sequences1

Expression4

Biological1

Crucial2

Therapies1

Substance1