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  • molecules
  • Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour types, and in engineered cells overexpressing oncogenic RAS. (jove.com)
  • Protein
  • This study," says lead author Xiaoguang Liu, an assistant professor of neurology at GUMC, "provides novel evidence that USP13 affects development and clearance of Lewy body protein clumps, suggesting that targeting USP13 may be a therapeutic target in Parkinson's disease and other similar forms of neurodegeneration. (medicalnewstoday.com)
  • proteins
  • Required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. (abcam.com)
  • version
  • Retrotope's current Phase 1b/2a clinical trial in Friedreich's ataxia aims to determine the safety and efficacy of RT001, a highly stabilized version of the cardiolipin forming fat, linoleic acid. (retrotope.com)
  • cell
  • Here, we provide direct genetic evidence that the knockout of glutathione peroxidase 4 (Gpx4) causes cell death in a pathologically relevant form of ferroptosis. (jove.com)
  • In sum, we demonstrate that ferroptosis is a pervasive and dynamic form of cell death, which, when impeded, promises substantial cytoprotection. (jove.com)
  • Its main driving factors are internal: genetic instability initiated by driver mutations and microenvironment, which enables selective pressure while forming the environment for cell transformation and their survival. (chemweb.com)
  • complete
  • In contrast to other members of the phospholipase D family, contains only one PLD phosphodiesterase domain, suggesting that it has a single half-catalytic and requires homodimerization to form a complete active site (PubMed:17028579). (abcam.com)
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  • Alternative
  • There are two principal ideas that generate alternative network forms: Time and space stages can be system- atically exchanged to form new fabrics, and deeper networks of five or perhaps more stages can be Binarry. (tradeforexglobal.com)