• On the other hand, both Foxo3a - and Foxo4 -null mice were viable and grossly indistinguishable from their littermate controls, indicating dispensability of these two members of the Foxo transcription factor family for normal vascular development. (pnas.org)
  • RESULTS -The aP 2 -FLAG-Δ256 mice showed improved glucose tolerance and insulin sensitivity accompanied with smaller-sized adipocytes and increased adiponectin (adipoq) and Glut 4 (Slc2a4) and decreased tumor necrosis factor α (Tnf) and chemokine (C-C motif) receptor 2 (Ccr2) gene expression levels in white adipose tissue (WAT) under a high-fat diet. (diabetesjournals.org)
  • In the nematode Caenorhabditis elegans, mutations of the insulin/insulin-like growth factor-1 receptor homologue Daf-2 gene cause developmental arrest at the dauer stage. (semanticscholar.org)
  • This compilation provides a unique, up-to-date view of this enigmatic, highly evolutionary conserved family of transcription factors with a diverse array of functions in aging and longevity, cancer, and metabolism. (elsevier.com)
  • Our results suggest that, in addition to their documented promoter function, Fkh1p and Fkh2p coordinate early transcription elongation and pre-mRNA processing. (sciencemag.org)
  • Fkh factors associate with promoter and coding regions and influence RNAPII distribution at CLB2 . (sciencemag.org)
  • Fkh2p is the preferred component of the SFF factor, although Fkh1p substitutes in the absence of Fkh2p ( 5 ) and either factor is sufficient for activator recruitment ( 4 ). (sciencemag.org)
  • These initial observations lead us to conclude, first, that Fkh transcription factors, believed to be localized exclusively to promoters, are also associated with transcribed regions, and second, that these factors influence in opposite ways the distribution of RNAPII over the gene. (sciencemag.org)
  • We have analyzed the binding of Fkh factors to CLB2 with the use of chromatin immunoprecipitation (ChIP) in strains expressing epitopetagged Fkh factors ( 11 ). (sciencemag.org)
  • The HDAC activity of Sir2 results in tighter packaging of chromatin and a reduction in transcription at the targeted gene locus. (wikipedia.org)
  • aegypti genome contains 18 loci that encode putative Fox factors. (nih.gov)
  • Surprisingly, not only nontransformed cells, but also cancer cells such as human colon carcinoma cells, are forced into quiescence by Forkhead activation. (uu.nl)
  • We therefore propose that Forkhead inactivation by PKB signaling in quiescent cells is a crucial step in cell cycle reentry and contributes to the processes of transformation and regeneration. (uu.nl)
  • Furthermore, changes in the sub-cellular localization of FoxG1 in response to fibroblast growth factor 2 (FGF-2) were investigated in a neural precursor cell line. (uct.ac.za)
  • Very recent evidence showed that Treg abrogate CD8 + T cell-mediated tumor rejection in a transforming growth factor-β-dependent manner ( 7 ). (aacrjournals.org)