• Forhead box G1 (FoxG1) is a winged-helix transcription factor that plays a crucial role in the development of the telecephalon, the most rostral region of the brain Here, FoxG1 acts as a transcriptional repressor and maintains the population of cortical progenitor cells by promoting their proliferation and inhibiting differrentiation. (uct.ac.za)
  • Most importantly, long-term Forkhead activation causes a sustained but reversible inhibition of proliferation without a marked increase in apoptosis. (uu.nl)
  • RESULTS -The aP 2 -FLAG-Δ256 mice showed improved glucose tolerance and insulin sensitivity accompanied with smaller-sized adipocytes and increased adiponectin (adipoq) and Glut 4 (Slc2a4) and decreased tumor necrosis factor α (Tnf) and chemokine (C-C motif) receptor 2 (Ccr2) gene expression levels in white adipose tissue (WAT) under a high-fat diet. (diabetesjournals.org)
  • In the nematode Caenorhabditis elegans, mutations of the insulin/insulin-like growth factor-1 receptor homologue Daf-2 gene cause developmental arrest at the dauer stage. (semanticscholar.org)
  • Our results suggest that, in addition to their documented promoter function, Fkh1p and Fkh2p coordinate early transcription elongation and pre-mRNA processing. (sciencemag.org)
  • Fkh factors associate with promoter and coding regions and influence RNAPII distribution at CLB2 . (sciencemag.org)
  • Furthermore, changes in the sub-cellular localization of FoxG1 in response to fibroblast growth factor 2 (FGF-2) were investigated in a neural precursor cell line. (uct.ac.za)
  • Fkh2p is the preferred component of the SFF factor, although Fkh1p substitutes in the absence of Fkh2p ( 5 ) and either factor is sufficient for activator recruitment ( 4 ). (sciencemag.org)
  • The forkhead DNA binding domain (DBD) consists of three-helix bundle resting on a small antiparallel beta-sheet from which two extended loops protrude and create two wing-like structures. (semanticscholar.org)
  • These initial observations lead us to conclude, first, that Fkh transcription factors, believed to be localized exclusively to promoters, are also associated with transcribed regions, and second, that these factors influence in opposite ways the distribution of RNAPII over the gene. (sciencemag.org)
  • aegypti genome contains 18 loci that encode putative Fox factors. (nih.gov)
  • Very recent evidence showed that Treg abrogate CD8 + T cell-mediated tumor rejection in a transforming growth factor-β-dependent manner ( 7 ). (aacrjournals.org)
  • We therefore propose that Forkhead inactivation by PKB signaling in quiescent cells is a crucial step in cell cycle reentry and contributes to the processes of transformation and regeneration. (uu.nl)
  • Surprisingly, not only nontransformed cells, but also cancer cells such as human colon carcinoma cells, are forced into quiescence by Forkhead activation. (uu.nl)