ProteinGenesFoxo1Foxp3FOXC1FOXOEpithelial CellsFOXG1ExpressionRegulatesTranscriptional repressorZinc-finger transcription factorEpidermal growthChromosomeDomainSteatosisDiseasesDevelopmentFamilyEnergy metabolismPrognosticProliferationOverexpressionFork headHumanBiologicalStructuresInflammatory factorsTumorsActivityGrowthClassMiceCellsRisk factorsEstablishmentMolecular
Protein18
- Forkhead box D1 is a protein that in humans is encoded by the FOXD1 gene. (wikipedia.org)
- Forkhead d1 is a kidney expressed transcription factor maps at the chromosome 5 at position 5q12-q13, identified in Drosophila forkhead protein and mammalian HNF3 transcription factor. (wikipedia.org)
- Second, heparin binding epidermal growth factor and lastly, the bHLH protein G0S8. (wikipedia.org)
- Nakashima K , Hiyoshi S , Ohno K , Prognostic factors in dogs with protein-losing enteropathy . (avma.org)
- The FOXG1 gene provides instructions for making a protein known as forkhead box G1. (medlineplus.gov)
- This protein is a transcription factor, which means it helps regulate the activity of other genes. (medlineplus.gov)
- Specifically, the forkhead box G1 protein acts as a transcriptional repressor, turning off (repressing) the activity of certain genes when they are not needed. (medlineplus.gov)
- Forkhead box protein M1 (FOXM1) is a key transcription factor (TF) that regulates a common set of genes related to the cell cycle in various cell types. (mdpi.com)
- Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth factor-1 signaling pathways are most widely studied. (frontiersin.org)
- lt;p>Forkhead box O3 protein (FOXO3) is a transcription factor involved in the regulation of genes involved in many cellular processes, including DNA repair, tumor suppression, immune function, and resistance to oxidative stress. (feedburner.com)
- The p.Asn173His mutation affects a residue in the forkhead domain that is 100% conserved among vertebrate orthologs and is predicted to participate in protein-protein interactions. (molvis.org)
- Robust multiciliogenesis occurred when notch signaling was inhibited and was confirmed by (i) the assembly of multiple pericentrin-stained centrioles at the apical surface, (ii) expression of transcription factor forkhead box protein J1, and (iii) presence of multiple acetylated tubulin-labeled cilia projections in individual cells. (ca.gov)
- Violin plots show distribution of expression levels for Forkhead box protein (SMED30035239) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
- Expression of Forkhead box protein (SMED30035239) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
- Violin plots show distribution of expression levels for Forkhead box protein (SMED30035239) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
- Overall, 140 cases of esophageal cancer underwent an immunohistochemical analysis of the PD-L1 expression and its association with the expression of the α smooth muscle actin, fibroblast activation protein, CD8, and forkhead box P3 (FoxP3) positive cells. (bvsalud.org)
- The identification of mutations in the forkhead box protein 3 (FOXP3) gene associated with IPEX syndrome and a murine model has generated a considerable amount of interest and research. (medscape.com)
- Using information gathered from these mice, researchers mapped the forkhead box protein 3 (FOXP3) gene to Xp11.23-Xq13.3. (medscape.com)
Genes6
- In addition to this shortcoming, the focus of attention is often restricted to a few well-characterized Fox genes such as FoxA (forkhead), FoxC (crocodile) and FoxQ2. (lu.se)
- Purpose: To determine the genetic basis of autosomal dominant cornea plana (CNA1) through the performance of a genome-wide linkage analysis and screening of the decorin (DCN), dermatan sulfate proteoglycan 3 (DSPG3), forkhead box C1 (FOXC1), keratocan (KERA), lumican (LUM,) and paired-like homeodomain transcription factor 2 (PITX2) genes in members of an affected multigenerational family. (llu.edu)
- The forkhead box (Fox) genes encode transcription factors that control several key aspects of development. (ub.edu)
- Generating a pipeline for identifying Forkhead domains and using phylogenetics allowed us the phylogenetic reconstruction of Fox genes. (ub.edu)
- Alternatively, we find pronounced effects on the direct PLAGL2 target genes IGF2, a fetal growth factor, and ASCL2, an intestinal stem cell-specific bHLH transcription factor. (bvsalud.org)
- This work illustrates the robust effects of this zinc finger transcription factor in colorectal cancer (CRC) cell lines and nontransformed intestinal epithelium, with effects mediated, in part, via the direct target genes ASCL2 and IGF2. (bvsalud.org)
Foxo15
- We report that haploinsufficiency for the forkhead transcription factor Foxo1 reverses beta cell failure in Irs2(-/-) mice through partial restoration of beta cell proliferation and increased expression of the pancreatic transcription factor pancreas/duodenum homeobox gene-1 (Pdx1). (nih.gov)
- Photoactivation of AKT inhibited the transcriptional activity of Forkhead box transcription factor O1 (FoxO1), reducing expression of lipolytic enzymes and FFA generation and release. (google.com)
- p16/IGF-1 converges with fork-head box transcription factor O1 (FOXO1) via E2F1. (gene-tools.com)
- In vitro, p16 VM reduced biliary E2f1 and Foxo1 transcription by inhibiting RNA pol II binding and E2F1 binding at the Foxo1 locus, respectively. (gene-tools.com)
- Here we show that adenoviral delivery of constitutively nuclear forkhead box O1 (FoxO1) to mouse liver results in steatosis arising from increased triglyceride accumulation and decreased fatty acid oxidation. (jci.org)
Foxp32
- Intracellular expression of transcription factor forkhead box P3 (Foxp3) and interleukin (IL)-17 in the activated CD4 + T cells was assessed by flow cytometry. (bmj.com)
- The FOXP3 molecule is a 50-55 kD transcription factor also known as IPEX, JM2, Forkhead box 3, and Scurfin. (ancell.com)
FOXC12
- FOXC1 is a member of the FOX superfamily of transcription factors and is located in the cell nucleus. (hindawi.com)
- Forkhead box C1 (Foxc1) is a member of the forkhead transcription factor family that has been found to regulate in cell migration. (spandidos-publications.com)
FOXO2
- The forkhead box class O (FOXO) transcription factor FOXO3a has been suggested to function as a tumor suppressor in breast cancer. (ntu.edu.tw)
- FoxO transcription factors are considered effectors of the pathway regulating hepatic glucose production. (jci.org)
Epithelial Cells1
- In thymic epithelial cells, the research team upregulated a transcription factor called Forkhead box N1 (FOXN1), which had previously been implicated in age-related thymus shrinkage. (the-scientist.com)
FOXG11
- Is an ortholog of human FOXG1 (forkhead box G1). (wormbase.org)
Expression8
- The Forkhead box (Fox) transcription factor Foxa2 (HNF-3beta) and related family members Foxa1 (HNF-3alpha) and Foxa3 (HNF-3gamma) act in concert with other hepatocyte nuclear factors (HNF) to coordinately regulate liver-specific gene expression. (duke.edu)
- Mechanistically, Foxi2 stimulated AgRP expression by directly binding to it and activating its transcription. (figshare.com)
- Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
- The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
- High fat/high cholesterol diet (HFD) feeding increases biliary senescence, DR, and biliary insulin-like growth factor-1 (IGF-1) expression in mice. (gene-tools.com)
- Although the expression of MHC class I and II molecules can be upregulated by MSC exposure to inflammatory cytokines interferon-gamma (IFN- γ ) and tumor necrosis factor-alpha (TNF- α ), they are still unable to induce an immunological response [ 18 ]. (hindawi.com)
- Recent studies have shown that in these tumors, AR cooperates with other transcription factors such as the pioneer factor forkhead box A1 (FOXA1) and components of the canonical WNT pathway to enhance androgen-responsive gene expression, but it is likely that other feedback loops also modulate AR signaling and restrain basal gene expression. (aacrjournals.org)
- However, STAT3, a downstream transcription factor of the IL-6 signaling pathway, was directly complexed with NFκB p50, not NFκB p65, to upregulate the expression of KDM2A in CAFs. (bvsalud.org)
Regulates2
- 4 In addition, vascular endothelial growth factor (VEGF) is an angiogenic factor that regulates endothelial survival, proliferation, differentiation, and vascular permeability, and has been shown to be an important candidate for cancer therapy as it is upregulated in many tumors. (beckman.com)
- It possesses a unique forkhead domain combined with a fragment of the target gene to initiate transcription [ 10 ] and regulates various biological processes such as tumor cell differentiation, cell proliferation, and migration [ 11 ]. (hindawi.com)
Transcriptional repressor1
- Ni and colleagues found that transcription factor 7-like 2 (TCF7L2), a WNT effector and transcriptional repressor, interacted with FOXA1 and that its binding sites overlapped with FOXA1- and AR-binding sites in molecular apocrine breast cancer cells in the absence of androgen stimulation. (aacrjournals.org)
Zinc-finger transcription factor2
- It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. (cancerindex.org)
- We describe the common (and near-universal) activation of the zinc finger transcription factor and Let-7 target PLAGL2 in CRC and find that it is a key driver of intestinal epithelial transformation. (bvsalud.org)
Epidermal growth1
- Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
Chromosome1
- Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. (cancerindex.org)
Domain4
- Recent work demonstrated that the forkhead domain encoding gene FoxB is involved in dorsal-ventral axis formation in spider limbs. (lu.se)
- The Forkhead domain in FOXD1 is distinctive from other members of the same family except, FREAC-9 also known as FOXD2. (wikipedia.org)
- This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. (cancerindex.org)
- Mucus cells lining abnormal airways from patients with IPF expressed MUC5B and SOX2 but lacked SAM pointed domain containing ETS transcription factor (SPDEF) and forkhead box A3(FOXA3). (bmj.com)
Steatosis1
- Scholars@Duke publication: Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. (duke.edu)
Diseases1
- Physiological aging refers to the physiological degeneration occurring after maturity, while pathological aging involves age-related changes caused by various external factors such as various diseases. (frontiersin.org)
Development4
- Placental growth factor (PIGF) is a direct and physiologically relevant transcriptional target of FOXD1 and hence, it is co-expressed with FOXD1 for the development of renal stroma. (wikipedia.org)
- The results, published this week (April 8) in Development , represent "the first report of the regeneration of a whole, aged organ by a single factor," according to a comment from the journal. (the-scientist.com)
- Forkhead box (Fox) transcription factors evolved early in animal evolution and represent important components of conserved gene regulatory networks (GRNs) during animal development. (lu.se)
- This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. (bvsalud.org)
Family1
- It belong to transcription factor family that displays remarkable functional diversity and involved in a wide variety of biological processes. (wikipedia.org)
Energy metabolism1
- They modulate energy metabolism through the deacetylation of various substrates, including transcription factors, metabolic enzymes, and histones. (alliedacademies.org)
Prognostic1
- The present study aimed to identify differentially expressed tissue miRs associated with prognostic factors in CRC patients, through a systematic review of the Literature. (biorxiv.org)
Proliferation1
- Androgen receptor (AR)-regulated transcription is critical for the proliferation of the molecular apocrine breast cancer subtype, which is characterized by HER2 overexpression and estrogen receptor negativity. (aacrjournals.org)
Overexpression1
- Scientists have struck upon a method of getting the thymi of old mice to grow back simply through the overexpression of a transcription factor. (the-scientist.com)
Fork head1
- PREDICTED: fork-head box L2 transcription factor [Saccoglossuskowalevskii]. (bioinformatics.org)
Human1
- The forkhead box D3 ( FOXD3 ) gene encodes a forkhead transcription factor that plays an important role in neural crest specification in vertebrates and therefore may be involved in human eye disease. (molvis.org)
Biological1
- FOXO3a (forkhead box transcription factor 3a) is involved in regulating multiple biological processes in cancer cells. (chinaphar.com)
Structures1
- The name of was derived from two spiked head structures in the embryos of Drosophila forkhead mutant. (wikipedia.org)
Inflammatory factors2
- In addition, LPS can indirectly produce neuroinflammation by peripheral inflammatory factors diffusing into the CNS through the blood-brain barrier, thus leading to CNS inflammatory injury ( 1 ). (spandidos-publications.com)
- While some signals are mitogenic and proosteogenic, others function to inhibit osteogenesis and increase bone resorption, and it appears that a well-controlled, delicate balance of inflammatory factors is necessary for proper fracture repair [ 3 - 6 ]. (hindawi.com)
Tumors1
- One contributing factor is the presence of tumors that are less responsive or have increased malignancy when treated with conventional chemotherapy, radiotherapy, or a combination of these. (bvsalud.org)
Activity2
- Enables DNA-binding transcription factor activity. (wormbase.org)
- It has histone deacetylase activity and represses transcription when tethered to a promoter. (cancerindex.org)
Growth4
- First, PIGF initiates stromal signal that regulate epithelial differentiation which functions as a growth factor in reactive angiogenesis during wound healing and tumorigenesis. (wikipedia.org)
- Methods Naive CD4 + T cells were activated with anti-CD3, anti-CD28 and transforming growth factor (TGF)-β, in the presence or absence of ATRA. (bmj.com)
- Activin Induction of Follicle Stimulating Hormone is Mediated by Transforming Growth Factor Beta Activated Kinase-1 (TAK-1) in Pituitary Gonadotropes. (ncsu.edu)
- Progression of this disease occurs due to a combination of factors, including the presence of periodontopathic bacteria, high levels of proinflammatory cytokines, matrix metalloproteinases (MMPs), prostaglandin E2 (PGE2), low levels of anti-inflammatory cytokines including inter- leukin-10 (IL-10), transforming growth factor (TGF- β ) and tissue inhibitors of MMPs (TIMPs) (2,3). (bvsalud.org)
Class1
- It has been reported that Forkhead box transcription factor class O3a (Foxo3a) is expressed in rheumatoid arthritis, a chronic inflammatory condition accompanied by bone resorption, and plays a role in its pathology. (go.jp)
Mice1
- In mice, Foxd1 is expressed in the mesenchyme surrounding the pituitary gland, which is an essential source for signaling factors that regulate pituitary organogenesis. (wikipedia.org)
Cells2
- In U87 and U251 cells, TMZ (200 μM) induced DNA double strand breaks (DSBs) and nuclear translocation of apoptosis inducing factor (AIF), which was accompanied by BNIP3-mediated mitophagy and FOXO3a accumulation in nucleus. (chinaphar.com)
- Singularly, SPDEF, a transcription factor associated with mucus metaplasia, was rarely detected in mucus cells in IPF. (bmj.com)
Risk factors1
- Characterizing the Shared Genetic Underpinnings of Schizophrenia and Cardiovascular Disease Risk Factors. (cdc.gov)
Establishment1
- The forkhead box (FOX) and ETS transcription factor families have been shown to be important in endothelial specification and establishment. (beckman.com)
Molecular1
- AR-mediated MYC induction enforces AR-driven transcription in molecular apocrine breast cancer. (aacrjournals.org)