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  • vitro
  • Furthermore, we found that blocking PDL1 results in increased T-cell stimulation by antigen-presenting LECs in vitro . (frontiersin.org)
  • TCR stimulation of Blimp-1-deficient CD4 + T cells in vitro results in hyperresponsiveness that is revealed by robust proliferation in suboptimal stimulatory conditions and increased numbers of IL-2 producers, indicating that Blimp-1 is a negative regulator of IL-2 production ( 10 ). (rupress.org)
  • latent
  • To determine if activated monocytes (actMo) like DC can reactivate antigen-specific CTL, they were transduced with adenoviral vectors encoding the subdominant Epstein Barr virus antigens, latent membrane proteins (LMP) 1 and 2, which are expressed in Epstein Barr virus-positive malignancies. (semanticscholar.org)
  • immune response
  • However, a number of factors may affect the immune response to protective antigens, such as the ability of the vaccine strain to invade and colonize the host and the stability of the plasmid expression system. (pubmedcentralcanada.ca)
  • Notably, injection of IFN-treated HIV-1-pulsed DCs in SCID mice reconstituted with autologous PBLs resulted in the generation of a potent primary immune response, as evaluated by the detection of human antibodies to various HIV-1 antigens. (rupress.org)
  • inhibition
  • Cannabinoid inhibition of the T cell response to the native antigen was stereoselective consistent with the involvement of a cannabinoid (CB) receptor. (aspetjournals.org)
  • These findings suggest that the CB2 receptor may be involved in CB inhibition of antigen processing by macrophages in this system. (aspetjournals.org)
  • Chimeric antigen receptor ( CAR ) T cell therapy, together with checkpoint inhibition, has been celebrated as a breakthrough technology due to the substantial benefit observed in clinical trials with patients suffering from relapsed or refractory B‐cell malignancies. (embopress.org)
  • clinical
  • In this review, we provide a comprehensive overview of the clinical trials performed so far worldwide and analyze parameters such as targeted antigen and indication, CAR molecular design, CAR T cell manufacturing, anti‐tumor activities, and related toxicities. (embopress.org)
  • More than 200 CAR T cell clinical trials have been initiated so far, most of which aim to treat lymphoma or leukemia patients using CD 19‐specific CAR s. (embopress.org)
  • cell
  • Finally, our data also suggest that T-cell dependency on Kv1.3 or KCa3.1 might be irreversibly modulated by antigen exposure. (nature.com)
  • The invention also relates to methods of isolating a target cell or a target cell population that is defined by the presence of at least one common specific receptor molecule. (freepatentsonline.com)
  • This negative "second signal" opposes T cell receptor activation and leads to downregulation of T cell proliferation and promotes antigen specific tolerance. (frontiersin.org)
  • Moreover, in relation to molecular mimicry, it is well established that similarities between regions of antigens leading to T-cell cross-reactivity are the consequence of shared structural features rather than simply a reflection of sequence identity ( 28 ). (diabetesjournals.org)
  • Such structural similarities are difficult to identify by database searches, requiring instead the prior characterization of T-cell reactivity to the candidate environmental and self-antigen. (diabetesjournals.org)
  • Mice with a T cell-specific deletion of Prdm1 , encoding Blimp-1, have aberrant T cell homeostasis and develop fatal colitis. (rupress.org)
  • The ability of a macrophage hybridoma to function as an antigen-presenting cell was examined by the stimulation of a soluble protein antigen-specific helper T cell hybridoma to secrete interleukin-2. (aspetjournals.org)
  • THC exposure significantly reduced the T cell response to the native form of the antigen after a 24-h pretreatment of the macrophages with nanomolar drug concentrations. (aspetjournals.org)
  • B) Schematic representation of a T cell receptor (TCR) and four types of chimeric antigen receptors (CARs) being displayed on the surface of a T cell while contacting their antigen (red) on the tumor cell. (embopress.org)
  • Pooled CAR T cell products consist of two or more single‐targeting CAR T cell types with distinct antigen specificities. (embopress.org)
  • The interaction of DCs with pathogens leads to migration to secondary lymphoid organs where they can initiate a specific T cell response. (rupress.org)
  • Antigen and PHA stimulation, therefore, may involve different cell populations. (jimmunol.org)
  • exposure
  • The lymphocyte proliferative response to KLH and PPD stimulation could be inhibited as much as 95% by treatment from days 2 to 4 with 5 × 10 -6 M 5-bromo-2′-deoxyuridine (BrdU) and exposure to visible light. (jimmunol.org)
  • protein
  • For antigen processing and presentation via MHC protein You don´t need any living antigen. (bio.net)
  • Mutation of two key amino acids within any of the functional EF hands of DREAM (EFmDREAM) results in a protein insensitive to Ca 2+ that remains bound to DNA during Ca 2+ stimulation ( Carrion et al , 1999 ). (embopress.org)
  • induction
  • To date, induction of donor specific tolerance has remained an elusive goal for all but the most aggressive therapeutic strategies, suitable only for a small subset of patients. (frontiersin.org)
  • Thus, the induction of a specific, neutralizing IgM response early in the course of WNV infection limits viremia and dissemination into the central nervous system, and protects against lethal infection. (rupress.org)
  • knockdown
  • Importantly, specific transient knockdown of DREAM or KChIP‐2 induced basal expression of IL‐2 and IFNγ in wild‐type splenocytes. (embopress.org)
  • molecular
  • Identifying specific biomarkers for RA can clarify the underlying molecular mechanisms and can aid diagnosis and patient care. (medsci.org)
  • patients
  • Therefore, it is often not possible to make a specific diagnosis, and empiric therapy is generally administered in high-risk patients who are suspected of having an infection. (nih.gov)
  • However
  • The addition of a second antigen, however, markedly increased the 3 H-thymidine ( 3 H-T) incorporation within 1 day. (jimmunol.org)
  • findings
  • Despite these findings, there are few specific biomarkers that are useful for diagnosing and monitoring the progression of RA. (medsci.org)