Followed by reperfusion duration ischemia time. Medical search. Frequent questions

Studies have shown that puerarin reduced cerebral edema in rats with cerebral ischemia-reperfusion injury, removed lipid peroxidation products, enhanced antioxidant capacity, improved antioxidant activity of the brain tissue, and reduced the degree of focal cerebral ischemic injury [ 2 - 4 ]. (hindawi.com)
This shows that the Fas-pathway may play a role in the pathogenesis of the apoptosis of tubule cells during the early ischemic-reperfusion period. (wikipedia.org)
Prevents the damaging effect of free radicals, preserves the integrity of cell membranes, prevents the activation of neutrophils in the ischemic zone, prolongs the duration of the electrical potential, reduces the output of CKK from cells and the severity of myocardial ischemic damage. (lekarstwo.ru)
Although ideally positioned for immediate response to ischemic stroke (IS) and reperfusion, their progressive morphological transformation into activated cells has not been quantified. (biomedcentral.com)
CD11b expression, but not iNOS expression, was increased in regions of hyper- and de-ramified microglia during the course of ischemic stroke and 24 h of reperfusion. (biomedcentral.com)
Effect of ischemic time on survival in clinical lung transplantation. (jamanetwork.com)
Effect of donor age and ischemic time on intermediate survival and morbidity after lung transplantation. (jamanetwork.com)
Graft ischemic time and outcome of lung transplantation: a multicenter analysis. (jamanetwork.com)
The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. (cdc.gov)

When cerebral ischemia-reperfusion injury happened in patients, multiple pathological processes occur, such as leukocyte infiltration, platelet, and complement activation, which would result in cognitive dysfunction and inflammation. (hindawi.com)
The original phenolic hydroxyl in the puerarin molecules was substituted in order to change the blood-brain barrier permeability and thus enhance the efficacy for preventing cerebral ischemia/reperfusion injury. (hindawi.com)
The mouse model of cerebral artery ischemia/reperfusion injury was established to test the anticerebral ischemia-reperfusion injury activity of the puerarin derivatives. (hindawi.com)
The results showed that puerarin derivative P1-EA and P2-EA were resulting in an increased lipophilicity that enabled the derivatives to pass more efficiently through the blood-brain barrier, thus, improving the protective effects against cerebral ischemia/reperfusion injury. (hindawi.com)
Therefore, derivatives of puerarin may serve as promising approach to improve neuron function in ischemia-reperfusion brain injury-related disorders. (hindawi.com)
Studies have shown that VaD is frequently caused by ischemia-reperfusion injury. (hindawi.com)
In addition, we tested the anticerebral ischemia-reperfusion injury activity of these puerarin derivatives in order to determine their permeability through the blood-brain barrier and pharmacological activity. (hindawi.com)
PURPOSE: To investigate blood creatinine and renal histology in rats anesthetized with S(+)-ketamine (keta) or dexmedetomidine (dex) and submitted to kidney ischemia/reperfusion injury (IRI). (unesp.br)
In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients' survival rate. (researchsquare.com)
Previous studies have shown that ischemia/reperfusion (I/R) injury acts as a significant role in PGD(4), contributing to adverse short- and long-term clinical outcomes in the recipients. (researchsquare.com)
A recent article by Decuypere et al in AJKD explores the role of autophagy in kidney ischemia-reperfusion injury and therapy. (ajkdblog.org)
Renal surgery and coronary artery bypass grafting can produce renal ischemia and reperfusion injury. (wikipedia.org)
In studies of mice models, a high-fat diet can induce greater injury to the kidney with renal ischemia-reperfusion as compared to mice with normal diet. (wikipedia.org)
Abstract Hepatic ischemia/reperfusion (I/R) injury is a common clinical challenge. (123dok.net)
Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)
Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemia/reperfusion injury remains incomplete. (elifesciences.org)
2 Short-duration occlusion of cerebral or cardiac vessels as a result may leave a patient with transient or permanent injury. (silverchair.com)
Recent data suggested that initiating TH during CPR, before the reperfusion phase, would provide additional beneficial effects against post-anoxic brain injury. (medscape.com)
Moreover, some devices may selectively cool the brain primarily with less effect on core body temperature and thus more rapidly protect cerebral cells from ischemia/reperfusion injury. (medscape.com)
Due to the high vulnerability of the pancreas to ischemia-reperfusion injury, choices regarding preservation solution markedly affect pancreas transplant success. (frontierspartnerships.org)
As such, the dichotomous nature of these cells continues to confound our understanding of microglia-mediated injury after IS and reperfusion. (biomedcentral.com)
The purpose of this study was to quantitatively characterize the spatiotemporal pattern of microglia morphology during the evolution of cerebral injury after IS and reperfusion. (biomedcentral.com)
Quantitative analysis reveals a significant spatiotemporal relationship between microglia morphology and evolving cerebral injury in the ipsilateral hemisphere after IS and reperfusion. (biomedcentral.com)
Importantly, quantitative analyses of microglial morphology and activity are feasible and, in future studies, would assist in the comprehensive identification and stratification of their dichotomous contribution toward cerebral injury and recovery during IS and reperfusion. (biomedcentral.com)
Current methods of cold static storage have reached their limits in storage time due to the extent of ischemia-reperfusion (I/R) injury induced during static cold storage. (gotomydoctor.com)
The extent of reperfusion injury is directly proportional to preservation time in cold storage, and research has shown that with static storage methods, heart storage time will not exceed six hours. (gotomydoctor.com)
Additionally, machine reperfusion induces the production of ROS, which results in I/R injury to the heart. (gotomydoctor.com)
Reperfusion injury significantly impacts clinical outcome after pulmonary transplantation. (jamanetwork.com)
Ischemia-reperfusion injury after lung transplantation increases risk of late bronchiolitis obliterans syndrome. (jamanetwork.com)
Seibert AF, Haynes J, Taylor A. Ischemia-reperfusion injury in the isolated rat lung: role of flow and endogenous leukocytes. (jamanetwork.com)
de Perrot M, Liu M, Waddell TK, Keshavjee S. Ischemia-reperfusion-induced lung injury. (jamanetwork.com)
Ovechkin AV, Lominadze D, Sedoris KC, Robinson TW, Tyagi SC, Roberts AM. Lung ischemia-reperfusion injury: implications of oxidative stress and platelet-arteriolar wall interactions. (jamanetwork.com)
Endothelial cell (EC) activation plays a vital role inside the pathophysiology of ischemia/reperfusion injury, sepsis, vascular rejection of transplanted organs, and other illnesses linked for the vascular program. (translateinthetownships.com)
Retinal ischemia reperfusion injury (RIRI) is a conventional pathological process in various retinal vascular diseases. (por-journal.com)
Accordingly, this study aimed to investigate the pathological changes of retinal structure, expression of JAK-STAT signaling pathway hallmark proteins, and apoptosis at different time points after retinal ischemia reperfusion injury in rats. (por-journal.com)
Retinal ischemia reperfusion injury (RIRI) is a conventional pathological process in various retinal vascular diseases, such as glaucoma, retinal vascular obstruction, diabetic retinopathy, and so on, which can cause serious visual dysfunction, and the mechanism of RIRI is sophisticated ( 1 , 2 ). (por-journal.com)
The intestinal ischemia and reperfusion injury (intestinal-I/R) is a clinical problem associated with systemic inflammation, pulmonary microcirculation dysfunction and Acute Respiratory Distress Syndrome (ARDS). (fapesp.br)
At the same time, the effect of the intestinal-I/R after longer periods of reperfusion (1, 3 and 5 days) on the pulmonary injury and the regulating mechanisms of the pulmonary tecidual repair will be analyzed. (fapesp.br)
A sickle cell pain crisis is an inflammatory storm with ischemia-reperfusion injury that results in multiorgan damage the longer the duration of the crisis. (medicinehouse.com)
Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have made intermediate-term survival after lung transplantation an achievable goal. (ersjournals.com)
Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have contributed to increase the 1‐yr patient survival after lung transplantation (LTx) to 70-80% 1 . (ersjournals.com)
Dexmedetomidine is widely used for perioperative anesthesia/analgesia, and may have a more profound renal protection by stabilizing the sympathetic system, exerting anti-inflammatory effects and attenuating ischemia/reperfusion (I/R) injury. (medscape.com)
but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury. (cdc.gov)

Acute treatment with troglitazone increases susceptibility to ventricular fibrillation during myocardial ischemia and reperfusion. (diabetesjournals.org)
Reduces intracellular acidosis and phosphate content due to myocardial ischemia and reperfusion. (lekarstwo.ru)

Specifically, the gelatinases MMP-2 and MMP-9 have previously been considered to specifically injure the important components of the basal lamina around the cerebral blood vessels that precede microvascular damage in cerebral ischemia [ 1 ]. (biomedcentral.com)
When cerebral perfusion is jeopardized, a definitive corrective procedure is advised at a time when the patient is in a relatively stable condition. (nih.gov)
Patients with occlusive lesions of all four cervical arteries usually have severe cerebral ischaemia and their distal runoff is usually unable to be visualized on angiography. (nih.gov)
Male C57Bl/6 mice were subjected to focal cerebral ischemia and periods of reperfusion (0, 8 and 24 h). (biomedcentral.com)
Microglia were both hyper- and de-ramified in striatal and cortical brain regions (respectively) after 60 min of focal cerebral ischemia. (biomedcentral.com)

In this work we report on therapeutic efficacy of CS from mouse ADSC transduced to express human vascular endothelial growth factor 165 a/a isoform (VEGF165), which showed potency to restore perfusion and protect tissue in a model of limb ischemia. (biomedcentral.com)
CS were transplanted subcutaneously to mice with surgically induced limb ischemia and followed by laser Doppler perfusion measurements. (biomedcentral.com)
Delivery of ADSC by subcutaneous transplantation of CS is effective for stimulation of angiogenesis and tissue protection in limb ischemia with a potential for efficacy improvement by BV transduction to express VEGF165. (biomedcentral.com)

Rats were sacrificed at different time points after reperfusion. (por-journal.com)

In liver transplantation, tissue damage at reperfusion is mostly correlated with warm and cold ischemia times and leads in turn to poor graft function [13] and biliary complications [14,15]. (123dok.net)
The extension of the necrotic core into the penumbra is influenced by additional factors such as regional differences in the composition of brain tissue, the vulnerability of different cell types to ischemia, residual tissue perfusion and additional events such as reperfusion [ 2 - 4 ]. (biomedcentral.com)

However, this approach has limitations in the clinical setting since the patient needs to have the perfusion tracer injected prior to reperfusion and undergo imaging in a gamma camera within approximately 3 hours. (biomedcentral.com)
[ 20 ] in this study, IATH using cold fluids resulted in a lower coronary perfusion pressure, a greater need for epinephrine and a longer duration of CPR. (medscape.com)

In the situation of acute coronary occlusion, the myocardium supplied by the occluded vessel is subject to ischemia and is referred to as the myocardium at risk (MaR). Single photon emission computed tomography has previously been used for quantitative assessment of the MaR. It is, however, associated with considerable logistic challenges for employment in clinical routine. (biomedcentral.com)
Thirty-seven patients with early reperfused first-time ST-segment elevation myocardial infarction underwent CMR imaging within the first week after percutaneous coronary intervention. (biomedcentral.com)
8 Endothelial glycocalyx damage has been shown to prolong microbubble transit time through the coronary circulation. (silverchair.com)
A sudden increase in afterload may cause left ventricular dilation, increased pulmonary artery pressures, and myocardial ischemia, especially in patients with coronary artery disease. (openanesthesia.org)

Diseases such as sepsis can cause kidney ischemia too. (wikipedia.org)

We previously demonstrated that chronic pretreatment with a thiazolidinedione peroxisome proliferator-activated receptor (PPAR)-γ activator, troglitazone, improves recovery of left ventricular (LV) function and substrate metabolism after ischemia and reperfusion, without causing arrhythmias. (diabetesjournals.org)
After heart transplantation, the donor heart preservation with normoxic CM was associated with shorter re-beating time, histopathological scores, and left ventricular systolic diameter, higher ejection fraction, and fractional shortening of transplanted hearts. (researchsquare.com)

What causes kidney ischemia is not entirely known, but several pathophysiology relating to this disease have been elucidated. (wikipedia.org)

Outcomes are optimized if zone III occlusion times are 30-60 minutes or less. (openanesthesia.org)

Physical stress such as infarction, surgery and transplant may produce kidney ischemia. (wikipedia.org)
This study demonstrated that the endocardial extent of infarction as assessed by LGE CMR underestimates MaR in comparison to T2-weighted imaging, especially in patients with early reperfusion and aborted myocardial infarction. (biomedcentral.com)
Thus, time to reperfusion is thought to limit the transmural infarct progression rather than the endocardial extent of infarction. (biomedcentral.com)

Influence of graft ischemia time on outcomes following lung transplantation. (jamanetwork.com)

Images were acquired starting at 2 or 24 hours after reperfusion over the ipsilateral and contralateral cortex before and for 3 hours after, MMPSense750 was injected. (biomedcentral.com)

Kidney ischemia is a disease with a high morbidity and mortality rate. (wikipedia.org)
Possible causes of kidney ischemia include the activation of IL-17C and hypoxia due to surgery or transplant. (wikipedia.org)
citation needed] Kidney ischemia can be diagnosed by checking the levels of several biomarkers such as clusterin and cystatin C. While the duration of ischemia was used as a biomarker, it was found that it has significant flaws in predicting renal function outcomes. (wikipedia.org)
In studies of mice models, clamping of the kidney may result in kidney ischemia. (wikipedia.org)

The inflammatory profile may have variations from one person to another and may have variations in the same person at different times. (medicinehouse.com)

However, postoperative parameters including MV duration, ICU stay and hospital LOS appeared to be no significant decrease as a result of the dexmedetomidine use. (medscape.com)
The timing of dexmedetomidine administration in relation to cardiac surgery is emerging as an important consideration. (medscape.com)

Analysis of cortical and sulcal hyperintensity on gadolinium-enhanced FLAIR with iodinated contrast medium volume, procedural duration, number of angiographic runs, and DWI lesions was performed. (ajnr.org)
Cortical and sulcal hyperintensity on gadolinium-enhanced FLAIR is significantly associated with procedural time, and the frequency of angiographic runs suggesting a potential technical influence on the breakdown of the BBB, but no reported adverse clinical outcome or association with both iodinated contrast medium volume and DWI lesions was found. (ajnr.org)

Live cell morphology and process activity were measured from movies acquired in acute brain slices from GFP-CX3CR1 transgenic mice after IS and 24-h reperfusion. (biomedcentral.com)

This is a technique where one or two renal arteries are ligated for a period of time (30 min to 1 hour), and then released causing AKI. (ajkdblog.org)
Moreover, renal ischemia can cause the delay of graft function after renal transplant and can cause rejection of the transplant. (wikipedia.org)
however, DAXX mediates both Fas-dependent and TGF-beta-induced apoptosis and renal induction of TGF-beta is well documented in renal ischemia studies. (wikipedia.org)

A potential therapy is the intravascular administration of exogenous surface-active agents, which have been shown to decrease bubble adhesion to the vessel wall, 10 accelerate vessel reperfusion, 11,12 and attenuate thrombin formation 13 and platelet binding interactions otherwise provoked by gas microbubbles. (silverchair.com)

Initial stroke severity, degree of successful revascularization, and the side of ischemia were found to independently predict the functional outcome at 3 months after treatment. (ajnr.org)

Complement Receptor 4 Proteins Recombinant Proteins Additional testing might be significant to identify the actual mechanism leading to improved DKK1 production for the duration of infections and no matter if DKK1 is usually a marker of chronic or undetected infections secondary to other illnesses like FA. (translateinthetownships.com)
Complement at the same time as EC activation was assessed within the presence or absence of complement inhibitors displaying the versatility of your model for drug testing. (translateinthetownships.com)
As such, new drugs that would complement reperfusion by providing neural and cardiovascular protection and by targeting multiple abnormalities in ischemia are receiving increased attention. (cdc.gov)

Accordingly, we researched the pathological structure, protein expression changes and effect of JAK-STAT signaling pathway at different time points of RIRI in this study to provide an intact baseline. (por-journal.com)

H2S as a simple additive to preservation solution is not expected to remain in the solution for the full duration of preservation. (gotomydoctor.com)

When this exceesds the CPP, capillary collapse with ensuing muscle and nerve ischaemia occur. (openorthopaedicsjournal.com)

This retrospective study compared laboratory values and clinical features of 3 nonhuman primate models of lethal EVD to assess associations with improved survival time. (cdc.gov)

This study provides important findings on the distinct functions of resident and recruited macrophages during cardiac healing after myocardial ischemia. (elifesciences.org)
A compounding factor in critically ill or cardiac surgical patients with compromised circulation is that the glycocalyx is easily disrupted by hypoxia, 6 by use of cold cardioplegia solutions, 7 and with ischemia-reperfusion. (silverchair.com)

An increased requirement for pharmacologic or mechanical support in the weaning process was associated with higher morbidity and mortality and longer times on CPB. (medscape.com)

Past studies have experimented with either one-time injection of NaHS solution or 30-minute incubation with H2S before ischemia. (gotomydoctor.com)
Most studies are mostly conducted through drug intervention, and many studies select only one specific time point, such as 0, 6, 24, 48, 72, or 144 h after RIRI to apply drugs and then assess the therapeutic effect of drugs. (por-journal.com)

The time an organ can remain outside the body plays a crucial role in the organ transplantation system. (gotomydoctor.com)
The dynamic changes of hallmark proteins at different time points after RIRI indicate that JAK-STAT signaling pathway activates rapidly but weakens later and plays a vital role in RIRI, and apoptosis is involved in RIRI with a peak value at 24 h in the process, suggesting a potential therapeutic direction and time window for treating RIRI. (por-journal.com)

Some effects of H2S protection require the continued presence of H2S, such as ROS scavenging during ischemia. (gotomydoctor.com)
Adverse environmental effects of enough strength and duration cause unprogrammed cell death and immediate release of endogenous molecules or alarmines, which are normally inside the cells, into the intracellular environment. (hindawi.com)

In a multivariate logistic regression analysis, the type of AMI was classified based on electrocardiography findings (odds ratio 5.18, 95% confidence interval: 1.69-15.91, P=0.004) and was independently associated with a long prehospital delay time, indicating that patients with ST segment elevation MI would seek early medical care. (who.int)

In addition, a treatment paradigm by adapting exposure time is proposed to compensate MB decay to retain the persistence of BBB-opening efficiency in multiple FUS exposures. (nature.com)

There was no observed difference in survival rates when grafts were exposed to 6 or more hours of ischemia ( P = .41, log-rank test). (jamanetwork.com)

The HINE′s total score threshold for predicting gross motor retardation at 12 months was determined from a receiver operating characteristics curve, and the predictive validity, sensitivity and specificity were evaluated by calculating the area under the curve.Results:At each time point the average total HINE score of the delayed group was significantly lower than the normal group′s average. (bvsalud.org)

The time between transplantation and onset of BOS can range from a few months to several years, but in most series, the median time to diagnosis is 16-20 months. (ersjournals.com)

Before ischemia, acute troglitazone treatment had no effect on LV function, electrocardiogram, or substrate utilization. (diabetesjournals.org)
At the same time, the consumption of nitrates is reduced, after 2 weeks of treatment, exercise tolerance is increased, blood pressure drops decrease. (lekarstwo.ru)
Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)

This article describes a sequence of initial resuscitation strategies designed to improve the safety of tourniquet removal where greater than 2 hours of warm ischaemia time has elapsed after application. (army.gov.au)
Prehospital delay time ranged from 15 minutes to 10 days, with a median of 2 hours (interquartile range: 9.50). (who.int)

Anesthetized pigs underwent 90 min of regional LV ischemia and 90 min of reperfusion. (diabetesjournals.org)

The objective of the present study was to determine whether an alternate MMP activatable probe with a shorter optical imaging time, MMPSense ™ 750 FAST (MMPSense750), could be used for visualization of MMP activity in the early stages of ischemia reperfusion in a mouse model of stroke. (biomedcentral.com)

Anatomy33

Organisms13

Diseases40

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment64

Phenomena and Processes39

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science2

Named Groups2

Health Care20

Ischemic9

Injury43

Myocardial ischemia and reperfusion2

Cerebral5

Limb ischemia3

Rats1

Tissue2

Perfusion2

Coronary4

Sepsis1

Left ventricular2

Pathophysiology1

Occlusion1

Infarction3

Lung1

Ipsilateral1

Kidney4

Inflammatory1

Dexmedetomidine2

Lesions2

Mice1

Renal3

Vessel1

Revascularization1

Complement3

Pathological1

Preservation solution1

Occur1

Clinical1

Cardiac2

Morbidity1

Studies2

Role2

Effects2

Patients1

Exposure1

Survival1

Significantly1

Transplantation1

Treatment3

Hours2

Underwent1

Stroke1