Follicular differentiation cell differentiation. Medical search. Frequent questions

It is assured that the spectrum and the extent of the integrin expression of cancer cells correlate with their abilities of proliferation and invasion. (uni-marburg.de)
The thyroid gland forms as a proliferation of endodermal epithelial cells on the median surface of the developing pharyngeal floor. (medscape.com)
Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections 8 and blocking of B cell proliferation. (biolegend.com)
Here, we investigated whether the failure of IL-12 treatment for FL was due to T cell exhaustion, a condition characterized by reduced T cell differentiation, proliferation, and function, which has been observed in chronic viral infection. (jci.org)
It depends on a stage-wise developmental process that includes B cell activation, antigen processing and presentation to T follicular helper (Tfh) cells, proliferation and somatic hypermutation in GC, selection and eventual differentiation into antibody-secreting plasma cells (PC) or memory B cells. (umontreal.ca)
There are many causes of keratinization defects and they produce clinical signs by altering proliferation, differentiation, desquamation or combination between. (vin.com)
Therefore, the MAPK family governs almost all the physiological functions and processes such as cell adaptation, proliferation, differentiation, survival, and programmed cell death. (spandidos-publications.com)
Subsequently, inadequate regulation of cell proliferation and defective oncogene and/or suppressor gene expression promote the transition from preneoplastic conditions to neoplasia. (medscape.com)
These genes provide instructions for making proteins that are involved in the growth and division (proliferation) and maturation (differentiation) of cells within hair follicles . (medlineplus.gov)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the spleen, the liver, and the gastrointestinal tract. (msdmanuals.com)
Hodgkin Lymphoma Hodgkin lymphoma is a localized or disseminated malignant proliferation of cells of the lymphoreticular system, primarily involving lymph node tissue, spleen, liver, and bone marrow. (msdmanuals.com)

Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation. (rochester.edu)
Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness. (rochester.edu)
Moreover, in a clinical trial testing a combination of IL-12 and rituximab in patients with follicular B cell non-Hodgkin lymphoma (FL), those treated with IL-12 showed a lower response rate, suggesting that IL-12 actually plays a detrimental role. (jci.org)
There are many types of lymphoma , all classified based on their cell type, cell markers, location of the cancerous mutation, and how they grow. (lymphomainfo.net)
Small lymphocytic lymphoma , follicular small-cleaved cell lymphoma, and follicular mixed small-cleaved and large cell lymphomas were all considered low grade . (lymphomainfo.net)
Malignant blast cells (i.e. diffuse large B-cell lymphoma) are fast-growing and result in aggressive disease, whereas malignant mature lymphocytes (i.e. follicular lymphoma) behave indolently. (oncolink.org)
The t(14;18) translocation (characteristic for follicular lymphoma but also common in other types) results in activation of the BCL-2 gene and suppression of apoptosis. (oncolink.org)
Important types include follicular lymphoma and small lymphocytic lymphoma . (oncolink.org)
The diagnosis of CBCL is established by analysis of skin biopsy specimen, using histomorphology and cytomorphology, immunohistochemistry and phenotypic features, and genotyping and cytogenetic studies (see Workup of Cutaneous B-Cell Lymphoma). (medscape.com)
Marginal zone B-cell lymphoma (MZL) (MALT-type) is an indolent cutaneous lymphoma, accounting for approximately 10% of all cutaneous lymphomas. (medscape.com)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)

T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. (nih.gov)
Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. (nih.gov)
Upon their secretion by antigen-presenting cells, they exert both pro-inflammatory and anti-inflammatory receptor-mediated effects. (nature.com)
CD28 (Antigen CD28) is characterized as a co-receptor for the TCR (T-Cell Receptor)/CD3 (CD3 Antigen) complex and is responsible for providing the co-stimulatory signal required for T-cell activation. (proteinlounge.com)
They found that mice whose B cells lacked the receptor for INF-γ had significantly diminished numbers of flu-specific BRMs after influenza virus infection. (uab.edu)
Translocations are thought to occur during normal gene rearrangements (Ig, T-cell receptor). (oncolink.org)
In vitro induction experiments showed that differentiation of naïve T cells into Tfh cells was accompanied by an increase in D1-like receptor expression. (bmj.com)
Here we report that when mice lacking the RelA subunit of NF-κB are brought to term by breeding onto a tumor necrosis factor receptor (TNFR)1-deficient background, the mice that are born lack lymph nodes, Peyer's patches, and an organized splenic microarchitecture, and have a profound defect in T cell-dependent antigen responses. (rupress.org)
We utilize two complementary models, HEK293 cells and human iPSC-derived neurons, and delineate RBM12 as a novel repressor of the G protein-coupled receptor/cAMP/PKA (GPCR/cAMP/PKA) signaling axis. (bvsalud.org)
It regulates the receptor for cholesterol, takes it out of the blood stream and puts it into the cells. (cdc.gov)

Follicular helper T cells (Tfh) regulate the differentiation of germinal center B cells and maintain humoral immunity. (sciencegate.app)
Interleukin-10 (IL-10) is an immunosuppressive cytokine that signals through STAT3 to regulate T follicular helper (Tfh) cell differentiation and germinal center formation. (nih.gov)
MicroRNAs (miRNAs) regulate many physiological pathways, including development, cell differentiation, immune response as well as diseases by post-transcriptional processes. (tubitak.gov.tr)
Within the underlying theme of our research, we explore T cell responses from two complementary angles: the molecular pathways intrinsic to T cells, and the pathways that act in dendritic cells to cross-regulate T cell responses. (stjude.org)
Previous studies have found that DRDs can regulate differentiation of immune cells. (bmj.com)
Finally, in vitro experiments and RNA sequencing (RNA-seq) were used to explore the possible pathway by which DRDs regulate Tfh cell differentiation. (bmj.com)

REAL/WHO- [6] - classification includes leukemias and lymphomas, with 3 categories based on lineage and morphology (Hodgkin, B cell, and T/NK cell). (oncolink.org)
[ 1 , 2 ] They can be defined as lymphoproliferative skin infiltrates of T-cell, B-cell, or natural killer cell lineage, which primarily occur in and remain confined to the skin in most patients, without detectable extracutaneous manifestations at diagnosis. (medscape.com)
The WHO modification of the REAL classification of NHL is based on morphology and cell lineage. (medscape.com)

therefore, few institutions have extensive experience with Hürthle cell neoplasms. (medscape.com)
Although Hürthle cell carcinoma was previously considered a variant of follicular cell neoplasms, which are generally less aggressive, the 2017 World Health Organization (WHO) classification of endocrine tumors reclassified it as a distinct entity. (medscape.com)
According to the World Health Organization (WHO), these neoplasms are considered a variant of follicular carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type. (medscape.com)
Some investigators believe that this condition is distinct from other follicular cell neoplasms. (medscape.com)
Within the B-cell and T-cell categories, two subdivisions are recognized: precursor neoplasms, which correspond to the earliest stages of differentiation, and more mature differentiated neoplasms. (medscape.com)

For dendritic cell-mediated extrinsic control of T cell differentiation, we focus on metabolic and inflammatory pathways (see Du Nature 2018). (stjude.org)
Innate sensing and cell-autonomous resistance pathways in Legionella pneumophila infection. (sfb-tr84.de)
While individual pathways have been well studied in a variety of model systems, there remains much to uncover about how pathways are integrated to produce systemic changes in a cell, especially in dynamic conditions. (bvsalud.org)

[ 2 ] When multiple basaloid follicular hamartomas are associated specifically with myasthenia gravis and diffuse alopecia, the syndrome is known as Brown-Crounse syndrome. (medscape.com)

Long-term exposure of freshly isolated human CD4+ T cells to IL-12 in vitro caused T cell dysfunction and induced expression of TIM-3, a T cell immunoglobulin and mucin domain protein with a known role in T cell exhaustion, via an IFN-γ-independent mechanism. (jci.org)
We studied the involvement of cAMP and PKA in the regulation of the secretion of neurotrophic growth factors by macro-and microglial cells in the model of ethanol-induced neurodegeneration in vitro and in vivo. (bvsalud.org)

Basaloid follicular hamartoma (BFH) is a rare, benign adnexal tumor. (medscape.com)
The tumor is morphologically similar to infundibulocystic basal cell carcinoma. (medscape.com)
therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)
GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

The other half of the Nobel Prize went to Ralph M. Steinman for "his discovery of the dendritic cell and its role in adaptive immunity. (wikipedia.org)

CD137 plays roles in the costimulation, differentiation and survival of T cells and B cells. (bdbiosciences.com)
Targeting IL-10 signaling to impair CD4+ T cell survival and improve antiviral immune responses may represent a novel approach to limit viral persistence in ART-suppressed people living with HIV. (nih.gov)
Pituitary adenylate cyclase-activating polypeptide (PACAP) promotes both survival and neuritogenesis in PC12 cells through activation of nuclear factor ?B (NF-?B) pathway: involvement of extracellular signal-regulated kinase (ERK), calcium, and c-REL. (genscript.com)
PACAP promotes both survival and neuritogenesis in PC12 cells by activating NF-kappaB pathway, most likely via classical and alternative signaling cascades involving ERK1/2 kinases, Ca(2+), and c-Rel/p52 dimers. (genscript.com)
Correlation of TIM-3-expressing cells with clinical survival in FL patients. (jci.org)
C ) Kaplan-Meier curves for progression-free survival of FL patients ( n = 31) by the number of TIM-3 + cells (left), CD4 + TIM-3 + T cells (middle), or CD8 + TIM-3 + T cells (right) with a cutoff of 15%, 10%, or 2.5%, respectively. (jci.org)
D ) Kaplan-Meier curves for progression-free survival of FL patients ( n = 31) by the number of CD4 + PD-1 + T cells (left) or CD8 + PD-1 + T cells (right) with a cutoff of 12% or 2%, respectively. (jci.org)
In addition, the addition of VEGF to the culture medium can increase the survival rate of neurons in the cerebral cortex as well as the number and length of ganglion cell processes, to promote nerve growth. (spandidos-publications.com)

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. (nature.com)
Elle dépend d'un processus de développement séquentiel qui comprend: l'activation des lymphocytes B par l'antigène, le traitement et la présentation de l'antigène aux lymphocytes T auxiliaires, la prolifération et l'hypermutation somatique dans le CG, la sélection des lymphocytes B produisant des anticorps de haute affinité et finalement la différenciation en plasmocytes sécréteurs ou en lymphocytes B mémoire. (umontreal.ca)
Nous avons examiné le rôle des protéines CBL dans le développement et la différenciation des lymphocytes B du CG en utilisant des souris mutantes dans lesquelles l'expression des protéines CBL est, soit réduite conditionnellement avant l'initiation du GC (souris CBLdKO-Mb) ou pendant la réaction de formation du CG (souris CBLdKO-Cg). (umontreal.ca)
En effet les protéines CBL sont requises pour l'absorption, le traitement et la présentation de l'antigène aux cellules T auxiliaires par les lymphocytes B naïves. (umontreal.ca)
En effet en absence des protéines CBL, les lymphocytes B du CG peuvent encore se développer plus ou moins normalement, mais ne peuvent pas produire des clones ayant des BCRs de haute affinité, comparé aux lymphocytes B de type sauvage. (umontreal.ca)
Nos analyses ont aussi révélées que les protéines CBL contrôlent cette étape du développement des cellules B du CG en favorisant l'ubiquitination de IRF4, un facteur de transcription exprimé tardivement dans les lymphocytes B du CG ayant vraisemblablement acquis un BCR de haute affinité. (umontreal.ca)
Molecular sites on or in B-lymphocytes, follicular dendritic cells, lymphoid cells, and epithelial cells that recognize and combine with COMPLEMENT C3D. (bvsalud.org)
the remainder arise from T lymphocytes or natural killer cells. (msdmanuals.com)

On histopathology, this fibroinflammatory disease is characterized with specific findings such as lymphoplasmacytic infiltration of IgG4-positive plasma cells, obliterative phlebitis, and storiform fibrosis, in most cases accompanied by increased levels of serum IgG4 [ 10 ]. (hindawi.com)

This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on the cell metabolism of cyclic nucleotides such as cAMP, and on the intracellular Ca2+ signaling, which may avail the reduction of toxic effects promoted by chemotherapy, radiotherapy and immunotherapy, thus decreasing the incidence of interruption in antitumoral treatment. (researchgate.net)
2020. Cell Metabolism. (biolegend.com)
Our laboratory has a long-standing interest in immune signaling and cell metabolism underlying the differentiation and function of T cells, a central cell type in adaptive immunity and cancer immunotherapy. (stjude.org)
Lim SA, Su W, Chapman NM, Chi H . Lipid metabolism in T cell signaling and function. (stjude.org)
We suggest several models for how cells coordinate growth, metabolism, and other responses in budding yeast and how restructuring these processes enables anaerobic xylose utilization. (bvsalud.org)

Likewise B cells function as crucial antigen presenting cells in autoimmune diseases that are traditionally viewed as T cell mediated. (hindawi.com)
Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)
Another advance is the implementation of two-photon microscopy to visualize the movement of CD4 + T cells and their interactions with antigen-presenting cells during an immune response. (stemcell.com)
T cells are primed by antigen-presenting cells in the T cell zones of the periarteriolar lymphoid sheaths of the spleen, the paracortex of LNs, and the dome area of Peyer's patches (PPs) * lining the intestine. (rupress.org)

Cell Mol Immunol 19:299-302, 2022. (stjude.org)

They can be classified in four entities of various differentiation and prognosis. (uni-marburg.de)
OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
We found that extended exposure to IL-12 induced T cell exhaustion and contributed to the poor prognosis in FL patients. (jci.org)
The belief that T-cell lymphomas have a worse prognosis than B-cell lymphomas remains controversial. (oncolink.org)

The nature of disease (indolent vs. aggressive) is correlated to the stage of lymphocytic differentiation of the malignant cells. (oncolink.org)
Permissive histologic interpretation may result in the designation of some non-neoplastic Hürthle cell lesions as malignant tumors. (medscape.com)

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (T h 1)-specific immune responses and inhibits the development of IL-4-producing Th cells. (nature.com)
T PH cells appear to be uniquely poised to promote B-cell responses and antibody production within pathologically inflamed non-lymphoid tissues. (nature.com)
Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. (nature.com)
Neutralizing antiviral B cell responses. (smw.ch)
Reciprocal roles of T-cell help for B cells during adaptive immune responses and B-cell help in CD4+ T-cell activation are being increasingly recognized. (hindawi.com)
CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection. (proteinlounge.com)
This technology allows us to reasonably study physiological CD4 + T cell responses. (stemcell.com)
Thus, Tfh cell help is required for class-switched-specific BRM responses to influenza. (uab.edu)
Recognition of microbial viability via TLR8 promotes T follicular helper cell differentiation and vaccine responses. (sfb-tr84.de)

The caudal segment of the thyroglossal duct undergoes histologic differentiation into follicular elements at gestational weeks 10 and 11. (medscape.com)

In ART-treated rhesus macaques, cells harboring SIV-DNA by DNAscope were preferentially found in the LN B cell follicle in proximity to IL-10. (nih.gov)
Finally, we demonstrated that the in vivo neutralization of soluble IL-10 in ART-treated, SIV-infected macaques reduced B cell follicle maintenance and, by extension, LN memory CD4+ T cells, including Tfh cells and those expressing PD-1 and CTLA-4. (nih.gov)
The frequency of cutaneous lymphomas is 0.3 case per 100,000 population per year, with 10% (in the United States) to 20% (in Europe) being cutaneous B-cell lymphomas (CBCLs), marginal zone lymphomas, or follicle center lymphomas (FCLs). (medscape.com)
as the cells in the hair follicle divide, the hair strand (shaft) is pushed upward and extends beyond the skin, causing the hair to grow. (medlineplus.gov)
HN - 2008 BX - Von Ebner's Glands MH - Cumulus Cells UI - D054885 MN - A05.360.319.114.630.535.200.500 MN - A06.407.312.497.535.300.500 MN - A11.436.300.500 MS - The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. (bvsalud.org)

B-cell lymphomas account for the majority of nodal lymphomas, whereas primary cutaneous B-cell lymphomas (CBCLs) represent 20-25% of all cutaneous lymphomas. (medscape.com)

Retinoids and retinoid analogues exert their activities by interacting with nuclear receptors (RARs [retinoic acid receptors] or RXRs [retinoic X receptors]) on cells and by activating genes that contain RARE (retinoic acid response elements) or RXRE (retinoic X response elements) in their promoters (Michel, Jombard, & Démarchez, 1998). (medscape.com)
However, global transcriptomics highlight differences between T PH cells and T follicular helper cells, including altered expression of BCL6 and BLIMP1 and unique expression of chemokine receptors that direct migration to inflamed sites, such as CCR2, CX3CR1, and CCR5, in T PH cells. (nature.com)
The examination of the influence of VEGF on the integrin expression of the XTC cells in the sense of an "Inside-out" control loop could not prove an autocrine control loop in spite of the well known close interaction of integrins and VEGF receptors. (uni-marburg.de)
The results of flow cytometry showed that D1-like receptors were highly expressed in Tfh cells of patients with SLE and associated with disease activity. (bmj.com)
RNA-seq and RT-qPCR results indicate that D1-like receptors might promote Tfh cell differentiation through the Phosphatidylinositol3-kinase (PI3K)/protein kinase B (AKT)/Forkhead box protein O1 (FOXO1)/Kruppel-like factor 2 (Klf2) pathway. (bmj.com)
Conclusion Tfh cells in patients with SLE highly express D1-like receptors, which correlate with disease activity. (bmj.com)
D1-like receptors may promote Tfh cell differentiation through the PI3K/AKT/FOXO1/Klf2 pathway. (bmj.com)
In recent years, the MAPK family has been found to be an important signal-regulating enzyme between cell surface receptors and determinants of gene expression ( 8 ). (spandidos-publications.com)
The iodine hormone exerts its action on receptors on the nucleus in cells. (cdc.gov)

Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh differentiation, and antibody affinity maturation are both reduced in absence of type I interferon signaling. (nih.gov)
Through these mechanisms B cells are involved both in autoimmune diseases that are traditionally viewed as antibody mediated and also in autoimmune diseases that are commonly classified as T cell mediated. (hindawi.com)
B cells have antibody-dependent and antibody-independent pathogenic functions. (hindawi.com)
Binding of the Fc portion of the antibodies to FcR leads to activation of effector cells and further release of proinflammatory cytokines and proteolytic enzymes, mediators of antibody-dependent cell-mediated cytotoxicity (ADCC). (hindawi.com)
Left panel: antigen bound by antibody is taken up via FcR on APCs such as dendritic cells or macrophages. (hindawi.com)
One path is the B cells that differentiate into antibody producing cells. (uab.edu)
Unlike antibody-producing B cells that help fight the current infection, the long-lived, non-circulating lung-BRMs migrate to the lungs from draining lymph nodes. (uab.edu)
However, the UAB researchers found that, if mice were deficient in Tfh cells, or if the Tfh cells were blocked by an antibody, the lung-BRMs did not accumulate. (uab.edu)
The botryoid granuloma can be seen as a a central primary of coccoid bacterias and Compact disc3+ T cells bounded and infiltrated by F4/80+ macrophages and MPO+ neutrophils (bacterias also labeled using the MPO antibody). (woofahs.com)

The incubation of the two cancer cell lines (XTC, HTC+) without matrix components with a choice of the best examined and available integrin antibodies at this time had no effect on the VEGF secretion. (uni-marburg.de)
Since the blockade of integrins had no reducing effect on the high VEGF basic output of thyroid cancer cells, the regulation of the VEGF secretion is assumed to be very complex and does not only depend on integrin signalling. (uni-marburg.de)
The role of B cells in autoimmune diseases involves different cellular functions, including the well-established secretion of autoantibodies, autoantigen presentation and ensuing reciprocal interactions with T cells, secretion of inflammatory cytokines, and the generation of ectopic germinal centers. (hindawi.com)
Dual differentiation is thought to be responsible for combined mucin secretion and hormone production in this type of neoplasm. (bmj.com)

however, it needs to be emphasized that most autoimmune diseases are driven by a dysfunction in the immune network consisting of B cells, T cells, and other immune cells. (hindawi.com)
Lung-resident memory B cells produced during influenza are long-living immune cells that migrate to the lungs from draining lymph nodes and lie in wait as early responders that can quickly react to future infections. (uab.edu)
During a bout of influenza, B cells interact with other immune cells and then take different paths to defend the body. (uab.edu)
IL-22 has been identified as a cancer-promoting cytokine that is secreted by infiltrating immune cells in several cancer models. (cipsm.de)
We hypothesized that IL-22 regulation would occur at the interface between cancer cells and immune cells. (cipsm.de)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)

Follicular, papillary, anaplastic and medullary carcinomas. (uni-marburg.de)

Figure 4: PD-1 hi CXCR5 − CD4 + T cells promote plasma cell differentiation through IL-21 and SLAMF5 interactions. (nature.com)
During chronic infection, plasma IL-10 and transcriptomic signatures of IL-10 signaling were correlated with the cell-associated SIV-DNA content within LN CD4+ memory subsets, including Tfh cells, and predicted the frequency of CD4+ Tfh cells and their cell-associated SIV-DNA content during ART, respectively. (nih.gov)
It is a member of the immunoglobulin superfamily expressed on B-cells (from pro-B to blastoid B cells, absent on plasma cells) and follicular dendritic cells. (biolegend.com)
I am also interested in identifying how each of these subsets contribute to different aspects of the B cell response, such as the formation of plasma cells, germinal center B cells and memory B cells. (stemcell.com)
This protease activity has recently been ascribed to serine metalloprotease(s), including pregnancy-associated plasma protein-A (PAPP-A), which was first detected in human follicular fluid nearly 20 yr ago. (bioone.org)
Plasma cells do not express CD19. (biolegend.com)
Methods We first detected plasma catecholamine concentrations in patients with SLE and healthy controls by mass spectrometry, followed by reverse transcription-quantitative PCR (RT-qPCR) to detect DRD messenger RNA (mRNA) expression in peripheral blood mononuclear cells (PBMCs) and CD4 + T cells, and flow cytometry to detect DRD expression in Tfh cells. (bmj.com)
Results The plasma dopamine concentration in patients with SLE was significantly increased, and abnormal mRNA expression of DRDs was observed in both PBMCs and CD4 + T cells. (bmj.com)
Here, they undergo antigen-driven clonal expansion and differentiation into plasma and memory cells. (rupress.org)

The modulation of epidermal differentiation by retinoids led to its use in premalignant lesions, such as actinic keratoses (Verschoore et al. (medscape.com)
Generalized basaloid follicular hamartoma syndrome (GBFHS) subtype is inherited in an autosomal dominant pattern and has additional cutaneous features that include milia, comedonelike lesions, alopecia or hypotrichosis, and hypohidrosis. (medscape.com)
[ 6 ] The lesions associated with linear unilateral basaloid follicular hamartoma occur along the lines of Blaschko in a limited, mosaic pattern. (medscape.com)
Solitary/localized lesions are the usual presentations of acquired basaloid follicular hamartoma. (medscape.com)
In general, basaloid follicular hamartoma (BFH) lesions are asymptomatic small papules that remain stable for many years. (medscape.com)
[ 20 ] In hereditary basaloid follicular hamartoma, the lesions may gradually increase in size throughout childhood and then stabilize and become static upon reaching adulthood. (medscape.com)
Skin biopsy is important for distinguishing basaloid follicular hamartoma (BFH) lesions from other lesions in the differential diagnoses. (medscape.com)
Although no medications have been approved for basaloid follicular hamartoma (BFH) treatment, systemic isotretinoin has been reported to decrease the size of lesions and improve associated alopecia in a patient with multiple BFH and systemic lupus erythematosus (SLE). (medscape.com)
Follicular casts may be secondary lesions in demodectic mange, dermatophytosis and pyoderma. (vin.com)

Moreover they induce the upregulation of activating FcR on effector cells. (hindawi.com)

When the epidermal turnover time is decreased, eliminated cells become noticeable and sloughed cells are observed and become obvious. (vin.com)

Notably, imbalances in Tfh differentiation often lead to the development of autoimmune diseases, including inflammatory bowel disease (IBD). (sciencegate.app)
This new understanding of the role of B cells opened up novel therapeutic options for the treatment of autoimmune diseases. (hindawi.com)

The focus of my work is to better understand the factors that drive the differentiation program of different CD4 + T helper cell subsets. (stemcell.com)

CD19 is involved in B cell development, activation, and differentiation. (biolegend.com)
CD19, in association with CD21 and CD81, forms a molecular complex integral to B cell activation. (biolegend.com)

However, information is limited regarding the biological roles of miRNAs in the development of the follicular and luteal tissues in cows. (tubitak.gov.tr)
The main aim of the present study was to identify miRNAs that are expressed in the follicular and luteal tissues of cows. (tubitak.gov.tr)
We used a comparative RNA sequencing method to identify miRNA candidates that might play key roles in the follicular and luteal phases of Holstein cows. (tubitak.gov.tr)
Nine miRNAs were expressed at a high ratio: 8 in the follicular tissue and one in the luteal tissue. (tubitak.gov.tr)
These findings will be beneficial in future comprehensive studies on the miRNAs involved in regulating the development of follicular and luteal tissues in cows. (tubitak.gov.tr)

Beutler also worked in the City of Hope laboratory of Susumu Ohno, a geneticist known for his studies of evolution, genome structure, and sex differentiation in mammals. (wikipedia.org)
This review summarizes evidence for the role of proteolytic enzymes that degrade and inactivate insulin-like growth factor binding proteins (IGFBP) during follicular development in mammals. (bioone.org)
Epidermis in mammals is constantly being replaced by new cells that transform from the bottom layer of the epidermis up to the stratum corneum. (vin.com)

VEGF is purified from bovine pituitary follicular cells in 1959 and is a vascular endothelial cell-specific mitogen that promotes the growth of vascular endothelial cells. (spandidos-publications.com)

1 line of systemic therapy in case of participants ineligible for high-dose chemotherapy and autologous Hematopoietic stem cell transplantation (HSCT). (who.int)

During influenza infection, both Tfh and B cells are present at germinal centers in the lymph nodes that drain the lungs. (uab.edu)
Primed T cells and antigen-activated B cells then migrate into the primary follicles where they associate with follicular dendritic cells (FDCs), giving rise to germinal centers (GCs). (rupress.org)

Desmosomes, molecular complexes of adhesion proteins, connect the cells, keeping follicular contents confined within the lumen. (medscape.com)
These proteins are involved in signal transduction from ectoderm to mesenchyme during development of the fetus and are indispensable for the differentiation of ectoderm-derived structures such as eccrine sweat glands, teeth, hair, skin, and/or nails. (springer.com)
It was based on immunologic tests that identified the proteins that cancer cells made. (lymphomainfo.net)
Roquin proteins preclude spontaneous T cell activation and aberrant differentiation of T follicular helper (Tfh) or T helper 17 (Th17) cells. (cipsm.de)
Flavitrack will ultimately also contain buildings or 3D versions for any flavivirus proteins enabling combined series/structure evaluation to characterize common B- and T-cell epitopes account for Prp2 the functional effects of mutations and determine highly conserved areas. (bioskinrevive.com)

Another study in mice, by Johansson et al, indicated "that embryonic thyroid differentiation is an asynchronous process," one that spans "several developmental stages of thyroid organogenesis. (medscape.com)
Analyses of TNFR1/RelA-deficient embryonic tissues and of radiation chimeras suggest that the dependence on RelA is manifest not in hematopoietic cells but rather in radioresistant stromal cells needed for the development of secondary lymphoid organs. (rupress.org)

With the exception of EDA1 and NEMO , both localized on the X chromosome, all other genes encoding components of the TNFα-related signaling pathway involved in differentiation of skin appendages, are localized on the autosomes (Table 1 ). (springer.com)

Development of TH1 CD4 + T cells through IL-12 produced by Listeria -induced macrophages. (nature.com)
The researchers asked whether the requirement for IFN-γ signaling in lung-BRM development was intrinsic to B cells, meaning the interferon was producing effects inside the B cells. (uab.edu)
Increases in the amount of PAPP-A mRNA in granulosa cells during follicular development occurs in some but not all species, indicating that other proteases or protease inhibitors may be involved in IGFBP degradation. (bioone.org)
It is a member of the Ig superfamily, expressed on all pro-B to mature B cells (during development) and follicular dendritic cells. (biolegend.com)
Meanwhile, the cross-reactivity of CD8+ and CD4+ T cells response to Dengue and Zika viruses provide important clues for further development of potential treatments. (frontiersin.org)
Previous studies have shown that B cell development and activation in GC are controlled by different molecular mechanisms, such as protein phosphorylation, transcription, microRNA, and epigenetic modification. (umontreal.ca)
Targeted gene deletion and radiation chimera analyses have provided insights into the molecular machinery underlying the development of secondary lymphoid organs, emphasizing the importance of crosstalk between hematopoietic and nonhematopoietic cells. (rupress.org)

The cytokine IL-12 induces IFN-γ production by T and NK cells. (jci.org)

The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. (cdc.gov)
Th9 cells were first identified as a Th2 subpopulation have many important roles. (cdc.gov)

Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. (nih.gov)
This approach revealed a markedly expanded population of PD-1 hi CXCR5 − CD4 + T cells in synovium of patients with rheumatoid arthritis. (nature.com)
Rather, using multidimensional cytometry, transcriptomics, and functional assays, we define a population of PD-1 hi CXCR5 − 'peripheral helper' T (T PH ) cells that express factors enabling B-cell help, including IL-21, CXCL13, ICOS, and MAF. (nature.com)
Figure 1: Expanded PD-1 hi CXCR5 − CD4 + T cells in joints and blood of patients with seropositive RA. (nature.com)
Figure 2: Synovial PD-1 hi CXCR5 − CD4 + T cells express factors associated with B-cell help. (nature.com)
Figure 3: High-dimensional analyses of PD-1 hi CXCR5 − and PD-1 hi CXCR5 + cells identify shared and distinct features. (nature.com)

CD137 is expressed on activated T cells, B cells, monocytes, and follicular dendritic cells. (bdbiosciences.com)
Spleen and MLN contain abundant T cells without discernible follicular corporation, exhibit serious depletion Adrucil cell signaling of B Adrucil cell signaling cells, and also have improved amounts of monocytes/macrophages and granulocytes markedly, in keeping with compensatory extramedullary myelopoiesis. (woofahs.com)

Hürthle cells are observed in both neoplastic and nonneoplastic conditions of the thyroid gland (eg, Hashimoto thyroiditis , nodular and toxic goiter ). (medscape.com)

2021. Cell Rep. 36:109570. (biolegend.com)
2021. Cell Mol Gastroenterol Hepatol. (biolegend.com)
Cell 184:1245-1261, 2021. (stjude.org)

Nat Cell Biol 24:1642-1654, 2022 (highlighted by News and Views "PTEN checkMAITs type-17 innate-like T cells" in the same issue). (stjude.org)
[ 5 ] The 2022 WHO classification of endocrine tumors has replaced the term Hürthle cell carcinoma with oncocytic carcinoma. (medscape.com)

Significant changes in the percentages of naïve, central memory T (TCM), and effector memory (TEM) cells and their CD4+ and CD8+ subsets were found in the peripheral blood of mice with colitis using flow cytometry. (sciencegate.app)
She currently works in Dr. Marc Jenkins' lab as a PhD candidate, investigating the role of CD4 + T cell subsets in germinal center and memory B cell formation and isotype switching. (stemcell.com)
Circulating Helper T-Cell Subsets and Regulatory T Cells in Patients With Common Variable Immunodeficiency Without Known Monogenic Disease. (cdc.gov)

Lymphoblastic , small non-cleaved cell, and large cell immunoblastic lymphomas were all considered high grade. (lymphomainfo.net)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)
With few exceptions, stem cell transplantation is usually reserved for patients with aggressive lymphomas after incomplete remission or relapse. (msdmanuals.com)

Here we showed that deletion of Roquin-encoding alleles specifically in regulatory T (Treg) cells also caused the activation of conventional T cells. (cipsm.de)

Hürthle cell carcinoma of the thyroid gland is an unusual and relatively rare type of differentiated thyroid cancer. (medscape.com)

In the test series the Hurthle cell line XTC, the follicular cell line HTC+, the anaplastic cell line and the cell line Hth74 as well as a cell line isolated from natural thyroid tissue (Thy1) were examined. (uni-marburg.de)

These results suggested that curcumin effectively regulated the differentiation of naïve, TCM, and TEM cells in the peripheral blood to alleviate DSS-induced experimental colitis, which might be related to the inhibition of JAK1/STAT5 signaling activity. (sciencegate.app)
The pituitary gland produces thyroid stimulating hormone (TSH) that goes into the blood stream to activate thyroid cells, which then secrete T3 and T4 into the peripheral tissues. (cdc.gov)

Linear unilateral basaloid follicular hamartoma (LUBFH) subtype is also known as linear unilateral basal cell nevus with comedones, linear unilateral basal cell nevus, and basal cell and linear unilateral adnexal hamartoma. (medscape.com)

Lymph and Thymus nodes lacked follicular corporation, demonstrating uniformly prominent reticular stroma rather, immature mononuclear leukocytes, and wide-spread apoptosis Adrucil cell signaling (Fig. (woofahs.com)

Deposited immune complexes can activate complement and effector cells. (hindawi.com)
These anaphylatoxins promote release of proinflammatory cytokines and serve as chemoattractants for effector cells. (hindawi.com)
T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)

CD28 co-stimulation in T-cell homeostasis: a recent perspective. (proteinlounge.com)

The Jenkins lab studies how antigen-specific CD4 + T cells are generated, and how these cells promote the B cell response using novel techniques to track antigen-specific cells in vivo. (stemcell.com)

The aim of this thesis was to give a survey of the interaction of integrins, VEGF and the extracellular matrix (ECM) by using a cell culture model of different thyroid carcinomas. (uni-marburg.de)
The spectrum of the integrins of the oncogenic (XTC, HTC+, Hth74) and the normal cells (Thy1) was found out by immunhistochemical tests. (uni-marburg.de)
All cells expressed a great spectrum of integrins whereas in comparison the cell line of normal tissue contains the smallest spectrum. (uni-marburg.de)

Two cancer cell lines (XTC, HTC+) were incubated on different matrix components and the VEGF expression was examined via ELISA. (uni-marburg.de)
In a further examination of XTC cells, integrin antibodies and integrin blocking RGD sequences (RGDS) were used to suppress the stimulating effect of FN on VEGF. (uni-marburg.de)
The RGD sequences increased the intra- and extra cellular VEGF concentration of the XTC cells proportional to the RGDS-concentration. (uni-marburg.de)
The influence of VEGF on the integrin spectrum of XTC cells was analysed by FACS. (uni-marburg.de)

Retinoids are potent agents that can normalize abnormal growth and differentiation in keratinocytes (American Academy of Dermatology [AAD], 2003). (medscape.com)
An important factor of cancer progression was recognized in the capacity of thyroid carcinoma cells to angiogenesis, procuring them an unlimited growth and the invasion of the surrounding tissue. (uni-marburg.de)
Overall, only about 33% of Hürthle cell tumors demonstrate signs of that invasive growth that indicates malignancy and the possibility of metastasis. (medscape.com)

Here we use mass cytometry to analyse activated T cells in joint tissue from patients with rheumatoid arthritis, a chronic immune-mediated arthritis that affects up to 1% of the population 2 . (nature.com)
Thus, these data support a role for IL-10 in maintaining a pool of target cells in lymphoid tissue that serve as a niche for viral persistence. (nih.gov)
The only way to tell the cell types apart was by looking under a microscope, and the updated tissue tests available nowadays can categorize cancerous cells much better. (lymphomainfo.net)

Anatomy70

Organisms7

Diseases7

Chemicals and Drugs87

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes57

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Proliferation12

Lymphoma11

Receptor10

Regulate6

Lineage3

Neoplasms5

Pathways3

Diffuse1

Vitro2

Tumor6

Dendritic cell1

Survival8

Lymphocytes8

Accompanied by in1

Metabolism5

Antigen-prese4

Immunol1

Prognosis4

Malignant2

Responses9

Histologic1

Follicle5

Nodal1

Receptors9

Antibody9

Secretion4

Immune cells6

Papillary1

Plasma9

Lesions9

Induce1

Epidermal1

Autoimmune diseases2

Helper cell subsets1

CD192

Luteal5

Mammals3

Promotes1

Systemic1

Germinal centers2

Proteins5

Embryonic2

Signaling pathway involved1

Development7

Cytokine1

Roles2

CXCR56

Monocytes2

Nodular1

20213

20222

Subsets3

Lymphomas3

Treg1

Thyroid gland1

Anaplastic1

Peripheral2

Subtype1

Uniformly1

Effector3

Homeostasis1

Vivo1

Integrins3

VEGF4

Growth3

Tissue3