PleomorphismEpitheliumTumorsEpithelial cellsBenignDysplasiaSquamousCarcinomaTumor cellsNeoplasmsStem Cell TransCellularCharacteristicMalignant cellsNucleiThyroiditisAdenomaNeoplasticLymphatic systemPredominanceLymphomaCancersTissuesMembraneAbnormalProteinsPleomorphicClustersLiverNuclearMarkersCytoplasmMetastaticCommonCancer cellsShape
Pleomorphism1
- Sebaceous carcinoma is an outright malignant neoplasm with prominent cellular pleomorphism and anaplasia. (medscape.com)
Epithelium2
- Controversy exists about the origin of Hürthle cells, which generally are thought to derive from the follicular epithelium. (medscape.com)
- A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
Tumors5
- Although Hürthle cell carcinoma was previously considered a variant of follicular cell neoplasms, which are generally less aggressive, the 2017 World Health Organization (WHO) classification of endocrine tumors reclassified it as a distinct entity. (medscape.com)
- [ 5 ] The 2022 WHO classification of endocrine tumors has replaced the term Hürthle cell carcinoma with oncocytic carcinoma. (medscape.com)
- Overall, only about 33% of Hürthle cell tumors demonstrate signs of that invasive growth that indicates malignancy and the possibility of metastasis. (medscape.com)
- On balance, Hürthle cell tumors may be considered to be more likely to metastasize than follicular tumors. (medscape.com)
- Permissive histologic interpretation may result in the designation of some non-neoplastic Hürthle cell lesions as malignant tumors. (medscape.com)
Epithelial cells8
- Hashimoto?s is categorized clinically by gradual thyroid failure, with or without goitre formation due to autoimmune mediated destruction of the thyroid gland involving apoptosis of thyroid epithelial cells. (gbgroupinc.com)
- A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. (lookformedical.com)
- A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)
- It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
- A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (lookformedical.com)
- These cellular clusters were delimited by a rim of epithelial cells, corresponding to basaloid cells. (medscape.com)
- Epithelial cells have a specific microscopic structure with different lateral , apical, and basal membrane domains. (amboss.com)
- A benign tumor that arises from glandular epithelial cells. (amboss.com)
Benign1
- A benign mass composed of mature cells that are native to the tissue of origin but have abnormal tissue organization (e.g. (amboss.com)
Dysplasia1
- The cells which constitute the tumor eventually undergo metaplasia , followed by dysplasia then anaplasia , resulting in a malignant phenotype. (explained.today)
Squamous5
- Given their pre-cancerous nature, if left untreated, they may turn into a type of skin cancer called squamous cell carcinoma. (wikipedia.org)
- Untreated lesions have up to a 20% risk of progression to squamous cell carcinoma, so treatment by a dermatologist is recommended. (wikipedia.org)
- If clinical examination findings are not typical of AK and the possibility of in situ or invasive squamous cell carcinoma (SCC) cannot be excluded based on clinical examination alone, a biopsy or excision can be considered for definitive diagnosis by histologic examination of the lesional tissue. (wikipedia.org)
- Carcinoma squamous cell. (lookformedical.com)
- The report shows squamous cell carcinoma on several biopsies. (pdfcoffee.com)
Carcinoma8
- Hürthle cell carcinoma of the thyroid gland is an unusual and relatively rare type of differentiated thyroid cancer. (medscape.com)
- Hürthle cell carcinoma. (medscape.com)
- therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)
- Obviously, this factor has a major impact in interpreting the natural history of this disease and adds to the controversy about the aggressiveness of Hürthle cell carcinoma. (medscape.com)
- According to the World Health Organization (WHO), these neoplasms are considered a variant of follicular carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type. (medscape.com)
- An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (lookformedical.com)
- It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)
- Basal cell carcinoma for example rarely metastasizes. (explained.today)
Tumor cells3
- A cell line derived from cultured tumor cells. (lookformedical.com)
- After the tumor cells come to rest at another site, they re-penetrate the vessel or walls and continue to multiply, eventually forming another clinically detectable tumor. (explained.today)
- When tumor cells metastasize, the new tumor is called a secondary or metastatic tumor, and its cells are similar to those in the original or primary tumor . (explained.today)
Neoplasms2
- therefore, few institutions have extensive experience with Hürthle cell neoplasms. (medscape.com)
- Some investigators believe that this condition is distinct from other follicular cell neoplasms. (medscape.com)
Stem Cell Trans3
- Effect of Testicular Boost in Children With Leukemia Receiving Total Body Irradiation and Stem Cell Transplant: A Single-Institution Experience. (stanfordchildrens.org)
- Children with leukemia who receive fractionated total body irradiation (fTBI) with 12 to 13.2 Gy as part of conditioning for hematopoietic stem cell transplant are frequently treated with an additional 4 Gy testicular boost to reduce the risk of testicular relapse. (stanfordchildrens.org)
- Following that, patients may be eligible for a stem cell transplant, and/or an extended course of immunotherapy that is meant to prolong cancer remission. (rarediseases.org)
Cellular1
- [ 2 ] Oncocytic cells in the thyroid are often called Hürthle cells, and oncocytic change is defined as cellular enlargement characterized by an abundant eosinophilic granular cytoplasm as a result of accumulation of altered mitochondria. (medscape.com)
Characteristic2
- and follicular destruction, which is a characteristic hallmark of thyroiditis. (gbgroupinc.com)
- Lobules contain basaloid cells at the periphery and mature sebaceous cells, with characteristic cytoplasmic vacuoles toward the center. (medscape.com)
Malignant cells1
- To do so, malignant cells break away from the primary tumor and attach to and degrade protein s that make up the surrounding extracellular matrix (ECM), which separates the tumor from adjoining tissues. (explained.today)
Nuclei2
- Confocal microscopy revealed sebaceous lobules composed by clusters of ovoid cells with dark nuclei and bright, highly refractile glistening cytoplasm. (medscape.com)
- Enlargement , polymorphism , polychromasia , increased cell count and/or enlarged nucleoli are all signs of increased activity of nuclei . (amboss.com)
Thyroiditis1
- Hürthle cells are observed in both neoplastic and nonneoplastic conditions of the thyroid gland (eg, Hashimoto thyroiditis , nodular and toxic goiter ). (medscape.com)
Adenoma2
- Histologic section of sebaceous adenoma showing a predominance of sebaceous cells with prominent cytoplasmic vacuoles. (medscape.com)
- Sebaceous epithelioma lacks the lobular architecture and sebaceous maturation of sebaceous adenoma, and contains an obvious preponderance of undifferentiated cells. (medscape.com)
Neoplastic1
- Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. (lookformedical.com)
Lymphatic system3
- Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, which is a form of cancer that affects the lymphatic system. (rarediseases.org)
- Mantle cell lymphoma belongs to a group of diseases known as non-Hodgkin's lymphomas, which are related malignancies (cancers) that affect the lymphatic system. (rarediseases.org)
- Metastasis involves a complex series of steps in which cancer cells leave the original tumor site and migrate to other parts of the body via the bloodstream, via the lymphatic system, or by direct extension. (explained.today)
Predominance1
- Histologic section of sebaceous epithelioma showing a predominance of basaloid cells. (medscape.com)
Lymphoma1
- MCL is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. (rarediseases.org)
Cancers2
- 14. Which of the following lymphatic cancers is associated with multinucleated Reed-Sternberg cells and EBV? (mockdocs.org)
- Lymphomas are cancers that involve white blood cells, and can be divided depending on the type of cell involved, either B-lymphocytes or T-lymphocytes. (rarediseases.org)
Tissues3
- Lymphatic tissues also include the thymus, a relatively small organ behind the breastbone that is thought to play an important role in the immune system until puberty, as well as the bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. (rarediseases.org)
- [3] [4] It is generally distinguished from cancer invasion , which is the direct extension and penetration by cancer cells into neighboring tissues. (explained.today)
- Some cancer cells known as circulating tumor cell s acquire the ability to penetrate the walls of lymphatic or blood vessel s, after which they are able to circulate through the bloodstream to other sites and tissues in the body. (explained.today)
Membrane1
- Know normal platelet count, increased bleeding time, increased PTT *Captopril is a teratogen *MOA of Amphotericin B Punches holes in ergosterol of the fungal cell membrane *Tons of biostats. (pdfcoffee.com)
Abnormal1
- [8] This means that if breast cancer metastasizes to the lungs, the secondary tumor is made up of abnormal breast cells, not of abnormal lung cells. (explained.today)
Proteins2
- Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes. (rarediseases.org)
- By degrading these proteins, cancer cells are able to breach the ECM and escape. (explained.today)
Pleomorphic1
- The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. (lookformedical.com)
Clusters1
- A monomorphous cell population of Hürthle cells arranged in loosely cohesive clusters and single cells. (medscape.com)
Liver1
- A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
Nuclear1
- Some new hypotheses were suggested as well, i.e., under the effect of particular biochemical and/or physical stressors, cancer cells can undergo nuclear expulsion with subsequent macrophage engulfment and fusion, with the formation of cancer fusion cells (CFCs). (explained.today)
Markers1
- CD16 and CD56 are markers for NK Cells *Rx for Mycoplasma pneumonia (cold agglutinins) mentioned in stem Erythromycin, Tetracycline *Guy had occult blood in stool and fibrosis in kidney Polyarteritis Nodosa *What type of HSN reaction is the PPD test for TB Type IV HSN Rx *ADH hormone 2nd messenger adenylyl cyclase / cAMP *Pt. (pdfcoffee.com)
Cytoplasm1
- The cells are polyhedral and have abundant granular cytoplasm with well-defined cell borders. (medscape.com)
Metastatic1
- Currently, three main theories have been proposed to explain the metastatic pathway of cancer: the epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) hypothesis (1), the cancer stem cell hypothesis (2), and the macrophage-cancer cell fusion hybrid hypothesis (3). (explained.today)
Common1
- Sebaceous carcinomas are common on the eyelid and tend to present with pagetoid extension of atypical sebaceous cells in the conjunctiva or in the epidermis. (medscape.com)
Cancer cells1
- The first-line treatment typically includes chemotherapy combined with immunotherapy, which is a combination of medications that destroy the cancer cells. (rarediseases.org)
Shape1
- [ 4 ] Hürthle cells are large and polygonal in shape, with indistinct cell borders. (medscape.com)