AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsHealth Care
Adenocarcinoma, FollicularThyroid NeoplasmsCarcinoma, Papillary, FollicularCarcinoma, PapillaryCarcinomaAdenomaThyroidectomyThyroid GlandThyroid NoduleGoiter, NodularAdenoma, OxyphilicBiopsy, Fine-NeedleGoiterThyroid DiseasesSkull NeoplasmsCarcinoma, Squamous CellCarcinoma, MedullaryTumor Markers, BiologicalCarcinoma, HepatocellularImmunohistochemistryThyroglobulinGalectin 3Adenocarcinoma, PapillaryIodine RadioisotopesAdenocarcinomaCarcinoma in SituBiopsy, NeedleReverse Transcriptase Polymerase Chain ReactionPrognosisRetrospective StudiesSensitivity and SpecificityLiver NeoplasmsCarcinoma, Ductal, BreastRNA, MessengerCarcinoma, Basal CellGene Expression ProfilingCarcinoma, Transitional CellCarcinoma, BronchogenicCarcinoma, Intraductal, NoninfiltratingCarcinoma, Adenoid CysticCarcinoma, Small CellCarcinoma, LobularCarcinoma, NeuroendocrineNeoplasm InvasivenessNasopharyngeal NeoplasmsCell Line, TumorBreast NeoplasmsNeoplasm StagingGene Expression Regulation, NeoplasticTumor Cells, CulturedLung NeoplasmsCarcinoma, MucoepidermoidCarcinoma, AdenosquamousCarcinoma, EndometrioidHead and Neck NeoplasmsCarcinoma, EmbryonalEsophageal NeoplasmsMouth NeoplasmsCarcinoma, Merkel CellCarcinoma, DuctalLymphatic MetastasisOvarian NeoplasmsAdrenocortical CarcinomaColonic NeoplasmsCarcinoma, VerrucousCarcinoma, Signet Ring CellNeoplasm MetastasisUrinary Bladder NeoplasmsStomach NeoplasmsNeoplasm ProteinsSkin NeoplasmsNeoplasm Recurrence, Local
Arising from follicular cellsMetastasisTumorMetastatic follicular thyroid carcinomaNonaggressive follicular carcinomasVariantPapillary or follicularMalignantBasal Cell CarcAdenoma and carcinomaSubtypeLymphomaNeoplasmNeoplasmsDiagnosisMedullary carcinomasThyroid glandAggressiveLesionSquamousLess differentiatedPatientsAnaplastic carcinomaHepatocellular carcinomaOncocyticExpression in thyroidPoorlyLesionsProgressionMalignancyType of thyroid cancerRenalTransitional cellCancersMolecularOvaryCellsGenesTumorsHurthleOncologyAutoimmune
Arising from follicular cells2
  • FTC and other thyroid neoplasms arising from follicular cells (adenomas, papillary/follicular carcinoma, and noninvasive follicular thyroid neoplasm with papillary-like nuclear features [NIFTP]) show a broad range of overlapping clinical and cytologic features. (medscape.com)
  • Thyroid neoplasms arising from follicular cells (adenoma, carcinoma, and follicular/papillary carcinoma) show a broad range of overlapping clinical and cytologic features. (medscape.com)
Metastasis12
  • Kisakol G, Guney E, Kabalak T. Follicular thyroid carcinoma with late choroidal metastasis. (iranpath.org)
  • Ozdemir N, Senoglu M, Acar UD, Canda MS. Skull metastasis of follicular thyroid carcinoma. (iranpath.org)
  • Metastasis of thyroid carcinoma to the mandible. (iranpath.org)
  • Thyroid carcinoma with isolated spinal metastasis: case history and review of the literature. (iranpath.org)
  • Orbital metastasis as primary manifestation of thyroid carcinoma. (iranpath.org)
  • Basu S, Nair N, Aravind N. Unilateral proptosis with thyrotoxicosis resulting from solitary retroorbital soft tissue metastasis from follicular carcinoma thyroid. (iranpath.org)
  • Bilateral Orbital Metastasis of Follicular Thyroid Carcinoma: a Rare Case Report', Iranian Journal of Pathology , 9(3), pp. 229-233. (iranpath.org)
  • We present a fascinating and instructive case of unexplained suppression of thyroglobulin (Tg) levels following resection of a presumed carcinoid tumour, subsequent re-examination of which revealed it to be a solitary metastasis from a follicular thyroid carcinoma.The patient, RB is a 79-year-old woman who presented 11 years ago with a 2-week history of neck swelling. (endocrine-abstracts.org)
  • 6 ] Follicular thyroid cancer metastasis to the brain is rare. (surgicalneurologyint.com)
  • Metastasis of clear cell renal cell carcinoma (ccRCC) to the thyroid gland is rare, and simultaneous occurrence of ccRCC and papillary thyroid carcinoma (PTC) is even rarer. (spandidos-publications.com)
  • However, thyroid metastasis of ccRCC combined with papillary thyroid carcinoma (PTC) is rarely reported. (spandidos-publications.com)
  • After the operation, the pathological examination results suggested the following: Renal clear cell carcinoma, pT1aN0M0, the tumor sized ~4.0×4×3.5 cm 3 , with no lymph node cancer metastases or distant metastasis. (spandidos-publications.com)
Tumor9
  • Follicular thyroid carcinoma (FTC) is a well-differentiated tumor. (medscape.com)
  • UDC cases that developed out of well-differentiated thyroid carcinomas showed frank overexpression of cMYC in the undifferentiated tumor components. (biomedcentral.com)
  • This study aimed to evaluate the locoregional recurrence rate of follicular thyroid carcinoma (FTC) and to assess the appropriate frequency of postoperative ultrasonography (US) surveillance for detecting tumor recurrence . (bvsalud.org)
  • Follicular tumor is more likely to come back and spread. (medlineplus.gov)
  • The tumor cells were arranged in focal acinar or follicular pattern with a round-to-oval nucleus, moderate anisonucleosis, fine nuclear chromatin, and moderate-to-abundant fragile cytoplasm with the focal presence of fine granules. (cytojournal.com)
  • Trichilemmal carcinoma (TC) is a rare cutaneous tumor thought to be derived from the follicular outer root sheath (ORS). (jcadonline.com)
  • Its therapeutic use is limited to the treatment of hypercalcemia and Paget's osteopathy, and as a tumor marker in medullary carcinoma. (teknon.es)
  • Histopathological examination revealed a tumor consistent of small follicles, composed of uniform round nuclei without papillary thyroid carcinoma nuclear features, suggestive of metastatic follicular thyroid carcinoma to the brain. (surgicalneurologyint.com)
  • Differentiated thyroid carcinoma is a curable tumor, especially when diagnosed early. (bvsalud.org)
Metastatic follicular thyroid carcinoma3
  • Pathologic examination showed metastatic follicular thyroid carcinoma. (iranpath.org)
  • Metastatic follicular thyroid carcinoma to the maxilla. (iranpath.org)
  • Considering the rarity of metastatic follicular thyroid carcinoma to the brain, the present article outlines its clinical presentation, neuroradiological findings, pathological features, and outcome. (surgicalneurologyint.com)
Nonaggressive follicular carcinomas2
  • Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas. (medscape.com)
  • A study of differential gene expression profiling of aggressive and nonaggressive follicular carcinomas identified 94 genes that distinguish follicular carcinomas from follicular adenomas (including PBP and CKS2 ) and 4 genes that distinguish aggressive follicular carcinomas from nonaggressive follicular carcinomas ( NID2, TM7SF2, TRIM2, and GLTSCR2 ). (medscape.com)
Variant6
  • Papillary/follicular carcinoma must be considered a variant of papillary thyroid carcinoma (mixed form). (medscape.com)
  • Hurthle cell carcinoma should be considered a variant of FTC. (medscape.com)
  • Immunohistochemical studies using specific monoclonal antibodies for cMYC and BRAF V600E were performed on tissue microarrays built from follicular cell-derived thyroid carcinomas (25 papillary, 24 follicular, 24 oncocytic variant of follicular, and 21 undifferentiated). (biomedcentral.com)
  • Herein, we utilized IHC for cMYC in a tissue microarray (TMA) study performed on a spectrum of follicular cell-derived thyroid carcinomas, including papillary ( n = 25), follicular ( n = 25), oncocytic variant of follicular ( n = 25), and undifferentiated ( n = 22) carcinomas. (biomedcentral.com)
  • Materials and methods: Thyroid resections during an 11-year period, with histologic diagnosis of follicular variant of papillary thyroid carcinoma (FVPTC), were retrospectively reviewed to identify NIFTP. (elsevierpure.com)
  • Predicting Histological Subtypes of Follicular Variant Of Papillary Thyroid Carcinoma Based on Cytomorphology. (cytopathology.org)
Papillary or follicular1
  • Most thyroid cancers are papillary or follicular carcinomas and usually are not highly malignant and are seldom fatal. (msdmanuals.com)
Malignant3
  • Using Serial Analysis of Gene Expression, we identified five genes that are absent in a malignant follicular thyroid carcinoma (FTC) library, but expressed in follicular adenoma (FTA) and normal thyroid libraries. (johnshopkins.edu)
  • Trichilemmal carcinomas (TCs) are rare, malignant, adnexal neoplasms that differentiate from the outer root sheath (ORS) of the hair follicle. (jcadonline.com)
  • Sebaceous carcinoma is an outright malignant neoplasm with prominent cellular pleomorphism and anaplasia. (medscape.com)
Basal Cell Carc1
  • 3 While the clinical differential diagnosis commonly includes basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and keratoacanthoma, the histopathological differential also includes trichilemmoma, trichoepithelioma, clear cell SCC, clear cell porocarcinoma, and clear cell hidradenocarcinoma. (jcadonline.com)
Adenoma and carcinoma1
  • The distinction between Hürthle cell adenoma and carcinoma is based on presence of capsular or vascular invasion, or both. (cap.org)
Subtype4
  • Thyroid-like follicular renal cell carcinoma is rare subtype of renal cell carcinoma. (wikipedia.org)
  • Follicular thyroid carcinoma (FTC) is the second most common subtype of thyroid carcinoma, accounting for approximately 10% to 15% cases of differentiated thyroid carcinoma (DTC) in western countries [ 1 ]. (e-enm.org)
  • HCC used to be classified as a subtype of follicular cancer. (thyroid.org)
  • Metastatic brain lesions, of thyroid origin, are rare manifestations of differentiated thyroid cancer, with papillary thyroid carcinoma being the most common subtype. (surgicalneurologyint.com)
Lymphoma4
  • The monoclonal antibody rituximab (Rituxan®) , when added to standard chemotherapy as a first-line treatment for follicular lymphoma , significantly delayed the progression of the disease and produced higher response rates, according to findings reported at the American Society of Clinical Oncology (ASCO) annual meeting last week by Dr. Kevin Imrie of the Toronto-Sunnybrook Regional Cancer Center in Canada. (lymphomainfo.net)
  • Early results of the trial appeared in Blood in February, 2005 but the more extensive analysis Dr. Imrie reported provides "the first hard evidence that rituximab's demonstrated efficacy with recurrent disease" in follicular and other types of lymphoma extends to first-line treatment. (lymphomainfo.net)
  • follicular lymphoma (C82. (who.int)
  • non-follicular lymphoma (C83. (who.int)
Neoplasm2
  • Introduction: Noninvasive follicular thyroid neoplasm with papillary-like features (NIFTP), represents a distinct class of thyroid neoplasms with very low risk of adverse outcome and a set of strict histologic criteria. (elsevierpure.com)
  • The neoplasm has features consistent with derivation from follicular cells. (acvr.org)
Neoplasms5
  • Current National Comprehensive Cancer Network (NCCN) guidelines recommend lobectomy plus isthmusectomy as the initial surgery for patients with follicular neoplasms, with prompt completion of thyroidectomy if invasive FTC is found on the final histologic section. (medscape.com)
  • Ito Y, Uramoto H, Funa K, Yoshida H, Jikuzono T, Asahi S. Delta Np73 expression in thyroid neoplasms originating from follicular cells. (medscape.com)
  • These neoplasms can show follicular, trabecular, solid, or papillary growth patterns with occasional nuclear grooves or nuclear pseudoinclusions. (cap.org)
  • 18 With the exception of the ovarian neoplasms, the same carcinomas analyzed for gene expression were also examined for HE4 by immunohistochemistry on tissue microarrays (see below). (nature.com)
  • Various central nervous system neoplasms have been associated with familial nonpolyposis gut carcinoma, and appropriate imaging should be performed in the presence of suggestive signs or symptoms. (medscape.com)
Diagnosis3
  • Diagnosis of thyroid follicular carcinoma by the vascular pattern and velocimetric parameters using high resolution pulsed and power Doppler ultrasonography. (medscape.com)
  • For this reason, a surgical procedure to remove all or a large portion of the thyroid gland may be necessary to obtain sufficient tissue for a definitive diagnosis of follicular thyroid cancer. (medscape.com)
  • A finding of invasion of the subcutaneous tissue favors a diagnosis of carcinoma over that of adenoma/epithelioma. (medscape.com)
Medullary carcinomas2
  • Follicular, papillary, anaplastic and medullary carcinomas. (uni-marburg.de)
  • Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. (novusbio.com)
Thyroid gland6
Aggressive5
  • Follicular carcinoma of the thyroid with aggressive metastatic behavior in a pregnant woman: Report of a case and review of the literature. (iranpath.org)
  • Merkel Cell Carcinoma (MCC) is a very rare and aggressive skin cancer that usually develops when a person is in his or her 70s. (lymphomainfo.net)
  • Overall, HCC has more aggressive features and a poorer prognosis than follicular thyroid carcinomas. (thyroid.org)
  • In contrast, anaplastic carcinoma is quite aggressive and has a poor prognosis, while patients with metastatic medullary carcinoma may live for many years but generally succumb to their cancer. (msdmanuals.com)
  • Merkel cell carcinoma (MCC), an uncommon but aggressive form of skin cancer. (cdc.gov)
Lesion1
Squamous1
  • Nasopharyngeal carcinomas (NPC) are non-keratinizing squamous cell carcinomas of the nasopharynx associated with Epstein-Barr virus (EBV). (researchgate.net)
Less differentiated1
  • [ 32 ] Also helpful may be demonstration of lipid contents in the vacuoles of the sebaceous cells in less differentiated carcinomas. (medscape.com)
Patients7
  • Long-term follow-up of patients with papillary and follicular thyroid cancer: a prospective study on 715 patients. (medscape.com)
  • Overall, about 5% of patients with thyroid cancer have metastases beyond the cervical or mediastinal area on initial presentation, as do 2-3% of patients with papillary thyroid cancer and 11% of patients with follicular thyroid cancer. (medscape.com)
  • Postoperative ultrasonography surveillance in patients with follicular thyroid carcinoma: a multicenter study. (bvsalud.org)
  • A widely accepted therapy is 131 I for patients with hyperthyroidism caused by Graves' disease, toxic nodular disease, euthyroid multinodular goiters, and differentiated thyroid carcinomas ( 1 - 6 ). (snmjournals.org)
  • The incidence of papillary thyroid carcinoma has risen over the last several decades, primarily due to the incidental discovery of small cancers in patients undergoing neck ultrasonography, MRI, CT scans, or PET scans that include the neck in the imaging field. (msdmanuals.com)
  • The objective of the present study was to evaluate the effects of iodine 131 on the salivary glands by subjective symptom of dryness in the mouth (xerostomia) and reduced salivary flow (hyposalivation) of patients with differentiated thyroid carcinoma submitted to radioiodine therapy. (bvsalud.org)
  • A clinical longitudinal study with of 88 patients with differentiated thyroid carcinoma (papillary and follicular) who underwent complementary treatment with high single doses of iodine 131 (100 to 150 mCi). (bvsalud.org)
Anaplastic carcinoma1
  • Anaplastic carcinoma (also called giant and spindle cell cancer) is the most dangerous form of thyroid cancer. (medlineplus.gov)
Hepatocellular carcinoma2
  • Transforming mutations in GNAS have been well documented in human thyroid and pituitary tumours, and recent sequencing efforts have shown these mutations to be present in a wide variety of additional tumour types, including colon cancer, hepatocellular carcinoma, and parathyroid, ovarian, endometrial, biliary tract and pancreatic tumours. (nature.com)
  • Hepatocellular carcinoma (HCC) is primarily a malignancy of the liver, advancing from a damaged, cirrhotic liver to HCC. (wjgnet.com)
Oncocytic2
  • Hürthle cell (oncocytic) change is often seen in follicular epithelium. (cap.org)
  • More recently, in 2022, WHO recommended using the term "oncocytic carcinoma of the thyroid" instead of HCC. (thyroid.org)
Expression in thyroid2
  • Reports discussing cMYC protein expression in thyroid carcinomas are limited, with controversies pertaining to cMYC expression patterns noted in the literature. (biomedcentral.com)
  • Reports discussing cMYC protein expression in thyroid carcinomas are limited, and controversies exist pertaining to cMYC expression patterns (nuclear versus cytoplasmic immunoreactivity) in these tumors. (biomedcentral.com)
Poorly3
  • The clinical course of poorly differentiated thyroid carcinoma (insular carcinoma) - own observations. (nih.gov)
  • Carcinomas derived from thyroid follicular epithelium comprise papillary, follicular, poorly differentiated, and undifferentiated (anaplastic) carcinomas. (biomedcentral.com)
  • Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. (novusbio.com)
Lesions3
  • Many carcinomas are solid, while several cystic or mixed lesions are benign. (teknon.es)
  • It has also been observed in follicular lesions such as comedones and ruptured follicles. (medscape.com)
  • Hence, trichofolliculoma can be added to the list of follicular lesions in which focal acantholytic dyskeratosis may be observed as an incidental microscopic change. (medscape.com)
Progression3
  • Introduction : The identification of follicular thyroid adenoma-associated transcripts will lead to a better understanding of the events involved in pathogenesis and progression of follicular tumours. (johnshopkins.edu)
  • The aims of the current study were to clarify patterns and intensities of cMYC expression in follicular cell-derived thyroid carcinomas across a spectrum of cancer morphologies and disease aggressivities, to correlate cMYC with BRAF V600E expression, and to evaluate the potential role of cMYC in progression of well-differentiated thyroid carcinomas into less well-differentiated carcinomas. (biomedcentral.com)
  • An important factor of cancer progression was recognized in the capacity of thyroid carcinoma cells to angiogenesis, procuring them an unlimited growth and the invasion of the surrounding tissue. (uni-marburg.de)
Malignancy1
  • Thyroid carcinomas are the most frequent malignancy of endocrine organs. (uni-marburg.de)
Type of thyroid cancer2
  • Follicular thyroid carcinoma (FTC) is the second most common type of thyroid cancer after papillary carcinoma. (iranpath.org)
  • the most common type of thyroid cancer, which includes papillary and follicular thyroid cancers. (thyroid.org)
Renal1
  • Evidence also shows (synthesis and destruction) and is continually reused, that thyroid nodules and carcinoma prevalence increase while excess unused iodine is excreted through the renal with age (8) . (who.int)
Transitional cell1
  • However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)
Cancers1
Molecular2
  • The molecular pathogenesis of follicular thyroid carcinoma (FTC) is thought to be initiated by point mutations that result in dysregulation of the phosphatidylinositol-3 kinase (PI3K)/AKT signaling pathway. (medscape.com)
  • HE4 is one of more than 8900 different human genes represented on U95a GeneChips (Affymetrix, Santa Clara, CA, USA), which we used previously to develop a molecular classification of 175 human carcinomas based on patterns of gene expression. (nature.com)
Ovary1
  • Follicular Fluid-Derived Exosomal MicroRNA-18b-5p Regulates PTEN-Mediated PI3K/Akt/mTOR Signaling Pathway to Inhibit Polycystic Ovary Syndrome Development. (nih.gov)
Cells4
  • FTC originates in follicular cells and is the second most common cancer of the thyroid, after papillary carcinoma. (medscape.com)
  • Trichilemmal carcinoma shows many histologic features reminiscent of follicular ORS-notably, its glycogen-rich clear cells, trichilemmal keratinization, and similar immunostaining profile. (jcadonline.com)
  • Follicular cells in the gland produce the 2 main thyroid hormones. (msdmanuals.com)
  • Sebaceous carcinomas are common on the eyelid and tend to present with pagetoid extension of atypical sebaceous cells in the conjunctiva or in the epidermis. (medscape.com)
Genes1
  • Methods : NR4A1, one of the five genes, was validated in a set of 27 normal thyroid tissues, 10 FTAs and 14 FTCs and three thyroid carcinoma cell lines by real time PCR. (johnshopkins.edu)
Tumors3
  • Endocrine tumors in general have a propensity to invade local vasculature and in the case of thyroid carcinomas, there may be spread to the thoracic cavity via blood vessels prior to involvement of the regional lymph node. (acvr.org)
  • Objective: Laryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. (researchgate.net)
  • In a series of 175 human adult tumors, gene expression was highest in ovarian serous carcinomas. (nature.com)
Hurthle2
  • In the test series the Hurthle cell line XTC, the follicular cell line HTC+, the anaplastic cell line and the cell line Hth74 as well as a cell line isolated from natural thyroid tissue (Thy1) were examined. (uni-marburg.de)
  • 1 ] Differentiated thyroid cancer includes: papillary thyroid cancer, follicular thyroid cancer, and Hurthle-cell thyroid cancer. (surgicalneurologyint.com)
Oncology1
  • Guideline] NCCN Clinical Practice Guidelines in Oncology: Thyroid Carcinoma Version 2.2014. (medscape.com)
Autoimmune1
  • While thyroid volume and nodularity are high in iodine-deficient regions, autoimmune thyroid diseases and follicular thyroid carcinomas are more common in regions with excessive iodine intake (5). (who.int)