Folic acid supplementation on homocysteine. Medical search. Frequent questions

The researchers report that, while the low-dose folic acid supplements had no significant effect on homocysteine concentrations in the general study population, levels did significantly decrease in hyperhomocysteinemic subjects by 1.8 micromoles per litre. (nutraingredients-usa.com)
People with the so-called TT homozygote genotype with low folate status are reported to have higher homocysteine concentrations than the other genotypes, putting this subset at increased risk of CAD and cognitive decline. (nutraingredients-usa.com)
Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study. (thieme-connect.de)
Background Observational studies show that low concentrations of folate and elevated concentrations of homocysteine are associated with poor cognitive performance in the general population. (drjohnlapuma.com)
Results Compared to the placebo treatment, serum folate increased 5-fold and plasma total homocysteine concentrations decreased by ~25% after 3 years. (drjohnlapuma.com)
If the body does not have enough of these B vitamins, not enough homocysteine is converted, leading to higher levels of homocysteine concentrations in the bloodstream. (preeclampsia.org)
Serum homocysteine and folate concentrations are associated with prevalent age-related hearing loss. (sciencebasedhealth.com)
A reduction in PLP availability appears to primarily affect kynureninase activity, limiting NAD production and leading to higher concentrations of kynurenine, 3-hydroxykynurenine, and xanthurenic acid in blood and urine ( Figure 2 ) (9) . (oregonstate.edu)
Background: The efficacy of treatments that lower homocysteine concentrations in reducing the risk of cardiovascular disease remains controversial. (johnshopkins.edu)
1976). It has been shown by previous studies that patients who have angiographically determined coronary artery disease have an increase in the risk of death with increasing homocysteine concentrations (Nygard et al. (biomedjournal.com)
1997). Previous studies have reported an association between homocysteine concentrations and plasma markers of thrombosis activation in patients admitted for acute coronary syndrome (Al-Obaid et al. (biomedjournal.com)
2000). These findings have postulated that elevated homocysteine concentrations lead to increased myocardial injury in acute coronary syndrome and thus lead to worse prognosis of acute coronary syndrome. (biomedjournal.com)
High homocysteine concentrations increase one's risk for cardiovascular disease. (mthfrsupport.com.au)
Changes in plasma concentrations of total homocysteine (tHcy) reflect one aspect of the metabolic consequences of methyl group deficiency or nutrient supplementations. (nih.gov)
T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation. (cdc.gov)
Lower plasma folate concentrations were observed in coffee drinkers in a cross-sectional study, but dietary folate or supplemental folic acid were not taken into account [ 23 ]. (cdc.gov)

Randomized controlled trials have demonstrated that supplementation with B vitamins, including vitamin B 6 , could effectively reduce homocysteine levels. (oregonstate.edu)

[ 1 ] In patients with a baseline homocysteine level exceeding 9.1 umol/L, supplementation with B vitamins resulted in slowed progression of carotid intimal medial thickness (CIMT). (medscape.com)
Vitamin B9, also called folic acid or folate, is one of eight water-soluble B vitamins. (healthyplace.com)
Vitamin B9 works closely with vitamins B6 and B12 as well as the nutrients betaine and S-adenosylmethionine (SAMe) to control blood levels of the amino acid homocysteine. (healthyplace.com)
The link is being further examined by the B-Vitamin Treatment Trialists' Collaboration which should soon be better able to address the link between B-vitamins, homocysteine levels, cardiovascular health, and cognitive function. (nutraingredients-usa.com)
Data should soon be available on three to seven years of supplementation with B vitamins on cognitive function on about 20,000 of the 50,000 participants with previous cardiovascular or renal disease in the 12 large homocysteine-lowering trials for the prevention of cardiovascular events. (nutraingredients-usa.com)
Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study. (thieme-connect.de)
Supplementation with folate and vitamins B6 and B12 supports already healthy plasma levels of homocysteine. (goldenneedleonline.com)
Folic acid, together with vitamins B 6 and B 12 , helps break down homocysteine, and may help reverse the problems associated with elevated levels. (encyclopedia.com)
Earlier research has shown that supplementation with B vitamins-specifically, vitamins B6, B12, and folic acid-lowers homocysteine levels(5), a risk marker for heart and cognitive health. (nutritionaloutlook.com)
As newer research now shows, however, the effects of B vitamins for supporting the heart go beyond lowering homocysteine levels. (nutritionaloutlook.com)
Some evidence suggests that lowering homocysteine levels with prescription-strength folic acid and vitamins B12 and B6 for six months following coronary angioplasty reduced the risk of revascularization of target lesions and overall adverse cardiac events. (naturalmedicinejournal.com)
How do B vitamins fit into the homocysteine picture? (harvard.edu)
7-12] But linking higher homocysteine levels-and lower folate levels-with heart disease risk does not necessarily mean that lowering homocysteine by taking folate and other B vitamins will lower risk. (harvard.edu)
An elevated level of homocysteine may adversely affect blood flow in the inner ear, and studies have shown that levels of folic acid , as well as vitamins B6 and B12 , can influence homocysteine concentration in the blood. (sciencebasedhealth.com)
However, homocysteine lowering by B vitamins has failed to lower the risk of adverse cardiovascular outcomes in high-risk individuals. (oregonstate.edu)
Although supplementation with vitamin B 6 and other B vitamins has not been associated with improved cognitive performance or delayed cognitive deterioration in the elderly, recent studies suggest that vitamin B 6 might help reduce the risk of late-life depression. (oregonstate.edu)
However, emerging research indicates that nutritional interventions with essential minerals, vitamins, and specific fatty acids, such as omega 3s, may mitigate related risk factors for mental illness and promote optimal brain health, although additional research is required. (dsm.com)
B-vitamins, such as B6, B12 and folic acid, must undergo chemical changes before they can be utilized by the body. (shopglobal.com)
Folic acid has different properties and effects than other B vitamins because it can act as a methyl donor or a methyl acceptor depending on the situation. (readonline.blog)
Folic acid is likely one of the important nutritional vitamins, significant for girls who plan to turn out to be pregnant. (techtimesmedia.com)
For ladies who wish to be proactive concerning the well-being of their kids, you will need to complement with nutritional vitamins that comprise folic acid. (techtimesmedia.com)
Nevertheless, prenatal nutritional vitamins comprise the exact quantity of folic acid wanted to develop a wholesome fetus. (techtimesmedia.com)
Activated forms are important because traditional forms of vitamins B6, B12 and folic acid found in most other B-complex products must undergo chemical changes in order to be utilized by the body. (etnad3.com)
Overview of Vitamins Vitamins may be Fat soluble (vitamins A, D, E, and K) Water soluble (B vitamins and vitamin C) The B vitamins include biotin, folate, niacin, pantothenic acid, riboflavin (B2), thiamin (B1). (msdmanuals.com)

A recent study found that the prevalence of neural tube defects in the United States has decreased by 19% since the FDA authorized the fortification of grains with folic acid. (healthyplace.com)
Beginning in 1998, the United States mandated fortification of enriched cereal grain products with 140 µ g of folic acid per 100 g ( 2 ). (cdc.gov)
To provide updated estimates of the birth prevalence of NTDs in the period after introduction of mandatory folic acid fortification (i.e., the post-fortification period), data from 19 population-based birth defects surveillance programs in the United States, covering the years 1999-2011, were examined. (cdc.gov)
Mandatory folic acid fortification remains an effective public health intervention. (cdc.gov)
For example, although the general population of North America - where fortification of foods is mandated - on average achieves the RDA (recommended dietary allowance) of 400 mg/d for folate, clinical studies of folate in the restoration of endothelial function suggest that higher doses of folic acid are required to confer benefits on cardiovascular endpoints. (dsm.com)
The case for the folic acid fortification of foods, or at least for supplementation with folic acid, received a boost this week with the publication of new research showing that the positive effects of folic acid in reducing homocysteine levels and improving endothelial function can continue up to a year after therapy. (foodnavigator.com)
Not for nothing has the U.S. mandated folic acid fortification of so basic a staple as flour. (nutritionaloutlook.com)
And though the 1992 recommendation prescribed consuming 400 to 800 mcg of folic acid through a combination of dietary, fortified and supplementary sources, by 1998 the recommendation was to get 400 to 800 mcg via supplements and fortification in addition to whatever came from the diet. (nutritionaloutlook.com)
4] Since the advent of mandatory folic acid fortification in 1998, neural tube birth defects have dropped by 28%, and studies have shown that far fewer people have low levels of folate in their blood. (harvard.edu)
folic acid is the synthetic version used for food fortification and supplements. (globalhealing.com)
4,25-27 In Australia, voluntary fortification of selected foods with folic acid was permitted from 1995, with fortification of non-organic, bread-making flour mandated from September 2009. (who.int)
ABSTRACT This paper presents the trend of spina bifida and other neural tube defects in Oman after the nationwide implementation of folate supplementation of pregnant women in 1990 and the fortification of wheat flour with iron and folate in 1996. (who.int)
The reduction in spina bifida rates in Oman could be linked to the start of flour fortification but not the supplementation programme. (who.int)

Integral monitoring and education are needed for practitioners of handball sports to record their folic acid status, a factor that directly affects Hcy metabolism. (biomedcentral.com)
Folic acid is a vitamin needed by a number of enzymes essential for DNA synthesis and amino acid metabolism [ 1 ]. (biomedcentral.com)
Homocystinuria is a disorder of methionine metabolism, leading to an abnormal accumulation of homocysteine and its metabolites (homocystine, homocysteine-cysteine complex, and others) in blood and urine. (medscape.com)
The accumulation of homocysteine and its metabolites is caused by disruption of any of the 3 interrelated pathways of methionine metabolism-deficiency in the cystathionine B-synthase (CBS) enzyme, defective methylcobalamin synthesis, or abnormality in methylene tetrahydrofolate reductase (MTHFR). (medscape.com)
These practices for prevention of spontaneous abortion are supported by some studies suggesting a connection between impaired homocysteine metabolism and recurrent miscarriages. (healthyplace.com)
9 Both folate and vitamin B 12 are potent regulators of homocysteine metabolism through the modulation of the vitamin B 12 -dependent enzyme methionine synthase, which - in most tissues and cells - is the major (or only) pathway for the conversion of homocysteine to methionine, a critical component of the folate cycle. (dsm.com)
Homocysteine, generated in the metabolism of methionine, may have a role in the development of cardiovascular disease. (unboundmedicine.com)
In both fatty acid and amino acid metabolism, B12 helps to create red blood cells and provide the body energy. (preeclampsia.org)
The many biochemical reactions catalyzed by PLP-dependent enzymes are involved in essential biological processes, such as hemoglobin and amino acid biosynthesis, as well as fatty acid metabolism . (oregonstate.edu)
L-methylmalonyl-CoA mutase converts L-methylmalonyl-CoA to succinyl-CoA in the metabolism of propionate, a short-chain fatty acid [ 2 ]. (nih.gov)
Homocysteine (Hcy) is an amino acid which is an important intermediary compound in the metabolism of methionine. (biomedjournal.com)
An overabundance of homocysteine, or hyperhomocysteinemia, results from a breakdown in the methionine-homocysteine metabolism. (globalhealing.com)

Vitamin B6 supplementation, in conjunction with folic acid and vitamin B12, can lower homocysteine levels, thus reducing the risk for cardiovascular disease. (twofarmkids.com)
Several large randomized trials of B vitamin supplements to lower homocysteine levels and prevent heart disease and stroke failed to find a benefit. (harvard.edu)

With respect to mechanisms concerning the B-vitamin complex, it has long been established that folate deficiency leads to increased plasma homocysteine (hyperhomocysteinemia), an independent risk factor for coronary artery disease, stroke, peripheral vascular atherosclerosis, and both arterial and venous thromboembolism. (dsm.com)
Definitive guidelines for the management of hyperhomocysteinemia await the completion of randomized trials to establish the effect of vitamin supplementation on CAD events. (unboundmedicine.com)
Folic acid is known to lower plasma homocysteine levels, and high levels of the amino acid, hyperhomocysteinemia, are a marker for heart disease and thought to be a risk factor for atherosclerotic disease, which contributes to heart attacks. (nutraingredients-usa.com)
Woo's team focused on 29 study participants suffering from hyperhomocysteinemia (an elevated level of homocysteine concentration in the blood), testing their homocysteine levels and vascular responses after supplementing them 10mg of folic acid every day for a year. (foodnavigator.com)
Hyperhomocysteinemia, the condition of having too much homocysteine, causes numerous health issues within the body. (mthfrsupport.com.au)
The abundance of homocysteine causes hyperhomocysteinemia, which is a condition that results in fertility issues, mental health disorders, and cardiovascular problems. (mthfrsupport.com.au)
A specific supplementation program is essential to determine whether your hyperhomocysteinemia is affected by depression. (mthfrsupport.com.au)

The aim of this study was to determine the effect of folic acid supplementation on homocysteine levels and the cognitive and depressive status of a group of patients with eating disorders with low folate intake. (nih.gov)
Carotid stenosis appears to have a graded response to increased levels of homocysteine. (medscape.com)
Increased carotid plaque thickness has been associated with high homocysteine and low B-12 levels. (medscape.com)
Yoo et al studied both intracranial and extracranial vessels by MR angiography and reported that homocysteine levels were higher in patients with 2- or 3-vessel stenoses than in those with 1-vessel stenosis. (medscape.com)
Some researchers have even speculated that there is a connection between high levels of this amino acid and cervical cancer, but the results of studies regarding this have been inconclusive. (healthyplace.com)
Taking vitamin B6 by mouth, usually with folic acid, is effective for treating high homocysteine levels in the blood. (medlineplus.gov)
7,8 In fact, epidemiologic studies and clinical trials have consistently demonstrated that a 20% to 25% relative reduction in homocysteine levels is associated with a significant reduction in cardiovascular events. (dsm.com)
14 Moreover, the PACIFIC study - a double-blind, placebo-controlled, factorial randomized trial assessing the effects of two doses of folic acid versus placebo on plasma homocysteine levels - clearly demonstrated the beneficial effects of high-dose folic acid therapy in high-risk patients. (dsm.com)
Clinical trials have shown that supplementing with omega-3 fatty acids (found in fish oil) may help to maintain normal levels of triglycerides and cholesterol, support healthy blood pressure and promote normal platelet activity. (nutrametrix.com)
Maintaining healthy cholesterol and triglyceride levels, promoting optimal arterial function and supporting healthy homocysteine levels are all important to the overall health of the cardiovascular system. (nutrametrix.com)
nutraMetrix Heart Health™ TriActive™ targets three major areas, the arteries, cholesterol and homocysteine levels to promote the healthy performance of the body's cardiovascular system. (nutrametrix.com)
This unique formula uses a combination of dietary ingredients that have been shown to safely and effectively support optimal arterial function and help maintain normal cholesterol and homocysteine levels. (nutrametrix.com)
They are amino acids that assist with protein absorption, boost Adenosine Triphosphate (ATP) levels, and even increase growth hormone levels. (healthcanal.com)
This article reviews the available evidence on the association between plasma tHcy levels and CAD and the effect of lowering tHcy levels through vitamin supplementation or dietary intake. (unboundmedicine.com)
A low-dose daily supplement of folic acid improved levels homocysteine in people with high levels of the amino acid and could reduce the risk of coronary artery disease, suggests a small study from Taiwan. (nutraingredients-usa.com)
The findings may also have an impact on cognitive function with epidemiological studies reporting that high levels of homocysteine associated with suspected or confirmed dementia. (nutraingredients-usa.com)
Indeed, the Framingham study reported that people with homocysteine levels above 14 micromoles per litre of serum had twice the risk of dementia. (nutraingredients-usa.com)
This has led to the hypothesis that by lowering circulating levels of homocysteine by B vitamin supplements, the risk and occurrence of dementia could be reduced. (nutraingredients-usa.com)
Low-dose folic acid supplementation for eight weeks for the TT genotype people led to a significant 2.1 micromoles per litre reduction in homocysteine levels, and 1.4 micromoles per litre for people who carry the T-allele either hetero- or homozygously. (nutraingredients-usa.com)
It has been reported that vitamin B12 is a more important determinant of high homocysteine levels in people over 70 than folate, and some experts have called for future studies to focus on dietary supplementation of 1000 micrograms of B12 in elderly people. (nutraingredients-usa.com)
Plasma homocysteine levels and mortality in patients with coronary artery disease. (thieme-connect.de)
The researchers found that the participants showed a significant increase in plasma folate levels and a significant decrease in homocysteine at the end of the year compared to their levels before treatment began. (foodnavigator.com)
In the intervening decades, considerable research has not only corroborated their observations, but shown that raising mothers' folic acid levels via supplementation genuinely prevents neural tube defects. (nutritionaloutlook.com)
The authors of the meta-analysis examined if maternal serum homocysteine levels, folic acid supplementation, or gestational age could explain the variation in the results, but none significantly explained the difference between studies. (preeclampsia.org)
Higher levels of homocysteine have been associated with increased oxidative stress and endothelial damage (Serrano 2018), which may increase the risk of developing preeclampsia (Mardali 2020). (preeclampsia.org)
So if methylfolate is lacking (perhaps due to the common MTHFR genetic mutation), homocysteine is not converted and may build up to harmful levels. (preeclampsia.org)
Therefore, clinicians should measure methylmalonic acid and homocysteine levels if B12 levels are normal but vitamin B12 deficiency is still suspected, especially if the level is on the margins of normal, to confirm the direction of treatment. (cobfoundation.org)
6] Putting one and one together, he hypothesized that elevated levels of this breakdown product-called homocysteine-would contribute to the artery-clogging process of atherosclerosis. (harvard.edu)
Without enough folate, vitamin B6 , and vitamin B12 , this conversion process becomes inefficient and homocysteine levels increase. (harvard.edu)
On the flip side, homocysteine levels drop with increasing intakes of folate, vitamin B6, and vitamin B12. (harvard.edu)
Since these early observations about homocysteine, most but not all studies have linked high levels of homocysteine with a modest increase in risk of heart disease and stroke . (harvard.edu)
In addition, higher blood levels of the naturally occurring compound homocysteine (over 20 micro-moles per liter) were linked with a 64% higher risk. (sciencebasedhealth.com)
High levels of circulating homocysteine are associated with an increased risk of cardiovascular disease . (oregonstate.edu)
Levels of serum methylmalonic acid (MMA), a vitamin B12-associated metabolite, are the most sensitive markers of vitamin B12 status, and an MMA level greater than 0.271 micromol/L suggests vitamin B12 deficiency [ 6-8 ]. (nih.gov)
Also, a positive correlation was found between serum homocysteine levels and ejection fraction. (biomedjournal.com)
Serum homocysteine is associated with increased myocardial injury which has been quantified in the current study by serum cardiac troponin-I levels and ejection fraction, which are independent markers of the extent of myocardial damage in patients of acute coronary syndrome. (biomedjournal.com)
Homocysteine levels normalized with folic acid supplementation. (archive.org)
It's important to work with a practitioner because levels can drop quickly and the formula may need to be changed frequently to avoid homocysteine levels dropping too low. (mthfrsupport.com.au)
According to studies, the nervous system can be severely harmed by high levels of homocysteine in the body. (mthfrsupport.com.au)
High levels of homocysteine results in numerous biochemical imbalances in the body, and in the brain, which causes irreparable damage to our bodies and mental health. (mthfrsupport.com.au)
However, depression is not the only condition related to mental health that could show exacerbated symptoms due to high levels of homocysteine. (mthfrsupport.com.au)
Homocysteine levels are known to increase as we age. (mthfrsupport.com.au)
Homocysteine levels during pregnancy are relatively inconsistent as they continuously fluctuate. (mthfrsupport.com.au)
We investigated the effects of 2-year folic acid and vitamin B12 supplementation on cognitive performance in elderly people with elevated homocysteine (Hcy) levels. (amsterdamumc.org)
This multicenter, double-blind, randomized, placebo-controlled trial included 2,919 elderly participants (65 years and older) with Hcy levels between 12 and 50 µmol/L. Participants received daily either a tablet with 400 µg folic acid and 500 µg vitamin B12 (B-vitamin group) or a placebo tablet. (amsterdamumc.org)
Two-year folic acid and vitamin B12 supplementation did not beneficially affect performance on 4 cognitive domains in elderly people with elevated Hcy levels. (amsterdamumc.org)
Less severe elevations of homocysteine levels are more commonly observed as a result of heterozygous mutations of these enzymes, dietary deficits of folate or vitamin B 12 , or in patients with liver disease or decreased renal function [ 6 ]. (biomedcentral.com)
Folic acid can help reduce depression by modulating the levels of neurotransmitters, such as serotonin and dopamine, which regulate mood and emotions. (readonline.blog)
Folic acid can help protect heart health by lowering the levels of homocysteine, an amino acid that can damage the blood vessels and increase the risk of cardiovascular diseases. (readonline.blog)
B 2 supplementation has also been linked to improvement in iron levels in patients with sickle cell anemia. (sanescohealth.com)
In this study, patients with intermediate to severe Parkinson's disease were examined for how Resagiline and levodopa and benserazide hydrochloride affected their motor performance, serum levels of homocysteine (Hcy), and insulin-like growth factor (IGF-1). (bvsalud.org)
Without adequate folate, homocysteine levels increase. (globalhealing.com)
A Polish study found folic acid supplementation encourages normal cholesterol levels. (globalhealing.com)
In the study of 124 individuals, researchers observed significant reductions in LDL cholesterol levels in subjects who'd supplemented with .4 mg of folic acid daily for 12 weeks. (globalhealing.com)
The result is believed to have been derived from reduced homocysteine levels. (globalhealing.com)
A Korean study of elderly patients found that those suffering from dementia had the highest levels of homocysteine, and the lowest folate levels. (globalhealing.com)
1999-2000 survey design and data reducing blood levels of homocysteine degeneration (8-10). (cdc.gov)

Elevated level of plasma homocysteine has been demonstrated to be an independent risk factor for the development of coronary artery disease. (biomedjournal.com)

you must also engage in physical activity and eat a healthy diet with complete essential amino acids. (healthcanal.com)
When looking at cutting supplements, don't forget branched-chain amino acids. (healthcanal.com)
PLP is also a coenzyme for reactions that generate glucose from amino acids, a process known as gluconeogenesis (6) . (oregonstate.edu)
All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)

Pregnancy can put a woman at risk for folic acid deficiency as the fetus easily depletes a mother's nutrient reserves. (healthyplace.com)
Folic acid deficiency during pregnancy increases the risk for neural tube defects including cleft palate, spina bifida, and brain damage. (healthyplace.com)
Objective To determine the efficacy of high dose folic acid supplementation for prevention of pre-eclampsia in women with at least one risk factor: pre-existing hypertension, prepregnancy diabetes (type 1 or 2), twin pregnancy, pre-eclampsia in a previous pregnancy, or body mass index ≥35. (bmj.com)
Folic acid supports healthy neural tube formation, when taken prior to and early in pregnancy, in combination with a healthy diet. (goldenneedleonline.com)
During pregnancy, a folic acid deficiency may lead to preeclampsia, premature birth, and increased bleeding after birth. (encyclopedia.com)
But, says Jayesh Chaudhari, MS, CNS, senior director, R&D, Prinova Solutions (Carol Stream, IL), "Although spina bifida is believed to result from a combination of genetic and environmental factors," the fetus's increasing folic acid requirement over the gestational period suggests that "most spina bifida cases can be prevented by addressing the nutritional deficiency through folic acid supplementation early in pregnancy. (nutritionaloutlook.com)
That recommendation still stands and was reaffirmed in 2009 when the United States Preventative Services Task Force (USPSTF) issued an authoritative public health recommendation that all women either planning or capable of pregnancy- "that's all women," MacKay emphasizes-take a daily supplement that contains 400 to 800 mcg of folic acid. (nutritionaloutlook.com)
So what is the Role of Folic Acid (Vitamin B9) during pregnancy? (preeclampsia.org)
Vitamin B9 (folate or folic acid) plays a key role in fertility, pregnancy and the health of the baby. (preeclampsia.org)
High homocysteine - It can affect your brain, your heart and your pregnancy. (mthfrsupport.com.au)
However, high amounts of homocysteine during pregnancy can result in adverse outcomes to both mother and child. (mthfrsupport.com.au)
Folic acid can help support pregnancy by preventing neural tube defects, which are birth defects that affect the brain and spinal cord of the fetus. (readonline.blog)
Folic acid can help you be more prepared and proactive for your health and wellness by preventing anemia, supporting pregnancy, reducing depression, and protecting heart health. (readonline.blog)
You can use folic acid as a supplement before, during, or after certain situations that require more folate, such as pregnancy, menstruation, or illness. (readonline.blog)
Folic acid has various functions and benefits for your health and wellness, such as preventing anemia, supporting pregnancy, reducing depression, and protecting heart health. (readonline.blog)
[ 4 ] A 2012 study reported that previously infertile patients who took a nutritional supplement, which included folic acid, experienced significant improvement in sperm motility and successfully achieved pregnancy with their partners. (globalhealing.com)
23,24 Folic acid supplementation one month prior and three months post conception is recommended to reduce the risk of an NTD-affected pregnancy. (who.int)

However, folic acid supplements do not seem to lower plasma homocysteine in patients with CAD with normal plasma homocysteine level. (nutraingredients-usa.com)
People who are at high risk of strokes and heart disease may greatly benefit by taking folic acid supplements. (encyclopedia.com)
To correct a folic acid deficiency, supplements are taken in addition to food. (encyclopedia.com)
What's nice about the folic acid story," says MacKay, "is that you can usually stop someone in their tracks just by reminding them that the recommendations provide a very strong foundation for why supplements are valuable, and for why they have an important public health role. (nutritionaloutlook.com)
Data from the CDC's National Health and Nutrition Examination Survey (NHANES) show that from 2003 to 2006-when it last reviewed folic acid status-75% of non-pregnant women ages 15 to 44 did not consume the recommended daily intake of folic acid from diet and supplements combined for preventing neural tube defects. (nutritionaloutlook.com)
Folate is found naturally in foods such as leafy green vegetables, eggs, and citrus fruits, while folic acid is the synthetic version used in fortified foods and supplements. (preeclampsia.org)
The UL for adults for folic acid from fortified food or supplements (not including folate from food) is set at 1,000 mcg a day. (harvard.edu)
Folic acid can also be obtained from supplements or fortified foods. (readonline.blog)

Taking a combination of folic acid, vitamin B6, and vitamin B12 by mouth doesn't reduce the risk of developing colorectal polyps. (medlineplus.gov)
Taking a combination of folic acid, vitamin B6, and vitamin B12 by mouth doesn't prevent broken bones in people with osteoporosis. (medlineplus.gov)
Supplementation with a combination of folic acid, vitamin B6, and vitamin B12 did not decrease the risk of breast cancer. (naturalmedicinejournal.com)
Dr. Spray's Folate+ provides a combination of folic acid (often referred to as vitamin B9), vitamin B6 and vitamin B12 in a great tasting, easy to use, oral spray. (drsprays.com)

Methylfolate, the active form of folic acid, plays a role in converting homocysteine into methionine, an essential amino acid in humans. (preeclampsia.org)
Folate and vitamin B12 play key roles in converting homocysteine into methionine, one of the 20 or so building blocks from which the body builds new proteins. (harvard.edu)

There remain opportunities for prevention among women with lower folic acid intakes, especially among Hispanic women, to further reduce the prevalence of NTDs in the United States. (cdc.gov)
Apart from the prevention of congenital malformations by supple- mentation of folic acid, the association of folate intake and cardiovascular diseases has been studied. (thieme-connect.de)
Adequate intake of folic acid is vital for the prevention of several types of birth defects , particularly NTDs. (encyclopedia.com)
The effects of vitamin B12 supplementation on the prevention or progression of Alzheimer's disease remain unclear. (naturalmedicinejournal.com)
This is not the first time folic acid has been linked to the prevention of hearing loss. (sciencebasedhealth.com)
Our aim was to do a meta-analysis of relevant randomised trials to assess the efficacy of folic acid supplementation in the prevention of stroke. (johnshopkins.edu)
Interpretation: Our findings indicate that folic acid supplementation can effectively reduce the risk of stroke in primary prevention. (johnshopkins.edu)
Xu X, Qin X, Li Y, Sun D, Wang J, Liang M, Wang B, Huo Y, Hou F. Efficacy of Folic Acid Therapy on the Progression of Chronic Kidney Disease: The Renal Substudy of the China Stroke Primary Prevention Trial. (andeal.org)

Many neural tube defects (such as spina bifida) are believed to be preventable if women of childbearing age supplement their diets with folic acid. (healthyplace.com)
In 1992, the U.S. Public Health Service recommended that all women capable of becoming pregnant consume 400 µ g of folic acid daily to prevent neural tube defects (NTDs) ( 1 ). (cdc.gov)
In 1998, the U.S. Food and Drug Administration ( FDA ) required food manufacturers to add folic acid to enriched bread and grain products to boost intake and to help prevent neural tube defects (NTD). (encyclopedia.com)
No wonder the CDC recommended in 1991 that women with a family history of neural tube defects supplement with folic acid-a recommendation that the agency extended to all women in 1992. (nutritionaloutlook.com)
Folic acid has been well-studied for its ability to prevent neural tube defects, which is why women who are pregnant or trying to conceive are encouraged to take a prenatal vitamin that includes folic acid. (preeclampsia.org)
Folic acid, also referred to as vitamin B9, is a nutrient that performs a vital function within the fetal growth of the neural tube. (techtimesmedia.com)
RÉSUMÉ Cet article présente la tendance du spina bifida et d'autres malformations du tube neural à Oman, après la mise en place au niveau national de la supplémentation en acide folique chez les femmes enceintes en 1990, et l'enrichissement de la farine de blé en fer et en acide folique en 1996. (who.int)

An increased homocysteine level is associated with a higher risk of strokes. (medscape.com)

Conversion of homocysteine back to methionine, catalyzed by MTHFR and methylcobalamin, is termed the remethylation pathway. (medscape.com)
In addition, adequate intake of vitamin B-12, along with folic acid and vitamin B-6, is critical for the conversion of homocysteine to methionine, thereby supporting a healthy cardiovascular system. (bayho.com)
Methionine synthase catalyzes the conversion of homocysteine to the essential amino acid methionine [ 1 , 2 ]. (nih.gov)

The researchers looked at potential genetic defects in the metabolic pathway of homocysteine involving the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene mutation. (nutraingredients-usa.com)
Anywhere between 25-60% of the US population have a variation in one of their MTHFR genes that changes how they convert folic acid. (preeclampsia.org)

The study was designed as a randomised, prospective clinical trial, which included 24 participants assigned to two treatment groups for six months: supplemented group (SG) (10 mg/day of folic acid [ACFOL]) and a placebo group (PG). (nih.gov)
Sujetos y métodos: Estudio clínico randomizado y prospectivo en el que se incluyeron 24 pacientes asignados a dos grupos de tratamiento durante un período de 6 meses: grupo suplementado (SG) (10 mg/día de ácido fólico [ACFOL®]) y grupo placebo (PG). (nih.gov)
Lead researcher Ping-Ting Lin from the Chung Shan Medical University, Taiwan, and co-workers recruited 46 people (42 men, average age 73) and randomly assigned to either a placebo group or a folic acid group (General Nutrition Corp.) for eight weeks. (nutraingredients-usa.com)
818 healthy people ages 50 to 75 took either 800 micrograms of folic acid/day or placebo for 3 years in a new Dutch dementia study, the abstract is below. (drjohnlapuma.com)
200 pmol/L at screening, recruited from municipal and blood bank registries in the Netherlands were randomized to receive 800 microgram/day folic acid as an oral supplement or placebo for 3 years. (drjohnlapuma.com)
1] Eventually, two large trials in which women were randomly assigned to take folic acid or a placebo showed that getting too little folate increased a woman's chances of having a baby with spina bifida or anencephaly and that getting enough folate could greatly reduce the incidence of these birth defects. (harvard.edu)

And the message of that finding has spread so thoroughly that prenatal folic acid supplementation is as much a matter of public awareness as it is of public health policy. (nutritionaloutlook.com)

There are conflicting findings about the potential benefit or harm of taking folic acid plus vitamin B6 and vitamin B12 following angioplasty. (naturalmedicinejournal.com)

Maternal folic acid (FA) ingestion during the periconceptional period has been found to decrease the risk of giving birth to an infant with a NTD [ 3 , 4 , 5 , 6 ]. (cdc.gov)

Folic acid is a synthetic form of folate, a B vitamin that is involved in many processes in the body, especially in the production and maintenance of healthy blood cells, DNA synthesis, and cell division. (readonline.blog)
Folic acid is a man-made form of folate, a B vitamin that is naturally found in some foods, especially green leafy vegetables, beans, nuts, seeds, and fortified cereals. (readonline.blog)

However, a large number of relative studies could prove the influence of folate on the homocysteine concentration of plasma which is considered a risk factor for cardiovascular diseases. (thieme-connect.de)
It was, for instance, not possible to find out whether an increased homocysteine concentration contributes to the pathogenesis of atherosclerosis or whether it denotes an indirect risk factor for cardiovascular diseases such as a folic-acid deficiency. (thieme-connect.de)

The aims of this study were to evaluate nutritional status for macronutrients and folic acid in members of a high-performance handball team, and determine the effect of a nutritional intervention with folic acid supplementation and education. (biomedcentral.com)
Nutritional, laboratory and physical activity variables were recorded at baseline (Week 0), after 2 months of dietary supplementation with 200 μg folic acid (50% of the recommended daily allowance) (Week 8) and after 2 months without supplementation (Week 16). (biomedcentral.com)
however, whether this mutation alone can lead to cerebrovascular events or whether it requires additional environmental or nutritional lack of folic acid to cause symptomatic homocysteinemia is unclear. (medscape.com)

A low-dose (400 microg/d) rather than a high-dose of folic acid supplementation may be sufficient to reduce plasma homocysteine concentration in hyperhomocysteinemic patients with CAD. (nutraingredients-usa.com)
A recent study conducted by researchers from Johns Hopkins University (Baltimore, MD), Duke University (Durham, NC) and Stanford University (Palo Alto, CA) investigated the immune-health effects of vitamin D supplementation in 40 patients with MS.(4) The study also evaluated the tolerability of a low dose versus a high dose of vitamin D in these patients. (nutritionaloutlook.com)

The new study, published in the journal Nutrition Research (Vol. 26, pp. 460-466), reports that even a low-dose folic acid supplement (400 micrograms) could lead to significant reductions in hyperhomocysteinemic elderly people. (nutraingredients-usa.com)
That is why women of childbearing age are urged to take extra folic acid as a supplement. (harvard.edu)

Betaine supplementation has a lowering effect on post-methionine load tHcy. (nih.gov)

Folic acid is necessary for the proper growth and development of the fetus. (encyclopedia.com)
When there is too much homocysteine in the blood it can cause damage to the vascular system, which in turn may lead to increases in blood pressure, vascular abnormalities in the mother and fetus, and ultimately preeclampsia. (mthfrsupport.com.au)

At baseline and end of the intervention, anthropometric, dietary and biochemical parameters (plasma homocysteine [Hcy], serum and red blood cell folate) were recorded. (nih.gov)
The dietary requirement for niacin and the niacin coenzyme , nicotinamide adenine dinucleotide (NAD), can be also met, though to a fairly limited extent, by the catabolism of the essential amino acid tryptophan in the tryptophan-kynurenine pathway ( Figure 2 ). (oregonstate.edu)

Clinically, many naturopathic and other doctors recommend the use of vitamin B complex 50 mg per day with additional folic acid 800 to 1,000 mcg per day to try to prevent miscarriage (also known as spontaneous abortion). (healthyplace.com)
Daily consumption of 1,000 mcg of folic acid for three or more months has resulted in improved cervical cells upon repeat Pap smears. (encyclopedia.com)

There was no effect on plasma lipids or uric acid, but there was a lower glucose and insulin peak concentration after consumption of the FVPD compared with the sugar-matched control. (cambridge.org)
"The significant result of this study was that a low dose of folic acid supplementation (400 microg/d) could significantly decrease plasma homocysteine concentration in hyperhomocysteinemic patients with CAD but not in normohomocysteinemia patients," wrote the researchers. (nutraingredients-usa.com)
It was discovered that folic acid can lower the homocysteine concentration. (thieme-connect.de)

Folic acid itself is not biologically active, but its biological importance is due to tetrahydrofolate and other derivatives after its conversion from dihydrofolic acid in the liver. (medscape.com)

Folic acid deficiency can cause megaloblastic anemia, a condition characterized by large and immature red blood cells that cannot function properly. (readonline.blog)

This is why sufficient daily intake of folic acid is necessary. (encyclopedia.com)
You should also balance your intake of folic acid with other nutrients, such as vitamin B12, vitamin C, iron, and zinc, to support your overall health and wellness. (readonline.blog)

Probable benefits of increasing folic acid intakes. (thieme-connect.de)

Animal foods, with the exception of liver, are poor sources of folic acid. (healthyplace.com)
Subsequently, the liver turns fatty acid to ketone bodies for fuel, a process known as ketosis, which causes Ketonemia (high ketone level in the blood) that decreases the blood's pH, leading to DKA. (wikipedia.org)
It increases the appetite and stimulates the production of stomach acid for digestion and it aids in maintaining a healthy liver. (encyclopedia.com)
Folic acid is mainly absorbed in the small intestine and converted into its active form, 5-methyltetrahydrofolate (5-MTHF), in the liver and other tissues. (readonline.blog)

Plasma homocysteine as a risk factor for cardiovascular disease: The European Concerted Action Project. (thieme-connect.de)
A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. (thieme-connect.de)
Homocysteine and risk of ischemic heart disease and stroke. (thieme-connect.de)
An elevated blood level of the amino acid homocysteine has been identified as a risk factor for some of these diseases. (encyclopedia.com)
Using large amounts of folic acid (e.g., over 5,000 mcg per day) can mask a vitamin B 12 deficiency and thereby risk of irreversible nerve damage. (encyclopedia.com)
Relative risk (RR) was used as a measure of the effect of folic acid supplementation on the risk of stroke with a random effect model. (johnshopkins.edu)
Folic acid deficiency can be associated with increased depression risk and reduced response to antidepressant treatment. (readonline.blog)
Elevated hs-CRP and homocysteine represent raised cardiovascular risk. (bvsalud.org)
Although stroke can have many causes and no one measure is a complete safeguard, folate, or the supplemental form folic acid, have been recommended for use to reduce the risk. (globalhealing.com)
A Harvard Medical School trial of women with a risk of age-related macular degeneration (AMD) explored the impact of B vitamin therapy (including folic acid, vitamin B6, and B12). (globalhealing.com)
Researchers concluded that daily supplementation might help the fight in reducing the risk of AMD. (globalhealing.com)
current evidence does not support claims that folate supplementation increases or reduces the risk of various cancers. (msdmanuals.com)
Periconceptional folic acid supplementation has been shown to decrease the risk of NTDs. (who.int)
Additionally, we investigated whether the risk would be greater in women who failed to ingest the recommended amount of folic acid. (cdc.gov)

Folic acid supplementation spares betaine as a methyl donor. (nih.gov)

Homocysteinemia, a separate but related entity, is defined as elevation of the homocysteine level in blood. (medscape.com)
Folic acid also works closely together with vitamin B12 to regulate the formation of red blood cells and to help iron function properly in the body. (healthyplace.com)
And also venous blood investigation for electrolytes, glucose, and acid-base status. (wikipedia.org)
A deficiency of folic acid may lead to anemia, in which there is decreased production of red blood cells. (encyclopedia.com)
Others have found this combination supplementation to increase restenosis (reoccurrence of narrowing of a blood vessel). (naturalmedicinejournal.com)
Homocysteine functions to maintain blood vessels, being a vital intermediate molecule in the creation of primary methyl donors. (mthfrsupport.com.au)
Folic acid can help prevent anemia by supporting the production and maturation of red blood cells, which carry oxygen throughout the body. (readonline.blog)
The nicotinic acid form reduces blood cholesterol, while niacinamide is helpful for arthritis and early onset type 1 diabetes. (sanescohealth.com)

As mentioned, pregnant women who are deficient in folic acid are more likely to have children with birth defects. (healthyplace.com)

Anatomy3

Diseases15

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes16

Technology, Industry, Agriculture7

Named Groups1

Health Care10

Concentrations16

Reduce homocysteine levels1

Vitamins24

Fortification13

Metabolism12

Lower homocysteine levels2

Hyperhomocysteinemia7

Levels57

Coronary artery1

Amino acids4

Pregnancy17

Supplements8

Combination of folic acid4

Converting homocysteine into methionine2

Prevention8

Neural7

Increased homocysteine level1

Conversion of homocysteine3

MTHFR2

Placebo6

Prenatal1

Vitamin B6 and vitamin1

Maternal1

Form of folate2

Cardiovascular diseases2

Nutritional3

High-dose2

Supplement2

Methionine load1

Fetus2

Dietary2

1,000 mcg2

Concentration3

Biologically active1

Deficiency can cause1

Intake2

Intakes1

Liver4

Risk14

Methyl donor1

Blood8

Birth defects1