Loading...
  • therapies
  • Now the institute has a more immediate goal: boosting therapies that are much further along in development and more often rely on less glamorous adult stem cells. (spokesman.com)
  • Here, we critically review the state of art about mesenchymal stem cell role in myelodysplastic syndromes and acute myeloid leukemia, focusing on immune escaping mechanisms as a target for available and future anticancer therapies. (hindawi.com)
  • Employees from the university and Novo Nordisk will be working here on deriving the cell lines that are expected to define a new quality standard in production of stem cell-based therapies, reports the company. (hollandbio.nl)
  • Our collaboration with UCSF is also expected to accelerate current and future partnerships to develop stem cell-based therapies for treatment of other serious chronic diseases", said Mads Krogsgaard Thomsen, executive vice president and chief science officer of Novo Nordisk. (hollandbio.nl)
  • Novo Nordisk has an ambition to pursue further collaborations to develop stem cell-based therapies for other serious chronic diseases. (hollandbio.nl)
  • Longeveron LLC, a biopharmaceutical company that develops stem cell therapies for age-related diseases, is currently seeking up to 30 participants for the randomized, placebo-controlled, doubled-blinded trial. (miamijewishhealth.org)
  • These cells genetically matched the donor organism from which they came.This gives them the ability to create patient specific pluripotent cells, which could then be used in therapies or disease research. (wikipedia.org)
  • This self-regeneration capacity gives rise to alternatives to classical cellular therapies whereby administration of growth factors such as Thymosin β4 for cell activation and migration are solely necessary. (wikipedia.org)
  • After selling Centocor to Johnson and Johnson for $5.2 billion in 1999, Schoemaker went on to form Neuronyx, Inc., a biotech company focused on developing cellular therapies. (wikipedia.org)
  • treatments
  • If we went 10 years and had no clinical treatments, it would be a failure," said the institute's director, Alan Trounson, a stem cell pioneer from Australia. (spokesman.com)
  • At CIRM, we never forget that we were created by the people of California to accelerate stem cell treatments to patients with unmet medical needs, and act with a sense of urgency to succeed in that mission. (ca.gov)
  • For example, through partnerships with the Swedish biotech company Biolamina and Lund University, activities have been initiated to develop stem cell-based treatments for Parkinson's disease. (hollandbio.nl)
  • Gearhart notes that such experiments are already under way and that some people see them as a necessary step toward using human stem cells as treatments to replace or repair brain cells lost in conditions like Parkinson s disease or Lou Gehrig s disease. (innovations-report.com)
  • Yet further treatments using stem cells could potentially be developed due to their ability to repair extensive tissue damage. (wikipedia.org)
  • Injection of cardiomyogenic and/or angiogenic stem cells have been proposed as alternatives to existing treatments. (wikipedia.org)
  • Hua Eleanor Yu and her group are studying the involvement of STAT3 with cancer cells and the immune system, and developing possible drug treatments to attack tumor cells. (wikipedia.org)
  • Taking genomic sequences of these individual cells would allow for patient-specific treatments and furthering understanding of AD disease models. (wikipedia.org)
  • iPSCs
  • In addition to circumventing ethical and moral disputes associated with the use of blastocyst-derived embryonic stem cells (ESCs), iPSCs provide new perspectives for personalised medicine in the future. (europeanpharmaceuticalreview.com)
  • Further chemical analyses to develop safer drugs can be done through sequence information and cell-culture tests on iPSCs. (wikipedia.org)
  • regeneration
  • The exact role of microglia cells in the regeneration after a stroke is not entirely clear, but we do know that pericytes play an important role in protecting the brain against disease and injury. (medicalxpress.com)
  • MoTP is a useful tool for elucidating melanocyte stem cell regeneration, recruitment and. (focusbiomolecules.com)
  • Moreover, the results suggested strongly a potential ability of these cells to regenerate the arteries of the heart (called coronary arteries), and this regeneration improved the mechanical function of the heart, improving the heart failure condition of these patients. (innovations-report.com)
  • These results confirmed that pleiotrophin induces stem cell regeneration following injury," said Chute. (innovations-report.com)
  • Furthermore, there are vast developments in tissue engineering, which involve leveraging of technologies from biomaterials, molecular medicine, biochemistry, nanotechnology, genetic and biomedical engineering for regeneration and cell expansion targets to restructure and/or repair human organs. (wikipedia.org)
  • Persistent activation of the p38 MAPK pathway in muscle satellite cells (muscle stem cells) due to ageing, impairs muscle regeneration. (wikipedia.org)
  • clinical
  • MIAMI - A clinical trial for a sophisticated stem cell therapy for Alzheimer's patients will soon be underway at Miami Jewish Health. (miamijewishhealth.org)
  • Most of the existing clinical trials attempt to address these proteins without having a way to replace or rejuvenate damaged cells. (miamijewishhealth.org)
  • This clinical trial attempts to replace the cells themselves and holds the promise for rebuilding what was damaged. (miamijewishhealth.org)
  • The Duke team is already conducting further experiments to determine if pleiotrophin is necessary for normal stem cell growth and development, and Chute says it will be important to conduct additional animal studies before moving into human clinical trials. (innovations-report.com)
  • In early 2009, the FDA approved the first human clinical trials using embryonic stem cells. (wikipedia.org)
  • Moustapha Kassem is a co-founder of Stem Cell Treatment Center at Odense University Hospital (OUH), where stem cell therapy is being introduced into clinical practice and PhD graduate school of Stem Cells and Related Technologies. (wikipedia.org)
  • tissue
  • This new stem cell will be able to make personalized replacement tissue which will not have rejection problems from the body's immune system. (blogspot.com)
  • The team then used gene therapy to insert the correct laminin gene into the growing cells and grafted the new tissue onto the patient's body. (innovations-report.com)
  • Adult stem cells are generally limited to differentiating into different cell types of their tissue of origin. (wikipedia.org)
  • Her work focused on using pluripotent stem cells to create lung epithelial tissue in mice, and examining the potential effects of these results in human medicine. (wikipedia.org)
  • Subcutaneous adipose tissue is also a source of mesenchymal stem cells and have demonstrated positive outcomes in terms of cardiovascular tissue remodeling. (wikipedia.org)
  • However, cardiac remodling remains limited due to limited cell residency, impact of mechanical forces onto cell survival and tissue hypoxia. (wikipedia.org)
  • Once these MSCs are ready for re-implanation, they are usually transferred with growth factors to allow for continued cell growth and engraftment to the damaged tissue. (wikipedia.org)
  • tumor cells
  • Hendrix and colleagues discovered that metastatic tumor cells do not express Lefty, allowing them to overproduce Nodal in an unregulated manner. (innovations-report.com)
  • However, when the group exposed metastatic tumor cells to the microenvironment of hESCs containing Lefty, they witnessed dramatically reduced Nodal expression (production) in these cancer cells together with decreased tumor cell growth and invasiveness and an increase in apoptosis, or programmed cell suicide. (innovations-report.com)
  • This methylation damages the DNA and triggers the death of tumor cells. (wikipedia.org)
  • organs
  • Washed off cells reach other organs or die, which can be an issue at the time of prepare ICH module 8. (wikipedia.org)
  • cancer
  • Then she administered an anti-cancer agent that the cells converted into a highly toxic drug. (spokesman.com)
  • It is concentrating its vast financial resources on projects that could cure conditions such as age-related macular degeneration, AIDS, sickle cell disease and various types of cancer. (spokesman.com)
  • Tumor Angiogenesis: A Focus on the Role of Cancer Stem Cells, Physiologic and Pathologic Angiogenesis Dan Simionescu, IntechOpen, DOI: 10.5772/66402. (intechopen.com)
  • In addition, it has not been completely elucidated whether cancer-associated MSCs belong primarily to the abnormal clone or emerge after leukemic stem cell induced environmental damage. (hindawi.com)
  • Single cell analysis plays an important role in risk management related to organ transplants, cancer, heart failure, renal diseases, and infectious disease testing by performing fast, accurate, and effective tests. (apnews.com)
  • Inhibits growth and/or proliferation in a variety of cancer cells.2 PD 325901 enhances self-renewal of embryonic stem cells. (focusbiomolecules.com)
  • During cancer progression, malignant cells also receive and release signals from their microenvironment, cues that promote tumor growth and metastasis. (innovations-report.com)
  • Although exposure to a hESC microenvironment inhibited Nodal expression and tumor growth in both metastatic melanoma and breast cancer cells, the breast cancer cells underwent more complex reprogramming. (innovations-report.com)
  • Melanoma cells responded to the hESC-derived factors within three days, but breast cancer cells required two additional days to achieve the most significant reduction in Nodal. (innovations-report.com)
  • Yet, despite the inherent differences between melanoma cells and breast cancer cells, these divergent tumor types both underwent cell suicide following exposure to the hESC microenvironment. (innovations-report.com)
  • The cancer stem cell technologies on which OncoMed depends are licensed from the University of Michigan where they were developed by the founders of the company. (wikipedia.org)
  • however, Stemline and Verastem remain the only two competitors solely focused on cancer stem cells. (wikipedia.org)
  • One analyst holds that OncoMed is the best positioned of the three companies focused on the cancer stem cell area. (wikipedia.org)
  • Gerd Pfeifer was able to prove a definitive link between smoking and lung cancer, by demonstrating genetic damage in lung cells, caused by a chemical in cigarette smoke. (wikipedia.org)
  • Professor Visvader has published work considering the role of Cells of Origin in Cancer and in particular focuses on the role of stem cells which she believes may be a key to understanding breast cancer. (wikipedia.org)
  • immune system
  • Furthermore, the immune system, both adaptive and innate, encompassing mesenchymal-derived cells, has been shown to take part to the leukemic niche. (hindawi.com)
  • and ThymiStem , a program to develop stem cell approaches to boosting the immune system by repairing the thymus, a key organ for producing important immune cells. (ku.dk)
  • In Type-1 diabetes, the immune system kills the beta cells, while in Type-2 diabetes, insulin sensitivity decreases making the body require more and more insulin, which the beta cells are unable to provide, eventually leading to beta cell failure. (ku.dk)
  • Together with Cornell University, Novo Nordisk has also made progress in developing an encapsulation device that will protect the beta cells that are transplanted into patients from attack by the immune system. (hollandbio.nl)
  • Groundbreaking work by Hendrix and colleagues is elucidating how, by becoming more like unspecialized stem cells, aggressive melanoma cells gain enhanced abilities to migrate, invade and metastasize while remaining virtually undetected by the immune system. (innovations-report.com)
  • Because the cells would be from the patient s own body, his or her immune system wouldn t reject them. (innovations-report.com)
  • The resulting cells would be genetically identical to the somatic cell donor, thus avoiding any complications from immune system rejection. (wikipedia.org)
  • genetically
  • Their goal is to take blood stem cells from people with cystinosis, genetically-modify them to remove the mutation that causes the disease, then return them to the patient. (ca.gov)
  • They also experimented with genetically modified mesoangioblasts, restoring healthy versions of alpha sarcoglycan gene to the cells. (innovations-report.com)
  • cardiac stem
  • Recent studies[citation needed] have suggested that mammal hearts also host naturally occurring cardiac stem cells which are capable of differentiating themselves into cardiomyocytes, endothelial cells and cardiac fibroblasts. (wikipedia.org)
  • After a year in Louisville in the lab of prof. Bolli, focusing on cardiac stem cell treatment, he became a staff cardiologist at the UMC Utrecht. (wikipedia.org)
  • 1998
  • In 1998, her work helped lead to the discovery of the trophoblast stem cell, which has assisted in showing how congenital anomalies in the heart, blood vessels, and placenta can occur. (wikipedia.org)
  • researcher
  • He was the first researcher to use RNA to block the progress of the virus that causes HIV/Aids by degrading the HIV virus within infected cells. (wikipedia.org)
  • molecular
  • Single cell analytics helps assess cellular heterogeneity and aids in analysis of pathways and processes at a molecular level. (apnews.com)
  • methylation patterns
  • Various alterations in cell adhesion, metabolism, cytokine signaling, autophagy, and methylation patterns of tumor-derived mesenchymal stem cells have been demonstrated, contributing to the genesis of a leukemic permissive niche. (hindawi.com)
  • Stem cell epigenomic studies are also looking into DNA methylation patterns, specifically characteristics of hydroxy methylation versus overall methylation and the difference between methylation of CpG-island rich and CpG poor promoters. (wikipedia.org)
  • gene expression
  • Arrayit Pathways™ Focused Human Genome Microarrays enable targeted gene expression analysis of every major cellular pathway in the human body. (arrayit.com)
  • In 1999 he was awarded the Otto Hahn Medal of the Max Planck Society for his Ph.D. thesis on endothelial cell specific gene expression. (wikipedia.org)