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Epilepsy, Temporal LobeTemporal LobeSclerosisMagnetic Resonance ImagingAnterior Temporal LobectomyElectroencephalographyHippocampusFrontal LobePilocarpineAtrophyPsychosurgeryParahippocampal GyrusEpilepsy, Complex PartialFunctional LateralityBrain MappingDominance, CerebralFocal AdhesionsNeuropsychological TestsMemoryAmnesiaSeizuresBrainImage Processing, Computer-AssistedEpilepsyMemory DisordersStatus EpilepticusEpilepsy, Frontal LobeEntorhinal CortexAnomiaEpilepsies, PartialParietal LobeAutomatismOccipital LobeMental RecallRecognition (Psychology)AmygdalaDentate GyrusSeizures, FebrileCerebral CortexNeurosurgical ProceduresAnticonvulsantsOptic Lobe, NonmammalianNeural PathwaysNerve NetBrain DiseasesMossy Fibers, HippocampalLimbic SystemTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonNamesSemanticsKainic AcidTechnetium Tc 99m ExametazimeElectrodes, ImplantedAnalysis of VarianceAlzheimer DiseaseMemory, EpisodicAutobiography as TopicAmobarbitalCognition DisordersNeuronsProsopagnosiaAmnesia, RetrogradeFrontotemporal Lobar DegenerationEpilepsy, Tonic-ClonicVideo RecordingVerbal LearningLanguagePhotic StimulationGangliogliomaDelirium, Dementia, Amnestic, Cognitive DisordersFaceReaction TimeDisease Models, AnimalGlomerulosclerosis, Focal SegmentalDiffusion Tensor ImagingConvulsantsTime FactorsBrain Damage, ChronicImage Interpretation, Computer-AssistedLimbic EncephalitisPattern Recognition, VisualAmnesia, AnterogradeAnisotropyKluver-Bucy SyndromeTomography, X-Ray ComputedOximesFocal InfectionSchizophreniaThalamusCreatineDiffusion Magnetic Resonance ImagingVerbal BehaviorEpilepsy, GeneralizedAphasiaAssociation LearningCerebrovascular CirculationKindling, NeurologicMemory, Short-TermNeocortex
SeizureMesialPatients with temporalTonic-clonic sMedicallyMedialLeft temporalDrug-resistantFrontal lobeHippocampusEpilepsiesCause temporal lobe epiNeurologyAtrophyCortical dysplasiaLateralLobectomyOnsetNeocorticalPosteriorPsychiatricOccipital lobeComplex partialPartial seizuresBrainParietalILAEAbnormalitiesResectionBehavioralEpilepsiaImpairmentOccurCEREBRAL CORTEXNeurologicalRefractory epilepsyClinicalMedicationsShows focalElectrographic
Seizure34
  • Medically intractable temporal lobe epilepsy is amenable to epilepsy surgery with a very high seizure-free rate. (medscape.com)
  • Seizure symptoms and behavior distinguish seizures arising from the medial temporal lobe from seizures arising from the lateral (neocortical) temporal lobe. (wikipedia.org)
  • A focal impaired awareness temporal lobe seizure occurs if a person becomes unaware during any part of the seizure. (wikipedia.org)
  • A dystonic posture on one side of the body commonly indicates seizure onset from the opposite side of the brain e.g. right arm dystonic posture arising from a left temporal lobe seizure. (wikipedia.org)
  • In comparison to mesial temporal lobe seizures, lateral temporal lobe seizures are briefer duration seizures, occur with earlier loss of awareness, and are more likely become a focal to bilateral tonic-clonic seizure. (wikipedia.org)
  • People with focal, awareness impaired seizures may or may not remember any or all of the symptoms or events during the seizure. (medlineplus.gov)
  • This may be associated with autonomic phenomena and anxiety similar to those observed in the simple partial (focal aware) phase of a temporal lobe seizure. (medscape.com)
  • Seizure outcome after temporal lobectomy for temporal lobe epilepsy: a Kaplan-Meier survival analysis. (medscape.com)
  • Trans-middle temporal gyrus selective amygdalohippocampectomy for medically intractable mesial temporal lobe epilepsy in adults: Seizure response rates, complications, and neuropsychological outcomes. (medscape.com)
  • If someone stays aware during a seizure, it is called a focal onset aware seizure (formerly called a simple partial seizure ). (teenshealth.org)
  • If someone loses awareness during the seizure, it is called a focal onset impaired awareness seizure (formerly called a complex partial seizure ). (teenshealth.org)
  • Someone having a focal onset impaired awareness seizure may stare, rub their hands, or smack their lips. (teenshealth.org)
  • Sometimes a focal seizure can develop (or generalize ) into a seizure that involves both sides of the brain. (teenshealth.org)
  • This is called a focal to bilateral tonic-clonic seizure . (teenshealth.org)
  • People may mistake a person having a focal seizure as daydreaming or staring off into the distance. (webmd.com)
  • Once the temporal lobe seizure ends, you may find yourself feeling confused. (webmd.com)
  • A temporal lobe seizure can become a more serious tonic-clonic (or grand mal) seizure that causes convulsions and makes you lose consciousness. (webmd.com)
  • History was relevant for medically intractable focal epilepsy with multiple seizure types since early adolescence. (psychiatrist.com)
  • The 2 main categories of epileptic seizures are focal (partial) seizure and generalized seizure. (hopkinsmedicine.org)
  • Before a focal seizure, your child may have an aura, or signs that a seizure is about to occur. (hopkinsmedicine.org)
  • This is more common with a complex focal seizure. (hopkinsmedicine.org)
  • Complex focal seizure. (hopkinsmedicine.org)
  • This type of seizure often occurs in the area of the brain that controls emotion and memory function (temporal lobe). (hopkinsmedicine.org)
  • The patients had electrodes temporarily implanted into their temporal lobes so that doctors could observe the focal point of a seizure. (beforeitsnews.com)
  • Using EEG technology, researchers were able to detect pathological brain activity associated with seizures up to thirty minutes before a seizure occurred in patients with temporal lobe epilepsy. (neurosciencenews.com)
  • To distinguish these pro-ictal states, Pati's team studied a prospective, consecutive series of 15 patients with temporal lobe epilepsy who underwent limbic thalamic recordings in addition to routine intracranial EEG for seizure localization. (neurosciencenews.com)
  • The researchers were able to detect pro-ictal states in patients with temporal lobe epilepsy at least 35 minutes before seizure onset. (neurosciencenews.com)
  • Temporal lobe epilepsy is the most common seizure disorder, affecting some 50 million people globally. (neurosciencenews.com)
  • Narrow-spectrum AEDs usually work more effectively for a specific type of seizure, such as focal seizures . (medicalnewstoday.com)
  • Doctors use this drug widely in both children and adults to treat focal or partial seizures, generalized tonic-clonic seizures, and mixed seizure types. (medicalnewstoday.com)
  • In a blinded, randomized, placebo-controlled pre-clinical trial, the EKC lentivector robustly reduced seizure frequency in a male rat model of focal neocortical epilepsy characterized by discrete spontaneous seizures. (ucl.ac.uk)
  • For example, patients with temporal lobe epilepsy, where there is agreement between EEG findings and a structural abnormality on an MRI, can have up to an 80% chance of seizure freedom with surgery. (efmn.org)
  • In another study looking at early epilepsy surgery versus medication therapy for mesial temporal lobe epilepsy (MTLE), 11 of 15 in the surgery group compared to 0 of 23 in the medical group were seizure-free at their two-year follow-up. (efmn.org)
  • 24 hours, lethargy, or change in personality) or ataxia, AND have 1 or more of the following: fever (T38C), seizure(s), focal neurologic findings, CSF pleocytosis, abnormal EEG or neuroimaging study. (cdc.gov)
Mesial9
Patients with temporal6
Tonic-clonic s2
Medically5
  • The "Natural" History of Medically Treated Temporal Lobe Epilepsy: What Can an Evidence-Based Approach Tell Us? (hindawi.com)
  • We systematically reviewed the literature to describe the "natural" history of medically treated temporal lobe epilepsy (TLE). (hindawi.com)
  • Temporal lobe epilepsy (TLE) is the most frequent medically refractory epilepsy syndrome seen in epilepsy outpatient clinics. (hindawi.com)
  • 3 The clinical picture may be further complicated by epilepsy patients who undergo temporal lobectomy for medically intractable seizures, with reports of at-risk patients developing de novo psychosis or deterioration of psychiatric illness in the literature. (psychiatrist.com)
  • 4,5 Our case presents a medically complex patient with multiple risk factors, presenting with psychotic symptoms in the context of TLE with right temporal lobectomy. (psychiatrist.com)
Medial4
  • Temporal lobe epilepsy (TLE) was defined in 1985 by the International League Against Epilepsy (ILAE) as a condition characterized by recurrent, unprovoked seizures originating from the medial or lateral temporal lobe. (medscape.com)
  • Investigations of memory in rats and nonhuman primates have demonstrated functional specialization within the medial temporal lobe (MTL), a set of heavily interconnected structures including the hippocampal formation and underlying entorhinal, perirhinal, and parahippocampal cortices. (jneurosci.org)
  • Current theories of medial temporal lobe (MTL) memory organization are in conflict regarding two major issues. (jneurosci.org)
  • In chronic traumatic encephalopathy, the spectrum of hyperphosphorylated tau pathology ranged in severity from focal perivascular epicentres of neurofibrillary tangles in the frontal neocortex to severe tauopathy affecting widespread brain regions, including the medial temporal lobe, thereby allowing a progressive staging of pathology from stages I-IV. (nih.gov)
Left temporal4
  • During the video EEG the typical epileptic activity was registered in the left temporal lobe. (neurolrc.ru)
  • The cortical surface electrodes were implanted over the left temporal lobe for a neurophysiologic monitoring. (neurolrc.ru)
  • Preservation of calculation skills in the face of total language dissolution (production and comprehension) has been reported with focal left temporal lobe atrophy probably as a result of PickпїЅs disease anxiety symptoms duration [url=http://www.hardenfoundation.org/cheap-med/phenergan/]cheap 25 mg phenergan mastercard[/url]. (ehd.org)
  • Left temporal atrophy was the primary predictor of auditory/verbal memory (partial r 's = 0.55-0.61), and both left and right temporal atrophy predicted visual/spatial memory performance (partial r 's = 0.51-0.67). (ajnr.org)
Drug-resistant6
  • NRTX-1001 is an inhibitory neuron cell therapy derived from human embryonic stem cells (hESCs) for the prospective treatment of drug-resistant focal epilepsy (MTLE). (ca.gov)
  • Transplantation of inhibitory neuron cell therapy is a novel therapeutic strategy that has shown promise in preclinical studies and could potentially provide a non-tissue-destructive therapeutic option for suppressing seizures in people with drug-resistant focal epilepsy. (ca.gov)
  • Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial. (medscape.com)
  • The objective of this study was to characterize temporal and - spectral patterns of ANT ictal recruitment in drug-resistant temporal lobe epilepsy (TLE). (biorxiv.org)
  • Inactivating this nerve-cell population also induces the same cognitive losses that characterize chronic, drug-resistant temporal lobe epilepsy in humans, the scientists found. (sciencedaily.com)
  • Drug-resistant epilepsy is often focal, including Temporal lobe epilepsy (TLE). (lu.se)
Frontal lobe3
  • Frontal lobe complex partial seizures (focal impaired awareness seizures) have certain distinct characteristics. (medscape.com)
  • Models predicting learning consistency retained frontal lobe atrophy measures (partial r 's = 0.44-0.68). (ajnr.org)
  • In families with an inherited frontal lobe dementia (some of which have been found to be pathologically or clinically indistinguishable from Pick disease), linkage to markers on chromosomes 17, 9, and 3 have been reported. (medscape.com)
Hippocampus3
Epilepsies4
  • Under the International League Against Epilepsy (ILAE) 2017 classification of the epilepsies, focal onset epilepsy occurs from seizures arising from a biological neural network within a single cerebral hemisphere. (wikipedia.org)
  • Prospective, population-based studies were limited to those recruiting only childhood-onset TLE or those reporting TLE as a subgroup of cohorts of focal epilepsies. (hindawi.com)
  • Past studies of continuous electroencephalography (EEG)-the measurement and recording of electrical activity in different parts of the brain-have suggested that seizures in people with focal-onset epilepsies tend to occur during periods of heightened risk, represented by pathologic brain activities known as "pro-ictal states. (neurosciencenews.com)
  • Across all epilepsies (vs. controls) robust changes in the corpus medullare and posterior lobe "non-motor" regions were observed, with maximal differences in bilateral VIIB and Crus II lobules. (bvsalud.org)
Cause temporal lobe epi2
Neurology1
Atrophy2
  • MR imaging generated measures of lesion burden (fluid-attenuated inversion recovery hyperintense volume), general atrophy (brain parenchymal fraction), central atrophy (lateral ventricle volume), and lobar atrophy (regional brain parenchymal fraction of frontal, temporal, parietal, and occipital lobes in each hemisphere). (ajnr.org)
  • Primary progressive aphasia is a focal atrophy syndrome that may be associated with Pick disease, Alzheimer disease, or other pathology. (medscape.com)
Cortical dysplasia2
Lateral4
Lobectomy1
  • This was followed by a right temporal lobectomy with amygdalohippocampectomy once the patient reached adulthood. (psychiatrist.com)
Onset2
  • Temporal lobe epilepsy is the most common type of focal onset epilepsy among adults. (wikipedia.org)
  • In contrast, inactivating these cells, known to neuroscientists as mossy cells, facilitates the spread throughout the brain of the electrical hyperactivity initially localized at a seizure's onset, causing the full-blown behavioral symptoms of temporal lobe epilepsy. (sciencedaily.com)
Neocortical1
  • A randomized, blinded pre-clinical study demonstrated therapeutic effectiveness in a rodent model of focal neocortical epilepsy. (ucl.ac.uk)
Posterior9
  • MRI scan showed the moderate cortical thickening, presumably FCD, in the posterior compartment of middle temporal gyrus correlated with EEG data. (neurolrc.ru)
  • Impairment of number processing is common with focal and diffuse brain disease and is typically associated with left posterior lesions. (bmj.com)
  • Third, the visual Arabic system would involve the inferior temporo-occipital cortex and the posterior superior parietal lobes. (bmj.com)
  • the EEG shows rhythmic theta activity over the right posterior temporal region and rhythmic epileptic activity from the right temporal to right fronto-central regions, concomitant with the appearance of convergent strabismus due to adduction of the right eye without conjugate left eye abduction (right arrow). (jle.com)
  • Maximum volume loss was observed in the corpus medullare ( d max =0.49) and posterior lobe grey matter regions, including bilateral lobules VIIB ( d max = 0.47), Crus I/II ( d max = 0.39), VIIIA ( d max =0.45) and VIIIB ( d max =0.40). (bvsalud.org)
  • Findings were most pronounced in TLE-HS and ETLE with distinct neuroanatomical profiles observed in the posterior lobe. (bvsalud.org)
  • Phenytoin treatment was associated with reduced posterior lobe volume. (bvsalud.org)
  • Significance: We provide robust evidence of deep cerebellar and posterior lobe subregional grey matter volume loss in patients with chronic epilepsy. (bvsalud.org)
  • Volume loss was maximal for posterior subregions implicated in non-motor functions, relative to motor regions of both the anterior and posterior lobe. (bvsalud.org)
Psychiatric2
Occipital lobe2
Complex partial2
Partial seizures1
  • Epileptiform discharges help clinicians to separate generalized from focal (ie, partial) seizures. (medscape.com)
Brain18
Parietal1
ILAE1
Abnormalities2
  • Multiple electroencephalography scans including stereoelectroencephalography had been performed, with multifocal abnormalities noted to be originating independently from both temporal lobes. (psychiatrist.com)
  • Magnetic resonance imaging findings show the characteristic abnormalities of edema and/or abnormal enhancement in one or both temporal and frontal lobes, the insular cortex, and the angular gyrus. (orpha.net)
Resection1
  • Afterwards the focal cortical resection in the middle temporal gyrus was performed without postoperative deterioration of speech and memory functions. (neurolrc.ru)
Behavioral1
Epilepsia1
  • La displasia cortical focal en el lóbulo temporal se asocia a EPILEPSIA DEL LÓBULO TEMPORAL. (bvsalud.org)
Impairment2
  • Damage following open head injuries tends to be focal, not diffuse, and the implications for subsequent impairment tend, also, to be focal and limited. (brainline.org)
  • Unlike Alzheimer disease, which typically presents with impairment of recent memory associated with entorhinal cortex and hippocampal dysfunction, Pick disease typically affects the frontal and/or anterolateral temporal lobes. (medscape.com)
Occur1
  • Seizures with focal low-frequency electrographic correlates: These patterns may occur at 1-1.5 Hz frequency and are generally seen in severe cerebral insults, such as severe hypoxic-ischemic encephalopathy. (medscape.com)
CEREBRAL CORTEX1
Neurological1
  • You should get an evaluation from a doctor if you suspect that temporal seizures or other neurological issues may be causing your feelings of déjà vu. (webmd.com)
Refractory epilepsy1
  • In individuals with refractory epilepsy, particularly focal epilepsy, surgical evaluation should be considered early. (efmn.org)
Clinical3
  • We present the clinical case of successful surgical treatment of patient with epilepsy due to FCD located in the dominant temporal lobe. (neurolrc.ru)
  • Clinical diagnosis is suggested in the encephalopathic, febrile patient with focal neurologic signs. (nih.gov)
  • This demonstration of efficacy in a clinically relevant setting, combined with the improved safety conferred by cell type-specific expression and integration-deficient delivery, identify EKC gene therapy as ready for clinical translation in the treatment of refractory focal epilepsy.SIGNIFICANCE STATEMENTPharmacoresistant epilepsy affects up to 0.3% of the population. (ucl.ac.uk)
Medications2
Shows focal1
  • Perfusion-weighted imaging clearly shows focal cortical-subcortical cerebral blood flow increase in the right frontal eye field area, correlating with the ictal epileptic activity. (jle.com)
Electrographic1
  • Seizures with focal high-frequency electrographic correlates: These patterns typically evolve over 10-20 seconds and are usually seen with focal cerebral insults, such as strokes. (medscape.com)