AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Focal Nodular HyperplasiaAdenoma, Liver CellHyperplasiaLiver NeoplasmsHemangiomaLiver DiseasesContrast MediaSulfur HexafluorideLiverCarcinoma, HepatocellularKeratin-7Magnetic Resonance ImagingImage EnhancementContraceptives, OralTomography, X-Ray ComputedTomography, Spiral ComputedKeratin-19Gadolinium DTPAProstatic HyperplasiaAngiographyHepatectomySensitivity and SpecificityPolysaccharidesParathyroid GlandsDieldrinHyperparathyroidism, SecondaryBrunner GlandsDesogestrelContraceptive Agents, FemaleSpermatogenesis-Blocking AgentsPregnancy RateLevonorgestrelPregnancyContraceptives, Oral, Hormonal
MalignantTumorsCentral scarAdenomasFibrolamellar carcinomaEpithelial HyperplasiaNodulesPrecursor lesionHypervascularMass LesionsSolid lesionsFLLsSmall lesionsCystic lesionsVascular lesionsDetect2022PatientsParenchymalDifferentialHistologicallyCharacteristicHepatobiliaryCEUSCONGENITALClinical GuidelineDiagnosticProliferationPancreasFindingsClassificationDetectionInflammatoryBiopsyUltrasoundPhenotypeMalignanciesGlandularContrast enhancementNeoplasticCharacteristics
Malignant4
  • Meanwhile, we were the first to demonstrate that SMI blood flow signal percentage (VI) was correlated with MVD in malignant lesions. (biomedcentral.com)
  • There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant. (lookformedical.com)
  • All LR-M lesions were malignant, and 62.1% (36/58) were non-HCC malignancies. (e-ultrasonography.org)
  • The readers classified each lesion as malignant or benign by means of definite diagnostic criteria. (unipa.it)
Tumors6
  • Benign liver tumors include hepatocellular adenomas (HCAs), hemangiomas , hamartomas, and focal nodular hyperplasia (FNH). (medscape.com)
  • Benign lesions in children represent 30% of hepatic tumors and are most commonly vascular in origin (eg, hemangiomas, hemangioendotheliomas). (medscape.com)
  • Magnetic resonance imaging (MRI) of the liver can be useful in detecting and characterizing primary tumors, and MRI may be slightly more sensitive than CT scanning in detecting multiple intrahepatic recurrent lesions. (medscape.com)
  • [ 1 ] In his review of liver tumors and tumorlike liver lesions, Edmondson included a report of a 14-year-old girl with an unusually long survival following hepatic resection for liver cancer. (medscape.com)
  • Moreover, it is also difficult to distinguish HCC from benign hepatocellular tumors such as focal nodular hyperplasia and hepatocellular adenoma [ 11 , 12 ]. (e-ultrasonography.org)
  • MRI is a powerful tool for detection, characterization, and surveillance of both cystic pancreatic lesions, such as serous and mucinous tumors, and intraductal papillary mucinous tumors, as well as neuroendocrine tumors. (stanford.edu)
Central scar5
  • You may find that these patients have a characteristic central scar called "focal nodular hyperplasia. (medscape.com)
  • the classic appearance is a lesion with a central scar. (msdmanuals.com)
  • [ 47 ] This is in contrast to focal nodular hyperplasia, in which the central scar, which is in reality a vascular entity, enhances on arterial-phase CT scan images. (medscape.com)
  • [ 48 ] This difference generally distinguishes fibrolamellar carcinoma from focal nodular hyperplasia but is not absolute, as up to 25% of fibrolamellar carcinoma cases may in fact demonstrate delayed enhancement of the central scar. (medscape.com)
  • Additionally, fibrolamellar carcinoma and focal nodular hyperplasia share several features, such as a stellate central scar on imaging studies and copper accumulation on histological examination, that have prompted some to suggest that focal nodular hyperplasia may be a benign precursor lesion to fibrolamellar carcinoma. (medscape.com)
Adenomas1
Fibrolamellar carcinoma4
  • Fibrolamellar carcinoma must be carefully differentiated from focal nodular hyperplasia because their management differs. (medscape.com)
  • However, fibrolamellar carcinoma requires aggressive treatment by liver resection, while focal nodular hyperplasia, a benign disease, does not require treatment unless the patient is symptomatic. (medscape.com)
  • As noted above, the ability to differentiate fibrolamellar carcinoma from other lesions that also demonstrate central scars is useful. (medscape.com)
  • [ 6 ] and no histological precursor lesion to fibrolamellar carcinoma has been identified. (medscape.com)
Epithelial Hyperplasia2
  • Focal epithelial hyperplasia (FEH) or Heck's disease is a rare, benign, oral condition that is associated with infection by human papillomavirus type 13, 32 or both. (nih.gov)
  • multifocal epithelial hyperplasia. (nih.gov)
Nodules2
  • Focal nodular hyperplasia (FNH) is a polyclonal tumour-like hepatic lesion characterised by parenchymal nodules, connective tissue septa without interlobular bile ducts, pronounced ductular reaction and inflammation. (aabioetica.org)
  • 2016 ) Washout appearance in Gd-EOB-DTPA-enhanced MR imaging: A differentiating feature between hepatocellular carcinoma with paradoxical uptake on the hepatobiliary phase and focal nodular hyperplasia-like nodules. (neurotree.org)
Precursor lesion2
  • Such a developmental flaw is termed aberrant differentiation, and the resultant precursor lesion is designated melanocytic dysplasia. (nih.gov)
  • If melanoma is to develop via a precursor lesion, however, the nevus with melanocytic dysplasia is that precursor. (nih.gov)
Hypervascular1
Mass Lesions1
  • This text provides a comprehensive and state-of-the-art overview of the evaluation and management of liver mass lesions. (dentalbooks.net)
Solid lesions1
  • CT scanning and MRI of the abdomen and chest are used for indeterminate or solid lesions to further delineate the location, extent, and multiplicity of the lesions and to detect metastases. (medscape.com)
FLLs3
  • To investigate the capacity of Superb Microvascular Imaging (SMI) to detect microvascular details and to explore the different SMI features in various focal liver lesions (FLLs) and the correlation between SMI and microvessel density (MVD). (biomedcentral.com)
  • Early detection and diagnosis are important for the prevention and treatment of HCC, and ultrasound (US) has been recommended as the first imaging modality for screening focal liver lesions (FLLs) because it is noninvasive and widely available. (biomedcentral.com)
  • Purpose: to evaluate the role of contrast-enhanced ultrasound (CEUS) in the characterization of focal liver lesions (FLLs) for surgical patients selection. (unipa.it)
Small lesions2
  • Additionally, in several studies the DKI sequences used were based on planar echo (EPI) acquisition, which is susceptible to motion, metal and air artefacts and prone to low SNRs and distortions, leading to low quality images for some small lesions, which may affect the accuracy of the results. (biomedcentral.com)
  • However, Stanford researchers have developed a suite of tools that provide unprecedented high resolution images with fast snapshots that have helped detect these small lesions. (stanford.edu)
Cystic lesions3
  • Because the MR signal is so sensitive to fluid, fluids in the cystic lesions as well as in the ducts are well depicted. (stanford.edu)
  • Kalb B, Sarmiento JM, Kooby DA, Adsay NV, Martin DR. MR imaging of cystic lesions of the pancreas. (stanford.edu)
  • Diffusion-weighted MR imaging of solid and cystic lesions of the pancreas. (stanford.edu)
Vascular lesions1
  • Cystic or vascular lesions may not require any further imaging. (medscape.com)
Detect2
  • Basing on their characteristic appearance, common B-mode and color Doppler US can detect focal liver lesions, such as focal nodular hyperplasia (FNH) with a spoke-wheel shaped vascular pattern. (biomedcentral.com)
  • Colloid scintigraphy (liver‐spleen scans) allows visualization of the liver parenchyma through accumulation of colloid‐based radiotracers in reticuloendothelial cells and was widely used in the past to detect focal liver lesions [2] . (radiologykey.com)
20221
  • Objectives: Needs: References: Merva Soluk-Tekkesini1, John M. Wright2 , The World Health Organization Classification of Odontogenic Lesions: A Summary of the Changes of the 2022 (5th) Edition. (lmshq.org)
Patients6
  • 4. Brancatelli G, Federle MP, Grazioli L, Blachar A, Peterson MS, Thaete L. Focal nodular hyperplasia: CT findings with emphasis on multiphasic helical CT in 78 patients. (actaojs.org.ar)
  • Focal nodular hyperplasia of the liver: MR imaging and pathologic correlation in 37 patients. (actaojs.org.ar)
  • Epidemiologic characteristics are similar in that both lesions occur in young healthy patients who usually do not have a history of cirrhosis or liver disease. (medscape.com)
  • Thymus hyperplasia is present in two thirds of all patients with myasthenia gravis. (lookformedical.com)
  • A total of 145 High-risk patients for hepatocellular carcinoma (HCC) who underwent magnetic resonance imaging (MRI) followed by CNB for a focal hepatic lesion preoperatively were retrospectively enrolled. (e-ultrasonography.org)
  • Patients with a focal lesion in the setting of cirrhosis are often biopsied with FNA, although accuracy may be higher with needle biopsy. (eurocytology.eu)
Parenchymal1
  • Focal parenchymal defects are nonspecific, indicating the presence of space‐occupying processes. (radiologykey.com)
Differential3
  • Major topics covered include epidemiology, the use of different imaging modalities in the differential diagnosis of liver lesions, the use of biomarkers and immunohistochemical stains for diagnosis, and treatment of the different types of liver masses. (dentalbooks.net)
  • Uptake patterns of incidentally identified focal hepatic lesions encountered on the hepatogram can inform the differential, but other modalities such as US, CT, and MRI are required for further workup. (radiologykey.com)
  • [ 7 ] Knowledge of preceding treatment and the finding of other therapy-related changes, such as glandular atrophy, as well as basal cell hyperplasia, should alert to this differential. (medscape.com)
Histologically1
  • Histologically, the nodular lesions in the ileum showed severe granulomatous enteritis with large areas of necrosis and numerous multinucleated giant cells (Figure, panel A). Ziehl-Neelsen stain demonstrated large numbers of acid-fast bacilli in macrophages and multinucleated giant cells in the intestine ( Figure , panel B). The mesenteric lymph node also exhibited a granulomatous inflammation with multinucleated giant cells. (cdc.gov)
Characteristic2
  • If the pathway of differentiation is not followed, characteristic lesions result, and such lesions are regarded as the formal histogenetic precursors of melanoma. (nih.gov)
  • However, the elevated portal vein coefficient is characteristic of a benign lesion. (claripacs.com)
Hepatobiliary1
CEUS1
  • The lesion was constant in size for seven years and stay completely avascular in contrast-ehanced ultrasound (CEUS), probably a small residual pseudocyst. (sonographie.org)
CONGENITAL2
Clinical Guideline2
  • Co-Editor-in-Chief Jasmohan Bajaj, MD, MS, FACG interviews Brian C. Jacobson, MD, MPH, FACG on the recently published ACG Clinical Guideline for the diagnosis and management of gastrointestinal subepithelial lesions (17:50). (gi.org)
  • ACG clinical guideline: The diagnosis and management of focal liver lesions. (msdmanuals.com)
Diagnostic3
  • The diagnostic value of Gd-EOB-DTPA-MRI for the diagnosis of focal nodular hyperplasia: a systematic review and meta-analysis. (actaojs.org.ar)
  • Hepatic Pseudotumor Due To Nodular Fatty Sparing: The Diagnostic Role of Opposed-Phase MRI.A merican Journal of Roentgenology,2004;183:3,721-724. (actaojs.org.ar)
  • According to the American Association for the Study of Liver Diseases (AASLD) guidelines, biopsy is a diagnostic option for focal hepatic lesions depending on the Liver Imaging Reporting and Data System (LI-RADS) category. (e-ultrasonography.org)
Proliferation1
  • The common acquired melanocytic nevus is viewed as a focal proliferation of melanocytes, destined in most instances to follow a programmed pathway of differentiation that leads to disappearance of the nevus. (nih.gov)
Pancreas1
  • 60 years old male with chronic alcohol and nicotine use, pancreatitis 2013 with a small hypoechoic lesion in the pancreas corpus. (sonographie.org)
Findings1
Classification1
  • Cystic pancreatic lesions: a simple imaging-based classification system for guiding management. (stanford.edu)
Detection1
  • Today colloid imaging remains useful for confirmation of splenosis and extramedullary hematopoiesis, but has otherwise been superseded by US, CT, and MRI for detection and evaluation of liver lesions. (radiologykey.com)
Inflammatory1
  • The presence of enteric inflammatory lesions with presence of acid-fast bacilli, however, suggests an oral route of infection. (cdc.gov)
Biopsy1
Ultrasound1
  • 2016 ) Plaque structural stress assessed by virtual histology-intravascular ultrasound predicts dynamic changes in phenotype and composition of untreated coronary artery lesions. (neurotree.org)
Phenotype1
  • Its phenotype is changing from single lesions to multiple lesions owing to the reduction in estrogen exposure and increasing incidence of obesity and metabolic syndrome as driving factors in the formation of hepatic adenoma. (medscape.com)
Malignancies2
  • CNB correctly categorized all 24 LR-4 lesions, 16.7% (4/24) of which were non-HCC malignancies. (e-ultrasonography.org)
  • CNB correctly categorized 93.1% (54/58) of LR-M lesions, and 12.5% (3/24) of lesions with CNB results of HCC were confirmed as non-HCC malignancies. (e-ultrasonography.org)
Glandular1
Contrast enhancement1
  • CT scanning reveals typical features of peripheral contrast enhancement with subsequent isodense filling of the lesion and liver. (medscape.com)
Neoplastic1
  • The pathogenesis of this lesion remains speculative, and discussions about its neoplastic, developmental or reparative nature are frequent (5). (bvsalud.org)
Characteristics2
  • Characteristics of the cells may not be sufficient in many instances to yield a definitive diagnosis or indicate the probable behavior of the lesion. (merckvetmanual.com)
  • Histopathologically confirmed focal nodular hyperplasia of the liver: gadoxetic acid-enhanced MRI characteristics. (actaojs.org.ar)