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  • receptors
  • Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. (genome.jp)
  • Interactions between growth factor receptors and adhesion molecules: breaking the rules. (wikipathways.org)
  • bundles
  • Focal adhesions, also known as "focal contacts," were identified over 30 years ago by electron microscopy and described as electron-dense plaques associated with actin filament bundles [ 10 ]. (hindawi.com)
  • Focal adhesions had a corrugated dorsal surface formed by microfilament bundles spaced 127±50 nm (mean±s.d.) apart and protruding 118±26 nm over the substratum. (biologists.org)
  • regulation
  • Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. (genome.jp)
  • Modulation of the focal adhesion plaque provides a mechanism for the regulation of cellular adhesive strength. (rupress.org)
  • Modification of focal adhesion structure by PI 3-kinase and its lipid product, PtdIns (3,4,5)-P 3 , has important implications for the regulation of cellular adhesive strength and motility. (rupress.org)
  • vinculin
  • Case LB, Baird MA, Shtengel G, Campbell SL, Hess HF, Davidson MW, Waterman CM (2015) Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions. (springer.com)
  • signals
  • FAK contributes to FA scaffolding, and also transmits adhesion-dependent and growth factor-dependent signals into the cell [ 2 - 4 ]. (hindawi.com)
  • From collected signals and by their autocorrelation we evaluated the average lifetime and assembly rate of focal adhesion as function of substrate stiffness. (springer.com)