• It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells, but particularly specific in macrophages. (wikipedia.org)
  • This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling, (e.g., the LYN-CD22-SHP-1 pathway). (wikipedia.org)
  • The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). (wikipedia.org)
  • Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. (wikipedia.org)
  • During the early stages of adhesion, FAK expression in FAK-null cells enhances integrin activation to promote integrin binding and, hence, the adhesion strengthening rate. (biomedsearch.com)
  • Human epididymis protein 4 in association with Annexin II promotes invasion and metastasis of ovarian cancer cells. (nih.gov)
  • The scratch test, the Transwell assay and animal experiments were used to assess the invasive and metastatic abilities of ovarian cancer cells before and after transfection and HE4 protein treatment. (nih.gov)
  • one in which fibronectin promotes cytoskeletal reorganisation in the absence of pp125FAK tyrosine kinase activity and the other in which cells adhering to MASMC-ECM display elevated pp125FAK tyrosine kinase activity in association with an impaired ability to promote F-actin stress fibre and focal adhesion formation. (biologists.org)
  • 1994 ). The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAKand protein kinase C-to focal adhesions. (biologists.org)
  • We report here that Shigella invasion of epithelial cells requires rho activity, a ras-related GTP-binding protein. (rupress.org)
  • When esophageal adenocarcinoma cells were treated with TAE226, cell proliferation and migration were greatly inhibited with an apparent structural change of actin fiber and a loss of cell adhesion. (aacrjournals.org)
  • Transfected angiomotin as well as endogenous angiomotin protein were localized to the leading edge of migrating endothelial cells.Expression of angiomotin in endothelial cells resulted in increased cell migration, suggesting a stimulatory role of angiomotin in cell motility.These findings indicate that angiostatin inhibits cell migration by interfering with angiomotin activity in endothelial cells. (nih.gov)
  • Here we report the identification of angiomotin, a novel protein that mediates angiostatin inhibition of migration and tube formation of endothelial cells. (nih.gov)
  • Transfected angiomotin as well as endogenous angiomotin protein were localized to the leading edge of migrating endothelial cells. (nih.gov)
  • 8,9 In addition, Fak, a primary integrin effector that is known to play a key role in the responses of cells to mechanical stimuli through focal adhesion sites, 10-12 is rapidly activated by mechanical stimuli in cultured neonatal rat ventricular myocytes (NRVMs) 13,14 and in overloaded myocardium of adult animals. (ahajournals.org)
  • PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to each other and their surroundings) and spreading processes (how cells move around). (wikipedia.org)
  • This gene encodes a cytosolic protein tyrosine kinase that is found concentrated in the focal adhesions that form among cells attaching to extracellular matrix constituents. (wikipedia.org)
  • FAK is a protein of 125 kD recruited as a participant in focal adhesion dynamics between cells, and has a role in motility and cell survival. (wikipedia.org)
  • In unstimulated cells, most of the NF-κB is localized in the cytoplasm in complex with an inhibitory protein, IκB( Baldwin, 1996 ). (rupress.org)
  • In addition, whereas FAK-expressing cells responded to exerted forces by reorienting their movements and forming prominent focal adhesions, FAK-null cells failed to show such responses. (pnas.org)
  • Cells expressing Y397F FAK, which cannot be phosphorylated at a key tyrosine site, showed similar defects in migration pattern and force-induced reorientation as did FAK-null cells. (pnas.org)
  • In this study, we pursued the possibility that FAK is involved in focal adhesion-mediated responses of cells to physical signals. (pnas.org)
  • The name Crk is from "CT10 Regulator of Kinase" where CT10 is the avian virus from which was isolated a protein, lacking kinase domains, but capable of stimulating phosphorylation of tyrosines in cells. (wikipedia.org)
  • There are a wide variety of cells which express the protein L1, not only neuronal cells but also some non-neuronal ones. (wikipedia.org)
  • L1 has a static function as a cell adhesion molecule which connects different cells. (wikipedia.org)
  • Some studies have proved that L1 has a role in tumor growth, tumor cell invasion, metastasis of melanoma, ovarian and collon cancer due to an overexpression of the protein L1 that improves cell motion of the malignant cells. (wikipedia.org)
  • L1 is involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, cerebellar granule cell migration, neurite outgrowth on Schwann cells and interactions among epithelial cells of intestinal crypts. (wikipedia.org)
  • Within 30 minutes, MASMC exhibited well-developed F-actin stress fibres and prominent focal adhesions which immunostained intensely for vinculin, pp125FAK and phosphotyrosine. (biologists.org)
  • Focal adhesion kinase (Fak) has been implicated as a signaling molecule involved in the early response of cardiac myocytes to mechanical stress. (ahajournals.org)
  • The term kinase describes a large family of enzymes that are responsible for catalyzing the transfer of a phosphoryl group from a nucleoside triphosphate donor, such as ATP, to an acceptor molecule. (wikipedia.org)
  • The first crystal structure of the PTP1B catalytic domain revealed that the catalytic site exists within a deep cleft of the protein formed by three loops including the WPD loop with the Asp181 residue, a pTyr loop with the Tyr46 residue and a Q loop with the Gln262 residue. (wikipedia.org)
  • One of the important domain of nRTKs is the tyrosine kinase catalytic domain, which is about 275 residues in length. (wikipedia.org)
  • The NF-κB family of proteins consists of homo- or heterodimeric subunits of the Rel family, including p50 and p65. (rupress.org)
  • Talin, a cytoskeletal protein concentrated in regions of cell-substratum contact and, in lymphocytes, of cell-cell contacts. (wikipedia.org)
  • The FERM domain is located at the N terminus in the majority of proteins in which it is found. (wikipedia.org)
  • Ezrin, moesin, and radixin are highly related proteins (ERM protein family), but the other proteins in which the FERM domain is found do not share any region of similarity outside of this domain. (wikipedia.org)