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  • actin
  • Binding to the ECM is regulated by various signaling pathways that control the assembly and disassembly of three distinct, but functionally related actin and integrin-containing adhesion structures known as focal adhesions, podosomes, and invadopodia. (hindawi.com)
  • Focal adhesions, also known as "focal contacts," were identified over 30 years ago by electron microscopy and described as electron-dense plaques associated with actin filament bundles [ 10 ]. (hindawi.com)
  • receptor
  • On je transmembranski receptor koji se aktivira IGF-1 hormonom ( insulinu sličan faktor rasta 1 ) i srodnim hormonom IGF-2 . (wikipedia.org)
  • The Insulin-like Growth Factor 1 (IGF-1) Receptor is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2 . (thefullwiki.org)
  • MAPK
  • 10 ) revealed that YopP/YopJ binds and inactivates members of the MAPK kinase superfamily, which function as upstream MAPK activators. (jimmunol.org)
  • metastasis
  • Despite the recent advance in diagnosis and treatment of HCC, it remains a highly lethal disease due to recurrence of metastasis [ 2 ]. (hindawi.com)
  • Gene
  • Although highly homologous within their kinase domains (98% identity), the two gene products share only 36% identity in the last 76 C-terminal residues ( Woodgett, 1990 ). (biologists.org)
  • Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs. (semanticscholar.org)
  • integrins
  • Integrin-linked kinase (ILK) is the binding partner of β1 and β3 integrins, and has been ascribed essential roles in development, angiogenesis and tumourigenesis. (ebscohost.com)
  • activity
  • Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. (hmdb.ca)
  • Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. (abcam.com)
  • sequence
  • 2. A recombinant nucleic acid molecule comprising a promoter sequence operably linked to a nucleic acid molecule according to claim 1. (google.es)