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  • treatment
  • 5-Fluorouracil (5-FU) and its orally administered prodrug, capecitabine, are fluoropyrimidine-based chemotherapeutic agents that are widely used for the treatment of colorectal cancer and other solid tumors. (testcatalog.org)
  • dose of fluorouracil
  • The recommended dose of fluorouracil, administered in an infusional regimen in combination with leucovorin alone, or in combination with leucovorin and oxaliplatin or irinotecan, is 400 mg/m2 by intravenous bolus on Day 1, followed by 2400 mg/m2 to 3000 mg/m2 intravenously as a continuous infusion over 46 hours every two weeks. (drugs.com)
  • The recommended dose of fluorouracil, if administered in a bolus dosing regimen in combination with leucovorin, is 500 mg/m2 by intravenous bolus on Days 1, 8, 15, 22, 29, and 36 in 8-week cycles. (drugs.com)
  • The recommended dose of fluorouracil, administered as a component of a cyclophosphamide-based multidrug regimen, is 500 mg/m2 or 600 mg/m2 intravenously on Days 1 and 8 every 28 days for 6 cycles. (drugs.com)
  • The recommended dose of fluorouracil, administered as a component of a platinum-containing multidrug chemotherapy regimen, is 200 mg/m2 to 1000 mg/m2 intravenously as a continuous infusion over 24 hours. (drugs.com)
  • Your first dose of fluorouracil will be given in a hospital setting where you can be closely watched in case the medication causes serious side effects. (wellspan.org)
  • Efudex
  • Twenty patients had pharmacokinetic samples collected: 10 patients treated with fluorouracil cream 0.5% and 10 treated with Efudex ®† 5% Cream. (nih.gov)
  • however, only one patient receiving fluorouracil cream 0.5% and six patients receiving Efudex ® 5% Cream had a sufficient number of data points to calculate mean pharmacokinetic parameters. (nih.gov)
  • Five of 10 patients receiving fluorouracil cream 0.5% and nine of 10 patients receiving Efudex ® 5% Cream had measurable urine fluorouracil levels. (nih.gov)
  • Both fluorouracil cream 0.5% and Efudex ® 5% Cream demonstrated low measurable plasma concentrations for fluorouracil when administered under steady-state conditions. (nih.gov)
  • Cumulative urinary excretion of fluorouracil was low for fluorouracil cream 0.5% and for Efudex ® , corresponding to 0.055% and 0.24% of the applied doses, respectively. (nih.gov)
  • Efudex Solution consists of 2% or 5% fluorouracil on a weight/weight basis, compounded with propylene glycol, tris (hydroxymethyl) aminomethane, hydroxypropyl cellulose, parabens (methyl and propyl) and disodium edetate. (rxlist.com)
  • Efudex Cream contains 5% fluorouracil in a vanishing cream base consisting of white petrolatum, stearyl alcohol, propylene glycol, polysorbate 60, parabens (methyl and propyl), and purified water. (rxlist.com)
  • Efudex Solution is available in 10-mL drop dispensers containing either 2% ( NDC 0187-3202-10) or 5% ( NDC 0187-3203-10) fluorouracil and 25-mL drop dispensers containing either 2% ( NDC 0187- 3202-02) or 5% ( NDC 0187-3203-02) fluorouracil on a weight/weight basis compounded with propylene glycol, tris (hydroxymethyl) aminomethane, hydroxypropyl cellulose, parabens (methyl and propyl) and disodium edetate. (rxlist.com)
  • Efudex Cream is available in 40 g tubes containing 5% fluorouracil ( NDC 0187-3204-47) in a vanishing cream base consisting of white petrolatum, stearyl alcohol, propylene glycol, polysorbate 60, parabens (methyl and propyl), and purified water. (rxlist.com)
  • toxicity
  • Evaluation of 5-fluorouracil degradation rate and Pharmacogenetic profiling to predict toxicity following adjuvant Capecitabine. (cancerindex.org)
  • On account of the lack of predictive biomarkers of toxicity, we investigated whether polymorphisms of genes involved in fluoropyrimidine metabolism and 5-fluorouracil (5-FU) degradation rate were associated with outcomes of adjuvant capecitabine in patients with early stage gastrointestinal cancers. (cancerindex.org)
  • carcinomas
  • Fluorouracil is indicated alone or in combination for the palliative treatment of malignant tumours, particularly of the breast, colon or rectum, and in the treatment of gastric, primary hepatic, pancreatic, uterine (cervical particularly), ovarian and bladder carcinomas. (healthdirect.gov.au)
  • metabolism
  • There is evidence that the metabolism of fluorouracil in the anabolic pathway blocks the methylation reaction of deoxyuridylic acid to thymidylic acid. (nih.gov)
  • deficiency
  • Since DNA and RNA are essential for cell division and growth, the effect of fluorouracil may be to create a thymine deficiency that provokes unbalanced growth and death of the cell. (nih.gov)
  • Drugs
  • Occasional case reports of exposure to 5-fluorouracil, especially in the presence of concurrent therapy with other putative carcinogens, such as ionizing radiation, alkylating agents and other potent oncotherapeutic drugs, do not constitute evidence of carcinogenesis [ref: (inchem.org)
  • regimen
  • Individualize the dose and dosing schedule of fluorouracil based on tumor type, the specific regimen administered, disease state, response to treatment, and patient risk factors. (drugs.com)
  • patients
  • Neither chromosomal aberrations (in two patients) nor sister chromatid exchanges (in three patients) were induced following administration of 5-fluorouracil [ref: (inchem.org)
  • depend
  • How often you need fluorouracil injections will depend on many factors, including side effects and how your body responds to the medication. (wellspan.org)
  • rapidly
  • The effects of DNA and RNA deprivation are most marked on those cells that grow more rapidly and take up fluorouracil at a more rapid rate. (nih.gov)
  • Cells that are rapidly growing need more DNA, so they accumulate more 5-fluorouracil, resulting in their death. (wikipedia.org)
  • skin
  • Fluorouracil works by causing the death of cells which are growing fastest, such as abnormal skin cells. (cigna.com)
  • If fluorouracil comes into contact with your skin, wash the area with soap and water and contact your doctor, nurse or pharmacist. (drugs.com)
  • cream
  • Fluorouracil cream contains 0.5% fluorouracil, with 0.35% being incorporated into a patented porous microsphere (Microsponge ® ) composed of methyl methacrylate/glycol dimethacrylate crosspolymer and dimethicone. (nih.gov)