The dihydropyrimidine dehydrogenase (DPD) enzyme is responsible for the detoxifying metabolism of fluoropyrimidines, a class of drugs that includes 5-fluorouracil, capecitabine, and tegafur. (wikipedia.org)
gene, is the initial and rate-limiting enzyme of the metabolic pathway of fluoropyrimidines, such as 5-Fu, capecitabine and tegafur [6C8]. (insulin-receptor.info)
Adjuvant treatments include: 5-fluorouracil administered together with folinic acid, or more recently, oral fluoropyrimidines such as capecitabine, in combination with oxaliplatin or irinotecan. (biomedcentral.com)
Partial or complete lack of dihydropyrimidine dehydrogenase (DPD) enzyme functionality can increase the risk of severe drug toxicity during treatment with fluoropyrimidines (5-FU, capecitabine, tegafur). (agenabio.com)
Capecitabine (Xeloda ® ) is an oral fluoropyrimidine which is produced as a pro-drug of fluorouracil, and shows improved tolerability and intratumor drug concentrations following its tumor-specific conversion to the active drug. (wjgnet.com)
Note that in regimens that contain a fluoropyrimidine (5-FU or capecitabine), infusional fluorouracil can be replaced by capecitabine. (medscape.com)
Fluorouracil3
Tegafur is a chemotherapeutic prodrug of 5-fluorouracil (5-FU) used in the treatment of cancers. (wikipedia.org)
The major side effects of tegafur are similar to fluorouracil and include myelosuppression, central neurotoxicity and gastrointestinal toxicity (especially diarrhoea). (wikipedia.org)
En rekke DPYD genvarianter med mulig effekt på DPD enzymaktivitet er beskrevet, men den kliniske betydningen av mange av disse er begrenset. (anx.no)
For å predikere samlet enzymaktivitet fra DPYD genotype benyttes en aktivitetsscore for hvert allel (Henricks 2015). (anx.no)
DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis. (anx.no)
Chemotherapy5
Our results suggested TE-based chemotherapy was a suitable regimen for non-luminal patients with c.1627A G AG/GG genotype and fluoropyrimidine-based regimen should not be recommended for those patients. (insulin-receptor.info)
RESULTS Association between SNPs prognosis and status of sufferers with fluoropyrimidine-based chemotherapy, specifically in non-luminal subtype breasts cancer tumor Primers for 5 SNPs amplifications had been presented in Desk ?Desk11 and genotypic features and frequencies of 331 breasts cancer tumor specimens were shown in Desk ?Desk2.2. (insulin-receptor.info)
For patients with unresectable tumors, treatment with fluoropyrimidine- or taxane-based chemoradiotherapy (category 1 recommendation) or chemotherapy is acceptable. (medscape.com)
Chemotherapy based around a doublet or triplet platinum/fluoropyrimidine combination is given for metastatic disease. (medscape.com)
S1, an oral fluoropyrimidine anticancer agent, is widely used for the treatment of unresectable and/or metastatic gastric cancer and for adjuvant chemotherapy after potentially curable resection of stage II/III gastric cancer in Japan [ 1 ]. (springeropen.com)
Toxicity5
Gastrointestinal toxicity is the dose-limiting side effect of tegafur. (wikipedia.org)
S-1, an oral fluoropyrimidine derivative, as compared with gemcitabine, is non-inferior in terms of overall survival (OS) and is associated with lower hematologic toxicity. (cancerbiomed.org)
The clinical importance of DPD was initially identified due to severe or lethal toxicity in patients given fluoropyrimidines who are lacking in or possess low degrees of DPD activity [9C11]. (insulin-receptor.info)
Since that time, a lot more than 50 polymorphisms have already been reported to trigger fluoropyrimidine-associated toxicity in the treating malignancies such as for example colorectal carcinoma, gastroesophageal cancers and lymphoblastic leukemia [12C14]. (insulin-receptor.info)
G) which have been associated with fluoropyrimidine-associated toxicity. (bwc.nhs.uk)
Uracil2
It is a component of the combination drug tegafur/uracil. (wikipedia.org)
Tegafur/uracil Tegafur/gimeracil/oteracil El Sayed YM, Sadée W (September 1983). (wikipedia.org)
Genotype1
We found that non-luminal breast cancer patients transporting c.1627A G AG/GG genotype treated with fluoropyrimidine-based regimen presented a shorter overall survival (OS) and progression-free survival (PFS) compared with service providers treated with non-fluoropyrimidine regimen. (insulin-receptor.info)
Colorectal1
Used as first line therapy for patients with metastatic colorectal cancer when fluoropyrimidine alone is preferred. (indiangenericprice.com)
Gastric cancer1
1,2] For this reason, our cooperative group has focused on fluoropyrimidines modulated by leucovorin as therapy for advanced gastric cancer. (cancernetwork.com)
Oral2
S-1 is an oral fluoropyrimidine agent that consists of tegafur, 5- chloro-2, 4-dihydroxypyridine, and potassium oxonate. (bvsalud.org)
Vasospastic angina is a rare but potentially life-threatening adverse event (AE) of S1, an oral fluoropyrimidine anticancer agent. (springeropen.com)
Gimeracil17
Tegafur/uracil Tegafur/gimeracil/oteracil El Sayed YM, Sadée W (September 1983). (wikipedia.org)
Introduction: S-1 is an oral fluoropyrimidine anticancer drug that contains tegafur, gimeracil, and oteracil potassium. (ersjournals.com)
S-1 is a synthetic compound containing tegafur, gimeracil (which inhibits the 5-fluorouracil (5-FU) degradation enzyme), and oteracil (which reduces gastrointestinal toxicity) ( 9 - 11 ). (iiarjournals.org)
In the European Union, tegafur/gimeracil/oteracil is indicated for the treatment of advanced gastric cancer when given in combination with cisplatin. (alleviareindia.com)
Tegafur/gimeracil/oteracil, sold under the brand name Teysuno among others is a fixed-dose combination medication used for the treatment of advanced gastric cancer when used in combination with cisplatin, and also for the treatment of head and neck cancer, colorectal cancer, non-small-cell lung, breast, pancreatic, and biliary tract cancers. (alleviareindia.com)
Tegafur/gimeracil/oteracil (Teysuno) was approved for medical use in the European Union in March 2011. (alleviareindia.com)
What are the facts of Teysuno (Tegafur/gimeracil/oteracil)? (alleviareindia.com)
For Teysuno (tegafur/gimeracil/oteracil) capsules Indications And Usage, Dosage And Administration, Dosage Forms And Strengths and Drug Interactions. (alleviareindia.com)
How to get access Teysuno (tegafur/gimeracil/oteracil) capsules in India? (alleviareindia.com)
Confirmation of the order for Teysuno (tegafur/gimeracil/oteracil) capsules will be subject to the submission of a valid doctor's prescription and, if applicable, an import permit. (alleviareindia.com)
ALS serves as a facilitator, supplier & exporter in India assisting patients, doctors, and hospitals in importing the prescription medicine brand Teysuno (tegafur/gimeracil/oteracil) capsules. (alleviareindia.com)
For patients from following foreign countries seeking access to Teysuno (tegafur/gimeracil/oteracil) capsules , they can inquire and find further information by sending their inquiries to ALS. (alleviareindia.com)
Adjuvant tegafur-gimeracil-oteracil (S-1) is commonly used for gastric cancer in Asia, and tegafur-uracil (UFT) is another oral fluoropyrimidine when S-1 is unavailable. (biomedcentral.com)
Tegafur-uracil (UFT) is the first generation of oral DPD DIF, followed by tegafur-gimeracil-oteracil (S-1), the next generation of oral DPD DIF. (biomedcentral.com)
Dihydropyrimidine7
The dihydropyrimidine dehydrogenase (DPD) enzyme is responsible for the detoxifying metabolism of fluoropyrimidines, a class of drugs that includes 5-fluorouracil, capecitabine, and tegafur. (wikipedia.org)
Detoxifying metabolism of fluoropyrimidines requires dihydropyrimidine dehydrogenase (DPD, encoded by the DPYD gene), and reduced or absent activity of this enzyme can result in severe, and sometimes fatal, toxicity. (nih.gov)
Impact of pretreatment dihydropyrimidine dehydrogenase genotype-guided fluoropyrimidine dosing on chemotherapy associated adverse events. (nih.gov)
25. The tegafur-based dihydropyrimidine dehydrogenase inhibitory fluoropyrimidines, UFT/leucovorin (ORZEL) and S-1: a review of their clinical development and therapeutic potential. (nih.gov)
26. Dihydropyrimidine dehydrogenase (DPD) activity in gastric cancer tissue and effect of DPD inhibitory fluoropyrimidines. (nih.gov)
Dihydropyrimidine dehydrogenase (DPD) inhibitory fluoropyrimidine (DIF), the oral form prodrug of 5-flurouracil (5-FU), has been developed since 1980 [ 10 ], and is currently the most important chemotherapeutic agent used in adjuvant chemotherapy for advanced gastric cancer. (biomedcentral.com)
Strong association of a common dihydropyrimidine dehydrogenase gene polymorphism with fluoropyrimidine-related toxicity in cancer patients. (cdc.gov)
Adjuvant chemotherapy4
The purpose of this study was to evaluate the efficacy of fluoropyrimidine-based adjuvant chemotherapy for BTC patients undergoing microscopically margin-negative (R0) resection. (biomedcentral.com)
Patients were eligible if they received either fluoropyrimidine-based adjuvant chemotherapy or observation after R0 resection. (biomedcentral.com)
In the entire patient cohort, no significant differences were observed in 5-year overall survival (OS) rates (48.4% vs. 39.6%, P = 0.439) or 3-year recurrence-free survival (RFS) rates (49.1% vs. 39.5%, P = 0.299) between patients who received fluoropyrimidine-based adjuvant chemotherapy or observation. (biomedcentral.com)
Fluoropyrimidine-based adjuvant chemotherapy may prolong the survival of patients with stages II and III BTC after R0 resection. (biomedcentral.com)
Anticancer3
22. Anticancer activity and toxicity of S-1, an oral combination of tegafur and two biochemical modulators, compared with continuous i.v. infusion of 5-fluorouracil. (nih.gov)
23. Late phase II study of novel oral fluoropyrimidine anticancer drug S-1 (1 M tegafur-0.4 M gimestat-1 M otastat potassium) in advanced gastric cancer patients. (nih.gov)
S-1 is an oral anticancer agent containing tegafur, a metabolically activated prodrug of 5-FU, and 2 biochemical modulators [ 1 ]. (hindawi.com)
Prodrug2
Tegafur is a chemotherapeutic prodrug of 5-fluorouracil (5-FU) used in the treatment of cancers. (wikipedia.org)
Fluoropyrimidine carbamate prodrug from of 5-fluorouracil (5-FU). (medscape.com)
Gastric2
It belongs to a group of cancer medicines called fluoropyrimidines and is used to treat advanced gastric (stomach) cancer together with cisplatin (another cancer medicine). (healths4live.com)
1,2] For this reason, our cooperative group has focused on fluoropyrimidines modulated by leucovorin as therapy for advanced gastric cancer. (cancernetwork.com)
Chemotherapeutic1
The fluoropyrimidines are the mainstay chemotherapeutic agents for the treatment of many types of cancers. (nih.gov)
Metastatic3
It is also used to treat metastatic colorectal cancer (cancer of the colon and rectum that has spread elsewhere in the body) in patients who can no longer be treated with other fluoropyrimidines because of unacceptable side effects. (alleviareindia.com)
It has been shown that the breast cancer is sensitive to the most anti-tumour medicines, especially to doxorubicin and epirubicin (efficacy in 40-50% of patients with the metastatic breast cancer), methotrexate (efficacy in 35% of patients), fluorouracil and tegafur (efficacy in 25-34% of patients). (crimsonpublishers.com)
Chemotherapy based around a doublet or triplet platinum/fluoropyrimidine combination is given for metastatic disease. (medscape.com)
Deficiency1
G/haplotype B3 have partial DPD deficiency and require a dose reduction when treated with fluoropyrimidines. (nih.gov)
Treatment1
T was shown to be lethal in several cases shortly after initiation of treatment with fluoropyrimidine. (medscape.com)
Administration1
32. [Comparison of pharmacokinetics of 5-FU and alpha-fluoro-beta-alanine, a metabolite of 5-FU, in plasma after administration of UFT, tegafur, 5-FU or doxifluridine to rats]. (nih.gov)