• Resistance to flucytosine is rarely described for this species but was observed for 45 (35%) of 130 C. tropicalis isolates recovered from blood cultures in the Paris area in a 4-year survey. (cdc.gov)
  • The aims of this study were to test the hypothesis that the flucytosine-resistant isolates could represent a subgroup and to determine the relationship between epidemiologic and genomic data. (cdc.gov)
  • Our results suggest that a clone of flucytosine-resistant isolates, associated with malignancies and a lower mortality than that for other C. tropicalis isolates, is widespread in the Paris area. (cdc.gov)
  • Overall the isolates were susceptible to both amphotericin B (MIC90 1g/ml) and to 5-flucytosine (MIC90 0. (thefreedictionary.com)
  • We found that the antimycotic agent flucytosine inhibits the expression of the iron-starvation σ-factor PvdS, thereby repressing the production of major P. aeruginosa virulence factors, namely pyoverdine, PrpL protease, and exotoxin A. Flucytosine administration at clinically meaningful dosing regimens suppressed P. aeruginosa pathogenicity in a mouse model of lung infection. (pnas.org)
  • she was given liposomal amphotericin B and 5-flucytosine and was transferred to a referral hospital, where she received a lumbar puncture to drain CSF and endotracheal intubation for mechanical ventilation in the intensive care unit. (thefreedictionary.com)
  • An important limitation of the use of flucytosine in all three diseases has been drug resistance arising during therapy. (annals.org)
  • The in vitro and in vivo activity of flucytosine against P. aeruginosa, combined with its desirable pharmacological properties, paves the way for clinical trials on the anti- P. aeruginosa efficacy of flucytosine in humans. (pnas.org)
  • Owing to the unacceptably high mortality associated with CM, access to flucytosine needs to be prioritised in South Africa (SA), together with interventions such as earlier detection of cryptococcal disease. (scielo.org.za)
  • Symptoms of a flucytosine overdose are not well known but might include nausea, vomiting, diarrhea, and abdominal pain. (cigna.com)
  • First, while flucytosine is still registered with the Medicines Control Council (MCC), this registration has not been maintained. (scielo.org.za)
  • Currently, flucytosine is only available for compassionate use through an MCC application (section 21 of the Medicines and Related Substances Control Act 1965), a process that may take several weeks. (scielo.org.za)
  • If these efforts are successful, we motivate that flucytosine should be included in the SA Essential Medicines List for hospitals, along with amphotericin B. (scielo.org.za)
  • Allergy to Flucytosine, or any other anti-fungal medicines. (cashkaro.com)