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  • pore
  • KATP Channels are heteromultimers of Kir6 channels (the pore portion) and sulfonylurea receptor (the regulatory portion) which affect function of the heart, pancreatic beta cells, and kidney collecting ducts. (wellnessadvocate.com)
  • subfamilies
  • However, recent studies have revealed that several ion channels of different subfamilies are impacted by SAH and may contribute to delayed vasospasm. (hindawi.com)
  • Expression
  • In animal models, in response to subarachnoid blood, a dynamic transition of ion channel expression and function is initiated, with acute and long-term effects differing from each other. (hindawi.com)
  • Furthermore, expression patterns and function of ion channels appear to differ between main and small peripheral vessels, which may be key in understanding mechanisms behind subarachnoid hemorrhage-induced vasospasm. (hindawi.com)
  • Here, changes in calcium and potassium channel expression and function in animal models of subarachnoid hemorrhage and transient global ischemia are systematically reviewed and their clinical significance discussed. (hindawi.com)
  • Because vasospastic smooth muscle cells are known to be depolarized compared to controls [ 3 , 4 ], the expression and function of ion channels in these cells after SAH are of great interest. (hindawi.com)
  • Additionally, functional expression in HEK293T cells reveals properties supporting the proposal that this channel may provide the major K + -selective current component in the rat hepatocyte. (physiology.org)
  • Blood Flow
  • Plasma ATP is a potent vasodilator and is thought to play a role in the local regulation of blood flow. (springer.com)
  • These findings demonstrate that individuals with type 2 diabetes have lower plasma ATP concentrations during exercise and hypoxia compared with control individuals, and this occurs in parallel with lower blood flow. (springer.com)
  • Skeletal muscle blood flow is tightly regulated to match O 2 delivery with metabolic demand. (springer.com)
  • Moreover, these individuals have been reported to have a lower blood flow at rest and during exercise [ 7 , 8 ], potentially resulting in a mismatch between the rate of supply and demand of O 2 and metabolites. (springer.com)
  • cells
  • 1993 ) showed that AEA acts as a partial agonist to inhibit N-type Ca 2+ channels in differentiated N18 neuroblastoma cells. (aspetjournals.org)
  • In contrast to the Kv class, Kir channels are open at the resting potential of most cells and thus are their major hyperpolarizing influence ( 21 ). (physiology.org)
  • activity
  • AEA (10 μM) also inhibited Ca 2+ channels in a voltage-independent, CB1R-independent, and PTX-insensitive manner, whereas 2-AG and 2-AGE were devoid of this activity. (aspetjournals.org)
  • potentially
  • By analogy with other secretory epithelia, basolateral K + channels would provide the counterion, and potentially some of the driving force, for anion secretion and transepithelial water flow into the apical lumen (bile canaliculus) adjoining pairs of hepatocytes. (physiology.org)