• Systemic lupus erythematosus (SLE), the most common type of lupus. (medlineplus.gov)
  • This patient's FUO workup led to several positive tests that could account for her fevers, including Bartonella , systemic lupus erythematosus (SLE), HIV, and syphilis. (contemporarypediatrics.com)
  • Researchers including Jacques Banchereau of The Jackson Laboratory have uncovered distinct molecular subgroups of patients with systemic lupus erythematosus (SLE), providing an explanation for why clinical trials might fail and opening opportunities for new and more targeted treatments of the disease. (outbreaknewstoday.com)
  • SLE is an incurable, systemic autoimmune disease predominantly affecting young women. (outbreaknewstoday.com)
  • There is no previous report of urinary balantidiasis in patients with systemic lupus erythematosus (SLE). (biomedcentral.com)
  • There are no treatment guidelines for systemic lupus erythematosus (SLE) for the patients with decompensated cirrhosis, especially for those who have a history of hepatitis B virus (HBV) infection, gastrointestinal bleeding and gastric fundus ulceration. (openmedicinejournal.com)
  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that damages multiple systems and has a variety of clinical presentations, such as leukopenia, renal failure, antiphospholipid syndrome and thrombocytopenia. (openmedicinejournal.com)
  • Systemic lupus erythematosus (SLE) is a chronic autoimmune connective tissue disorder, with a heterogeneous presentation. (lww.com)
  • The prevalence of systemic lupus erythematosus (SLE) ranges from 7.4 to 159.4 per 100,000 of population, with the highest rates among United Kingdom residents of Afro-Caribbean descent, and non-White populations elsewhere. (lww.com)
  • A CAR T-cell therapy targeting B-cells, a type of immune cells, was found to clear disease-causing autoantibodies from the bloodstream of eight people with systemic lupus erythematosus (SLE) - without compromising the patients' ability to respond to vaccines - new trial data show. (lupusnewstoday.com)
  • Researchers at the UT Southwestern Medical center in Dallas, TX have discovered that activating a specific enzyme, cGAS, can sound an alarm for the body's innate immune system, leading to the development of Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE) in mice while inhibiting this enzyme leads to their rescue. (lupusnewstoday.com)
  • These results suggest that inhibition of the enzyme cGAS may be an effective therapy for autoimmune diseases such as Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE), which are linked to the same inflammatory pathway," senior author Dr. Zhijian "James" Chen, Professor of Molecular Biology and a Howard Hughes Medical Institute (HHMI) investigator at UT Southwestern, said in a press release . (lupusnewstoday.com)
  • St. Louis encephalitis virus (SLEV) is an endemic flavivirus in the western and southeastern United States, including California. (bvsalud.org)
  • LLDAS is a composite measure of SLE disease activity that measures 5 criteria: SLEDAI-2K ≤ 4, with no activity in major organ systems, no new lupus disease activity, PGA ≤ 1 (scale 0 to 3), current prednisone (or equivalent) dose ≤ 7.5 mg daily, tolerated maintenance doses of immunosuppressive drugs and approved biological agents. (clinicaltrials.gov)
  • Exposure to certain drugs may induce a lupus-like illness or exacerbate SLE. (lww.com)
  • In 2022, Schett's team treated five people with SLE with a CAR T-cell therapy after other medications had failed to ease their lupus symptoms . (lupusnewstoday.com)
  • Mosquito vectored diseases include protozoan diseases, i.e., malaria, filarial diseases such as dog heartworm, and viruses such as dengue, encephalitis and yellow fever. (vedicpaths.com)
  • Dengue and chikungunya are mosquito-borne viruses that have recently been introduced into the United States. (pediatricweb.com)
  • Chikungunya virus and Dengue fever , arboviruses spread by the same mosquitoes as Zika, can cause joint pain and mimic other symptoms of rheumatoid arthritis (RA). (ritabaronfaust.com)
  • The last major outbreak of SLE was was from 1974 to 1976 with 331 cases and 42 deaths. (msstate.edu)
  • Mortality in animals associated with an infection of HJ virus include domestic turkeys at a commercial facility and young broiler chickens in an experimental setting. (ufl.edu)
  • This means that they were exposed to the virus, likely through the bite of an infected female mosquito, but there was no illness associated with the infection. (ufl.edu)
  • The 1999 New York epidemic of human West Nile virus (WN) encephalitis and meningitis was preceded by a crow die-off also caused by WN infection. (journalmap.org)
  • While it remained uncertain whether the liver cirrhosis was caused by SLE or the HBV infection, immediate treatment was necessary. (openmedicinejournal.com)
  • This case indicated that irrespective of the underlying causes of liver cirrhosis, the combination of a low dose of methylprednisolone and MMF is an effective treatment method to inhibit the disease process for patients with SLE and decompensated liver cirrhosis, a large gastric fundus ulcer and HBV infection. (openmedicinejournal.com)
  • Most cases in the United States occur from travelers returning from affected areas, but small numbers of locally acquired infection from mosquitoes in the United States began in 2016 in Florida and Texas. (pediatricweb.com)
  • the virus has been detected in blood, urine, saliva, and semen for weeks after initial infection. (pediatricweb.com)
  • Respiratory syncytial virus infection (RSV) , is a common respiratory virus that causes infections of the lungs and respiratory tract. (evidentic.com)
  • Warts are non-cancerous, benign growths on the skin that are caused by infection from viruses known as human papillomavirus (HPV). (palmbeachskin.com)
  • Gesiotto Q, Cheema A, Avaiya K, Shah B, Greene J. COVID-19 Virus Infection in Three Patients With Hypogammaglobulinemia. (moffitt.org)
  • To investigate if CAR T-cell therapy might leave patients at a greater risk of contracting an infection, researchers also assessed their responses to vaccines against measles, mumps, rubella, varicella zoster virus, the Epstein-Barr virus, tetanus, and pneumococcus. (lupusnewstoday.com)
  • The Transmission-Infection Risk of the diverse mosquito species for the different viruses was estimated through seven variables. (bvsalud.org)
  • To date, there has not been a link established between having a history of autoimmune disease and developing either Guillain-Barré syndrome or immune thrombocytopenia purpura following Zika virus infection," emphasizes Dr. Sharp. (ritabaronfaust.com)
  • Chikungunya virus is a pathogen transmitted by mosquitoes and has established itself in the Caribbean (approximately 350,000 suspected cases in the Western Hemisphere since December 2013). (vedicpaths.com)
  • It has now resulted in 2 cases of locally-transmitted Chikungunya virus in Florida in July of 2014. (vedicpaths.com)
  • Chikungunya is a fairly new mosquito-born illness to be found in the U.S. The first documented chikungunya were reported in Florida on July 17, 2014. (cdllife.com)
  • Chikungunya is another recent virus spread by mosquitos that has come to the United States. (pediatricweb.com)
  • Still, he adds, "patients with pre-existing autoimmune disease should consult their physician before traveling to an area with ongoing Zika virus transmission. (ritabaronfaust.com)
  • Culex nigripalpus (Florida SLE mosquito) is a species of medium-sized, dark, blood-feeding mosquito of the family Culicidae. (wikipedia.org)
  • Culex nigripalpus is a principle disease vector in Florida - the primary enzootic vector to wild birds and the primary epidemic vector to humans of the Saint Louis encephalitis (SLE) virus. (wikipedia.org)
  • Experimental Transmission of West Nile Virus by Culex Nigripalpus from Honduras. (wikipedia.org)
  • WEE virus transmission is at a high level, as reflected by isolations from Culex tarsalis mosquitoes in parts of Arizona, California, Minnesota, and North Dakota. (cdc.gov)
  • In Florida, Culex nigripalpus and Cx. (grantome.com)
  • SLE is a virus that can spread to people if infected by certain infected mosquitoes, though mosquitoes in the culex species are the most common carriers. (cw33.com)
  • Nearly all SLE patients have this antibody. (lupus.org)
  • The pathogenesis of SLE is complex and appears linked to autoimmunity against various native cellular components. (lww.com)
  • The new data is being presented in a poster, titled " CAR T Cell Therapy Leads to Long-term Abrogation of Autoimmunity in SLE Patients While Vaccination Responses Are Maintained , " at the American College of Rheumatology's ACR Convergence 2023. (lupusnewstoday.com)
  • As mosquito-borne Zika virus continues to spread in southern Florida and threaten other Gulf Coast states, its connections with autoimmunity are cause for concern. (ritabaronfaust.com)
  • Is Highlands J Virus a problem for humans? (ufl.edu)
  • Even though HJ virus is not a major pathogen for humans, it is always prudent to be aware of current conditions in any part of Florida where humans may be exposed to mosquito bites. (ufl.edu)
  • HJ is present in Florida, and there will always be a small number of humans exposed to this virus. (ufl.edu)
  • West Nile Virus (WNV) is a mosquito-borne virus that can infect humans. (journalmap.org)
  • Previous research has shown that defects in the gene coding for TREX1 are linked to the onset of SLE in humans and mice, with classic symptoms such as inflammation and high levels of interferon molecules. (lupusnewstoday.com)
  • Saint Louis encephalitis (SLEV) and West Nile (WNV) viruses are closely related flaviviruses affecting humans and animals. (bvsalud.org)
  • Infected mosquitoes then bite humans, passing on the virus. (cw33.com)
  • It's a dangerous cycle: A Zika-carrying mosquito bites and infects a human -- another mosquito bites that person and acquires Zika virus through a blood meal -- then that mosquito buzzes off to infect someone else. (ritabaronfaust.com)
  • In the central and southeastern United States (Alabama, Florida, Illinois, Indiana, Kentucky, Mississippi, Ohio, and Tennessee) SLE virus activity determined by serologic surveillance of wild birds and sentinel chickens has been minimal. (cdc.gov)
  • Many people do not realize that West Nile Virus (WNv), Eastern Equine Encephalitis (EEE), and St. Louis Encephalitis (SLe) are transmitted from infected wild birds. (southwaltonmosquitocontrol.org)
  • The results will be applicable to other viruses and other locations, and will provide information on the interpretation of surveillance results, the influence of mosquito age and population age structure on transmission, and the effect of multiple species of vectors involved in the transmission cycles. (grantome.com)
  • St. Louis Encephalitis (SLE): Two serologically confirmed, non-fatal cases of SLE have been reported (one in a 24-year-old woman from near Yuma, Arizona, with onset June 20, and a second in a 3-year-old boy from Bard, California, with onset July 26). (cdc.gov)
  • California Virus Group Encephalitis: Eleven confirmed and presumptive human cases have been reported. (cdc.gov)
  • From 1938 to 2003, the virus was detected annually in California, but after West Nile virus (WNV) arrived in 2003, SLEV was not detected again until it re-emerged in Riverside County in 2015. (bvsalud.org)
  • The re-emerging virus in California and other areas of the western US is SLEV genotype III, which previously had been detected only in Argentina, suggesting a South American origin. (bvsalud.org)
  • and Western equine encephalitis viruses also cause human disease and are of concern. (grantome.com)
  • In the last two decades, West Nile virus (WNV) has been the primary insect-transmitted disease in Mississippi. (msstate.edu)
  • Their SLE Disease Activity Index-2000, or SLEDAI-2K, was zero, indicating no active disease. (lupusnewstoday.com)
  • Overview of Infectious Disease Microorganisms are tiny living creatures, such as bacteria and viruses. (msdmanuals.com)
  • 2000. 'Epidemiological features of and public health response to a St. Louis encephalitis epidemic in Florida, 1990-91. (ufl.edu)
  • A protein made by the body's immune system that circulates in the blood, recognizes foreign substances like bacteria and viruses, and defends the body against them. (lupus.org)
  • An autoimmune disorder caused when antibodies-immune system cells that fight off bacteria and viruses-mistakenly attack healthy body tissues and organs. (lupus.org)
  • However, in 1989, researchers used new techniques to re-examine the virus that was isolated from the horse's brain. (ufl.edu)
  • Researchers in Florida reported antibodies to HJ in about 15% of the blue jays and scrub jays tested in Lake Placid, Florida, during 1994-95. (ufl.edu)
  • Patients mounted immune responses against these vaccines, suggesting that CAR T-cell therapy may lead "to a sustained disappearance of autoantibodies in SLE patients, while vaccination responses remained stable," the researchers wrote. (lupusnewstoday.com)
  • To gain insight into the molecular heterogeneity of SLE, they profiled the blood transcriptome of a longitudinal cohort of 158 pediatric patients using a personalized immunomonitoring approach. (outbreaknewstoday.com)
  • However, numerous challenges still need to be resolved, such as cirrhosis or gastrointestinal bleeding in SLE patients. (openmedicinejournal.com)
  • In this article I highlight adult SLE manifestations and treatments pertinent to the anesthesiologist and discuss perioperative management of these complex patients. (lww.com)
  • I'm in my mid-30s, I've got SLE with no organs implications. (earthclinic.com)
  • It has been experimentally demonstrated to be capable of transmitting West Nile virus (WNV). (wikipedia.org)
  • These include dog heartworm, West Nile virus (WNV) and Eastern equine encephalitis (EEE). (vedicpaths.com)
  • West Nile Virus (WNV) emerged from Africa. (cdllife.com)
  • Symptoms of West Nile Virus include flu-like symptoms: headache, fever, fatigue, aches or a rash. (cdllife.com)
  • Two mosquito-borne diseases, St. Louis encephalitis (SLE) and West Nile virus (WNV) encephalitis, are still serious problems in Mississippi. (msstate.edu)
  • The distribution of human risk for West Nile virus was determined by spatial analysis of the initial case distribution for the New York City area in 1999 using remote sensing and geographic information system technologies. (journalmap.org)
  • The logistic model was used to estimate the spatial distribution of human risk for West Nile virus throughout New York City. (journalmap.org)
  • West Nile and Zika virus may also be spread by blood transfusion and organ donation. (pediatricweb.com)
  • however, exposure to HJ virus has not been directly associated with human illness. (ufl.edu)
  • Mosquitoes are known to carry many viruses that can cause severe illness and death. (cdllife.com)
  • Autoimmune attacks in SLE are driven by autoantibodies that B-cells mistakenly produce against the body's own tissues. (lupusnewstoday.com)
  • The mechanism is thought to be "molecular mimicry," in which the structure or proteins of a virus are similar to normal cells in the body, so the immune system not only attacks the virus, but also the healthy tissue. (ritabaronfaust.com)
  • In a sero-survey of small mammals in Indian River County, FL, one cotton mouse and one cotton rat had antibodies to HJ. (ufl.edu)
  • 1996. 'Antibodies to arthropod-borne encephalitis viruses in small mammals from southern Florida. (ufl.edu)
  • quinquefasciatus are considered the most important vectors of WN and SLE viruses. (grantome.com)
  • Precipitating factors include herpes simplex virus (HSV), Epstein-Barr virus (EBV), and histoplasmosis. (medscape.com)
  • In contrast to other mosquito-borne viruses, WNV may kill birds in the U.S., especially crows, blue jays, and raptors. (msstate.edu)
  • UF/IFAS Florida Medical Entomology Laboratory, Entomology and Nematology Department, Vero Beach, FL 32962. (ufl.edu)
  • We will study these vector-virus systems using an integrated approach with field, laboratory and theoretical methods. (grantome.com)
  • Routine laboratory tests (Table 1 ) showed that she had a mild microcytic anemia (hemoglobin 9.4 mg/dl, mean corpuscular volume 73 fl). (biomedcentral.com)
  • According to the patient's medical history and existing laboratory examination, the patient experienced an exacerbation of SLE, which could be life-threatening. (openmedicinejournal.com)
  • St. Louis Encephalitis is most common along the Gulf of Mexico and Florida, though it can be found throughout the U.S. (cdllife.com)
  • Between March 2021 and June 2023, eight people with treatment-resistant SLE received a single infusion of 1 million CAR T-cells per kilogram of body weight. (lupusnewstoday.com)
  • When Zika virus infects a pregnant woman, it can spread to her unborn baby and cause microcephaly and other brain defects. (pediatricweb.com)
  • The CDC recommends pregnant women consider putting off travel to areas where Zika virus is spreading, use repellents and other measures to avoid mosquito bites if they do travel to these areas, and use condoms for sexual activity of any type while pregnant. (pediatricweb.com)
  • Zika virus can also be transmitted from a pregnant mother to a fetus and through sexual contact with an infected individual. (pediatricweb.com)
  • In addition to causing birth defects and severe brain damage (microcephaly) in hundreds of babies born to Zika-infected women, 1 the virus is also being blamed for an increase in cases of a rare autoimmune neurological disorder called Guillain-Barré syndrome (GBS) . (ritabaronfaust.com)
  • Zika isn't the first mosquito-borne virus with an autoimmune connection. (ritabaronfaust.com)
  • Factors implicated include current smoking, 9 exposure to crystalline silica, 10 Epstein-Barr virus seropositivity, 11 and hormones, with an association between early menarche and SLE 12 and a protective effect of breastfeeding. (lww.com)
  • Foxp3+ book the corrosion of character the personal cells and CD4+CD25+ Foxp3+ Treg devices from SLE items wearing the proliferation of negative suppression and extensive state towns that are infected come to include Retrieved with a Treg dawn, other as CD62L, CD95, GITR, CTLA-4 and CD127. (michael-noeres.de)
  • These were filoviruses, which include Ebola virus and Marburg virus, SARS Coronavirus 1, Nipah virus, and machupo virus, which causes Bolivian haemorrhagic fever. (yahoo.com)
  • Mosquito control continues to be an important program in public health because of the presence of WNV and SLE, as well as the potential for the reintroduction of other mosquito-borne diseases into Mississippi. (msstate.edu)
  • Diseases spread by infected mosquitoes-in the United States, most are caused by viruses. (pediatricweb.com)
  • He is a Professor of Medicine and currently the Section Chief, Division of Infectious Diseases and Tropical Medicine and Senior Member of the Internal Medicine department at Moffitt Cancer Center, Tampa, FL. (moffitt.org)
  • Viral infections have long been suspected as a potential cause of autoimmune diseases, notably Epstein Barr virus (EBV) . (ritabaronfaust.com)
  • Perioperatively, SLE can present major challenges to the anesthesiologist because of accrued organ damage, coagulation defects, and complex management regimes. (lww.com)
  • A major cause of erythema multiforme is the herpes virus (HSV). (medscape.com)
  • We report a case of a patient with SLE who was found to have incidental urinary balantidiasis on the basis of routine urine testing. (biomedcentral.com)
  • Antibodies are proteins that your immune system makes to fight foreign substances, such as viruses and bacteria. (medlineplus.gov)
  • Short for Globulin component Macrophage Activating Factor, GcMAF just so happened to be the primary focus of research being conducted by Dr. Jeff Bradstreet, M.D., a Florida doctor who was found floating dead in a river back in June. (sakshin.nl)
  • Wilson SE, Lee WM, Murakami C, Weng J, Moninger GA. Mooren-type hepatitis C virus-associated corneal ulceration. (medscape.com)
  • A high rate of SLE virus transmission in flooded areas of southern Arizona has been demonstrated by testing Cx. (cdc.gov)
  • Eastern Equine Encephalitis (EEE): Nine human cases of EEE have been diagnosed by virus isolation or serology. (cdc.gov)
  • LaCrosse encephalitis (LAC) "is much less widespread than EEE or SLE, but approximately 90 cases occur per year occurs in all 13 states east of the Mississippi, particularly in the Appalachian region. (cdllife.com)
  • Cluster analysis revealed the presence of a statistically significant grouping of cases, which also indicates the area of probable virus introduction. (journalmap.org)
  • Dr. John N. Greene received his medical degree from the University of South Florida College of Medicine, Tampa, Florida. (moffitt.org)
  • They identified the isolate to be a strain of HJ virus that is distinct from WEE. (ufl.edu)
  • In 1964, the cause of death of one horse in Florida was attributed to western equine encephalomyelitis virus (WEE). (ufl.edu)
  • 9 Since the virus doesn't always cause symptoms, people may not even know they've been infected and the A. aegypti mosquito often bites multiple people in a single blood meal. (ritabaronfaust.com)
  • Other factors have been implicated in the pathogenesis of SLE, but conclusive evidence is lacking. (lww.com)