TAMBOCORAcetateAtrial fibrillationAntiarrhythmicNegative inotropic effectEffects of flecainidePharmacist if you are allergicQuinidineIntravenousArrhythmiasVentricular tachycardiaCardiacSinus rhythmCardioversionPharmacodynamicsCYP2D6AllergicAntiarrhythmicsSerumConcentrations2023MyocardialIncreasesToxicityTherapeuticProlongationMedicationLiverTabletTreatmentAbsorbed from the gastrointestinal tractDoseCytochromePatientsAdverseHeartPreventEffectAdministrationHoursPlasmaRiskLevels
TAMBOCOR3
- TAMBOCOR™ (flecainide acetate) is an antiarrhythmic drug available in tablets of 50, 100, or 150 mg for oral administration. (nih.gov)
- Flecainide (Tambocor) Flecainide is used to reduce irregular heartbeat. (nih.gov)
- A recent study showed that short-term treatment with flecainide ( Tambocor ), following electrical cardioversion appears to lower the chance of relapses within weeks of the procedure. (rxwiki.com)
Acetate7
- A flecainide acetate inhalation solution was self-administered by each patient using a nebulizer, with 10 patients inhaling a 30 mg flecainide solution, 22 inhaling a 60 mg solution, 21 inhaling 90 mg solution and 19 inhaling a 120 mg solution. (medscape.com)
- Flecainide acetate is a white crystalline substance with a pKa of 9.3. (nih.gov)
- Flecainide acetate is a membrane-stabilizing antiarrhythmic agent that exhibits a local anesthetic effects. (medscape.com)
- Flecainide acetate is rapidly and almost completely absorbed from the gastrointestinal tract following oral administration. (medscape.com)
- Acute electrophysiological effects of flecainide acetate on cardiac conduction and refractoriness in man. (bmj.com)
- The electrophysiological effects of flecainide acetate (2 mg/kg as an intravenous infusion over five minutes) were assessed in 47 patients undergoing electrophysiological study. (bmj.com)
- Flecainide acetate treatment of paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation: dose-response studies. (bvsalud.org)
Atrial fibrillation12
- People with atrial fibrillation or atrial flutter who take flecainide may have a higher risk of developing certain types of irregular heartbeats. (medlineplus.gov)
- NEW YORK (Reuters Health) - Inhaled flecainide shows promise for returning patients with recent-onset atrial fibrillation (AF) to sinus rhythm, a new study suggests. (medscape.com)
- A lower concentration of flecainide is possible via inhalation because the drug is absorbed from the lungs into the pulmonary venous system, which flows to the heart's left atrium, where atrial fibrillation often occurs. (medscape.com)
- Flecainide is used mainly for treatment and prevention of ventricular arrhythmia, paroxysmal supraventricular tachycardia , paroxysmal atrial fibrillation , and paroxysmal atrial flutter . (medscape.com)
- Intravenous flecainide administration for conversion of paroxysmal atrial fibrillation in the emergency room]. (nih.gov)
- Tachycardia due to atrial flutter with rapid 1:1 conduction following treatment of atrial fibrillation with flecainide. (nih.gov)
- A short cut review was carried out to establish whether amiodarone is better than flecainide at restoring sinus rhythm in patients with atrial fibrillation. (bmj.com)
- Flecainide is an IC antiarrhythmic drug approved in 1984 from Food and Drug Administration for the suppression of sustained ventricular tachycardia and later for acute cardioversion of atrial fibrillation (AF) and for sinus rhythm maintenance. (encyclopedia.pub)
- Currently, flecainide is mostly used for sinus rhythm maintenance in atrial fibrillation patients without structural cardiomyopathy although recent studies enrolling different patient population demonstrated a good effectiveness and safety profile. (encyclopedia.pub)
- Currently, the use of flecainide in atrial fibrillation represents the main indication of the drug. (encyclopedia.pub)
- Flecainide should not be used to treat a certain type of irregular heartbeat ( persistent atrial fibrillation /flutter). (webmd.com)
- Flecainide can increase QRS duration especially with tachycardia (positive use dependence) and organize atrial fibrillation to atrial flutter. (towerhealth.org)
Antiarrhythmic4
- Flecainide is a class Ic antiarrhythmic agent. (wikipedia.org)
- As with all other antiarrhythmic agents, there is a risk of proarrhythmia associated with the use of flecainide. (wikipedia.org)
- As with all class I antiarrhythmic agents, flecainide increases the capture thresholds of pacemakers. (wikipedia.org)
- Flecainide is a class IC antiarrhythmic drug (AAD). (encyclopedia.pub)
Negative inotropic effect1
- In animals and isolated myocardium, a negative inotropic effect of flecainide has been demonstrated. (nih.gov)
Effects of flecainide2
- Because of the negative inotropic effects of flecainide, it should be used with caution in individuals with depressed ejection fraction, and may worsen congestive heart failure in these individuals. (wikipedia.org)
- While the toxic effects of flecainide are closely related to the plasma levels of the drug, it is unfeasible to check the plasma concentration in an individual on a regular basis. (wikipedia.org)
Pharmacist if you are allergic1
- tell your doctor and pharmacist if you are allergic to flecainide or any other medications. (medlineplus.gov)
Quinidine3
- In a randomized placebo-controlled double-blind trial, we compared flecainide to quinidine for treatment of ventricular ectopic depolarizations in 19 patients. (annals.org)
- A greater than 80% reduction of total ventricular ectopic depolarizations was obtained in eight of nine patients given flecainide and in five of ten patients given quinidine ( p = 0.09). (annals.org)
- Side effects were commoner with quinidine than flecainide ( p = 0.06). (annals.org)
Intravenous2
- Inhaled flecainide converts patients to sinus rhythm at a much lower - read 'safer' - plasma concentration compared to oral or intravenous treatments," said Dr. Crijns, a cardiologist at Maastricht University Medical Center in the Netherlands. (medscape.com)
- Four patients had serious adverse cardiac events, deemed related to the flecainide solution because they were consistent with those observed for oral and intravenous flecainide: Two cases of transient sinus arrest, one case of atrial flutter, and one case of bradycardia. (medscape.com)
Arrhythmias6
- Flecainide has been introduced into the treatment of arrhythmias in children. (wikipedia.org)
- Due to the narrow therapeutic index of flecainide, physicians should be alert for signs of toxicity before life-threatening arrhythmias occur like torsades de pointes. (wikipedia.org)
- Treatment of flecainide cardiac toxicity involves increasing the excretion of flecainide, blocking its effects in the heart, and (rarely) institution of cardiovascular support to avoid impending lethal arrhythmias. (wikipedia.org)
- Plasma levels of flecainide should be monitored, when feasible, especially in patients with severe liver or kidney failure, severe congestive heart failure, or life-threatening ventricular arrhythmias. (medscape.com)
- These electrophysiological properties strongly suggest that flecainide will be useful in the management of a wide variety of cardiac arrhythmias. (bmj.com)
- Because repolarization is not delayed flecainide is unlikely to induce ventricular arrhythmias related to prolongation of the QT interval. (bmj.com)
Ventricular tachycardia2
- Flecainide produced 100% suppression of nonsustained ventricular tachycardia and 99.5% suppression of paired ventricular depolarizations. (annals.org)
- Flecainide was first synthesized in 1972 and approved in 1984 from the Food and Drug Administration (FDA) for the suppression of sustained ventricular tachycardia [ 1 ] and later for acute cardioversion of AF and for sinus rhythm maintenance. (encyclopedia.pub)
Cardiac2
- Studies (notably the Cardiac Arrhythmia Suppression Trial) have shown an increased mortality when flecainide is used to suppress ventricular extrasystoles in the setting of acute myocardial infarction. (wikipedia.org)
- The researchers obtained electrocardiograms and flecainide-blood-plasma concentrations for each patient and tracked their cardiac rhythms for four hours using a Holter monitor to record adverse events. (medscape.com)
Sinus rhythm1
- Nearly half the patients (48%) who self-administered flecainide plus saccharin converted to sinus rhythm within 90 minutes of initiating inhalation. (medscape.com)
Cardioversion1
- Randomly selected patients took flecainide for four weeks or six months following electrical cardioversion. (rxwiki.com)
Pharmacodynamics1
- The pharmacodynamics of inhaled flecainide is different. (medscape.com)
CYP2D63
- Flecainide is metabolized in the liver via cytochrome (CYP2D6 and CYP1A2) in meta-O-dealkylated flecainide (active, but about one-fifth as potent) and meta-O-dealkylated lactam (inactive form), then excreted in the urine. (encyclopedia.pub)
- CYP2D6 genotype affects age-related decline in flecainide clearance: a population pharmacokinetic analysis. (cdc.gov)
- Serum flecainide S/R ratio reflects the CYP2D6 genotype and changes in CYP2D6 activity. (cdc.gov)
Allergic1
- On the assumption of a drug-induced allergic reaction, flecainide was withdrawn, after which liver enzymes rapidly returned to control values. (nih.gov)
Antiarrhythmics2
- This risk is probably increased when flecainide is co-administered with other class Ic antiarrhythmics, such as encainide. (wikipedia.org)
- Flecainide is in a class of medications called antiarrhythmics. (medlineplus.gov)
Serum1
- Maternal doses of flecainide up to 200 mg daily produce low levels in milk and undetectable infant serum levels. (nih.gov)
Concentrations2
- One-hour conversion rates back to normal rhythm increased with dosage as well as with the maximum plasma concentrations of flecainide. (medscape.com)
- Trough plasma concentrations are 0.2-1 µg/mL in most patients successfully treated with flecainide. (medscape.com)
20231
- Flecainide" Encyclopedia , https://encyclopedia.pub/entry/15951 (accessed November 28, 2023). (encyclopedia.pub)
Myocardial2
- Prospective participants were screened for their potential adverse responses, based on personal contraindications to flecainide such as heart failure, myocardial ischemia, or structural heart disease. (medscape.com)
- Flecainide works blocking the open-state fast inward Na+ channel Nav 1.5 [ 8 ] in a rate- and voltage-dependent manner, reducing the maximum rate of phase 0 rise of the action potential (Vmax) in fast channel-dependent myocardial fibers (mostly in His-Purkinje tissue and ventricular muscle, followed by atrial muscle) [ 9 ] . (encyclopedia.pub)
Increases1
- There is not enough information to tell whether taking flecainide also increases the risk of heart attack or death in people who have not had heart attacks within the past 2 years. (medlineplus.gov)
Toxicity1
- Signs of flecainide toxicity include marked prolongation of the PR interval and widening of the QRS duration on the surface ECG. (wikipedia.org)
Therapeutic2
- In adults, the reference range of the therapeutic trough of flecainide is 0.2-1 µg/mL. (medscape.com)
- The goal is to control or prevent arrhythmia with the lowest therapeutic plasma flecainide level. (medscape.com)
Prolongation1
- Flecainide may cause a condition that affects the heart rhythm (QT prolongation). (webmd.com)
Medication2
- Flecainide is a medication used to prevent and treat abnormally fast heart rates. (wikipedia.org)
- The flecainide trough level should be checked 3-5 days after starting the medication and less than one hour before the following dose. (medscape.com)
Liver2
- Because of the role of both the liver and the kidneys in the elimination of flecainide, the dosing of flecainide may need to be adjusted in individuals who develop either liver failure or kidney failure. (wikipedia.org)
- Although neither a reexposition with flecainide nor a liver biopsy was obtained, a flecainide-induced hepatitis seems probable. (nih.gov)
Tablet1
- Flecainide comes as a tablet to take by mouth. (medlineplus.gov)
Treatment4
- Flecainide is used in the treatment of many types of supraventricular tachycardias, including AV nodal re-entrant tachycardia (AVNRT) and Wolff-Parkinson-White syndrome (WPW). (wikipedia.org)
- In particular, flecainide has been useful in the treatment of ventricular tachycardias that are not in the setting of an acute ischemic event. (wikipedia.org)
- You may be hospitalized when you begin your treatment with flecainide. (medlineplus.gov)
- Arrhythmogenic effect of flecainide--treatment with i.v. magnesium]. (nih.gov)
Absorbed from the gastrointestinal tract1
- Flecainide, administered bis in die (immediate-release form) or once daily (controlled-release form), is nearly completely absorbed from the gastrointestinal tract with very high bioavailability (from 85% to 90%) [ 3 ] . (encyclopedia.pub)
Dose1
- Your doctor will probably start you on a low dose of flecainide and gradually increase your dose, not more than once every 4 days. (medlineplus.gov)
Cytochrome1
- In vitro metabolic studies have confirmed that cytochrome P450IID6 is involved in the metabolism of flecainide. (nih.gov)
Patients3
- A final group of 29 patients self-administered 120 mg flecainide in a solution that also contained saccharin. (medscape.com)
- The percentage of patients with successful conversion were 10% in the 30 mg group, 35% in the 60 mg group, 33% in the 90 mg group, 35% in the 120 mg group and 44% in the flecainide-plus-saccharin solution. (medscape.com)
- Given the 90-minute conversion rate for inhaled flecainide (per our study result) and the well-known low placebo conversion rate within the 90-minute time frame, the formal sample size in a randomized trial would be 250 patients," Dr. Crijns said. (medscape.com)
Adverse1
- Flecainide is not expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. (nih.gov)
Heart3
- In the long-term, flecainide seems to be safe in people with a healthy heart with no signs of left ventricular hypertrophy, ischemic heart disease, or heart failure. (wikipedia.org)
- In a study of people who had experienced heart attacks within the past 2 years, people who took flecainide were more likely to have another heart attack or to die than people who did not take flecainide. (medlineplus.gov)
- Had you had a heart attack in the 1980s, you might've been given a drug called encainide or flecainide to prevent irregular heart beats, which are common potentially fatal after-effects of heart attacks. (abc.net.au)
Prevent1
- Flecainide is used to prevent certain types of life-threatening irregular heartbeats. (medlineplus.gov)
Effect2
- Flecainide does not undergo any consequential presystemic biotransformation (first-pass effect). (nih.gov)
- Flecainide exerts a variable effect in terms of action potential duration (APD) and effective refractory period (ERP) on ventricular fibers and the Purkinje fibers. (encyclopedia.pub)
Administration1
- In individuals suspected of having the Brugada syndrome, the administration of flecainide may help reveal the ECG findings that are characteristic of the disease process. (wikipedia.org)
Hours2
- Some people may take flecainide once every 8 hours if they experience side effects or if their condition cannot be controlled by taking flecainide every 12 hours. (medlineplus.gov)
- The peak flecainide plasma concentration is generally reached within 2-3 hours. (medscape.com)
Plasma1
- A flecainide plasma trough level of less than 0.2 µg/mL is considered subtherapeutic. (medscape.com)
Risk2
- The risk of proarrhythmia is not necessarily associated with the length of time an individual is taking flecainide, and cases of late proarrhythmia have been reported. (wikipedia.org)
- Because of this serious risk and because flecainide has not been shown to help people with irregular heartbeats to live longer, flecainide should be used only to treat people with life-threatening irregular heartbeats. (medlineplus.gov)
Levels1
- Goji might increase the levels of flecainide in the body. (nih.gov)