Flavone derivatives flavones. Medical search. Frequent questions

This compound belongs to the class of organic compounds known as flavones. (drugbank.com)
The arylamide derivatives are an attractive class of organic compounds possessing various biological activities (Landucci et al. (springeropen.com)

Some synthetic derivatives from natural metabolites, such as flavonoid derivatives containing chromone (4 H -Benzopiran-4-one), are another kind of insecticide. (encyclopedia.pub)

In this study novel bisindolylmethanes and flavones were synthesized to identify potential inhibitors for bacterial infection, cancer, and diabetes. (uitm.edu.my)

β-Glucuronidase inhibitory property of some derivatives were found to be very potent (0.1-83.5 μM). (uitm.edu.my)

13,14 Among the secondary metabolites, the flavonoids are a group of compounds synthesized from cinnamic acid derivatives coupled with three acetate units that display several biological roles. (rsc.org)
Flavones consist of an attractive category of natural products possessing several biological activities (Zhao et al. (springeropen.com)

Bisindolylmethane and flavone are well-known natural product scaffolds having important pharmacophores and they have gained tremendous interest owing to their remarkable potency and activity profile towards various target diseases. (uitm.edu.my)

The flavonoids diversity showed a significant content of luteolin and its derivatives, except for Landoltia punctata that had significant apigenin content. (rsc.org)

Flavones are flavonoid derivatives with various bioactive effects, including AChE and BACE-1 inhibition. (nih.gov)
11. Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk. (nih.gov)

Flavonoids generally occur in plants as glycosylated derivatives and impart different color shades (blue, scarlet and orange in leaves, flowers and fruits ( Brouillard and Cheminat, 1988 ). (scialert.net)
Dietary flavonoids and synthetic derivatives have a well-known potential for biomedical applications. (degruyter.com)
Study of roots yielded 17 flavonoids: 13 flavones ( 1-13 ), two flavanones ( 14-15 ), a chalcone (2',4'-dihydroxy-3',6',2-trimethoxychalcone) ( 16 ), and a flavone glucoside ( 17 ). (stuartxchange.org)
A series of oxazinyl flavonoids were synthesized on the basis of flavone. (mdpi.com)

18. Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors. (nih.gov)
Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study. (nih.gov)
Flavone and isoflavone phytoestrogens are plant chemicals and are known to be competitive inhibitors of cytochrome P450 aromatase with respect to the androgen substrate. (nih.gov)
In combination with computer modeling, the binding characteristics and the structure requirement for flavone and isoflavone phytoestrogens to inhibit human aromatase were obtained. (nih.gov)

The flavones apigenin (3b) and luteolin (3a) are common in cereals grains and in aromatic herbs viz. (scialert.net)

Six of the synthetic flavones ( B4 , B5 , B6 , B8 , D6 and D7 ) had completely new structures. (nih.gov)
17. New synthetic flavone derivatives induce apoptosis of hepatocarcinoma cells. (nih.gov)
19. Synthetic flavonols and flavones: A future perspective as anticancer agents. (nih.gov)
Unlike most flavones, 5,6-benzoflavone is a synthetic chemical. (nih.gov)

The 3D-QSAR model and the information of the ligand-protein interaction will be helpful in the selection of flavones to be structurally modified and labeled by a radio nuclide for imaging Aβ(1-40) aggregates in the AD (Alzheimer's disease) brain. (unboundmedicine.com)
In the present study, over 30 ellipticine derivatives and structurally related compounds were examined for their ability to bind to the AhR, activate it to a DRE-binding form, induce the luciferase gene under control of a DRE-containing enhancer, and block activation of the AhR by TCDD. (nih.gov)

9. Enhanced susceptibility to apoptosis and growth arrest of human breast carcinoma cells treated with silica nanoparticles loaded with monohydroxy flavone compounds. (nih.gov)
Analysis of structural requirements for Ah receptor antagonist activity: ellipticines, flavones, and related compounds. (nih.gov)

Apigenin is a flavone (a subclass of bioflavonoids) primarily found in plants. (examine.com)
In foods and herbs, apigenin is often found in the more stable derivative form of apigenin-7-O-glucoside. (examine.com)

Certain ellipticine derivatives have been reported to bind to the AhR and inhibit the ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to transform the AhR to a form that recognizes a dioxin-responsive enhancer element (DRE) upstream of the cytochrome P4501A1 gene. (nih.gov)
The ability of several ellipticine derivatives to inhibit TCDD-elicited DRE binding and TCDD-induced luciferase activity was inversely related to their ability to alone stimulate these responses. (nih.gov)

5. Synthesis and Antiproliferative Activity of Thioxoflavones Mannich Base Derivatives. (nih.gov)
8. Synthesis and biological evaluation of quinoline analogues of flavones as potential anticancer agents and tubulin polymerization inhibitors. (nih.gov)
10. Design, synthesis and antiproliferative activity of functionalized flavone-triazole-tetrahydropyran conjugates against human cancer cell lines. (nih.gov)
12. Synthesis and anticancer activities of 3-arylflavone-8-acetic acid derivatives. (nih.gov)
13. Flavone-based arylamides as potential anticancers: Design, synthesis and in vitro cell-based/cell-free evaluations. (nih.gov)

1. Relationship Between the Structure of Methoxylated and Hydroxylated Flavones and Their Antiproliferative Activity in HL60 Cells. (nih.gov)
Extensive 3D-QSAR (quantitative structure-activity relationship) studies were performed on the fluorescent flavones, which are excellent ligands of Aβ(1-40) aggregates protein. (unboundmedicine.com)

Based on these data, a number of flavone derivatives were synthesized and tested for their relative agonist/antagonist activity. (nih.gov)

In order to further investigate the specific binding site of the flavones in the Aβ(1-40) aggregates, preliminary docking studies were performed. (unboundmedicine.com)

This study also provides a molecular basis as to why isoflavones are significantly poorer inhibitors of aromatase than flavones. (nih.gov)