AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
FlavivirusEncephalitis Viruses, Tick-BorneFlavivirus InfectionsGenome, ViralRNA, ViralNucleic Acid ConformationGenomeGenome, BacterialEncephalitis Viruses, JapaneseWest Nile virusDengue VirusEncephalitis Virus, JapaneseEncephalitis, Tick-BorneYellow fever virusGenome, PlantGenome, HumanEncephalitis Virus, Murray ValleyViral Nonstructural ProteinsPhylogenyWest Nile FeverGenome, MitochondrialEncephalitis Virus, St. LouisEncephalitis, ArbovirusCulicidaeSequence Analysis, DNAGenome, FungalBase SequenceGenome SizeVero CellsEncephalitis, JapaneseViral Envelope ProteinsMolecular Sequence DataGenome, ArchaealCercopithecus aethiopsCulexVirus ReplicationDengueEvolution, MolecularWest Nile Virus VaccinesRNA HelicasesEncephalitis, St. LouisGenome, InsectAntibodies, ViralYellow FeverCell LineAedesGenome, ProtozoanTogaviridae InfectionsAmino Acid SequenceGenomicsFlaviviridaeCricetinaeRepliconSequence AlignmentGenome, ChloroplastJapanese Encephalitis VaccinesViral ProteinsArboviruses
ZikaFlaviviridaeVirusesProteinsDengue virusInfectionPolyproteinEncephalitisMosquitoesWhole-genomeSequencesZIKVApproximately 11 kbRepliconFull-genomeReplication and PathogenesisAntibodiesVirionCapsidPathogenSerotypesGlycoproteinStructuralInfectVirologyComplete genomeAntibodyPositive sense single-stranded2023FamilyVaccineIsolatesGenesReplicateViral replicationImmuneAedesPathogenicSurrounded by a lipidSynthesisBiologyDiseasesVectorsSphericalStrandSequence
Zika20
  • The genus includes the West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika virus and several other viruses which may cause encephalitis, as well as insect-specific flaviviruses (ISFs) such as cell fusing agent virus (CFAV), Palm Creek virus (PCV), and Parramatta River virus (PaRV). (wikipedia.org)
  • Zika virus is a member of the Flaviviridae family and the genus Flavivirus (which includes yellow fever virus, West Nile virus, Japanese encephalitis virus, and dengue virus). (cdc.gov)
  • Zika virus (ZIKV), a mosquito-borne transplacentally transmissible flavivirus, is an enveloped virus with an ~10.8 kb plus-strand RNA genome that can cause neurological disease. (mdpi.com)
  • Zika virus is a member of the flavivirus family, which also includes yellow fever virus, dengue virus, Japanese encephalitis virus, and West Nile virus. (virology.ws)
  • Zika virus (ZIKV), a mosquito-transmitted flavivirus, re-emerged in the last decade causing serious human diseases including congenital microcephaly and Guillain-Barré syndrome. (unl.edu)
  • Researchers attempting to recover the entire Zika virus genome from an aborted fetus with microcephaly also observed virus particles in the brain. (asianscientist.com)
  • The medically important flaviviruses are Zika virus, dengue virus, Japanese encephalitis virus and West Nile virus. (asianscientist.com)
  • Zika belongs to the virus family Flaviviridae and the genus Flavivirus. (getjar.com)
  • Zika virus has a nonsegmented, single-stranded, positive-sense RNA genome. (getjar.com)
  • Zika virus (ZIKV), a mosquito borne flavivirus is a pathogen affecting humans in Asia and Africa. (biomedcentral.com)
  • The Zika virus is a mosquito-borne flavivirus. (healingpoint.in)
  • A significant number of insights have come from the Zika virus's genome. (healingpoint.in)
  • The Zika virus has an RNA genome, and thus a very high potential to accumulate mutations. (healingpoint.in)
  • Flaviviruses such as Zika virus, dengue virus, West Nile virus, yellow fever virus, and Japanese encephalitis virus cause widespread illness and death throughout the world. (nih.gov)
  • By investigating two of these receptors during infection by dengue and Zika viruses, scientists from the Institut Pasteur discovered that a precise region of the viral genome was recognized by a receptor known as RIG-I. Their discovery paves the way for the future development of vaccines for these diseases. (pasteur.fr)
  • Two of these protein receptors, RIG-I and MDA5, had previously been identified as playing a key role in the innate response against the replication of flaviviruses, a family of mosquito-borne viruses that includes dengue, yellow fever and Zika. (pasteur.fr)
  • Using an RLR-purification technique in conjunction with high-throughput sequencing and bioinformatics analysis, "we demonstrated that a precise region of the genomes of the dengue and Zika viruses (known as the 5' untranslated region) was recognized by RIG-I," explains Nolwenn Jouvenet, a scientist in the Viral Genomics and Vaccination Unit at the Institut Pasteur and last author of the paper. (pasteur.fr)
  • RIG-I Recognizes the 5' Region of Dengue and Zika Virus Genomes, Cell Reports , July 10, 2018. (pasteur.fr)
  • Spondweni virus (SPONV), a possible emerging virus, is a member of the Flaviviridae virus family, of the genus Flavivirus and belongs to a serogroup with the Zika virus. (spandidos-publications.com)
  • We extended these observations to two other flaviviruses, Dengue and Zika viruses. (nature.com)
Flaviviridae6
Viruses14
  • 2004 . Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses . (ajtmh.org)
  • However, viruses, being small in size, can only harbor a genome large enough to code for the minimal number of proteins required for the replication and maturation of the virions. (ox.ac.uk)
  • Alphavirus and Flavivirus are two viruses with a positive-strand RNA genome . (pediaa.com)
  • Alphavirus and Flavivirus are two RNA viruses that contain a positive-stranded RNA genome. (pediaa.com)
  • In contrast, Flavivirus refers to any group of RNA viruses, mostly having arthropod vectors, which cause several serious human diseases. (pediaa.com)
  • In brief, Alphavirus and Flavivirus are two genera of viruses that contain positive-sense RNA genomes. (pediaa.com)
  • St.Louis encephalitis, Japanese encephalitis, Powassan, tick-borne encephalitis viruses, dengue virus, and yellow fever virus are examples of the Flavivirus . (pediaa.com)
  • They identified it as a novel virus of the family to which yellow fever virus belongs: the flaviviruses, a group of RNA viruses often transmitted through the bite of infected arthropods. (gavi.org)
  • Flaviviruses comprise a genus of viruses that pose a significant burden on human health worldwide. (escholarship.org)
  • Disease Mechanisms of Toga viruses and Flavivirus Viruses are cytolytic, except for rubella. (slideshare.net)
  • Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects. (salehlab.eu)
  • The flavivirus family is comprised of RNA viruses- how about DNA viruses? (nature.com)
  • To further study the molecular epidemiology of TBE we characterize the genomes of sampled viruses using deep sequencing technique and bioinformatics. (oru.se)
  • The causative agents, enveloped single-strand RNA viruses from the genus Flavivirus with 4 serotypes, are transmitted by the bite of Aedes mosquitoes. (msdmanuals.com)
Proteins19
  • Role of structural disorder in the multi-functionality of flavivirus proteins. (ox.ac.uk)
  • EXPERT OPINION: Small sizes of viral genomes impose multifunctionality on their proteins, which is dependent on the excessive usage of intrinsic disorder. (ox.ac.uk)
  • The main difference between Alphavirus (Togavirus) and Flavivirus is that Alphavirus contains structural proteins at the 5′ end, whereas Flavivirus contains structural proteins at the 3′ end. (pediaa.com)
  • Alphavirus contains structural proteins at the 5′ end, while Flavivirus contains structural proteins at the 3′ end. (pediaa.com)
  • The structural proteins of the Alphavirus occur at the 5′ end of the genome. (pediaa.com)
  • The mature flavivirus particle comprises a nucleocapsid core surrounded by a lipid bilayer containing the membrane (M) (derived from the precursor prM) and envelope (E) proteins. (microbiologyresearch.org)
  • Availability http://carnot.utmb.edu/flavitrack Get in touch with ude.bmtu@niehcshc Supplementary details http://carnot.utmb.edu/flavitrack/B1S1.html 1 Launch Flaviviruses (FV) (+)-strand RNA infections in the same genus seeing that hepaci- and pestiviruses are in charge of many emerging individual encephalitic and hemorrhagic illnesses (Barrett and Higgs 2007 The ～10.5 kb genome encodes an individual polyprotein that's cleaved into 10 viral proteins (Fig. 1). (bioskinrevive.com)
  • Flavitrack will ultimately also contain buildings or 3D versions for any flavivirus proteins enabling combined series/structure evaluation to characterize common B- and T-cell epitopes account for Prp2 the functional effects of mutations and determine highly conserved areas. (bioskinrevive.com)
  • This positive-sense RNA genome can be directly translated into viral proteins. (getjar.com)
  • The genome is also peculiar: it encodes for a large polyprotein, which is further cleaved into capsid, membrane precursor (prM), envelope, and seven non-structural proteins. (healingpoint.in)
  • CDC's new flavivirus VLPs have structural proteins as the basis to form the viral particles. (nih.gov)
  • Their RNA genomes are translated using host ribosomes, synthesizing viral proteins that cooperate with each other and host proteins to reshape the host cell into a factory for virus replication. (escholarship.org)
  • Thus, dissecting the physical interactions between viral proteins and their host protein targets is essential in our comprehension of how flaviviruses replicate and how they alter host cell behavior. (escholarship.org)
  • Here, we review protein interactions between flavivirus and host proteins that contribute to virus replication, immune evasion, and disease. (escholarship.org)
  • The core of the virus is the nucleocapsid, a structure that is made of the viral genome along with C proteins. (medchemexpress.com)
  • The genome of the flavivirus TBEV consists of a single, positive-strand RNA molecule which encodes three structural and seven non-structural proteins. (univie.ac.at)
  • Flavivirus genomes defective in the production of infectious virus particles are constructed by deletion of one or more structural proteins and are characterized as replicons. (univie.ac.at)
  • By mapping and identifying interactions between viral proteins and the host cell, we aim to find suitable targets for the future development of antiviral drugs and to develop live attenuated flavivirus vaccines. (oru.se)
  • We also study viral replication using flavivirus replicon models which we can package in cell culture by co-expressing the structural proteins in our virus like particle system. (oru.se)
Dengue virus4
Infection9
  • The means by which flaviviruses establish persistent infection in their competent vectors and cause disease in humans depends upon several virus-host interactions, including the intricate interplay between flavivirus-encoded immune antagonists and the host antiviral innate immune effector molecules. (wikipedia.org)
  • As for other flaviviruses, antibodies against the E glycoprotein are likely important for protection against infection. (virology.ws)
  • Characterizing cross- flavivirus broadly neutralizing antibody ( bnAb ) responses can inform countermeasures that avoid enhancement of infection associated with non- neutralizing antibodies . (bvsalud.org)
  • We demonstrate a role for IgA in flavivirus infection and immunity with implications for vaccine and therapeutic strategies . (bvsalud.org)
  • ZIKV infection diagnosis relies on serology-which is challenging due to cross-reactions with other flaviviruses and/or absence or low titer of IgM and IgG antibodies at early phase of infection- virus isolation, which is labor intensive, time consuming and requires appropriate containment. (biomedcentral.com)
  • Non- neutralizing antibody can enhance flavivirus infection via Fc receptors on the macrophage. (slideshare.net)
  • Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts. (salehlab.eu)
  • We utilized a system to package TBEV replicons into virus particles to allow the infection of different cell types to study different aspects of the flavivirus biology including RNA recombination and packaging. (univie.ac.at)
  • This unique resource will be used to monitor the host response (including how the immune system responds to the infection), determine the complete genome sequence of infecting C. difficile and identify the intestinal microbiota by sequencing and culturing. (ukri.org)
Polyprotein3
  • The cellular ribosome is crucial to the replication of the flavivirus, as it translates the RNA, in a similar fashion to cellular mRNA, resulting in the synthesis of a single polyprotein. (wikipedia.org)
  • The RNA genome of this virus, tentatively designated OCFVPT, for O. caspius flavivirus from Portugal, encodes a polyprotein showing all the features expected for a flavivirus. (unl.pt)
  • Flaviviruses produce a polyprotein from the ssRNA genome. (storytellercentral.com)
Encephalitis9
  • Usutu virus (USUV) is a mosquito-borne zoonotic virus and one of the causes of flavivirus encephalitis in birds and occasionally in humans. (frontiersin.org)
  • Flaviviruses, the human pathogens responsible for dengue fever, West Nile fever, tick-borne encephalitis, and yellow fever, are endemic in tropical and temperate parts of the world. (nih.gov)
  • Flavivirus is also a disease-causing virus that causes encephalitis. (pediaa.com)
  • Expression of cloned envelope protein genes from the flavivirus tick-borne encephalitis virus in mammalian cells and random mutagenesis by PCR. (microbiologyresearch.org)
  • Motivation Properly annotated series data for flaviviruses which trigger diseases such as for example tick-borne encephalitis (TBE) dengue fever (DF) Western world Nile PHA-739358 (WN) and yellow fever (YF) can certainly help in the look of antiviral medications and vaccines to avoid their pass on. (bioskinrevive.com)
  • West Nile Virus (WNV) is a mosquito-transmitted flavivirus which causes encephalitis especially in elderly and immunocompromised individuals. (uzh.ch)
  • Infections by tick- and mosquito- borne Flavivirus is a gigantic global health problem causing serious diseases in humans including Dengue fever, West Nile encephalitis and Tick-borne encephalitis (TBE). (oru.se)
  • Japanese encephalitis is caused by the Japanese encephalitis virus (JEV), a flavivirus, and is closely related to St. Louis encephalitis and West Nile encephalitis. (medscape.com)
  • Japanese encephalitis virus, a flavivirus (single-stranded ribonucleic acid [RNA]), represents the most significant etiology of arboviral encephalitis worldwide. (medscape.com)
Mosquitoes5
  • We describe the isolation and characterization of an insect-specific flavivirus (ISF) from Ochlerotatus caspius (Pallas, 1771) mosquitoes collected in southern Portugal. (unl.pt)
  • Typically, flaviviruses get transmitted through the bite of infected mosquitoes and ticks. (nih.gov)
  • Defective viral genomes from chikungunya virus are broad-spectrum antivirals and prevent virus dissemination in mosquitoes. (salehlab.eu)
  • Moon SL, Dodd BJ, Brackney DE, Wilusz CJ, Ebel GD, Wilusz J. Flavivirus sfRNA suppresses antiviral RNA interference in cultured cells and mosquitoes and directly interacts with the RNAi machinery. (umich.edu)
  • Biotechnological approaches targeted toward ZIKV vector control include the development of transgenic mosquitoes to disrupt the genome pool of wild strains and use of an endosymbiotic bacterium to prevent replication of arboviruses within its vector. (bvsalud.org)
Whole-genome2
  • WG, whole-genome. (cdc.gov)
  • However, compared to other flaviviruses, USUV has received less research attention and there is therefore limited access to whole-genome sequences and also to in-depth phylogenetic and phylodynamic analyses. (frontiersin.org)
Sequences4
  • The database includes all publicly obtainable full-genome flavivirus sequences and access to series analysis equipment. (bioskinrevive.com)
  • Fig. 2 Primary components evaluation (PCA) of main flavivirus research sequences with differing identification to DV1 (Supplementary materials Desk S1) using the amount of pairwise BLOSUM ratings for eigenvector decomposition separates them relating to vector. (bioskinrevive.com)
  • GB virus C (GBV-C) evolutionary patterns revealed by analyses of reference genomes, E2 and NS5B sequences amplified from viral strains circulating in the Lisbon area (Portugal). (unl.pt)
  • The NS5 protein coding regions of African ZIKV isolates were sequenced and aligned with representative flaviviruses sequences from GenBank to design primers and probe from conserved regions. (biomedcentral.com)
ZIKV7
  • First, a full-length functional ZIKV cDNA clone was engineered as a bacterial artificial chromosome, with each reporter gene under the cap-independent translational control of a cardiovirus-derived internal ribosome entry site inserted downstream of the single open reading frame of the viral genome. (mdpi.com)
  • For example, examining flaviviruses closely related to ZIKV, the phylogenetic framework indicates New World monkeys are the most likely candidates to be potential reservoirs for ZIKV. (springer.com)
  • We illustrate that process by presenting a Flavivirus phylogeny case study for ZIKV and its taxonomic relatives, asking within this framework, which animals might serve as reservoirs for ZIKV. (springer.com)
  • To address the changes in the viral genome that may have led to increased virulence of the virus, I constructed an infectious cDNA clone for the historical ZIKV isolate MR766. (unl.edu)
  • Analyses of full-length genomes of over 300 ZIKV isolates revealed that one sequence motif, VNDT, containing an N-linked glycosylation site in the envelope (E) protein, is polymorphic, being absent in many of the African isolates while present in all isolates from the recent outbreaks. (unl.edu)
  • The assay was shown to detect 37 ZIKV isolates covering a wide geographic in Africa and Asia over 36 years but none of the 31 other flaviviruses tested showing high analytical specificity. (biomedcentral.com)
  • Like all flaviviruses, ZIKV is a single-stranded RNA virus with a positive-polarity RNA genome of approximately 11 kb. (biomedcentral.com)
Approximately 11 kb1
Replicon1
  • Functional analysis using replicon and genome-length RNAs of DENV-2 indicates that P85 is not important for viral replication. (rcsb.org)
Full-genome1
  • The most efficient method for HIV-1 genetic characterization involves full-genome sequencing, but the associated costs, technical features, and low throughput preclude it from being routinely used for the analysis of large numbers of viral strains. (unl.pt)
Replication and Pathogenesis1
  • Let's Get Physical: Flavivirus-Host Protein-Protein Interactions in Replication and Pathogenesis. (escholarship.org)
Antibodies2
  • Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses. (bvsalud.org)
  • The serotype of the virus was determined by performing indirect immunofluorescence ( 23 ) on cells from the cultures of C6-36 cells used for virus isolation with flavivirus-, dengue-, or serotype-specific monoclonal antibodies ( 23 , 24 ). (cdc.gov)
Virion3
  • However, the spherical virion of the Flavivirus is 40-50 nm in size. (pediaa.com)
  • Flavivirus nonstructural protein 2A (NS2A) is a component of the viral replication complex that functions in virion assembly and antagonizes the host immune response. (rcsb.org)
  • The viral genome is located inside the capsid of the virion, having a positive-sense polarity and a long open reading frame, which is flanked by untranslated regions at the 5' and 3' ends. (spandidos-publications.com)
Capsid1
Pathogen2
  • While the paper focused on flaviviruses, my interest focuses on Human Immunodeficiency Virus 1 (HIV‐1), which is a life‐threatening pathogen that still lacks a curative therapy or vaccine. (nature.com)
  • To this end we will evaluate in unprecendented detail the pathogen genome sequence, intestinal microbial composition and the host response in a case-control study of CDI hospitalised patients. (ukri.org)
Serotypes1
  • Dengue is a disease caused by four serotypes of a flavivirus of the same name ( 1 ). (cdc.gov)
Glycoprotein1
Structural4
  • In comparison, Flavivirus contains structural genes at the 3′ end. (pediaa.com)
  • Previous studies have suggested the protective role of the Toll-like receptor 3 (TLR3) pathway against WNV entry into the brain, while the WNV non-structural protein 1 (NS1) interferes with the TLR3 signaling pathway, besides being a component of viral genome replication machinery. (uzh.ch)
  • Researchers introduced an optimized plasmid to form the virus-like particles (VLPs) or non-structural protein 1 (NS1) into the cells and selected stably expressing cell populations for use to produce diagnostic antigens or immunogens for human and animal flavivirus vaccines. (nih.gov)
  • The structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production. (umich.edu)
Infect2
  • While dual-host flaviviruses can infect vertebrates as well as arthropods, insect-specific flaviviruses are restricted to their competent arthropods. (wikipedia.org)
  • Flaviviruses can infect cells of the monocyte-macrophage lineage. (slideshare.net)
Virology2
  • 13 Interactions Moléculaires Flavivirus-Hôtes, Department of Virology, Institut Pasteur. (nih.gov)
  • In the cellular and molecular virology group we focus primarily on improving the understanding of the flavivirus life cycle. (oru.se)
Complete genome1
Antibody1
  • CDC has identified and characterized distinct flavivirus cross-reactive epitopes (specific pieces of the antigen to which an antibody binds) that can improve serodiagnosis and vaccination against flaviviruses. (nih.gov)
Positive sense single-stranded2
  • Flaviviruses share several common aspects: common size (40-65 nm), symmetry (enveloped, icosahedral nucleocapsid), nucleic acid (positive-sense, single-stranded RNA around 10,000-11,000 bases), and appearance under the electron microscope. (wikipedia.org)
  • Flaviviruses have positive-sense, single-stranded RNA genomes which are non-segmented and around 10-11 kbp in length. (wikipedia.org)
20231
  • 2023) Flavivirus genome recoding by codon optimisation confers genetically. (tll.org.sg)
Family1
  • The known non-arboviruses of the flavivirus family reproduce in either arthropods or vertebrates, but not both, with one odd member of the genus affecting a nematode. (wikipedia.org)
Vaccine1
Isolates1
  • The lineage that wreaked havoc in the Americas is a sub-lineage with genomes similar to those of isolates from an outbreak in French Polynesia in 2013-2014. (healingpoint.in)
Genes1
  • Recognition of the genome of a virus initiates a signaling cascade that results in the expression of several hundreds of genes that are capable of blocking various stages of viral replication. (pasteur.fr)
Replicate1
  • Flaviviruses replicate in the cytoplasm of the host cells. (wikipedia.org)
Viral replication1
  • The topology model of DENV NS2A provides a good starting point for studying how flavivirus NS2A modulates viral replication and evasion of host immune response. (rcsb.org)
Immune2
  • The flavivirus nonstructural protein 1 (NS1) functions in genome replication as an intracellular dimer and in immune system evasion as a secreted hexamer. (nih.gov)
  • It is known that the innate immune response is based on the recognition of viral genomes by cellular receptors. (pasteur.fr)
Aedes1
  • Uncovering the repertoire of endogenous flaviviral elements in Aedes mosquito genomes. (salehlab.eu)
Pathogenic1
  • Many flaviviruses are host-specific and pathogenic, such as hepatitis C virus in the genus Hepacivirus. (ox.ac.uk)
Surrounded by a lipid1
  • Flavivirus is a virus that contains a single strand RNA genome, which is surrounded by a lipid membrane. (asianscientist.com)
Synthesis2
  • As frequently observed for ISF, the viral genomes seems to encode a putative Fairly Interesting Flavivirus ORF (FIFO)-like product, the synthesis of which would occur as a result of a -1 translation frameshift event. (unl.pt)
  • Oxidative stress influences positive strand RNA virus genome synthesis and capping. (umich.edu)
Biology1
  • 14 Unité de Génétique Fonctionnelle des Maladies Infectieuses, Department Genome and Genetics Centre National de la Recherche Scientifique, URA3012, Paris, France Systems Biology of Diseases Unit, Faculty of Science. (nih.gov)
Diseases1
  • What are some of the medically important diseases caused by flaviviruses? (asianscientist.com)
Vectors1
  • Transmission by both mosquito and tick vectors, and broad host tropism contribute to the presence of flaviviruses globally. (escholarship.org)
Spherical1
  • Flaviviruses are enveloped and spherical and have icosahedral geometries with a pseudo T=3 symmetry. (wikipedia.org)
Strand1
  • We describe the development of a new vector based on cowpea severe mosaic virus (CPSMV), a plus-strand RNA virus with its genome divided into two RNA segments, RNA1 and RNA2. (researchsquare.com)
Sequence1
  • This work reports the initial characterization, including near full-length sequence analysis, of an ISF which seems to form a divergent lineage within the ISF radiation, as indicated by phylogenetic analysis based on ac multiple sequence alignment of the NS5 flavivirus coding sequence. (unl.pt)