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  • vaccines
  • Dr. Bloom says that all flaviviruses have a similar genomic structure, and many scientists thought they would use the same survival mechanism and respond to the same vaccines and therapies, but the RML work shows otherwise. (rxpgnews.com)
  • protein
  • The NS4A protein is small and poorly conserved among the Flaviviruses. (ebi.ac.uk)
  • Nonstructural protein 2B and 3 of the flaviviruses (NS2BNS3) form an endoplasmic reticulum (ER) membrane-associated hetero-dimeric complex through the NS2B transmembrane region. (springer.com)
  • Crystal structure of a novel conformational state of the flavivirus NS3 protein: implications for polyprotein processing and viral replication. (springer.com)
  • Limited sequence identity with various isolates of hepatitis C virus and the relative positions of putative RNA helicases and RNA-dependent RNA polymerases in the predicted protein products of these molecules suggested that the GB agent contains two unique flavivirus-like genomes. (pnas.org)
  • The study released this week online in the Journal of Virology describes how a single virus protein--NS5--from the tick-borne Langat flavivirus counteracts the natural ability of interferon to combat the virus. (rxpgnews.com)
  • It was thought that the tick-borne flaviviruses would use the same protein, so the NS5 finding was unexpected. (rxpgnews.com)
  • species
  • These PCR products are subjected to hybridization on a microarray carrying 84 different oligonucleotide probes that represent all known Flavivirus species. (hindawi.com)
  • Twenty-six Flavivirus strains were tested with the assay, showing equivalent or superior characteristics compared with the original or even with species-specific RT-PCRs. (hindawi.com)
  • prevalent
  • Because of this, specific etiologic diagnosis may be difficult specially in areas where two or more flaviviruses are prevalent [ 3 ]. (hindawi.com)
  • JEV was the most prevalent Flavivirus in Oudomxay, Luangprabang, and Huaphan provinces and DENV4 was the most prevalent in Xiengkhouang province. (ajtmh.org)
  • detection
  • Validation experiments confirmed that the RT-qPCR exhibited roughly equal sensitivity of detection and quantification for all flaviviruses tested. (hindawi.com)
  • salivary
  • The NIAID scientists developed their model by dissecting three tick organs-the midgut, salivary glands and nervous tissue-and then culturing flaviviruses in those organs, evaluating their viability over several days. (nih.gov)
  • laboratory
  • This assay has been used as a screening and confirmation tool for Flavivirus presence in laboratory and field samples, and it performed successfully in international External Quality Assessment of NAT studies. (hindawi.com)
  • ZIKV
  • Thus, we evaluated the impact of heterotypic flavivirus immunity on ZIKV titers in biofluids of rhesus macaques. (harvard.edu)