Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene. (wikipedia.org)
FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling, and is also central to the decision for a preadipocyte to commit to adipogenesis. (wikipedia.org)
In the currently accepted model, FOXO1 negatively regulates adipogenesis by binding to the promoter sites of PPARG and preventing its transcription. (wikipedia.org)
by preventing its transcription, FOXO1 is preventing the onset of adipogenesis. (wikipedia.org)
During stimulation by insulin, FOXO1 is excluded from the nucleus and is subsequently unable to prevent transcription of PPARG and inhibit adipogenesis. (wikipedia.org)
However, there is substantial evidence to suggest that there are other factors that mediate the interaction between FOXO1 and the PPARG promoter, and that inhibition of adipogenesis is not entirely dependent on FOXO1 preventing transcription of PPARG. (wikipedia.org)
FOXO1 also activates transcription of phosphoenolpyruvate carboxykinase, which is required for gluconeogenesis. (wikipedia.org)
Considerable data support the idea that forkhead box O1 (Foxo1) drives the liver transcriptional program during fasting and is then inhibited by thymoma viral proto-oncogene 1 (Akt) after feeding. (nature.com)
Skeletal muscle FOXO1 (FKHR)-transgenic mice have less skeletal muscle mass, down-regulated type I (slow twitch / red muscle) fiber genes. (kpu.ac.jp)
We have previously shown that the forkhead transcription factor FoxO1 is a prominent transcriptional effector of GLP-1 signaling in the β-cell. (diabetesjournals.org)
Transcriptional6
These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
Fasting signals are relayed by various intracellular enzymes, such as kinases, phosphatases, acetyltransferases, and deacetylases, which affect the transcriptional activity of transcription factors and transcriptional coactivators for gluconeogenic genes. (e-enm.org)
More recent reports suggest that PRMTs can affect transcription by direct modification of transcriptional regulators. (e-enm.org)
Type II PRMTs (PRMT5, PRMT7, and PRMT9) are less well characterized and may function as transcriptional repressors, although some reports suggest that they can function as activators of transcription. (e-enm.org)
We have developed a model of insulin signalling in rodent adipocytes that includes both transcriptional feedback through the Forkhead box type O (FOXO) transcription factor, and interaction with oxidative stress, in addition to the core pathway. (biomedcentral.com)
Protein3
Protein arginine methyltransferases (PRMTs) were recently added to the list of enzymes that are critical for regulating transcription in hepatic gluconeogenesis. (e-enm.org)
Increasing evidence indicates that pro-inflammatory mediators, protein degradation-associated factors, and some other circulating mediators drive this process ( 18 ). (spandidos-publications.com)
Myostatin binding to type IIB activin receptor (ActRIIB) on muscle surface induces the recruitment and activation of activin receptor-like kinase 5 (ALK5), and eventually leads to forkhead box O3 (FoxO3a)-dependent transcription to promote muscle protein breakdown via the ubiquitin-proteasome system ( 23 ). (spandidos-publications.com)
Gene4
BCL2L11 expression can be stimulated by nerve growth factor (NGF), in addition to the forkhead transcription factor (FKHR-L1) which proposes a role of the BCL2L11 gene in neuronal and lymphocyte apoptosis. (neuromics.com)
The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. (sitoolsbiotech.com)
It also stimulates insulingene expression and insulin biosynthesis ( 6 ), in part via increased expression and activity of the β-cell-specific transcription factor Pdx1 ( 7 , 8 ). (diabetesjournals.org)
A forkhead transcription factor FKHR up-regulates lipoprotein lipase expression in skeletal muscle. (kpu.ac.jp)
Hepatic1
In hepatic cells this transcription factor seems to increase the expression of PEPCK and glycogen-6-phosphatase (the same enzymes that are blocked via the metformin/AMPK/SHP pathway). (wikipedia.org)
Kinase4
These exciting results suggest that FKHR isoforms may be critical effectors of PI 3-kinase/PDK1/PKB signalling in vivo. (dundee.ac.uk)
KIT is a receptor tyrosine kinase type III, which binds to stem cell factor. (inhibitorkit.com)
FLT3 (FMS-like tyrosine kinase 3) is a type III receptor tyrosine kinase (RTK) closely related to the platelet-derived growth factor (PDGF) receptor and c-Kit with important functions in the regulation of early hematopoietic cells. (ashpublications.org)
We have previously shown that GLP-1 transactivates the epidermal growth factor receptor ( 12 ) to subsequently activate phosphatidylinositol-3 kinase and Akt signaling ( 7 , 11 ). (diabetesjournals.org)
Gluconeogenesis1
Transcription of glucose 6-phosphatase subsequently decreases, which consequently decreases the rates of gluconeogenesis and glycogenolysis. (wikipedia.org)
Nucleus1
termed FKHR isoforms) are phosphorylated by PKB in cells, leading to their exit from the nucleus. (dundee.ac.uk)
Expression1
FLT3-ITD expression causes malignant transformation and factor-independent growth when expressed in factor-dependent cell lines. (ashpublications.org)
Type2
PRMT5, a predominant type II PRMT in mammals, represses transcription by promoting symmetric dimethylation of arginine 8 on histone H3 (H3R8) and symmetric dimethylation of arginine 3 on histone H4 (H4R3) [ 6 ]. (e-enm.org)
The role of type III PRMTs in the control of transcription has not been well characterized to date. (e-enm.org)
Target2
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
In earlier reports, PRMTs promoted active transcription of target genes by mediating asymmetric dimethylation of arginine residues on histones, resulting in increased acetylation and the subsequent activation of transcription. (e-enm.org)
Increase1
However, PRMT5 can also increase transcription under certain conditions [ 7 , 8 ]. (e-enm.org)
Effect1
Woods, YL & Rena, G 2002, ' Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRLI and AFX ', Biochemical Society Transactions , vol. 30, no. 4, pp. 391-397. (dundee.ac.uk)
PAX3-FKHR9
Alveolar rhabdomyosarcoma (ARMS) is consistently associated with the characteristic translocations t(2;13)(q35;q14) and t(1;13)(p36;q14), which encode for the PAX3-FKHR and PAX7-FKHR fusion oncoproteins respectively. (nih.gov)
We have investigated the relationship between PAX3-FKHR expression and ARMS histogenesis in primary tumors and cell culture systems. (nih.gov)
In a blinded histological review of discrepant primary tumors in which there was PAX3-FKHR expression but embryonal histology, we found small areas of alveolar histology in 6 of 11 cases. (nih.gov)
This suggests that histology alone may under-represent the association between PAX3-FKHR and ARMS, and we investigated this link by examining the effect of ectopic PAX3-FKHR expression on RMS cells. (nih.gov)
Two cell lines, RD and HX170C, were stably transfected with a PAX3-FKHR expression construct. (nih.gov)
In cloned transfectants derived from both lines, PAX3-FKHR expression resulted in increased proliferative rate in vitro and promoted cell growth in the absence of added growth factors. (nih.gov)
We have used cDNA microarrays containing 1238 cDNAs to investigate the gene expression profile of a group of seven alveolar rhabdomyosarcoma (ARMS) cell lines characterized by the presence of the PAX3-FKHR fusion gene. (nih.gov)
Among these 37 were genes related to both primary (PAX3-FKHR) and secondary (CDK4) genetic alterations in ARMS. (nih.gov)
The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. (nih.gov)
FKHRL11
13. Forkhead family transcription factor FKHRL1 is expressed in human megakaryocytes. (nih.gov)
Pathway3
In hepatic cells this transcription factor seems to increase the expression of PEPCK and glycogen-6-phosphatase (the same enzymes that are blocked via the metformin/AMPK/SHP pathway). (wikipedia.org)
10. The death domain-containing kinase RIP1 regulates p27(Kip1) levels through the PI3K-Akt-forkhead pathway. (nih.gov)
18. Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels. (nih.gov)
Reciprocal1
Structural and functional studies of FKHR-PAX3, a reciprocal fusion gene of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma. (nih.gov)
Encode1
Several forms of human sarcoma, lymphoma, and leukemia are characterized by somatically acquired chromosome translocations that result in fusion genes that encode chimeric transcription factors with oncogenic properties. (nih.gov)
Apoptosis1
Furthermore PAK1 also inhibits apoptosis by inactivating and phosphorylating cell success forkhead transcription element FKHR [26]. (biongenex.com)
Regulates1
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. (nih.gov)