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TacrolimusTacrolimus Binding ProteinsImmunophilinsTacrolimus Binding Protein 1AImmunosuppressive AgentsCalcineurinPolyenesDepsipeptidesD-Ala(2),MePhe(4),Met(0)-ol-enkephalinAmino Acid IsomerasesPeptidylprolyl IsomeraseNitro CompoundsSirolimusCalmodulin-Binding ProteinsCefiximeLipopeptidesAcrylamidesCarrier ProteinsCyclosporinsHeat-Shock ProteinsPeptides, CyclicRats, Inbred ACINicotinamide PhosphoribosyltransferasePhosphoprotein PhosphatasesChromobacteriumAlkynesStreptomycesRyanodine Receptor Calcium Release ChannelRats, Inbred LewMolecular Sequence DataGraft RejectionEchinocandinsOxazinesAllylestrenolNeurokinin-1 Receptor AntagonistsImmunosuppressionNFATC Transcription FactorsReceptors, Neurokinin-2PhenylbutyratesHistone Deacetylase InhibitorsLiver TransplantationAntibiotics, AntineoplasticDose-Response Relationship, Drug5-alpha Reductase InhibitorsDrug SynergismAmino Acid SequenceDipeptidesMice, Inbred ICRCephalosporinsChromosomes, Artificial, P1 BacteriophageEnzyme InhibitorsRats, Inbred BBRats, Sprague-DawleyDNA-Binding ProteinsCefaclorCalciumAntifungal AgentsAlkadienesCells, CulturedIndolesAnti-Bacterial AgentsNeuroprotective AgentsHeart-Lung TransplantationGraft SurvivalHeart TransplantationTime FactorsCysteamineIsoxazolesT-LymphocytesOxymetazolineProtein BindingObturator NerveBase SequenceTransplantation, HomologousNeurokinin AOrgan TransplantationMolecular StructureRats, Inbred WFKidney TransplantationRabbitsRats, WistarEvans BlueUterine DiseasesHSP90 Heat-Shock ProteinsPiperidinesCyclophilinsSignal TransductionDogsAspergillus fumigatusCell LineCephalosporinaseLymphocyte ActivationSciatic NerveDisease Models, AnimalRNA, MessengerProdigiosinKidneyBinding SitesCaffeineBatch Cell Culture Techniques
TacrolimusFKBPImmunophilinELISA KitBinding ProteinEfficacyCyclosporineProteinsBindsCalcineurinRapamycinImmunosuppressantPhosphorylationTransplantationReceptorIncreasesMechanismDoseRejectionTreatmentResponseEffectStudyExpressionSamples
Tacrolimus6
  • We report the efficacy of tacrolimus (FK506) in increasing ENG and ALK1 expression. (aspetjournals.org)
  • Effects of tacrolimus (FK506) on encephalomyocarditic virus-induced diabetes in mice. (uchicago.edu)
  • Topical tacrolimus (FK506) and mometasone furoate in treatment of dyshidrotic palmar eczema: a randomized, observer-blinded trial. (qxmd.com)
  • This study was performed to compare the efficacy of tacrolimus (FK506) 0.1% ointment and mometasone furoate 0.1% ointment in the treatment of dyshidrotic palmoplantar eczema. (qxmd.com)
  • Tacrolimus (topical FK506) is an immunomodulator that acts as a calcineurin inhibitor. (medscape.com)
  • Efficacy and safety of Tacrolimus (FK506) in treatment of rheumatoid arthritis: a randomized, double blind, placebo controlled dose-finding study. (bvsalud.org)
FKBP3
  • Functional maturation of steroid hormone receptors requires ordered assembly into a large multichaperone complex consisting of receptor monomer, an Hsp90 dimer, the p23 cochaperone, and an FK506-binding protein (FKBP) family member or alternate peptidylprolyl isomerase-related cochaperone. (unboundmedicine.com)
  • Recent findings of over-activation of the TGF-b signal in FKBP12-knockout mouse prompted us to investigate if FK506, the canonical ligand of FKBP, can activate the TGF-b signal in BCLL. (unina.it)
  • It binds with high affinity to immunophilin FKBP (FK506-binding protein). (medscape.com)
Immunophilin2
  • Recently, we showed that p59 purified from human lymphocytes is an immunophilin (FKBP59) which binds both FK506 and rapamycin. (broadinstitute.org)
  • The immunophilin FK506 binding protein (FKBP51) confers short-loop negative feedback inhibition of the glucocorticoid signalling pathway. (uib.no)
ELISA Kit1
  • Description: A sandwich ELISA kit for detection of FK506 Binding Protein 1B from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (unicoupi.com)
Binding Protein9
  • P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors. (broadinstitute.org)
  • P59 [also known as FK506 binding protein 59 (FKBP59) or heat shock protein 56 (hsp56)] and heat shock proteins 90 and 70 (hsp90 and hsp70) associate with steroid receptors and are believed to maintain the receptors in an inactive state. (broadinstitute.org)
  • Magnetic Luminex Assay Kit for FK506 Binding Protein 5 (FKBP5) ,etc. (uscnk.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse FK506 Binding Protein 1B (FKBP1B) in Tissue homogenates, cell lysates and other biological fluids. (unicoupi.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human FK506 Binding Protein 1A (FKBP1A) in tissue homogenates, cell lysates and other biological fluids. (wannabe-anthropologist.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human FK506 Binding Protein 1A (FKBP1A) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (wannabe-anthropologist.com)
  • FK506 binding protein 7 is a protein that in humans is encoded by the FKBP7 gene. (wikipedia.org)
  • Rapid, Structure-Based Exploration of Pipecolic Acid Amides as Novel Selective Antagonists of the FK506-Binding Protein 51. (mpg.de)
  • FK506-binding protein 5 (FKBP5) binds to glucocorticoid receptors and modulates glucocorticoid sensitivity. (nih.gov)
Efficacy1
  • Figure 2: Mdr-1 deactivation by pharmacological inhibition with TQD or Abcb1a - Abcb1b knockout ( Abcb1a - Abcb1b −/− ) potentiates the neuroprotective efficacy of FK506 and rifampicin (Rif). (nature.com)
Cyclosporine2
  • All but two of the responder samples underwent apoptosis also when cultured with FK506, but not with cyclosporine. (unina.it)
  • The deleterious effects of long-term cyclosporine A, cyclosporine G, and FK506 on bone mineral metabolism in vivo. (bvsalud.org)
Proteins1
  • Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins. (mpg.de)
Binds1
  • Here we provide evidence that rabbit uterine p59 also binds FK506 and rapamycin and that p59 or its homologue is associated with nontransformed progesterone receptors of rabbit uterus and chicken oviduct. (broadinstitute.org)
Calcineurin2
  • FK506 and CsA, although structurally unrelated, appear to target similar signal transduction pathways in hematopoietic cells by inhibiting the action of calcineurin, a serine/threonine phosphatase. (ox.ac.uk)
  • FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice. (cdc.gov)
Rapamycin3
  • The association of p63 to the p59 complex was inhibited by FK506 and rapamycin, suggesting that p63 could be a potential target for the immunosuppressive actions of these two drugs. (broadinstitute.org)
  • The microbial products cyclosporin A (CsA), FK506 and rapamycin are potent immunosuppressive agents. (ox.ac.uk)
  • A structural analog of FK506, rapamycin, inhibits cellular function by a different molecular mechanism. (ox.ac.uk)
Immunosuppressant2
  • An inhibitor of CN, the immunosuppressant, FK506, prevented cadmium-induced testicular damage in five pathological categories, including vascular endothelial and seminiferous epithelial endpoints. (cdc.gov)
  • FK506, a novel immunosuppressant isolated from a Streptomyces. (bvsalud.org)
Phosphorylation1
Transplantation3
  • These results suggest that the mechanism of action of FK506 involves a partial correction of endoglin and ALK1 haploinsufficiency and may therefore be an interesting drug for use in patients with HHT who undergo transplantation. (aspetjournals.org)
  • Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology. (ox.ac.uk)
  • FK506 appears to have a higher therapeutic index than CsA, and has been used with encouraging results in clinical transplantation trials. (ox.ac.uk)
Receptor2
  • Our study shows that FK506 removed FKBP12 from its binding to the TGF-b-receptor. (unina.it)
  • We demonstrate that FK506 activates the TGF-b receptor I kinase activity in BCLL which transduces apoptosis by a mitochondrial-dependent pathway. (unina.it)
Increases2
  • Here, we find that the immunosuppressor FK506 increases the protein and mRNA expression of ENG and ALK1 in cultured endothelial cells and enhances the TGF-β1/ALK1 signaling pathway and endothelial cell functions like tubulogenesis and migration. (aspetjournals.org)
  • The Mdr-1 inhibitor TQD preferably increases brain concentrations of FK506 and rifampicin in the ischemic brain. (nature.com)
Mechanism1
  • The protection afforded by FK506, found by the current study, indicated that CN is likely to be important in the mechanism of cadmium toxicity in the testis and possibly other organs. (cdc.gov)
Dose1
Rejection1
  • The liver was transplanted, and the immunosuppressor FK506 was used to prevent the rejection. (aspetjournals.org)
Treatment4
  • After the first month of FK506 treatment, the internal and external telangiectases, epistaxes, and anemia disappeared. (aspetjournals.org)
  • The dyshidrotic area and severity index showed a more than 50% reduction of baseline values after 2 weeks of active treatment both for FK506 (P =.003) and mometasone furoate (P =.022) in palmar areas. (qxmd.com)
  • After active treatment, a nonsignificant increase in the dyshidrotic area and severity index was seen with FK506 treated areas. (qxmd.com)
  • Treatment with FK506 offers the possibility for rotational therapy with mometasone furoate in long-standing cases of chronic dyshidrotic palmar eczema. (qxmd.com)
Response1
  • Overall, response to FK506 occurred in 33 samples. (unina.it)
Effect4
  • The effect of FK506 on transforming growth factor beta signaling and apoptosis in chronic lymphocytic leukemia B cells. (unina.it)
  • FK506, reported to abrogate tolerance to azole drugs at low cell density, had no effect on tolerance at high cell density and in biofilm. (who.int)
  • Densitometric analysis was performed to observe the effect of FK506 on the bone mineral density. (bvsalud.org)
  • Clinical observation on the effect of Wuzhi soft capsule on FK506 concentration in membranous nephropathy patients. (cdc.gov)
Study1
  • Our study shows that most BCLL cells escape the homeostatic control of TGF-b and that FK506 restores the TGF-b signal in a proportion of non responder samples. (unina.it)
Expression1
  • 2013) Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster. (uni-tuebingen.de)
Samples1
  • Thirteen samples non sensitive to TGF-b were sensitive to FK506. (unina.it)