Fission yeast schizosaccharomyces schizosaccharomyces pombe proteins. Medical search. Frequent questions

Saccharomyces cerevisiae (budding yeast) also have two anillin-like proteins, Boi1p and Boi2p. (wikipedia.org)
We have previously shown that budding yeast Mak11, whose homologues in other eukaryotes were described as modulating a p21-activated protein kinase function, accumulates in Rlp24-associated pre-60S complexes when their maturation is impeded in Saccharomyces cerevisiae. (pasteur.fr)
His PhD dissertation entitled "Genetic approaches to the study of Rheb GTPase" utilized the model organisms, Saccharomyces cerevisiae and Schizosaccharomyces pombe , to elucidate Rheb's function in arginine uptake and nutrient sensing. (usc.edu)
Members of this group include the MAPKKs Polymyxin B resistance protein 2 (PBS2) from Saccharomyces cerevisiae, Wis1 from Schizosaccharomyces pombe, and related proteins. (umbc.edu)
This subfamily is composed of Schizosaccharomyces pombe Nak1, Saccharomyces cerevisiae Kic1p (kinase that interacts with Cdc31p) and related proteins. (umbc.edu)
Regions upstream of genes are longer than in budding yeast (Saccharomyces cerevisiae), possibly reflecting more-extended control regions. (inrae.fr)

In addition, they play important roles in gene transcription (via activation of mitogen activated protein (MAP) kinase pathways and, in higher eukaryotes, the transcription factor NFκB), generation of reactive oxygen species, apoptosis, and cell-cycle progression. (biomedcentral.com)
Nbl1 (novel Borealin-like 1) physically associates with known CPC components, affects the kinase activity and stability of the S. pombe Aurora B homologue, Ark1, colocalizes with known CPC subunits during mitosis, and shows sequence similarity to human Borealin. (uky.edu)
During this highly polarized growth, micro-tubules are responsible for the placement of the cell-end marker proteins, the Teal-Tea4/Wsh3 complex, which recruits the Pom1 DYRK-family protein kinase. (escholarship.org)
Results: Pom1 kinase physically interacts with Rga4, which has a GAP (GTPase-activating protein) domain for Rho-family GTPase. (escholarship.org)
Protein kinases (PKs), MAP kinase kinase (MAPKK) subfamily, fungal PBS2-like proteins, catalytic (c) domain. (umbc.edu)
The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)
The mitogen-activated protein (MAP) kinase signaling pathways are important mediators of cellular responses to extracellular signals. (umbc.edu)
In addition, we investigated several cell cycle-related proteins and found that co-knockdown of hTopBP1 and hMYH significantly diminished cell cycle arrest due to compromised checkpoint kinase 1 (Chk1) activation. (biomedcentral.com)
Stress-activated protein kinase pathway functions to support protein synthesis and translational adaptation in response to environmental stress in fission yeast. (ox.ac.uk)
The stress-activated protein kinase (SAPK) pathway plays a central role in coordinating gene expression in response to diverse environmental stress stimuli. (ox.ac.uk)
Protein synthesis was further reduced in mutants disrupting the SAPK pathway, including the mitogen-activated protein kinase Wis1 or the mitogen-activated protein kinase Spc1/Sty1, suggesting a role for these stress response factors in this translational control. (ox.ac.uk)
The fission yeast polo related kinase Plo1 is required to assemble the mitotic spindle, the prophase actin ring that predicts the site for cytokinesis and for septation after the completion of mitosis (Ohkura et al. (kent.ac.uk)
Nak1 (also known as N-rich kinase 1), is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. (umbc.edu)

Moreover, we found that Skb15, the Mak11 homologue in Schizosaccharomyces pombe, also associated with preribosomes and affected 60S biogenesis in fission yeast. (pasteur.fr)
However, a Borealin homologue has never been characterized in the fission yeast, Schizosaccharomyces pombe. (uky.edu)
Here, we isolate a previously uncharacterized S. pombe protein through association with the Cdc14 phosphatase homologue, Clp1/Flp1, and identify it as a Borealin-like member of the CPC. (uky.edu)
Thus, this study characterizes a fission yeast Borealin homologue and reveals a previously unrecognized connection between the CPC and the process of cytokinesis in S. pombe. (uky.edu)
Human Rad 9 ( hRad9 ) was originally identified as a structural homologue of yeast schizosaccharomyces pombe rad 9 , which can partially rescue the sensitivity of rad 9 null yeast to hydroxyurea, radiation damage and the associated checkpoint defects [ 1 ]. (biomedcentral.com)
Kic1p interacts with Cdc31p, the yeast homologue of centrin, and phosphorylates substrates in a Cdc31p-dependent manner. (umbc.edu)

The genome sequence of Schizosaccharomyces pombe. (genome.jp)
Professor Forsburg studies how chromosome duplication and maintenance contributes to overall genome stability using a simple model genetic system, the fission yeast Schizosaccharomyces pombe . (usc.edu)
Mitochondrial TAT transports folded proteins in those eukaryotes with TatA and TatC subunits encoded in the mitochondrial genome. (tcdb.org)
In the fission yeast Schizosaccharomyces pombe, the DNA damage response protein Brc1 binds phospho-histone H2A (Î³H2A)-marked chromatin during S-phase, but how Brc1 protects genome integrity remains unclear. (thebiogrid.org)
Database is richly annotated in the systemic information on the nomenclature, chemistry and structure of the DNA damage and drugs targeting nucleic acids and/or proteins involved in the maintenance of genome stability. (vifabio.de)
Accordingly, age-related DNA damage and genome instability were lower in fat body of the mutant, and overexpression of a minichromosome maintenance protein subunit extended lifespan. (bvsalud.org)
Transferring the functional annotation of a protein to its orthologs in other species is therefore routine in genome annotation. (biomedcentral.com)
Two proteins that are each others best hit (also known as reciprocal best hit (RBH) or symmetrical best hit) in a pair-wise genome comparison are considered orthologous. (biomedcentral.com)
The mechanism by which specific protein-DNA complexes induce programmed replication fork stalling in the eukaryotic genome remains poorly understood. (le.ac.uk)
We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. (inrae.fr)

Anillin is a conserved protein implicated in cytoskeletal dynamics during cellularization and cytokinesis. (wikipedia.org)
Fission yeast Rng3p: an UCS-domain protein that mediates myosin II assembly during cytokinesis. (thebiogrid.org)
By regulating filamentous actin, Cdc42 and Rac exert a profound effect on cell shape, polarity, migration, cell:cell and cell:matrix adhesion, protein traffic, and cytokinesis. (biomedcentral.com)

Fission yeast is a single-celled organism with chromosomes very similar to those in humans, and uses the same genes to maintain those chromosomes. (usc.edu)
KAT11 and H3K56 acetylation appear to correlate with actively transcribed genes and associate with the elongating form of Pol II in yeast (PMID:17046836). (embl.de)
Among CRE1 repressed transcripts, genes encoding unknown proteins and transport proteins were overrepresented. (biomedcentral.com)
This package provides a RangedSummarizedExperiment object of read counts in genes for a time course RNA-Seq experiment of fission yeast (Schizosaccharomyces pombe) in response to oxidative stress (1M sorbitol treatment) at 0, 15, 30, 60, 120 and 180 mins. (bioconductor.org)
This domain occurred 388 times on human genes ( 899 proteins). (umbc.edu)
This domain occurred 417 times on human genes ( 967 proteins). (umbc.edu)
In the fission yeast Schizosaccharomyces pombe genes embedded in histone H3 lysine 9 methylation (H3K9me) heterochromatin, deposited by the sole H3K9- methyltransferase Clr4, are transcriptionally silenced. (ed.ac.uk)
Two genes whose heterochromatin mediated repression results in resistance phenotype encode mitochondrial proteins: ppr4+, which encodes Ppr4 the translation regulator of [cox1+] and cup1+, which encodes LYR-domain protein Cup1. (ed.ac.uk)
Elevated oxidative stress triggers transcriptional reprogramming via the fission yeast oxidative stress response pathway, leading to upregulation of efflux pumps and antioxidant genes, resulting in caffeine and multidrug cross-resistance, explaining the phenotype of epimutants. (ed.ac.uk)
We identify highly conserved genes important for eukaryotic cell organization including those required for the cytoskeleton, compartmentation, cell-cycle control, proteolysis, protein phosphorylation and RNA splicing. (inrae.fr)
The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and, by inference, the proteins they encode, as well as all other biologically important sequences. (inrae.fr)

The CST complex is a phylogenetically conserved protein complex consisting of CTC1/Cdc13, Stn1 and Ten1 that protects telomeres on linear chromosomes. (nih.gov)
Fission yeast is a simple, single-celled organism with chromosomes very similar to those in humans, and has proven to be an important model for cell division. (usc.edu)
While a postdoctoral student at MIT, Tomomi Kiyomitsu discovered how dynein has a role as a motor protein in aligning the chromosomes in the middle of the cell during the metaphase of mitosis. (wikipedia.org)
Kinetochores are protein complexes on the chromosomes, whose function as linkers between spindle microtubules and chromosomes is crucial for proper cell division. (nature.com)
A model system where the targeting of the chromosomes to the spindle can be studied is meiosis I in the fission yeast Schizosaccharomyces pombe ( S. pombe ). (nature.com)

There are also numerous anillin-like protein homologues found outside of metazoans. (wikipedia.org)
Homologues of the yeast Oxa1 protein are found in chloroplasts of plants and in a wide variety of bacteria. (tcdb.org)
Yeast encode two distant YidC homologues, Oxa1 and Oxa2. (tcdb.org)
It is thus likely that the previously observed phenotypes for MAK11 homologues in other eukaryotes are secondary to the main function of these proteins in ribosome formation. (pasteur.fr)

SUN} {BEGIN} ********************** * SUN domain profile * ********************** Sad1/UNC-84 (SUN)-domain proteins are inner nuclear membrane (INM) proteins that are part of bridging complexes linking cytoskeletal elements with the nucleoskeleton. (expasy.org)

Cell division in many eukaryotes, including the fission yeast Schizosaccharomyces pombe, utilizes a contractile actomyosin ring. (thebiogrid.org)

The accumulation of hTopBP1 on chromatin and its subsequent interaction with hRad9 lead to cell cycle arrest, a process mediated by Chk1 phosphorylation and ataxia telangiectasia and Rad3-related protein (ATR) activation. (biomedcentral.com)
These findings suggest a role for the SAPK pathway in supporting translation initiation and facilitating adaptation to environmental stress in part through reducing eIF2alpha phosphorylation in fission yeast. (ox.ac.uk)

The contributors describe basic methods for culturing and genetically manipulating fission yeast, synchronization strategies for probing the cell cycle, technologies for assessing proteins, metabolites, and cell wall constituents, imaging methods to visualize subcellular structures and dynamics, and protocols for investigating chromatin and nucleic acid metabolism. (cshlpress.com)
Proteins involved in carbohydrate metabolism showed altered expression in the mutant intestine, and gut-specific overexpression of a lysosomal mannosidase increased autophagy, gut homeostasis, and lifespan. (bvsalud.org)

The chloroplast albino 3 (ALB3) protein appears to integrate the light harvesting chlorophyll-binding protein into thylakoid membranes using a pathway that is distinct from the chloroplast Sec translocation pathway. (tcdb.org)

abstract = "Genetic analysis of protein function requires a rapid means of inactivating the gene under study. (tau.ac.il)

Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac. (biomedcentral.com)
In an effort to understand the fundamental signaling elements, or 'core machinery', required for the function of these GTPases, we describe here the conservation and functional similarities of Cdc42 and Rac effectors in five different species: plant, yeast, fruit fly, roundworm and human. (biomedcentral.com)
Cdc42 and/or Rac homologs are found in fruit flies, round-worms and budding yeast. (biomedcentral.com)
The analysis of Cdc42 and Rac function in evolutionarily distant organisms is useful as a tool to uncover the basic activities of these proteins. (biomedcentral.com)
In mammalian cells, as many as twenty types of protein have been reported to bind to activated Cdc42 [ 2 ]. (biomedcentral.com)
This motif is found in Cdc42/Rac-associated proteins such as the protein kinases Pak, MRCK and Ack, the adaptor proteins Spec and WASP, and, in degenerate form, in the kinases MLK, Mekk4, adaptor Par6, scaffold protein IRSp53, and the Borg proteins. (biomedcentral.com)

The DNA in the cell is packaged with histone proteins into chromatin. (usc.edu)

Database includes illustrations of pathway, damage, protein and drug. (vifabio.de)
Human DNA topoisomerase II-binding protein 1 (hTopBP1) plays an important role in DNA replication and the DNA damage checkpoint pathway. (biomedcentral.com)
The ataxia telangiectasia and Rad3-related protein (ATR) signaling cascade is an important pathway involved in the checkpoint control mechanism [ 3 ]. (biomedcentral.com)
We examined the role of this pathway in the translational response to stress in Schizosaccharomyces pombe. (ox.ac.uk)

He further utilized the model organism, Schizosaccharomyces pombe , to investigate the role of the SPN/FACT complex in eukaryotic DNA replication. (usc.edu)

Schizosaccharomyces pombe Fe-sulfur cluster assembly protein Isu1 (isu1), mRNA. (genscript.com)

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis. (thebiogrid.org)
Mdm12p is the third mitochondrial outer membrane protein required for normal mitochondrial morphology and distribution to be identified in S. cerevisiae and the first such mitochondrial component that is conserved between two different species. (rupress.org)
Modifications to techniques commonly used in related species (e.g., budding yeast) are noted, as are useful resources for fission yeast researchers, including various databases and repositories. (cshlpress.com)
The well-studied fission yeast Schizosaccharomyces pombe is the focus throughout, but the emerging model S. japonicus a larger, dimorphic species with several desirable characteristics is also covered. (cshlpress.com)

Collectively, we propose that fission yeast Stn1 primarily safeguards the semi-conservative DNA replication at telomeres and subtelomeres. (nih.gov)
and the contribution of chromatin-modifying proteins to replication and repair. (usc.edu)
Many viruses use the microtubule transport system to transport nucleic acid/protein cores to intracellular replication sites after invasion host the cell membrane. (wikipedia.org)
Here we report that the non-homologous end-joining (NHEJ) protein Ku becomes critical for survival of replication stress in brc1âˆ† cells. (thebiogrid.org)
Replication origins in the DNA nucleate the ordered assembly of protein factors to form a prereplication complex (preRC) that is poised for DNA synthesis. (usc.edu)
Human DNA topoisomerase II-binding protein 1 (TopBP1) and its orthologs play important roles in DNA replication and checkpoint control [ 1 ]. (biomedcentral.com)
Sap1 was identified as a protein involved in mating-type switching in Schizosaccharomyces pombe, and has been shown to be involved in programmed replication fork stalling. (le.ac.uk)

ANI-1 and ANI-2 (proteins homologous to anillin) are essential for embryonic viability in both organisms. (wikipedia.org)

There are at least six types of lipids including fatty acids, isoprenoids, sterols, phospholipids, glycosylphosphatidylinositol anchors, and lipid-derived electrophiles, which can be covalently attached to proteins ( Chen et al, 2018 ). (life-science-alliance.org)
2018 ). Through YidC, proteins are inserted into the lipid bilayer via the SecYEG-dependent complex, but YidC functions as a chaperone in protein folding processes. (tcdb.org)

In this study, we demonstrate that S-palmitoylation mediated by Erf2-Erf4 and Akr1 palmitoylacyltransferases is required at multiple meiotic stages in the fission yeast Schizosaccharomyces pombe . (life-science-alliance.org)

Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. (thebiogrid.org)

Sequences and the proteins they encode. (gpiaca.com)

In S. pombe, the actomyosin ring is assembled at the medial cortex upon entry into mitosis and constricts at the end of anaphase to guide the centripetal deposition of the septum. (thebiogrid.org)
We have recently shown that MTs explore the space by pivoting around the SPB, which accelerates KC capture in mitosis in fission yeast 9 . (nature.com)

Mitochondria import nuclearly-encoded proteins, made in the cell cytoplasm, into the mitochondrial matrix where their mitochondrial targeting sequences are removed by proteolysis. (tcdb.org)
The matrix exposed C-terminal α-helical domain of Oxa1 can bind mitochondrial ribosomes to facilitate co-translational insertion of proteins into the mitochondrial membrane ( Jia et al . (tcdb.org)
Glutaminase liver isoform, mitochondrial is a protein in humans that is encoded by GLS2 gene. (cusabio.com)
When expressed in S. cerevisiae , the S. pombe Mdm12p homolog conferred a dominant-negative phenotype of giant mitochondria and aberrant mitochondrial distribution, suggesting partial functional conservation of Mdm12p activity between budding and fission yeast. (rupress.org)
The S. cerevisiae Mdm12p was localized by indirect immunofluorescence microscopy and by subcellular fractionation and immunodetection to the mitochondrial outer membrane and displayed biochemical properties of an integral membrane protein. (rupress.org)

This family contains the fungal KAT11 protein (previously known as RTT109) which is required for H3K56 acetylation. (embl.de)
Catalytic domain of Fungal Nak1-like Protein Serine/Threonine Kinases. (umbc.edu)

We report the adaptation to Schizosaccharomyces pombe of the anchor-away technique, originally designed in budding yeast by Laemmli lab. (tau.ac.il)
PBS2 and Wis1 are components of stress-activated MAPK cascades in budding and fission yeast, respectively. (umbc.edu)
PBS2 is the specific activator of the MAPK Hog1, which plays a central role in the response of budding yeast to stress including exposure to arsenite and hyperosmotic environments. (umbc.edu)
Kic1p is required by budding yeast for cell integrity and morphogenesis. (umbc.edu)

Dyneins are a family of cytoskeletal motor proteins that move along microtubules in cells . (wikipedia.org)
One of these components, the Mdm1p protein, is a cytoskeletal element that exhibits structural similarities to the intermediate filament proteins of animal cells ( McConnell and Yaffe, 1992 , 1993 ). (rupress.org)

Posttranslational protein S-palmitoylation regulates the localization and function of its target proteins involved in diverse cellular processes including meiosis. (life-science-alliance.org)

and proteins that interact with members of the Arp2/3 complex and hence the actin cytoskeleton (Table 1 ). (biomedcentral.com)
Here, the SUN domain can interact with the C- terminal tail of an outer nuclear envelope protein that binds to the cytoskeleton, including the centrosome [1,2,3]. (expasy.org)

These sequences represent the protein coding region of the isu1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. (genscript.com)
Bacteria also export (to the periplasm) N-tails of membrane proteins synthesized without leader sequences by a Sec (Type IIPS)-independent mechanism. (tcdb.org)
Fitch defined the terms orthology and paralogy as early as 1970, when only very few protein sequences were known [ 1 ]. (biomedcentral.com)
Blastp (protein blast): compares one or more protein query sequences to a subject protein sequence or a database of protein sequences. (shopambitionhustle.com)
The program compares nucleotide or protein sequences to sequence databases. (gpiaca.com)
The comparison of nucleotide or protein sequences from the same or different organisms is a very powerful tool in molecular biology. (gpiaca.com)

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. (thebiogrid.org)

Transition of the preRC to an active initiation complex is regulated by cyclin-dependent kinases and other signaling molecules, which promote further protein assembly and activate the mini chromosome maintenance helicase. (usc.edu)

In lower multicellular fungi, the C2H2 zinc finger CreA/CRE1 protein has been shown to act as the transcriptional repressor in this process. (biomedcentral.com)
Here, we performed tissue-specific transcriptional and proteomic profiling of long-lived Drosophila dilp2-3,5 mutants, and identified tissue-specific regulation of >3600 transcripts and >3700 proteins. (bvsalud.org)

This phenomenon can be explained if Cdcp4 has more than one essential function or, alternatively, if two mutant proteins assemble to form a functional complex. (ubc.ca)
The functional inactivation of WD40 repeat protein Mak11 interfered with the 60S rRNA maturation, led to a cell cycle delay in G(1), and blocked green fluorescent protein-tagged Rpl25 in the nucleoli of yeast cells, indicating an early role of Mak11 in ribosome assembly. (pasteur.fr)
A "no-hybrids" screen for functional antagonizers of human p53 transactivator function: dominant negativity in fission yeast. (ox.ac.uk)
We have developed a functional "no-hybrids" screen in the fission yeast Schizosaccharomyces pombe based on the transcription transactivator activity of human p53. (ox.ac.uk)

Yeast spindle pole body assembly component MPS3, essential for nuclear division and fusion. (expasy.org)

Conclusions: Low endogenous levels of testosterone may be related to reduced cognitive ability, and testosterone substitution may improve some aspects of cognitive ability, protein blast. (gpiaca.com)

In mammalian cells, S-palmitoylate is added by a family of 23 transmembrane zinc finger DHHC (Asp-His-His-Cys)-containing protein acyl transferases and is removed by fatty acyl protein thioesterases ( Malgapo & Linder, 2021 ). (life-science-alliance.org)
Mammalian sperm-associated antigen 4 protein (SPAG4), may assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail. (expasy.org)
Mammalian sperm-associated antigen 4-like protein (SPAG4L). (expasy.org)

It is important to understand the functions and regulatory mechanisms of protein lipidation, which will advance our understanding of their pathological relevance, leading to strategies for targeting protein lipidation for therapeutic applications. (life-science-alliance.org)
In the present study, we combine experiments and theory to explore the mechanisms of kinetochore capture at the onset of meiosis I in fission yeast. (nature.com)
Studies using fission yeast were instrumental in identifying fundamental mechanisms that govern cell division, differentiation, and epigenetics, to name but a few. (cshlpress.com)
We will review these mechanisms and describe the state of knowledge about the proteins involved. (usc.edu)

A role of Akr1 S-palmitoylating the nuclear fusion protein Tht1 to function in karyogamy is identified. (life-science-alliance.org)
This method relies on a rapamycin-mediated interaction between the FRB- and FKBP12-binding domains to relocalize nuclear proteins of interest to the cytoplasm. (tau.ac.il)
We demonstrate a rapid nuclear depletion of abundant proteins as proof of principle. (tau.ac.il)
This nuclear protein existed in hyperphosphorylated forms which may be those of the hRad9-hRad1-hHus1 complex. (biomedcentral.com)
hRad9 is a nuclear protein that interacts with hRad1 and hHus1 to form a hetero-trimeric complex (the 9-1-1 complex) which is then loaded onto DNA [ 9 ]. (biomedcentral.com)
It also contains a nuclear localization sequence (NLS) that targets the hRad9 protein into the nucleus [ 11 ]. (biomedcentral.com)
In addition to the SUN domain, these proteins contain a transmembrane sequence and at least one coiled-coil domain and localize to the inner nuclear envelope. (expasy.org)
SUN proteins are anchored in the inner nuclear envelope by their transmembrane segment and oriented in the membrane such that the C-terminal SUN domain is located in the space between the inner and outer nuclear membrane. (expasy.org)
Caenorhabditis nuclear migration and anchoring protein UNC-84. (expasy.org)
DOI=10.1083/jcb.200601062 [ 3] Graumann K., Runions J., Evans D.E. "Characterization of SUN-domain proteins at the higher plant nuclear envelope. (expasy.org)

SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
In order to shed light on this process we carried out structural investigations on the essential fission yeast protein Sap1. (le.ac.uk)

Originaly identified based on an ~150-amino acid region of homology between the C terminus of the Schizosaccharomyces pombe Sad1 protein and the Caenorhabditis elegans UNC-84 protein, SUN proteins are present in the proteomes of most eucaryotes. (expasy.org)
Caenorhabditis SUN domain-containing protein 1 (sun-1), involved in centrosome attachment to the nucleus. (expasy.org)

Fatty acylation is a type of protein lipidation with the attachment of saturated and unsaturated fatty acids to the glycine, serine, lysine, or cysteine residues of proteins. (life-science-alliance.org)
Palmitoylation targets several protein residues, including serine (O-palmitoylation) and cysteine (S-palmitoylation or N-palmitoylation when it occurs at the N-terminal of the protein). (life-science-alliance.org)

Fission yeast are unicellular, rod-shaped fungi that divide by medial fission. (cshlpress.com)

At the onset of meiosis I in the fission yeast S. pombe , the KCs are far apart from SPBs and telomeres, and SPBs are clustered together 2 . (nature.com)

The human anillin cDNA, located on Chr7, encodes a 1,125-amino acid protein with a predicted molecular mass of 124 kD and a pI of 8.1. (wikipedia.org)

PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. (umbc.edu)

The Schizosaccharomyces pombe Cdc4 protein is required for the formation and function of the contractile ring, presumably acting as a myosin light chain. (ubc.ca)

RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal protein gene expression in Schizosaccharomyces pombe. (anid.cl)

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. (thebiogrid.org)

Some proteins known to contain a SUN domain are listed below: - Fission yeast spindle pole body-associated protein Sad1. (expasy.org)

2022 ). The YidC transmembrane (TM) groove is essential for a high- affinity interaction, and the hydrophilic nature of the YidC groove plays an important role in protein transport across the cytoplasmic membrane bilayer to the periplasmic side. (tcdb.org)

Activation of ATR phosphorylates a number of downstream proteins that coordinate the cell cycle checkpoint. (biomedcentral.com)

Thestructure reveals a buried autoacetylated lysine residue that we show is alsoacetylated in the Rtt109 protein purified from yeast cells. (embl.de)
Immunoblotting with and without dephosphorylation was used to define the protein isolated from breast cancer cells. (biomedcentral.com)
Increased hRad9 protein was observed in breast cancer cells nucleus compared to non-tumor epithelium. (biomedcentral.com)
To further examine the role of hRad9 in breast cancer cells, we now report on the histologic expression of the hRad9 protein and its different molecular forms in primary breast cancer and normal tissues. (biomedcentral.com)
Exposing wild-type cells to osmotic stress (KCl) resulted in a rapid but transient reduction in protein synthesis. (ox.ac.uk)
A protein discovered in the late 1970s has been shown to defend human cells from becoming cancerous. (shopambitionhustle.com)

Protein lipidation is a unique co- or posttranslational modification in which lipid moieties are covalently attached to proteins. (life-science-alliance.org)

Anatomy12

Organisms6

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes69

Information Science3

Health Care2

Saccharomyces6

Kinase13

Homologue6

Genome10

Cytokinesis3

Genes11

Chromosomes5

Homologues4

Complexes1

Eukaryotes1

Phosphorylation2

Metabolism2

Translocation1

Abstract1

Cdc426

Histone1

Pathway4

Model organism1

MRNA1

Species4

Replication7

Homologous1

20182

Meiotic1

Chromatin1

Encode1

Mitosis2

Mitochondrial5

Fungal2

Budding4

Cytoskeletal2

Regulates1

Cytoskeleton2

Sequences6

PREY1

Kinases1

Transcriptional2

Functional4

Component1

Endogenous1

Mammalian3

Mechanisms4

Nuclear10

Structural2

Caenorhabditis2

Cysteine2

Medial1

Meiosis1

CDNA1

Residues1

Contractile1

Gene expression1

Indirect immunofluorescence1

Spindle1

Transmembrane1

Downstream1

Cells6

Lipid1