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  • recognize
  • The DNA-binding domains of individual ZFNs typically contain between three and six individual zinc finger repeats and can each recognize between 9 and 18 basepairs. (wikipedia.org)
  • If the zinc finger domains perfectly recognize a 3 basepair DNA sequence to generate a 3-finger array that can recognize a 9 basepair target site. (wikipedia.org)
  • Without methods to account for this "context dependence", the standard modular assembly procedure often fails unless it is used to recognize sequences of the form (GNN)N. Numerous selection methods have been used to generate zinc-finger arrays capable of targeting desired sequences. (wikipedia.org)
  • gene
  • Zinc finger nucleases have also been used in a mouse model of haemophilia and a clinical trial found CD4+ human T-cells with the CCR5 gene disrupted by zinc finger nucleases to be safe as a potential treatment for HIV/AIDS. (wikipedia.org)
  • typically
  • see: Zinc finger chimera for more info on zinc finger selection techniques) The non-specific cleavage domain from the type IIs restriction endonuclease FokI is typically used as the cleavage domain in ZFNs. (wikipedia.org)
  • second
  • This system combines pre-selected pools of individual zinc fingers that were each selected to bind a given triplet and then utilizes a second round of selection to obtain 3-finger arrays capable of binding a desired 9-bp sequence. (wikipedia.org)
  • large
  • Initial selection efforts utilized phage display to select proteins that bound a given DNA target from a large pool of partially randomized zinc-finger arrays. (wikipedia.org)
  • 1991
  • In 1991 craft commentator Helen Schamroth wrote "If there is one underlying common philosophy of the work at Fingers it is an original, innovative approach to design solutions, a contemporary response to customer interests, and meeting their aesthetic and emotional needs. (wikipedia.org)
  • hand
  • Dupuytren's contracture is a progressive hand condition that affects how much you can move or straighten your fingers. (webmd.com)
  • The device is attached to the wrist and fitted over the hand and the residual fingers. (asme.org)
  • Extend the first two fingers of your hand, together. (usingenglish.com)
  • Approach the lip of the ramp with a moderate speed and when you are in the air, flip your hand upwards so that the board does a back flip and you completely leave your fingers off the bike. (angelfire.com)
  • Music
  • Apart from producing and writing music for Japanese stars such as UA, and theme songs such as for the hit anime B't X, Fingers is the "point man" with the concert music production company Smash Japan, producers of Fuji Rock Festival, the largest music festival in Japan. (wikipedia.org)
  • In 2013, Two Fingers composed the theme music for the BBC America/Space original series Orphan Black. (wikipedia.org)
  • together
  • Moreover, Christians, when persecuted by the Romans, used the symbol of crossed fingers in order to recognize one another and assemble for Holy Mass. "When they were persecuted in Rome, Christians would secretly come together with the sign of the fish, and they would hold up their crossed fingers, as a Sign of the crossed emblem that had once been on the vestments of the army of Barabbas. (wikipedia.org)
  • Records
  • The 1787 A Provincial Glossary, with a Collection of Local Proverbs, and Popular Superstitions by Francis Grose records the recommendation to keep one's fingers crossed until one sees a dog to avert the bad luck attracted by walking under a ladder. (wikipedia.org)
  • tips
  • The commercial version of Funk Fingers had Velcro fingertip holders, and the tips were dipped in "rubberizing tool grip" for an optimal playing surface. (wikipedia.org)
  • third
  • Max-A-Million's follow up third and fourth singles "Sexual Healing" and "Everybody's Groovin'" are also produced by 20 Fingers. (wikipedia.org)
  • cross
  • As a result, some judges would cross their fingers whenever they said the phrase as a result of concern for the criminal's soul as they said it as a prayer. (wikipedia.org)
  • call
  • We call them Sunday fingers because you wear them to church or dinner and then throw them in a drawer for the week. (asme.org)
  • plastic
  • Researchers at the University of Turku have discovered that the bacterium attaches to plastic medical devices using tiny finger-like structures. (utu.fi)
  • start
  • Once in the air start turning the head around in your fingers, making the whole bike spin around as one. (angelfire.com)
  • moving parts
  • Dan Didrick is the inventor of X-Fingers, stainless steel prosthetic fingers in which each digit contains 23 moving parts or more. (asme.org)
  • Each finger contains 23 moving parts, though depending on the complexity of the case-such as whether the wearer retains a residual finger or not-it could contain more. (asme.org)