• Ample evidence shows that pro-atherosclerotic disturbed flow induces sustained activation of atherogenic genes in endothelial cells to promote their oxidation, inflammation, cell cycle progression and proliferation, whereas pulsatile shear stress tends to maintain endothelial cells in a quiescent and less proliferative state with a low level of oxidation and inflammation [16] , [17] . (plos.org)
  • Although leukocyte count and serum C-reactive protein did not suggest inflammation, empiric antimicrobial chemotherapy with ceftriaxone, ampicillin, gentamicin, and acyclovir was started immediately. (cdc.gov)
  • We previously showed that genotoxic stress induced an active extracellular release of nucleophosmin (NPM) in human cardiac mesenchymal progenitor cells, and that serum deprivation provokes NPM secretion from human endothelial cells, eliciting inflammation via nuclear factor kappa B (NF-kB) transcriptional activation. (frontiersin.org)
  • In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. (hindawi.com)
  • For example, research has found strong associations for the Human papiloma virus (HPV) and cervical cancer, Helicobacter pylori bacterial infection and gastric adenocarcinoma , the hepatitis B virus and cirrhosis and hepato-cellular carcinoma, asbestos-induced inflammation and lung cancer, and cigarette smoke-induced inflammation and lung, bowel and pancreatic cancer. (sherrytorkos.com)
  • In other words, inflammation protects the tumour from attack by the immune system. (sherrytorkos.com)
  • Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
  • Together our results reveal the potential ability of gefitinib to initiate sterile inflammation via two distinct mechanisms, and identified IL-1β and HMGB1 as key determinants of gefitinib-induced inflammation that may provide insights into gefitinib-induced interstitial pneumonitis. (nature.com)
  • Proven by the use of apoptosis-resistant cellular models and autophagic assays, such isoquinoline alkaloid-induced cytotoxic effect involves energy- and autophagy-related gene 7 (Atg7)-dependent autophagy that resulted from direct activation of AMP activated protein kinase (AMPK). (oncotarget.com)
  • Studies have shown that xanthine dehydrogenase (XDH)-derived reactive oxygen species (ROS) accelerates tumor growth, and also induces mutations or produces cytotoxic effects concurrently. (medsci.org)
  • Both the innate stimuli, such as lipopolysaccharides and Poly inositol-cytosine and adaptive stimuli, that is, cytokine mix, were able to induce the extracellular release of NPM in immortalized keratinocytes and human skin fibroblasts in the absence of cytotoxicity. (frontiersin.org)
  • K can From a variety of extracellular Ren stimuli Ren Ren signals such as growth factors, ligands for G-protein-coupled receptors, cytokines, and vitamin D3, the p85 subunit of regulation at the plasma membrane, such as catalytic subunit recruit p110 PI P2 4 5 PI converts 3.4, 5 P3. (microrna1.com)
  • Immunoprecipitation revealed that pulsatile shear stress induced the coupling of ubiquitin with PDCD4 expression. (plos.org)
  • Atherosclerosis plaques preferentially develop at arterial branches and curvatures under low and oscillatory or even static shear stress induced by disturbed blood flow as opposed to in straight parts, featuring protective unidirectional pulsatile shear stress [14] , [15] . (plos.org)
  • The higher (600 mg) dose ameliorated the stress induced by the test, and produced significantly improved self-ratings of calmness and alertness. (lifeextension.com)
  • Telomeric DNA damage-induced mitochondrial dysfunction and increased reactive oxygen species production are hallmarks of premature senescence. (oaepublish.com)
  • The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
  • This study demonstrates that debcl and the pro-fission gene drp1 are necessary downstream of buffy to trigger a mitochondrial fragmentation during rbf1 -induced apoptosis. (sdbonline.org)
  • During cellular starvation, AMPK induces autophagy by phosphorylating Ulk1, the mammalian counterpart of ATG1, at Ser 317 and 777 [ 3 , 4 ]. (oncotarget.com)
  • We previously identified ethoxyquin (EQ) as a potent neuroprotective compound through a phenotypic screen against three neurotoxic drugs and demonstrated that it prevents development of peripheral neuropathy in paclitaxel and cisplatin models of chemotherapy-induced peripheral neuropathy (CIPN). (nature.com)
  • The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine. (peacehealth.org)
  • People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status. (peacehealth.org)
  • The chemotherapy drug cisplatin may cause kidney damage, resulting in depletion of calcium and phosphate. (peacehealth.org)
  • The chemotherapy drug cisplatin may cause depletion of sodium due to kidney damage which sometimes occurs in people treated with cisplatin. (peacehealth.org)
  • Patients with inoperable head and neck cancer were treated with a spleen peptide preparation (Polyerga) in a double-blind trial during chemotherapy with cisplatin and 5-FU. (peacehealth.org)
  • Acetyl-L-carnitine in the amount of 1,000 mg three times per day for eight weeks has been shown to improve nerve damage (neuropathy) caused by the chemotherapy drug cisplatin. (peacehealth.org)
  • He developed the Chang and SIOP Ototoxicity Grading Scales, and is actively involved in several human clinical trials looking at the prevention of cisplatin ototoxicity that may drastically decrease the number of children developing hearing loss after chemotherapy. (stanford.edu)
  • Gain of function and loss of function experiments showed that PDCD4 induced turnover (proliferation and apoptosis) of HUVECs. (plos.org)
  • PDCD4 induces turnover (proliferation and apoptosis) of HUVECs. (plos.org)
  • Interestingly, rbf1 -induced apoptosis leads to a debcl - and drp1 -dependent Reactive Oxygen Species production, which in turn activates the Jun Kinase pathway to trigger cell death. (sdbonline.org)
  • Findings from the Cusack Laboratory have shown that conventional anti-cancer therapies, such as radiation and chemotherapy, induce resistance mechanisms under the control of the gene transcription factor NF-kappaB. (massgeneral.org)
  • In the Kcne2 potassium channel ancillary subunit knockout model, disruption of this gene induces achlorhydria and is related to reduced parietal cell protein secretion and abnormal parietal cell morphology. (medscape.com)
  • These findings demonstrate that BP regulatory gene(s) exist within the differential chromosome segment trapped in the SHR-Lx congenic strain and that this region of chromosome 8 plays a major role in the hypertension of SHR vs. BN-Lx rats. (jci.org)
  • Moreover, NPM is crucial for inflammatory gene expression induced by tumor necrosis factor alpha (TNF-α) and lipopolysaccharides (LPS) in fibroblasts and macrophages ( 6 ). (frontiersin.org)
  • Our findings demonstrate that BCG inoculation reduced tumor growth and prolonged mouse survival in models of lung melanoma metastasis and orthotopic lung adenocarcinoma. (bvsalud.org)
  • Importantly, improved intravesical bacterial immunotherapy using MBTVAC induced eradication of fully established bladder tumors, both as a monotherapy and specially in combination with the immune checkpoint inhibitor antiprogrammed cell death ligand 1 (anti PD-L1). (bvsalud.org)
  • Growing evidence demonstrates that various cancer treatment modalities, including chemotherapy, radiation therapy, targeted therapy, immunotherapy, hormone therapy, stem cell or bone marrow transplant, and surgery [ 3 - 5 ] , cause premature senescence, as reviewed elsewhere [ 6 - 8 ] . (oaepublish.com)
  • In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage. (peacehealth.org)
  • During the same period, she received intravenous chemotherapy, in the form of 790 mg (500 mg/m 2 ) fluorouracil (5-FU) and 32 mg (20 mg/m 2 ) calcium folinate, for 5 consecutive days at 3-week intervals. (psychiatryinvestigation.org)
  • After her 4th 5-FU and folinate calcium chemotherapy cycle on May 15th, her behavior changed rapidly. (psychiatryinvestigation.org)
  • The rise in PTHrP allows for the rise in calcium while protecting the maternal skeleton. (medscape.com)
  • Low calcium levels decrease the threshold of excitation of neurons, causing them to have repetitive responses to a single stimulus. (medscape.com)
  • Scientists studying phage warfare have long known that a major disruption to the system - like high-dose UV radiation, carcinogenic chemicals, or even some chemotherapy drugs - can kick all the resident phages into kill mode. (princeton.edu)
  • Pulsatile shear stress induces ubiquitin-proteasome-mediated degradation of PDCD4 via a PI3K/Akt pathway in HUVECs. (plos.org)
  • PI3K confinement Lich Is particularly important for the growth and survival of the cell with embroidery and is an important means of cellular Transformation FF Ren, another condition Cilomilast SB-207499 known to induce the expression of NKG2D ligands for rdern. (microrna1.com)
  • Gesamtverm Gens MCMV infection PI3K/Akt our data, based on data with HCMV and that this activation to induce signaling through PI3K p110a RAE RAE first required significant induction in cells infected with MCMV There are three classes obtained enzymes in the superfamily of PI3K class I, II and III. (microrna1.com)
  • 3 When our temperature increases, hypothalamic neurons induce sweating and cutaneous vasodilation to dissipate heat. (ajnr.org)
  • The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
  • The directed expression of Buffy in DA neurons provides protection and counteracts the alpha-synuclein-induced Parkinson disease-like phenotypes. (sdbonline.org)
  • In clinical conditions, parietal cell dysfunction can be induced by antiparietal cell antibodies. (medscape.com)
  • Senescence-associated secretory phenotype (SASP) can be induced by telomere dysfunction. (oaepublish.com)
  • Chronic inflammatory changes related to gastric Helicobacter pylori infection can also induce parietal cell changes. (medscape.com)
  • Furthermore, this inflammatory response can compromise the response to chemotherapy. (sherrytorkos.com)
  • Factors that promote atherosclerosis, including cigarette smoking, hypertension, atherogenic lipoproteins, and hyperglycemia, give rise to a variety of noxious stimuli that cause the release of chemicals and the activation of cells involved in the inflammatory process. (sherrytorkos.com)
  • Ethoxyquin (EQ), a quinolone-based antioxidant, has demonstrated neuroprotective properties against several neurotoxic drugs in a phenotypic screening and is shown to protect axons in animal models of chemotherapy-induced peripheral neuropathy. (nature.com)
  • Neurologic abnormalities induced by heat stroke involve the brain (especially the basal ganglia and thalami), cerebellum, anterior horn cells in the spinal cord, and peripheral nerves. (ajnr.org)
  • Since our data suggest that required to induce early events of viral infection RAE 1, we have a situation where. (microrna1.com)
  • The pathophysiology of erythema multiforme (EM) is still not completely understood, but it is probably immunologically mediated and appears to involve a hypersensitivity reaction that can be triggered by a variety of stimuli, particularly bacterial, viral, or chemical products. (medscape.com)
  • We report the case of a woman who developed an acute manic episode after receiving 5-FU chemotherapy during treatment for rectal cancer. (psychiatryinvestigation.org)
  • Today, it constitutes the standard of care for many cancer patients, along with surgery and chemotherapy. (springer.com)
  • Drug resistance hinder most cancer chemotherapies and leads to disease recurrence and poor survival of patients. (oncotarget.com)
  • It's an analysis of data from the SEER database, looks at tens of thousands of older patients, and has a few notable findings. (pallimed.org)
  • Patients generally have chemotherapy after surgery for cancer, regardless of its stage. (psychiatryinvestigation.org)
  • Given that protein aggregates in liver cells are closely linked to alcoholic liver disease, these findings suggest that quercetin could be a useful treatment for patients with this condition. (qualitycounts.com)
  • Obese children with leukemia have higher rates of chemotherapy resistance and higher relapse rates than thinner kids, according to recent findings published online in Cancer Research, a journal of the American Association for Cancer Research. (dotmed.com)
  • Emerging evidence suggests that the component secreted by exosomescan promote tumor survival,angiogenesis and metastasis, and also mediate tumor microenvironment induced drug resistance and immune escape. (bbrc.in)
  • In this review, we summarize recent findings about the regulation of the immune response by histamine. (hindawi.com)
  • In addition, they modify the body's immune responses to diverse stimuli. (nih.gov)
  • Dr. Cusack wrote the first clinical trial of combination chemotherapy with the drug bortezomib for solid organ malignancies, reported in the journal Cancer . (massgeneral.org)
  • In conclusion, isoquinoline alkaloid is a new class of compound that induce autophagic cell death in drug-resistant fibroblasts or cancers by exhibiting its direct activation on AMPK. (oncotarget.com)
  • PSDDS wherein the drug release is controlled primarily by the delivery system, stimuli induced PSDDS in which release is controlled by the stimuli, such as the pH present in the intestinal tract. (scialert.net)
  • The pH range of fluids in various segments of the gastrointestinal tract may provide environmental stimuli for responsive drug release. (scialert.net)
  • The prevention of diabetes-induced mtDNA deletions may be a potential mechanism of the neuroprotective effects of EQ in diabetic neuropathy. (nature.com)
  • The noise-induced hearing loss is well known in studies related to the workplace. (bvsalud.org)
  • This habit in this young population is increasing the risk for the acquisition of music-induced hearing loss, the author of this study noted that 14% of youth surveyed reported risk behavior for acquiring auditory loss 4 . (bvsalud.org)
  • Analysis revealed that Buffy acted to rescue the associated loss of locomotor ability observed in the alpha-synuclein-induced model of PD, while Buffy RNA interference resulted in an enhanced alpha-synuclein-induced loss of climbing ability. (sdbonline.org)
  • These findings demonstrate that the supramolecular polysaccharide nanotheranostics can not only inhibit kinase signaling pathway in aggressive tumor, but also monitor targeted therapy response early. (ntno.org)
  • First, achlorhydria has been defined by a peak acid output in response to a maximally effective stimulus that results in an intragastric pH greater than 5.09 in men and greater than 6.81 in women. (medscape.com)
  • Telomeric DNA damage response induced by some cancer treatments can persist for months, possibly accounting for long-term sequelae of cancer treatments. (oaepublish.com)
  • The efficacy of SPNs in inducing cancer cell death by inhibition of kinase signaling and imaging the response was evaluated in murine BRAFV 600E melanoma (D4M) and triple-negative breast cancer (4T1) cell lines. (ntno.org)
  • Key findings: The extract of I. obliquus caused significant tumor suppressive effects in both models. (researchgate.net)
  • Significance: Our findings suggest that the I. obliquus extract could be used as a natural remedy for cancer suppression by promoting energy metabolism. (researchgate.net)
  • Intracerebroventricular injection has been used to inject drugs that induce a diseased state to create animal models for a variety of diseases. (wikipedia.org)
  • Numerous studies have revealed the critical role of premature senescence induced by various cancer treatment modalities in the pathogenesis of aging-related diseases. (oaepublish.com)
  • Methods: ICH was induced by collagenase injection into the striatum of wild type (C57BL/6J) anticoagulated mice (warfarin or rivaroxaban) and Mmp10 -/- mice. (unav.edu)
  • Most dramatically, lemon balm extracts induced sleep in mice that had been given tiny (non-sleep-inducing) doses of traditional sedative medications. (lifeextension.com)
  • En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
  • Mechanistically, IV BCG induced tumor-specific CD8+ T cell responses, which were dependent on type 1 conventional dendritic cells, as well as NK cell-mediated immunity. (bvsalud.org)
  • Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. (peacehealth.org)
  • I could see the different cells undertaking all the possible phage production combinations - inducing one of the phages, inducing another, inducing both. (princeton.edu)
  • And some of the cells were not inducing either of the phages. (princeton.edu)
  • It may also invade and proliferate within heart and coronary artery endothelial cells, and, along with Streptococcus sanguis, it may also induce platelet aggregation associated with thrombus formation. (medscape.com)
  • This compound has several uses in a variety of health conditions, and it may be useful in combating nausea and vomiting caused by chemotherapy. (cbdcontent.org)
  • It may be useful in treating chemotherapy-induced nausea, among other conditions. (cbdcontent.org)
  • CBDA inhibits vomiting induced by movement or toxins, and it also delays the onset of nausea. (cbdcontent.org)
  • CBDA also inhibited nausea caused by anticipatory stimuli, including sights, sounds, and the smell of chemotherapy. (cbdcontent.org)
  • It was hypothesized that dopamine release in the striatal system induced by pleasure songs are involved in the cardiac autonomic regulation. (bvsalud.org)
  • Together, these data show G-CSF as a potent modulator of the mesolimbic dopamine circuit and its ability to appropriately attend to salient stimuli. (jneurosci.org)
  • On the basis of abnormal findings on a magnetic resonance imaging scan (MRI) performed 12 hours after admission ( Figure 1A and 1B ), attending physicians diagnosed meningoencephalitis of unknown origin. (cdc.gov)
  • The opposite extreme is hypothermia, which is defined as a drop of 2.0°C in body temperature (we begin to shiver at about 36.0°C). Hypothermia is generally due to exposure to inclement weather or is induced for medical procedures. (ajnr.org)
  • The central nervous system is relatively safe from such toxicity because the blood-brain barrier protects it, and it has a slower cell proliferation rate. (psychiatryinvestigation.org)
  • A comprehensive review of antioxidants and chemotherapy leaves open the question of whether supplemental antioxidants definitely help people with chemotherapy side effects, but it clearly shows that antioxidants need not be avoided for fear that the actions of chemotherapy are interfered with. (peacehealth.org)
  • In a double-blind study, Japanese researchers found that the combination of vitamin E , vitamin C, and N-acetyl cysteine (NAC) -all antioxidants-protected against chemotherapy-induced heart damage without interfering with the action of the chemotherapy. (peacehealth.org)
  • Exposing people to what researchers have called a "scapegoat stimulus" just before the administration of chemotherapy can direct the food aversion to the "scapegoat" food instead of more important parts of the diet. (peacehealth.org)
  • In another 2004 study, lemon balm was examined for its effect on laboratory-induced stress in humans. (lifeextension.com)
  • It remains unclear how important this effect is or if people taking chemotherapy should take taurine supplements. (peacehealth.org)
  • Examples include the treatment of Spinal Muscular Atrophy (SMA), the administration of chemotherapy in gliomas, and the administration of drugs for long-term pain management. (wikipedia.org)
  • These findings may have implications for the treatment of cancer. (cbdcontent.org)
  • However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage. (peacehealth.org)
  • When we get cold, the hypothalamus does the opposite and induces shivering that increases heat production. (ajnr.org)
  • This report contains modifications to the previously published recommendations of the Advisory Committee on Immunization Practices (ACIP) and is based on an ACIP review of the IOM findings and new research on vaccine safety. (cdc.gov)
  • A modified form of vitamin A has been reported to work synergistically with chemotherapy in test tube research. (peacehealth.org)
  • Although research remains incomplete, the idea that people taking chemotherapy should avoid antioxidants is not supported by scientific research. (peacehealth.org)
  • Silpe, who had come back to Bassler's lab as a postdoctoral research associate after performing postdoctoral studies at Harvard, had taken the lead on finding the triggers. (princeton.edu)
  • A benefit of this pathogen-induced model is that it shows Alzheimer's-like symptoms, while also exhibiting Aβ pathology. (wikipedia.org)
  • The patient presented manic symptoms after 4th cycle of 5-FU chemotherapy after surgery of rectal cancer. (psychiatryinvestigation.org)
  • After cessation of chemotherapy and administration of olanzapine and divalproex sodium, symptoms were subsided within 10 days. (psychiatryinvestigation.org)
  • The primary pediatrician documented a subtle, generalized muscular hypotension at the age of 9 months but did not consider this finding remarkable enough to investigate further (sonographic examination of the central nervous system showed normal results immediately after birth and 2 weeks later). (cdc.gov)
  • Cooling may be achieved via invasive means (catheters that pump cold saline solution into veins) or noninvasively (water blankets and cool caps that contain crylon gel at −30°C). Cool caps are used for neonatal encephalopathy but also for less serious problems such as alopecia induced by chemotherapy (in the latter, the cold results in decreased scalp blood flow protecting the hair follicles). (ajnr.org)
  • Subsequently, the expression of Buffy was altered in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
  • Dr. Cusack organized the Mass General Peritoneal Surface Malignancy Program in 2011 and treated his first patient with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in October 2011. (massgeneral.org)
  • First, the Roux-en-Y gastric bypass surgery involves formation of a 15- to 30-mL fundal pouch. (medscape.com)
  • Findings on physical examination in hepatic encephalopathy include asterixis and fetor hepaticus. (medscape.com)