• Pregnancy and sickle cell anemia (SCA) were diagnosed using standard protocols. (scielo.br)
  • Other causes of anemia include blood loss, inadequate production of red blood cells (aplastic anemia,) or increased destruction of red blood cells (hemolytic anemia) that may present lifelong health problems. (optometrytimes.com)
  • Recurrent Nocardia sepsis in a patient with sickle cell anemia receiving continuous deferoxamine. (symptoma.com)
  • Today, they are employed in the treatment of various neoplastic and non-neoplastic diseases such as various types of cancer (1, 2), sickle cell anemia (3), HIV infection (4, 5), thrombocythemia (6) and psoriasis (7). (moam.info)
  • Sickle cell anemia (SCA) is the most common and severe form of SCD, resulting from genetic inheritance of HbS genes from both progenitors (SS genotype) 1 . (bvsalud.org)
  • Premature destruction of sickle red blood cells leads to hemolytic anemia. (bvsalud.org)
  • BACKGROUND: Sickle cell disease (SCD) is an inherited chronic life-threatening disorder with increasing prevalence in Europe. (bvsalud.org)
  • Findings highlighted a widespread prevalence of poor knowledge about SCD among healthcare providers and the public. (nih.gov)
  • Conclusion: The current study shows iron sufficiency in most cases of pregnancy with SCA and suggests that evaluation of iron status must be made before initiating iron prophylaxis in pregnant women with SCA, especially in regions having a high prevalence of sickle cell hemoglobinopathy. (scielo.br)
  • 1 , 4 , 5 The prevalence and natural history of elevated jet velocity in children with sickle cell disease at steady state are largely unknown. (haematologica.org)
  • The prevalence was significantly higher in study participants who did not sleep in insecticide-treated bed nets, participants who were not on co-trimoxazole prophylaxis and those whose CD4 + T cell count was below 200 cells/μL. (biomedcentral.com)
  • To evaluate the manifestations of sickle cell disease on the orofacial complex through a review of current literature concerning prevalence of dental caries, periodontal disease, temporomandibular joint disorders and radiographic alterations of maxillofacial bones. (bvsalud.org)
  • As many as 10-15% of patients with vertebral osteomyelitis develop neurologic findings or frank spinal-cord compression. (medscape.com)
  • Scholars@Duke publication: Religiosity/spirituality and pain in patients with sickle cell disease. (duke.edu)
  • FINDINGS: A total of 79 patients (mean age 9.8 ± 4.0 years). (bvsalud.org)
  • To develop patient-reported experience measure surveys for patients with sickle cell disease (SCD) to understand their healthcare and lived experience in the UK and for their use in future to inform healthcare service development. (nih.gov)
  • Disease states known to predispose patients to osteomyelitis include diabetes mellitus,[2] sickle cell disease, acquired immune deficiency syndrome (AIDS), intravenous (IV) drug abuse, alcoholism, chronic steroid use, immunosuppression, and chronic joint disease. (medscape.com)
  • Objectives: Describe and evaluate the perception of the prejudice against the disease and its impact on the quality of life of patients with sickle cell disease. (scielo.br)
  • Design and Methods A prospective multicenter study of 310 patients aged 3-20 years old with sickle cell disease under basal conditions and 54 matched controls was conducted. (haematologica.org)
  • Echocardiographic estimation of pulmonary artery pressure by measuring the tricuspid valve regurgitant jet velocity has been validated as a useful screening method for pulmonary hypertension in adult patients with sickle cell disease. (haematologica.org)
  • 1 - 3 Even though this definition includes mild elevations in pulmonary artery pressure, adult sickle cell disease patients with a regurgitant jet velocity of 2.5 m/sec or more have an increased risk of mortality. (haematologica.org)
  • justifiant de ce fait une meilleure prise en charge de ces patients. (bvsalud.org)
  • La présente étude détermine la prévalence de l'infection par le virus de l'hépatite C en en determinant les génotypes ainsi que les facteurs y associés dans ce groupe de patients. (bvsalud.org)
  • Preclinical studies also suggest INCB059872 could help combat small-cell lung cancer and Ewing Sarcoma, and clinical trials are currently underway to test the drug's efficacy in patients with sickle-cell disease, as well as its safety in patients with advanced malignancies. (genengnews.com)
  • The evaluation of the growth pattern and pubertal development of a group of patients with sickle-cell anaemia from childhood to adulthood. (bvsalud.org)
  • Thirty patients with sickle-cell anaemia (mean age= 13.93 years) were evaluated at Te1 and 26 patients (mean age = 25.08 years) at Te3. (bvsalud.org)
  • Patients with sickle-cell anaemia showed growth impairment and pubertal delay compared with healthy controls. (bvsalud.org)
  • In sickle cell trace, the heterozygosis for genes of normal (HbA) and mutant (HbS) hemoglobins (AS genotype) does not exhibit clinical symptoms of the disease under physiological conditions 3,5 . (bvsalud.org)
  • These cells, which typically turn into white blood cells to fend off infection, don't differentiate. (genengnews.com)
  • Sickle cell disease (SCD) is associated with chronic haemolysis, immuno-suppression and suscepti- bility to infections, which may trigger infection-associated haemolysis (IAH). (bvsalud.org)
  • The bacteria adhere to nasopharyngeal, pulmonary, and endothelial cells. (stjude.org)
  • Background Elevation of echocardiography-determined tricuspid regurgitant jet velocity predicts high systolic pulmonary artery pressure and early mortality in adults with sickle cell disease. (haematologica.org)
  • Nevertheless, an association between hemolysis and pulmonary hypertension in sickle cell disease has been questioned because, in most studies thus far, not all markers of hemolysis have had significant associations with estimated pulmonary artery pressure. (haematologica.org)
  • She produces the podcast VitaminSC3 with the Sickle Cell Community Consortium to share patient stories and bring hope. (socialhealthnetwork.com)
  • Review typical imaging findings in vertebral osteomyelitis. (nih.gov)
  • [2] Thus a diagnosis of vertebral osteomyelitis should be assumed (without the need for a disc space aspiration or another tissue sampling) in a patient with S. aureus bacteremia within the preceding 3 months and compatible spine magnetic resonance imaging (MRI) findings. (nih.gov)
  • The Silent Cerebral Infarct Multicenter Transfusion (SIT) Trial requires 1880 children with sickle cell disease from 28 pediatric clinical sites in the U.S., Canada, U.K., and France to undergo a screening MRI of the brain to detect the presence of silent cerebral infarct-like lesions. (diagnosticimaging.com)
  • Sitting in a conference room in Washington D.C. twenty years ago, my clinical colleagues, Drs. Diana Cutts, Patrick Casey, Carol Berkowitz, and Maureen Black, and I shared disturbing and tragic stories of the consequences of the 1996 welfare reform on the health of children. (childrenshealthwatch.org)
  • Diarrheal disease due to the protozoan Cyclospora cayetanensis had not been previously reported among American military trainees in the U.S. This report describes the life cycle of the protozoan and highlights the difficult nature of source finding and the importance of clinical suspicion for cyclosporiasis in persistent gastrointestinal illness. (health.mil)
  • Several of the complications observed in sickle cell disease (SCD) are influenced by variation in hematologic traits (HT), such as fetal hemoglobin (HbF) level and neutrophil count. (haematologica.org)
  • Several other HT have been associated with SCD-related complications, notably elevated white blood cell (WBC) count and neutrophil count with survival, 2 , 6 , 7 low hemoglobin (Hb) levels with composite severe outcomes and death, 7 , 8 and platelet (PLT) count with ACS. (haematologica.org)
  • Sickle cell disease (SCD) includes genetic blood disorders in which morphologic alterations of erythrocytes are caused by presence of the sickle hemoglobin (HbS). (bvsalud.org)
  • however, a globally standardised solution for patient transition from paediatric to adult sickle cell disease health care is unlikely to address the challenges. (bvsalud.org)
  • We highlighted priorities to consider for any young person with sickle cell disease transitioning from paediatric to adult health care: skills transfer, increasing self-efficacy, coordination, knowledge transfer, linking to adult services, and evaluating readiness (the SICKLE recommendations). (bvsalud.org)
  • These findings highlight the need for identifying a widely accepted gold standard for diagnosis of bacterial pneumonia in children. (studyslide.com)
  • Sickle cell crisis. (aetna.com)
  • 6 Most studies were not prospective and some of the children were evaluated during a vasoocclusive crisis or other exacerbation of sickle cell disease. (haematologica.org)
  • ABSTRACT Introduction: The perception of prejudice against, and stigmatization of, sickle cell disease (SCD) leads the patient to perceive a different treatment, due to the disease stigma and maybe related to a worse quality of life (QoL). (scielo.br)
  • The sickle-cell anaemia group lower showed Z-scores for weight (p = 0.0002), height (p= 0.0184) and body mass index (p = 0.0011) than the control group at Te1. (bvsalud.org)
  • 0.0001) were lower in the sickle-cell anaemia group. (bvsalud.org)
  • Men showed greater weight commitment than women at the three study times (Te1: p= 0.0340, Te2: p= 0.0426 and Te3: p= 0.0387) and lower body mass index in Te3 (p= 0.0155) in the sickle-cell anaemia group. (bvsalud.org)
  • There was a significant increase in weight when comparing Te1 with Te3 (p= 0.0009) and in height when comparing Te1 with Te2 (p= 0.0292) and with Te3 (p= 0.0003) in the sickle-cell anaemia group. (bvsalud.org)
  • Age at menarche was delayed and lower in the sickle-cell anaemia group (mean = 15 years). (bvsalud.org)
  • At Te1, TSH levels were higher (p= 0.0080) and T3 levels were lower (p= 0.0020) in the sickle-cell anaemia group. (bvsalud.org)
  • Women with sickle-cell anaemia showed no fertility problems. (bvsalud.org)
  • The findings highlight the need to investigate the intention of paternity and fertility among men with sickle-cell anaemia. (bvsalud.org)
  • While IAEMH is associated with severe anaemia due to intravascular haemolysis caused by red cell invasion, oxidative injury, auto-antibodies, and/or pathogen-haem interaction, IAIMH is associated with haemophagocytic tri-lineage destruction of haematopoietic precursors in the bone marrow. (bvsalud.org)
  • Malaria leads to an increase in HIV viral load and a decline in CD4+ T cell count. (biomedcentral.com)
  • Erythrocytes in sickle form, cellular expression of polymerization of deoxygenated HbS, cause intermittent vascular obstruction, leading to tissue ischaemia and consequent chronic damage in organs and endocrine glands. (bvsalud.org)
  • Funding: This operate acknowledges FFABR (Fondo finanziamento attivitBase di ricerca from MIUR, Ministry of Education, Universities and Analysis, Italy) for monetary assistance.OT10.Look for EV signature in sickle cell illness Sisareuth Tana, Celine Gounoua, Marc Romanab, Stephane Mornetc, Alain R. BrissondaIntroduction: Antithrombin (AT) is really a glycoprotein involved inside the regulation of blood coagulation. (ack1inhibitor.com)
  • Staphylococcus aureus is the commonest cause, though other organisms should be considered based on age (eg Group B streptococci in neonates, Kingella Kingae in 6 months to 4 years), immunisation status ( Haemophilus influenzae) and underlying illness (eg Salmonella in children with sickle-cell disease). (rch.org.au)
  • Sickle cell disease (SCD), the most frequent monogenic disease worldwide, is caused by mutations in the β-globin gene. (haematologica.org)
  • Findings from this study indicated that 26% of children experienced social and language regression, and of those with regression, 76% had regained lost skills upon completion of the study. (cdc.gov)
  • BACKGROUND: There is no reliable marker for detecting early renal disease in early children with sickle cell disease (SCD). (bvsalud.org)
  • Scientists say their new study has overturned settled science, finding a new cause for a metabolic disease that causes neurological damage and sometimes death in Native American children. (pacmedrx.com)
  • Family functioning, medical self-management, and health outcomes among school-aged children with sickle cell disease. (onescdvoice.com)
  • Medium-only approach controls had only a tiny per cent of human mapping.Summary/Conclusion: miRNAs are identified at reduced relative levels in cells and releasate than indicated by legacy sequencing solutions. (ack1inhibitor.com)
  • Their study findings also show that the drugs are not associated with increased mortality, as had been reported in an earlier study. (digitalnaturopath.com)
  • This interaction allows bacterial entry into cells and results in transmigration. (stjude.org)
  • She is also serving as acting team leader for Red Cell and Iron disorders team. (onescdvoice.com)
  • Cell Host & Microbe 31:681-682, 2023. (stjude.org)
  • Sickle-cell disease (SCD) is the most common serious inherited disease, with 300,000 affected individuals born yearly worldwide, with three-quarters of them in Africa. (nature.com)
  • Religion/spirituality has been identified by individuals with sickle cell disease (SCD) as an important factor in coping with stress and in determining quality of life. (duke.edu)
  • Individuals with sickle cell trait had significantly lower antibody levels to all blood-stage antigens, and recessive homozygotes for CD36 (rs321198) had significantly lower anti-malarial antibody levels to MSP2. (edu.au)
  • The disease is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. (wikipedia.org)
  • Being overweight or obese may cause greater DNA damage to breast cells in women who carry BRCA gene mutations, researchers discover. (pacmedrx.com)
  • Research has shown that lysine-specific histone demethylase 1 (LSD1) plays an essential role in the self-renewal of these "leukemic stem cells," Incyte principal investigator Sang Hyun Lee, Ph.D., tells GEN . Building on this finding, Dr. Lee and colleagues developed an LSD1 inhibitor called INCB059872, which spurs myeloid cell differentiation. (genengnews.com)
  • These compounds were recently proven to be cytotoxic agents against monocytic THP-1 cell lines, whereas N,N',N''-tribenzyloxyisocyanuric acid exerted antimicrobial activity against E. coli strains (12). (moam.info)
  • Specifically, CD8+ cells, also known as cytotoxic T cells, burst onto the scene, while other immune system suppressor cells drop off, Dr. Hermann tells GEN . (genengnews.com)
  • Our findings recommend that analysis of ATT enriched in EV preparations may well be valuable to acquire insights in to the pathogenesis and be of assistance inside the diagnostic algorithm of ATT deficiency. (ack1inhibitor.com)
  • Although this study makes use of iPSCs, equivalent final results would most likely be obtained with other cells. (ack1inhibitor.com)
  • Such epigenetic marks are essential for cells to develop normally. (genengnews.com)
  • However, the presence of gallstones is a frequent incidental finding and does not always necessitate treatment, in the absence of identifiable disease. (wikipedia.org)
  • The mean corpuscular volume (MCV), a measure of the average volume of red blood cells, was 70.6 fL. (optometrytimes.com)
  • When astronauts travel to space, the experience depletes their red blood cells and bone, according to a new study. (durenrx.com)
  • Sickle cell disease is a life-threatening inherited condition designated as a public health priority by WHO. (bvsalud.org)
  • The findings of the paper provide an important entry point to the discussion on the relevance and scope of EU public mental health action. (lu.se)
  • Cell lines and transfected cell systems augment this study with particular emphasis on perturbations in the biology of selectins, integrins, matrix adhesion, and chemokine receptors. (stjude.org)
  • On the whole, the findings of the present study demonstrated that among the elderly outpatients, a 3‑day course of intravenous remdesivir was associated with favourable outcomes. (spandidos-publications.com)
  • The pilot survey was available to UK participants only and was administered through web-based questionnaires, face-to face completion and in sickle cell community events. (nih.gov)
  • Aiming to increase the influence of patient voice in the development of SCD-related research, we set out to develop patient centered actions in the frame of International Scientific Conferences in collaboration with the ERN-EuroBloodNet, Oxford Blood Group, Annual Sickle Cell Disease and Thalassaemia Conference (ASCAT), the European Hematology Association and the British Society of Hematology. (bvsalud.org)
  • Amyloid angiopathy is another pathologic finding in the AD spectrum, in which Aβ accumulates in the media of small arteries. (medscape.com)
  • What could be truly exciting, Dr. Lee notes, is the combination of LSD1 inhibitors with antibodies that block programmed cell death-1 (PD-1), a cell surface receptor that keeps the immune system in check. (genengnews.com)
  • Kanthasamy discovered that the protein kinase-C (specifically PKCd) is killing the dopamine-producing cells which Parkinson's sufferers lack and he, and his research staff, discovered a compound that neutralizes the cell-killing kinase-C and allows the dopamine-producing cells to survive and function. (digitalnaturopath.com)
  • Thanks to the generous support from early funders including Share our Strength and the W.K. Kellogg Foundation, we were able to grow our research project, recruit more experts - including Dr. John Cook who helped develop the gold standard for measuring food insecurity in the U.S. - analyze our data and publish our findings in journals. (childrenshealthwatch.org)
  • The findings suggest that a graduated measure is useful for assessing the degree of uncertainty of the observers and subtle effects of different factors upon the judgment of patient's pain. (researchgate.net)
  • Recommendations and a practical algorithm were developed using the findings. (biomedcentral.com)
  • Elle is a mom of twin girls, one of whom lives with sickle cell disease and type 1 diabetes. (socialhealthnetwork.com)
  • However, in sickle cell disease (SCD) primarily due to repeated blood transfusions and hemolysis-induced recycling of iron, its supplementation during pregnancy remains questionable and may be harmful. (scielo.br)
  • It is used mainly to reduce blood volume, red cell mass and iron stores. (aetna.com)
  • In biliary colic, lab findings are usually within normal limits. (wikipedia.org)
  • Prevenir y tratar los niveles de glucosa en sangre superiores a lo normal. (fotocentrum.pl)