• One therapeutic approach involves targeting the molecular pathway that controls cell death. (asbmb.org)
  • Identification of molecular pathway resulting in pituitary tumorigenesis remains challenges in endocrine oncology. (cancerindex.org)
  • Based on the findings, the inhibition of miR-543 was found to play a tumor suppressive role in PA through the down-regulation of Wnt/β-catenin pathway by negatively regulating Smad7. (cancerindex.org)
  • Moreover, integrated proteomic and metabolomic revealed that the protein digestion and absorption is the common enrichment KEGG pathway. (iasp-pain.org)
  • The study reveals a new pathway for molecular intervention against pulmonary oxidative injury and fibrosis. (cdc.gov)
  • Time-resolved serial synchrotron crystallography captures all key states of catalysis while revealing allosteric transmission pathway between the two subunits of the enzyme. (analytica-world.com)
  • Ahn is currently working at the University of Colorado and is conducting research on cell signaling, information and proteomics, and molecular biophysics. (wikipedia.org)
  • We've combined neutron scattering experiments with large-scale simulations on ORNL's main supercomputer to reveal that pretreated softwood lignin aggregates are characterized by a highly folded surface," said Smith, who directs ORNL's Center for Molecular Biophysics and holds a Governor's Chair at University of Tennessee. (sciencedaily.com)
  • Ahn was elected president of the American Society for Biochemistry and Molecular Biology (ASBMB) in the summer of 2015. (wikipedia.org)
  • Dr. Gaurav Chopra and Professor Michael Levitt in the Department of Structural Biology used molecular dynamics simulations involving a state-of-the-art Quantum Mechanical Polarizable Force Field (QMPFF3) to study the hydration of buckminsterfullerene, the smallest hydrophobic nanosphere widely referred to as a buckyball or C 60 . (phys.org)
  • Below are a few TBI-focused research highlights from American Society for Biochemistry and Molecular Biology journals. (asbmb.org)
  • New research from UCL, investigating the biology of a rare genetic mutation that enables carrier Jo Cameron to live virtually without pain and fear while also healing quickly, discovered that the mutation in FAAH-OUT gene 'turns down' FAAH gene expression, affecting molecular pathways related to wound healing and mood, thereby offering potential new targets for drug discovery. (lifeboat.com)
  • The findings are published in the latest edition of the journal Nature Structural & Molecular Biology. (hutton.ac.uk)
  • This time-lapse sequence of structures reveals dynamic motions as a fundamental element in the molecular foundations of biology. (analytica-world.com)
  • For example, by integrating genomic and proteomic data, proteogenomics is providing new insights into cancer biology and revealing potential therapeutic targets . (cdc.gov)
  • A consanguineous family of Somali origin with four affected children was ascertained and recruited for molecular genetic analysis. (molvis.org)
  • Carrier molecular genetic testing is available in a clinical setting. (orpha.net)
  • To try to answer that, we looked for molecular differences that could reveal aspects of motor neuron diversity-and the study started with a molecular screen to try and find genetic differences between different subtypes of motor neurons. (scientificamerican.com)
  • What I find most interesting is the idea that the embryonic tissue that goes on to form limb and the motor neurons is regulated by coordinated molecular mechanisms-under the guidance of a genetic program that has been conserved over the course of evolution. (scientificamerican.com)
  • Various genetic causes result in HCM as an isolated finding. (medscape.com)
  • ECs from Black and White patients display important differences in their histologic types, molecular subtypes, driver genetic alterations, and therapeutic targets. (bvsalud.org)
  • Genetic testing in ambulatory cardiology clinics reveals high rate of findings with clinical management implications. (cdc.gov)
  • Our findings provide novel empirical evidence that standing genetic diversity of phytoplankton resting stage allows populations to evolve rapidly (20-50 generations) and flexibly on timescales relevant for seasonal bloom progressions. (lu.se)
  • Our functional analysis revealed that the molecular signature of En2 -/- cerebellum and hippocampus shares convergent pathological pathways with ASD, including abnormal synaptic transmission, altered developmental processes and increased immune response. (biomedcentral.com)
  • The latest study elucidates how this mutation reduces the expression of the FAAH gene and impacts other molecular pathways associated with mood and wound healing. (lifeboat.com)
  • These findings strengthen the evidence that desirable and undesirable consequences of status epilepticus-induced TrkB activation are mediated by distinct signaling pathways downstream of this receptor. (jneurosci.org)
  • These findings reveal new regulatory signaling pathways for gastric cancer stem cells, thus it give new insights on potential early diagnosis and/or molecular therapy for gastric cancer. (nih.gov)
  • For example, Prof. Giguère's discovery and characterization of the estrogen-related receptors (ERRs) revealed a major regulatory node of cellular metabolism that is highly relevant to metabolic disorders, cardiovascular disease, several prominent cancers , and many other diseases. (mcgill.ca)
  • Characterization of these mutants for altered brain anatomy and activity has revealed over one third have phenotypical abnormalities. (harvard.edu)
  • Our findings elucidate the complementary nature of AHPO and ToF-SIMS during chemical characterization of eumelanin traces in fossilized organismal remains. (lu.se)
  • Molecular Characterization of Endometrial Carcinomas in Black and White Patients Reveals Disparate Drivers with Therapeutic Implications. (bvsalud.org)
  • Here we provide insights into the molecular signatures of eusociality within the termites. (nature.com)
  • The structures provided insights into a minimal Cas9 scaffold and revealed the remarkable mechanistic diversity of the CRISPR-Cas9 systems. (broadinstitute.org)
  • The insights garnered from these findings could potentially pave the way for novel drug targets and foster further research in these domains. (lifeboat.com)
  • This research exemplifies one of the important contributions that public aquariums and zoos like Shedd can make to both scientific research and conservation efforts, while raising public awareness by revealing new biological insights into the species," said Dr. David Roberts, senior research scientist at Seqwater and a lead author on the study. (sheddaquarium.org)
  • In parallel, we used hydrogen-deuterium exchange (HDX) coupled with mass spectrometry (MS) approach to gain molecular insights into ancHLD-RLuc protein dynamics, and identification of conformationally rich regions that could be important for the catalytic reaction. (europa.eu)
  • Many of these results parallel molecular mechanisms of eusocial evolution in Hymenoptera. (nature.com)
  • Therefore, identifying the molecular mechanisms common to both origins of eusociality is crucial to understanding the fundamental signatures of these rare evolutionary transitions. (nature.com)
  • These findings add limited evidence to study this topic, while further studies are needed to explain the potential molecular mechanisms. (frontiersin.org)
  • Understanding the molecular signaling mechanisms by which SE transforms a brain from normal to epileptic may reveal novel targets for preventive and disease-modifying therapies. (jneurosci.org)
  • Understanding the molecular signaling mechanisms underlying the development of TLE may identify novel therapeutic targets. (jneurosci.org)
  • Thus, the combination of proteomics and metabolomics opens new avenues for the research of the molecular mechanisms of tramadol toxicity. (iasp-pain.org)
  • These findings reveal potential epigenetic markers of risk and precursors of disease in childhood and adolescence, although further research is needed to investigate potential causal inference and the underlying molecular mechanisms. (who.int)
  • Sixteen (84.2%) laboratories in 13 countries indicated that they had capacity in place for molecular detection of MERS-CoV, while three laboratories used referral mechanisms instead. (who.int)
  • Having a precise description of water s structure is critical to constructing accurate simulations of molecular events, including protein folding, substrate binding, macromolecular recognition, and complex formation. (phys.org)
  • There were many challenges to overcome in designing and implementing QMPFF3-based molecular dynamics simulations especially to study the behavior of water molecules next to hydrophobic surfaces at atomic detail and subpicosecond time resolution. (phys.org)
  • Molecular dynamics simulations revealed a critical role of the L9 light chain in integrity of the homotypic interface, which likely impacts PfCSP affinity and protective efficacy. (nature.com)
  • Here, by using first-principles molecular dynamics simulations, we studied the local structures in the liquid and amorphous SST at various temperatures. (osti.gov)
  • Advanced molecular detection (AMD) technology is helping investigators trace connections between cases of HIV-1 infections in a rural Indiana outbreak. (cdc.gov)
  • advanced molecular detection (AMD) technology helped answer others. (cdc.gov)
  • These findings reveal a potential connecting factor involved in TBI-related dementia and an early-detection marker for patients. (asbmb.org)
  • Molecular detection of Leishmania spp. (who.int)
  • Several laboratories worldwide established molecular detection of MERS-CoV by reverse transcriptase polymerase chain reaction (RT-PCR) early in the outbreak. (who.int)
  • case confirmation has relied predominantly on molecular detection methods. (who.int)
  • All 16 laboratories with MERS-CoV testing capacity responded that they had a standard operating procedure for molecular detection of MERS-CoV in place, with 12 choosing to incorporate MERS-CoV into their standard algorithm for respiratory pathogens. (who.int)
  • Tracing those genes attributable to particular cell types-the building blocks of brain circuits-the study authors point to a unique molecular signature for each cortical cell type. (neurosciencenews.com)
  • Analyses of endogenous Kv2.2 in cortical neurons in situ and recombinant Kv2.2 expressed in heterologous cells reveal that Kv2.2 is largely refractory to stimuli that trigger robust, phosphorylation-dependent changes in Kv2.1 clustering and function. (jneurosci.org)
  • These results identify a molecular mechanism that contributes to heterogeneity in cortical neuron ion channel function and regulation. (jneurosci.org)
  • Molecular diagnosis was performed at the Fundação Ezequiel Dias (FUNED) in Belo Horizonte. (scielo.br)
  • However, contrast‑enhanced ultrasound (CEUS) may reveal the characteristic features of HEHE to aid diagnosis. (spandidos-publications.com)
  • HEHE diagnosis usually relies on histological, immunohistochemical and molecular features but some imaging features are highly suggestive of this lesion. (spandidos-publications.com)
  • Diagnosis is suspected based on the clinical findings of hypotonia, macrocephaly and head lag. (orpha.net)
  • Mutation screening can be performed for molecular diagnosis. (orpha.net)
  • Newswise - DALLAS - March 29, 2018 - Researchers from UT Southwestern's Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Internal Medicine's Division of Nephrology recently published work in Nature that reveals the molecular structure of the so-called "anti-aging" protein alpha Klotho (a-Klotho) and how it transmits a hormonal signal that controls a variety of biologic processes. (newswise.com)
  • One of the major, paradigm-changing findings revealed by solving the protein complex structure is that the circulating form of soluble a-Klotho can actually serve as a co-receptor for FGF23. (newswise.com)
  • The knowledge of the structure of the protein, along with its molecular binding partners, will enable us to greatly advance the understanding of how a-Klotho works and also how to best design therapeutic strategies and novel agents that can either activate or block FGF23-a-Klotho interaction and signaling as needed. (newswise.com)
  • Metabolomics analysis revealed that differential expressed metabolites mainly involved in protein ingestion and absorption, fatty acid biosynthesis, steroid hormone biosynthesis and bile secretion. (iasp-pain.org)
  • By cataloguing the molecular processes by which cells maintain and modify protein levels, proteomic studies offer another dimension of information that may help advance our understanding of health and disease. (cdc.gov)
  • These findings reveal the molecular mechanism of the unique NPNV selectivity of L9 and emphasize the importance of anti-homotypic affinity maturation in protective immunity against P. falciparum . (nature.com)
  • Findings unveil the complexity of beta coronavirus attachment, suggesting a more intricate mechanism of host cell invasion than previously understood. (news-medical.net)
  • BDNF signaling thru TrkB receptor tyrosine kinase is one molecular mechanism promoting TLE. (jneurosci.org)
  • Here we analyzed the molecular mechanism of the fibrogenic response to PQ and its inhibition by Res and Nrf2. (cdc.gov)
  • Poor crystallibility and long-term (>3 months) crystallization process of RLuc appeared to be major drawbacks in the acquisition of structural data that should provide the molecular dissection of RLuc catalytic reaction mechanism. (europa.eu)
  • Genomic medicine in Africa: a need for molecular genetics and pharmacogenomics experts. (cdc.gov)
  • Our latest findings reveal the molecular structure of RodA and identify targetable spots where new antibacterial drugs could bind and subvert its work," said study senior investigator Andrew Kruse , associate professor of biological chemistry and molecular pharmacology at Harvard Medical School. (harvard.edu)
  • The National Institute of Neurological Disorders and Stroke emphasizes funding support for laboratories investigating the molecular and clinical factors of TBIs. (asbmb.org)
  • For example, a recent article in Nature Communications described proteomic profiling of 300 breast cancer samples, which revealed biological subtypes with distinct clinical outcomes and different survival rates. (cdc.gov)
  • Here, analysis of 1,882 prospectively sequenced ECs using a clinical FDA-authorized tumor -normal panel revealed a significantly higher prevalence of high- risk histologic and molecular EC subtypes in self -identified Black (n = 259) compared with White (n = 1,623) patients . (bvsalud.org)
  • These findings emphasize the importance of incorporating diverse populations into molecular studies and clinical trials to address EC disparities. (bvsalud.org)
  • To identify the molecular basis for autosomal recessively inherited congenital non-syndromic pulverulent cataracts in a consanguineous family with four affected children. (molvis.org)
  • Now, in another scientific first described March 28 in Nature , members of the same research team have revealed the molecular building blocks-and a structural weak spot-of a key member of that family. (harvard.edu)
  • Specifically, the protein's molecular profile reveals structural features reminiscent of other proteins whose architecture Kruse has disassembled. (harvard.edu)
  • Over 20% of patients taking Nirmatrelvir-ritonavir therapy, commonly known as Paxlovid, suffer from the rebound, compared to less than the 2% chance seen in other treatment groups, a Harvard Medical School study revealed. (medicaldaily.com)
  • Our comprehensive analysis of prospectively clinically sequenced ECs revealed significant differences in their histologic and molecular composition and in the presence of therapeutic targets in Black versus White patients . (bvsalud.org)
  • Chest radiography revealed no pathological findings. (scielo.br)
  • Study published in Cell by Allen Institute for Brain Science examines cellular and molecular organization of human and mouse brain. (neurosciencenews.com)
  • This study reveals a high degree of similarity among human individuals. (neurosciencenews.com)
  • Several findings in the study point to differences and similarities between humans and mice. (neurosciencenews.com)
  • According to the study, only 21% of gene expression in the visual cortex exhibited differences between human and mouse, but the nature of those differences may reveal more about what makes us uniquely human. (neurosciencenews.com)
  • Despite the limited number of animals used in the study, our bioinformatic analysis indicates the En2 -/- mouse is a valuable tool for investigating molecular alterations related to ASD. (biomedcentral.com)
  • The study provides evidence for how FGF23 signals to cells by forming a complex with a-Klotho and the two other molecular partners. (newswise.com)
  • Based on this revolutionary finding, the identification and subsequent study of novel receptor/hormone response systems completely transformed the science of endocrinology. (mcgill.ca)
  • This study first revealed that there was a positive association between exposure to DEHP metabolites and the risk of AOH. (frontiersin.org)
  • The study reveals that the SARS-CoV-2 delta variant was transmitted from humans to lions at a Singapore zoo, emphasizing the risk to captive and endangered animals. (news-medical.net)
  • The study of PSCs has relied on an anatomy-based approach, as the identities of cell-specific PSC molecular markers have remained elusive. (elifesciences.org)
  • Our study reveals the role of Sc atoms in the liquid and amorphous structure, paving the way for the application of Sc-based phase-change memory. (osti.gov)
  • The proposed study aims to identify how single cells decide to form communities, and how, using molecular machineries, they localize themselves along a preferred spatial niche in communities. (harvard.edu)
  • The molecular-scale view provided in this latest study suggests how the wiring process may have evolved. (scientificamerican.com)
  • Study co-author Thomas Jessell, who co-directs Columbia University's Zuckerman Institute , talked to Scientific American about the findings and their implications. (scientificamerican.com)
  • What experiments did you do for this study, and what were your main findings? (scientificamerican.com)
  • A study reveals that those who suffer from depression have a smaller hippocampus than non-suffering individuals. (medicaldaily.com)
  • Another recent study used proteomic profiling of liver biopsies to describe the molecular landscape of hepatocellular carcinoma, the most common type of liver cancer. (cdc.gov)
  • Pharmacogenomics implementation in cardiovascular disease in a highly diverse population: initial findings and lessons learned from a pilot study in United Arab Emirates. (cdc.gov)
  • In order to further delineate the molecular pathology of autosomal recessive cataracts, we investigated a consanguineous family with nuclear pulverulent cataracts and identified a novel germline CRYBB1 mutation. (molvis.org)
  • We studied measures of molecular signaling and cell death in a model of SE in mice of both sexes, including wild-type and TrkB Shc/Shc mutant mice in which a point mutation (Y515F) of TrkB prevents the binding of Shc to activated TrkB kinase. (jneurosci.org)
  • However, the specific solutions are remarkably different, thus revealing a striking case of convergence in one of the major evolutionary transitions in biological complexity. (nature.com)
  • Their findings will have a significant impact on biological processes. (phys.org)
  • The findings reveal distinct molecular markers specific to each species. (neurosciencenews.com)
  • A growing number of molecular markers that recognize subsets of glial cells throughout the nervous system have been identified ( Jäkel and Dimou, 2017 ). (elifesciences.org)
  • Our results show that AHPO is sensitive to changes in the melanin molecular structure already during mild heat and pressure treatment (resulting, e.g., in increased C-C cross-linking), whereas harsh maturation leads to extensive loss of eumelanin-specific chemical markers. (lu.se)
  • RESULTS: Static-binding assays revealed that Angpt-2 bound to VWF with high affinity (KD,app ∼3 nM) in a pH and calcium-dependent manner. (imperial.ac.uk)
  • Assays of 58 strains originating from sediment resting stages revealed no difference in the average tolerance to copper between the two populations. (lu.se)
  • Proteomic analysis revealed 31 differential expressed serum proteins (9 increased and 22 decreased) in tramadol-treated mice (oral, 50 mg/kg, 5 weeks) as compared with the control ones. (iasp-pain.org)
  • Immunocytochemistry and voltage-clamp recordings from outside-out macropatches reveal distinct cellular expression patterns for Kv2.1 and Kv2.2 in intratelencephalic and pyramidal tract neurons of L5, indicating circuit-specific requirements for these Kv2 paralogs. (jneurosci.org)
  • Detailed analysis of ToF-SIMS spectra acquired prior to experimental treatment revealed significant differences between the investigated eumelanins. (lu.se)
  • This work illustrates how state-of-the-art neutron scattering and high-performance supercomputing can be integrated to reveal structures of importance to the energy biosciences," Smith said. (sciencedaily.com)
  • In summary, we deciphered the cellular heterogeneity and the molecular dynamics during fibrocartilage differentiation. (elifesciences.org)
  • These findings will serve as a springboard for revealing drivers of PSC differentiation and function. (elifesciences.org)
  • These molecular signatures may reflect and contribute to species-specific functions. (neurosciencenews.com)
  • Sequencing of the ITS1 region of the Trypanosoma species detected herein revealed that camels were infected with T. evansi and T. simiae. (researchgate.net)
  • These findings provide a revised maximum age to aid in the conservation management of this species. (sheddaquarium.org)
  • Researchers use cryo-EM and molecular dynamics to reveal conformational changes in the spike proteins of human coronavirus HKU1 upon binding with a receptor. (news-medical.net)
  • Researchers examined the antigenicity of the emerging SARS-CoV-2 subvariant BA.2.86, finding that it is not resistant to neutralizing antibodies from previously infected or vaccinated individuals, although it does show increased binding affinity to the ACE-2 receptor. (news-medical.net)
  • The researchers say their findings also shed new light on how kidney disease leads to an abnormal thickening of heart muscle tissue called hypertrophy, which is a leading cause of death in people with kidney disease caused by high blood pressure, diabetes, and other illnesses. (newswise.com)
  • The findings are central to understanding chronic diseases, such as obesity and diabetes, as fat cells produce hormones critical for metabolic control, the researchers said. (news-medical.net)
  • Researchers have revealed the surface structure of lignin aggregates down to 1 angstrom -- the equivalent of a 10 billionth of a meter or smaller than the width of a carbon atom. (sciencedaily.com)
  • Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Potsdam (both in Germany) and the University of Toronto (Canada) have pieced together a detailed time-lapse movie revealing all the major steps during the catalytic cycle of an enzyme. (analytica-world.com)
  • The researchers used time-resolved X-ray crystallography to take molecular snapshots during the turnover reaction of this natural enzyme at physiological temperatures. (analytica-world.com)
  • The analysis published today reveals high consistency of gene expression among different regions of the human cortex-the outer rind of the mammalian brain responsible for sophisticated information processing-specifically the temporal and visual cortices. (neurosciencenews.com)
  • Using a newly generated transgenic mouse in which PSCs are specifically labeled, we show that PSCs have a unique molecular signature that includes genes known to play critical roles in PSCs and synapses. (elifesciences.org)
  • The authors provided convincing evidence for the heterogeneity of postnatal enthesis growth and the molecular dynamics and signaling networks during enthesis formation. (elifesciences.org)
  • Using recent techniques such as targeted genome editing, whole-brain activity imaging, brain atlas registration, and behavioral profiling, Thyme wants to analyze how these genes contribute to psychiatric disorders through disruption of molecular, cellular, developmental and behavioral processes. (harvard.edu)
  • This time-lapse movie revealed eighteen time points from 30 milliseconds to 30 seconds, covering all key catalytic states that lead to the breaking of the C-F bond. (analytica-world.com)
  • Here we used cryo-EM to understand the molecular basis of these unique functional properties. (nature.com)
  • This project aimed to employ in-lab reconstructed dual-function (dehalogenase/luciferase) ancestral enzyme (ancHLD-RLuc) to decipher molecular evolution steps leading to the functional divergence of modern-day HLD and RLuc enzymes, and to explore how this knowledge could be exploited biotechnologically. (europa.eu)
  • Our overall findings revealed that chronic exposure to tramadol changed the proteomic and metabolomic profile of mice. (iasp-pain.org)
  • Scientists applied molecular-based techniques to facilitate the research using a sample of preserved fin tissue from Granddad. (sheddaquarium.org)
  • Translating proteomics research findings is challenging in the face of complex and dynamic cellular-level processes. (cdc.gov)
  • Additionally, isolation and targeting of PSCs for interrogation of molecular function in vivo and in vitro has not been possible. (elifesciences.org)
  • Here we reveal that TrkB-mediated activation of Akt protects against hippocampal neuronal death in vivo following status epilepticus. (jneurosci.org)
  • While great progress has been made in understanding the cellular and physiological characteristics of PSCs, very little is known about the molecular composition of these cells ( Ko and Robitaille, 2015 ). (elifesciences.org)
  • Overall, our findings highlight the importance of TEs as regulatory agents and their dynamic activity during development, adult life, and disease in the human brain. (lu.se)
  • These are accompanied by major changes in gene regulation and the molecular evolution of caste determination. (nature.com)
  • The latest findings, however, go a step further and pinpoint a potential weak link in the protein's makeup. (harvard.edu)
  • Evidence based on serologic and molecular findings revealed the presence of one-celled parasites that closely resemble Babesia bovis, which is one of the causative agents of bovine babesiosis, in WTD. (usda.gov)
  • molecular techniques were applied to samples from 64 cutaneous leishmaniasis patients referred to Herat regional hospital during 2013. (who.int)
  • AMD data visualization techniques are revealing how closely these two outbreaks are co-occurring with useable, easy to interpret graphics. (cdc.gov)
  • and molecular basis are discussed. (who.int)
  • Our crystallographic findings provided unprecedented molecular views of the Renilla-type luciferases complexed with a non-oxidizable coelenterazine analogue, coelenteramide and coelenteramine, revealing as-yet-unseen molecular details of bioluminescent reaction. (europa.eu)
  • Molecular typing revealed a unique strain of C. avium . (cdc.gov)
  • We have identified neuron-glia antigen 2 (NG2) as a unique molecular marker of S100β+ PSCs in skeletal muscle. (elifesciences.org)
  • Our findings revealed that cells reduce tension upon deformation by thinning the cell monolayer, thereby providing excess tissue area. (tu-dresden.de)
  • Second, it reveals something about the behaviour of cells. (hutton.ac.uk)
  • The α-crystallins are heat shock proteins that function as molecular chaperones. (molvis.org)