Findings injuries ischemia reperfusion. Medical search. Frequent questions

Sprague-Dawley rats were used as experimental animals, and middle cerebral artery occlusion was used to make cerebral ischemia/reperfusion model. (molecularhydrogenstudies.com)
Primary cortical neurons were subjected to glucose deprivation (GD), oxygen-glucose deprivation (OGD) or simulated ischemia-reperfusion (I/R). Ischemic stroke was induced in C57BL/6J mice by middle cerebral artery occlusion, followed by reperfusion. (scienceopen.com)
Transient middle cerebral artery occlusion was induced for 1 hour followed by 12-hour to 7-day reperfusion in C57/BL6 mice. (scienceopen.com)
Adeno-associated viral (AAV)-NRP-1 was stereotaxically inoculated into the cortex and ipsilateral striatum posterior of adult male Sprague-Dawley (SD) rats before a 90-min transient middle cerebral artery occlusion (tMCAO) and subsequent reperfusion. (biomedcentral.com)
The model used in this study was established by middle cerebral artery occlusion (MCAO) and reperfusion. (biomedcentral.com)
Cerebral ischaemia is caused by middle cerebral artery occlusion, which leads to some brain tissue damage, accompanied by inflammation and immune response [ 2 ]. (biomedcentral.com)

The present invention is based on the surprising finding that the peptides of the invention have protective cardiovascular effects without simultaneous administration of other compounds, specifically they have protective effects on the heart against ischemia-reperfusion injury. (justia.com)
We have recently shown that postischemic administration of intralipid protects the heart against ischemia-reperfusion injury. (silverchair.com)

Qi et al ( 9 ) reported that GP protected against DNA damage in neurons in I/R-induced cerebral injury. (spandidos-publications.com)
Upregulation of HIF-1 expression may play a neuroprotective role in animal models of focal cerebral ischemia ( 6 ). (spandidos-publications.com)
Former researches proved that low-concentration of hydrogen can be used to ameliorating cerebral ischemia/reperfusion injury. (molecularhydrogenstudies.com)
Water electrolysis-derived hydrogen inhalation had neuroprotective effects on cerebral ischemia/reperfusion injury in rats with the effect of suppressing oxidative stress and inflammation, and it is a possible new hydrogen resource to electrolyze water at the bedside clinically. (molecularhydrogenstudies.com)
Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats: a possible new hydrogen resource for clinical use. (molecularhydrogenstudies.com)
The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia-reperfusion injury model. (scienceopen.com)
In this review, we discussed the recent findings of spatio-temporal evolution of BBB injury in the early stages of cerebral ischemia and its association with intracerebral hemorrhage following tPA thrombolysis. (nih.gov)
However, whether NRP-1 can repair mitochondrial structure and promote functional recovery after cerebral ischemia is still unknown. (biomedcentral.com)
Both in vitro and in vivo models of cerebral ischemia/reperfusion (I/R) injury presented a sharp increase in NRP-1 expression. (biomedcentral.com)
During the early stage of cerebral I/R injury, significantly-swollen mitochondria decrease adenosine triphosphate (ATP) and produce excessive reactive oxygen species (ROS) and oxidative stress, finally resulting in cell death [ 6 ]. (biomedcentral.com)
Therefore, promoting the mitochondrial structural repair and functional recovery is the crucial for the amelioration of the neurological damage after cerebral ischemia. (biomedcentral.com)
The abundance and diversity of the intestinal flora in rats decreased after cerebral ischaemia - reperfusion injury (CIRI). (biomedcentral.com)
According to the World Health Organization, cerebral ischaemia is the second leading cause of death and the third leading cause of disability in the world [ 1 ]. (biomedcentral.com)
According to the theory of TCM, cerebral ischaemia, which is also called stroke, can be induced by hyperactivity of liver Yang, disordered diet, stagnation of blood, etc. (biomedcentral.com)
Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)

Following myocardial infarction (MI), elderly patients have a poorer prognosis than younger patients, which may be linked to increased coronary microvessel susceptibility to injury. (jci.org)
These findings suggest that BAG3 may provide a therapeutic target in patients undergoing reperfusion after myocardial infarction. (uthscsa.edu)
In the present study we examined whether myocardial conduction cells (MCC, Purkinje fibers) are more vulnerable to ischemia/reperfusion injury than working myocardial cells and whether the damage is due to necrosis or apoptosis. (uni-luebeck.de)
Pharmacodynamic Interaction of Garlic with Gliclazide and Ramipril on Myocardial Injury in Diabetic Rats Concurrent therapy of herbs with conventional regimen has been extensively reported for alleviating morbidities such as diabetes and cardiac manifestations. (diabetestalk.net)

A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
Rats, subjected to bilateral renal ischemia (45 min) followed by reperfusion (6 h), were administered EUK-134 (0.3 and 3 mg/kg, i.v.) prior to and during reperfusion, after which biochemical and histological indicators of renal dysfunction and injury were measured. (scienceopen.com)

moreover, in vivo grafts demonstrated reduced neutrophilic infiltrate/fibrosis/overall injury. (uwo.ca)
In vivo quantification of VCAM-1 expression in renal ischemia reperfusion injury using non-invasive magnetic resonance molecular imaging. (ox.ac.uk)
An intravital model for imaging the adult and aged IR-injured beating heart in real time in vivo was used to demonstrate heightened basal and injury-induced neutrophil recruitment, and poorer blood flow, in the aged coronary microcirculation when compared with adult hearts. (jci.org)
Here we investigate the effect of EUK-134, a synthetic superoxide dismutase and catalase mimetic, (i) on renal dysfunction and injury caused by I/R in vivo and (ii) on proximal tubular cell (PTC) injury and death caused by oxidative and nitrosative stress. (scienceopen.com)
In vivo rat hearts or isolated Langendorff-perfused mouse hearts were subjected to ischemia followed by reperfusion with intralipid (0.5%, 1% and 2% ex-vivo, and 20% in vivo), cyclosporine-A (0.2 μM, 0.8 μM, and 1.5 μM ex- vivo and 10 mg/kg in vivo), or vehicle. (silverchair.com)

METHODOLOGY AND FINDINGS: Mice subject to unilateral, transient (30 minutes) renal ischemia and subsequent reperfusion received intravenous VCAM-MPIO (4.5 mg iron/kg body weight). (ox.ac.uk)
IPC is described as short, transient, and nonlethal ischemia periods and subsequent reperfusion which is performed before IR injury and can protect the kidney against long-term ischemia [ 6 - 8 ]. (hindawi.com)

In contrast, DCD livers with 30 and 60 min DWIT suffered from greater mitochondrial injury and inflammation as measured by increased perfusate Lactate, FMN- and HMGB-1-levels with subsequent Toll-like-receptor activation during NRP. (bvsalud.org)
Persons with SCD produce abnormal hemoglobin that causes erythrocytes to become rigid and deform under low oxygen conditions, leading to ischemia-reperfusion injury in the microvasculature with subsequent organ damage and pain. (cdc.gov)

Autophagy is a process that relies on lysosomal pathways for the degradation of cytoplasmic proteins and organelles and plays an important role in the pathology of brain injury such as hypoxia ischemia[ 3 ]. (ijpsonline.com)
Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)
We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)
Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)

The findings suggest that targeting IL-1b could suppress inflammation associated with multiple inflammatory diseases, including multiple sclerosis , ischemia-reperfusion injury, atherosclerosis, liver disease, pancreatitis, psoriasis, inflammatory bowel disease , and infectious diseases . (edu.au)
In addition, it will be of great interest to explore the therapeutic opportunities for nitrate and nitrite in diseases such as hypertension, atherosclerosis, and ischemia-reperfusion injury. (sciencewatch.com)

In the present study, a hepatic I/R‑injury model was successfully established using C57BL/6 mice. (spandidos-publications.com)
Furthermore, GP exhibits a therapeutic effect on chronic hepatic injury, fibrosis, as well as fatty liver disease, which were induced by a high fat, high cholesterol diet and alcohol in mice ( 5 , 8 ). (spandidos-publications.com)
Therefore, in the present study the protective effects of GP against I/R-induced hepatic injury in mice was studied. (spandidos-publications.com)
Sham group (n = 6), mice underwent same anesthetic and surgical procedures except for ischemia induction. (biomedcentral.com)
After the end of reperfusion phase mice were sacrificed, blood samples were collected directly from the heart for determination of serum TNF-a, IL-6, urea and Creatinine. (biomedcentral.com)
The mice were treated with 45 min unilateral renal ischemia and reperfusion (I/R) to induce an acute renal injury. (oncotarget.com)
After three days of I/R injury, rotenone at a dose of 200 ppm in food was administered to the mice. (oncotarget.com)

Cardiac ischemia-reperfusion injury (IRI) occurs intra-operatively during heart transplantation (HTx), underpinning graft survival. (uwo.ca)
Cardiac ischemia-reperfusion injury (IRI) occurs when transplanting a heart from donor to recipient. (uwo.ca)
The "ischemia" phase of cardiac IRI occurs when the donor heart is being collected and blood/oxygen is not going to the heart. (uwo.ca)
This is known as the "reperfusion" phase in cardiac IRI. (uwo.ca)
By understanding the links between Ca2+, electrical excitability and energy production, we hope to understand the cellular basis of cardiac arrhythmias, ischemia-reperfusion injury, and sudden death. (hopkinsmedicine.org)
While altered BAG3 expression has been associated with cardiac dysfunction, its role in ischemia/reperfusion (I/R) is unknown. (uthscsa.edu)
If treated with cardiopulmonary resuscitation, however, cardiac arrest is survivable, but survivors often show evidence of injury in selectively vulnerable regions of the brain. (cdc.gov)

Abstract Hepatic ischemia/reperfusion (I/R) injury is a common clinical challenge. (123dok.net)

One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
Therefore, in the present study, we evaluated the effect of mitochondrial complex 1 inhibition by rotenone on the chronic renal damage induced by acute ischemia-reperfusion. (oncotarget.com)
These findings suggested that inhibition of mitochondrial complex-1 activity by rotenone could retard the progression of AKI to CKD probably via protecting the mitochondrial function to some extent. (oncotarget.com)

Intestinal ischaemia-reperfusion and hyperamylinaemia are both associated with severe acute pancreatitis. (uaeu.ac.ae)
The aim of this study was to examine the relationship between intestinal-ischaemia reperfusion and plasma amylin in an experimental model. (uaeu.ac.ae)
Intestinal histology was consistent with an ischaemia-reperfusion injury, whereas pancreatic histology was normal. (uaeu.ac.ae)
The unique finding that plasma amylin concentration is increased with intestinal ischaemia-reperfusion injury warrants further investigation. (uaeu.ac.ae)
Necrotizing enterocolitis (NEC), which typically occurs in the second to third week of life in premature, formula-fed infants, is characterized by variable damage to the intestinal tract, ranging from mucosal injury to full-thickness necrosis and perforation (see the image below). (medscape.com)

Gypenoside (GP), the predominant component of Gynostemma pentaphyllum, exhibits a therapeutic effect on chronic hepatic injury, fibrosis and fatty liver disease via its anti-inflammatory and anti‑oxidant activity. (spandidos-publications.com)
We conclude that the anti-inflammatory and antioxidant effects of Boswellia could be beneficial in ameliorating kidney and liver damage after AKI and that TLR9 might be the connection that signals liver injury in response to renal damage. (boswellia.org)
Our findings showed that boswellic acids, by their antioxidant and anti-inflammatory properties, negate the detrimental effects of cyclophosphamide on the bladder, suggesting boswellic acids as promising therapeutic alternatives for cystitis. (boswellia.org)
Dexmedetomidine is widely used for perioperative anesthesia/analgesia, and may have a more profound renal protection by stabilizing the sympathetic system, exerting anti-inflammatory effects and attenuating ischemia/reperfusion (I/R) injury. (medscape.com)

Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. (frontiersin.org)
Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). (mdpi.com)
Partial kidney ischemia-reperfusion (IR) injury is the principal cause of acute kidney injury. (hindawi.com)

I/R injury, through the liberation of radical oxygen species and the activation of inflammatory pathways, induces cellular injury and mi-crocirculatory damage, which translate to organ dysfunc-tion, morbidity, and increased health care costs [7, 8]. (123dok.net)
This may also have an effect on the remote ischemia-reperfusion damage and reduce cardiovascular morbidity in this group. (prinsesmaximacentrum.nl)

NRP-1 can produce neuroprotective effects against I/R injury to the brain by activating the Wnt/β-catenin signaling pathway and promoting mitochondrial structural repair and functional recovery, which may serve as a promising candidate target in treating ischemic stroke. (biomedcentral.com)

Our findings of an enhanced age-related coronary microcirculatory dysfunction in reperfused hearts may explain the poorer outcomes in elderly patients following MI. (jci.org)
EUK-134 produced a significant reduction in renal dysfunction and injury caused by I/R. Specifically, serum creatinine levels, an indicator of renal dysfunction, were reduced from 227 ± 11 (n = 12, I/R only) to 146 ± 9 µ M (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
The findings emphasize the role of concomitant oxidative and nitrosative stress and the role of peroxynitrite in the ensuing renal dysfunction. (scienceopen.com)
These sequelae of renal ischemia are a result of endothelial dysfunction, which is most probably responsible for the 'no-reflow' phenomenon and further aggravation of tubular ischemia during the early reperfusion period. (scienceopen.com)
In conclusion, the intricate relations between endothelial and epithelial cells, based in part on the relations between endothelial and inducible nitric oxide synthases, are perturbed in renal ischemia primarily as a result of endothelial dysfunction precipitating epithelial injury. (scienceopen.com)
Acute kidney injury and early allograft dysfunction are 2 common complications after liver transplant. (ectrx.org)

IR promotes a cascade of molecular events that lead to renal vascular and tubular damage and, ultimately, acute kidney injury (AKI) [ 2 - 4 ]. (hindawi.com)
Strikingly, after three weeks treatment with rotenone, we found that the unilateral I/R-induced tubular damage, tubulointerstitial fibrosis were all attenuated by rotenone as determined by the tubular injury score, Masson staining, and the levels of collagen-I, collagen-III, fibronectin, PAI-1, and TGF-β. (oncotarget.com)
This overview provides information on the pathophysiology of the inducible nitric oxide synthase/nitric oxide (iNOS/NO) system in the injury to cultured renal tubular epithelia, freshly isolated proximal tubules, and the whole organ after hypoxic or ischemic insult. (scienceopen.com)

Lentivirus (LV)-NRP-1 was transfected into rat primary cortical neuronal cultures before a 2-h oxygen-glucose deprivation and reoxygenation (OGD/R) injury to neurons. (biomedcentral.com)
Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)

The lectin pathway is multifaceted with activities spanning from complement activation to coagulation, autoimmunity, ischemia-reperfusion injury and embryogenesis. (nih.gov)
Ultrastructural and light-microscopic findings are consistent with coagulation necrosis, rather than apoptosis. (uni-luebeck.de)

Ischemia-reperfusion injury occurs when circulation is abruptly restored following prolonged ischemia and it is well-known that high levels of calcium and tissue neutrophil accumulation cause cellular damage and produce reactive oxygen species (ROS) during reperfusion and trigger IR injury [ 1 ]. (hindawi.com)
The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)
The production of antioxidant enzymes that scavenge free radicals in ischemic tissue is then impaired, thereby exacerbating the damage caused by these free radicals in the post ischemic reperfusion tissue. (frontiersin.org)
It has been demonstrated that I/R-induced hepatic injury is initially triggered by reactive oxygen species (ROS), which induce oxidative damage and apoptosis, an important mechanism for cell death following hepatic I/R injury ( 2 ). (spandidos-publications.com)
However, if we can understand how this damage happens, we may be able to develop strategies to avoid this injury in future. (uwo.ca)
Ischemia preconditioning (IPC) against IR also was recognized as a process to minimize the kidney damage caused by IR [ 5 ]. (hindawi.com)
Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain damage. (scienceopen.com)
Due to its direct contribution to edema and HT, reperfusion-associated BBB damage has been extensively studied, while BBB damage that occurs within the thrombolytic time window is largely neglected. (nih.gov)
Of note, ischemia-induced BBB damage in the early stroke stages is increasingly appreciated to negatively affect the safety and efficacy profiles of thrombolytic therapy for ischemic stroke. (nih.gov)
Therefore, it is of great significance finding an effective target to offset the I/R-induced neuronal damage. (biomedcentral.com)
In liver transplantation, tissue damage at reperfusion is mostly correlated with warm and cold ischemia times and leads in turn to poor graft function [13] and biliary complications [14,15]. (123dok.net)
Conclusions: Ischemia/reperfusion injury due to cardioplegic arrest inflicts significant damage on subendocardial MCC, but not on working myocardium. (uni-luebeck.de)
Low-grade ischemia-reperfusion in claudicants leads to damage of local tissues and remote organs. (prinsesmaximacentrum.nl)
Since this damage is partly caused by oxygen-derived free radicals (ODFR), scavenging these ODFR could reduce the local and remote injury. (prinsesmaximacentrum.nl)

Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)
Acute kidney injury (AKI) has been widely recognized as an important risk factor leading to the occurrence and progression of chronic kidney disease (CKD). (oncotarget.com)
Acute kidney injury (AKI) is a sudden incident that is linked with a high lethality rate commonly due to distant organ injury. (boswellia.org)

Histopathological findings revealed a considerable reduction in cellular infiltration, edema, epithelial denudation, and bleeding. (boswellia.org)

The injury an organ sustains during recovery, preservation, and transplantation occurs primarily as a result of ischemia and hypothermia. (medscape.com)

While developmental senescence and acute senescence may positively contribute to the fine-tuning of embryogenesis and injury repair, chronic senescence, when unresolved promptly, plays a crucial role in kidney fibrogenesis and CKD progression. (frontiersin.org)

As an example, nitrite mediates vasodilation via NO formation, and it protects against ischemia-reperfusion injury in animal models. (sciencewatch.com)

Other important safety findings (pancreatitis, hypoglycemia, kidney function) were also discussed, but were overshadowed by the heart failure discussion. (closeconcerns.com)

Ischemia/reperfusion (I/R) is a predominant cause of hepatic injury, which is of clinical significance following liver surgery, hemorrhagic shock and liver transplantation ( 1 ). (spandidos-publications.com)
The conducted study focuses on how we can reduce injury to the heart during heart transplantation. (uwo.ca)
By analyzing these questions, this research might be useful in humans to potentially reduce the rate of injury during heart transplantation. (uwo.ca)
Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
The transplantation of a "foreign" organ, despite meticulous matching for donor-recipient compatibility, leads to a complex adaptive and innate immune system-mediated injury. (medscape.com)
Although aimed at protecting the host from infection, in the context of transplantation, this injury leads to allograft rejection. (medscape.com)
The cut surface shows the characteristic findings of the disease for which lung transplantation was indicated. (medscape.com)
The Food and Drug Administration (FDA) is announcing a public workshop to discuss the effects of ischemia/ reperfusion injury ( IRI ) on outcomes in kidney transplantation. (myast.org)
Ischemia and reperfusion (I/R) is an unavoidable condition during free flap transplantation. (intechopen.com)

In conclusion, the present study indicated that GP effectively protected against I/R-induced hepatic injury via its anti-oxidative and anti-apoptotic bioactivity. (spandidos-publications.com)
Oxidative and nitrosative stress plays important roles in the pathogenesis of renal ischemia/reperfusion (I/R) injury. (scienceopen.com)
We propose that EUK-134 reduces renal I/R injury not only via reduction of oxidative stress, but also by reducing nitrosative stress caused by renal I/R. (scienceopen.com)
These findings indicate that administering extra antioxidants to claudicants reduces oxidative stress in these patients. (prinsesmaximacentrum.nl)

FINDINGS: Healthy control livers (DBD) showed minimal signs of inflammation during 2 h NRP and achieved 100% posttransplant recipient survival. (bvsalud.org)
In contrast, donor-HOPE (instead of NRP) led to significantly less mitochondrial-complex-I-injury and inflammation. (bvsalud.org)

While studies using various materials to overcome ischemia-reperfusion (IR) injury are becoming increasingly common, studies on the effects of botulinum toxin A (BoTA) on IR injury in musculocutaneous flaps are still limited. (hindawi.com)
Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3? (biomedcentral.com)
The objective of present study was to assess the effects of MK-886 and DITPA on renal I/R injury. (biomedcentral.com)
Protection of the heart against injury from acute ischemia remains challenging for emergency physicians and cardiologists because there are no therapies proven to directly protect the heart against the deleterious effects of ischemia in humans. (mcw.edu)
Cannabinoids in marijuana have safety effects against ischemia-reperfusion injury, a condition that happens when blood supply is revitalized in oxygen-deprived cells. (jangadasea.com)

In this study, we found that local BoTA preconditioning yielded significant protection against IR injury in a rat musculocutaneous flap model. (hindawi.com)
In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
Sprague-Dawley rats, exposed to renal injury via ischemia-reperfusion model, were administered a daily regimen of 1000 or 2000 mg/kg Boswellia for seven days then rats were sacrificed on day eight. (boswellia.org)

Physical findings in patients with NEC can be primarily GI, primarily systemic, indolent, fulminant, or any combination of these. (medscape.com)

Given that protein aggregates in liver cells are closely linked to alcoholic liver disease, these findings suggest that quercetin could be a useful treatment for patients with this condition. (qualitycounts.com)
This review aims at giving the last updates regarding the role of hepatic I/R and liver parenchymal quality injury in the setting of oncological liver surgery, using a ''bench-to-bedside'' approach. (123dok.net)
Numerous preclinical models have depicted the impact of I/R injury and hepatic parenchymal quality (steatosis, age) on increased cancer growth in the injured liver. (123dok.net)
Putative pathophysiological mechanisms linking I/R injury and liver cancer recurrence include an increased implantation of circulating cancer cells in the ischemic liver and the upregulation of proliferation and angiogenic factors following the ischemic insult. (123dok.net)
Although limited, there is growing clinical evidence that I/R injury and liver quality are associated with the risk of post-sur-gical cancer recurrence. (123dok.net)
the liver, I/R injury is at the source of poor outcomes after surgical procedures such as hepatectomy and liver trans-plantation [7]. (123dok.net)
The major drawback of such strategies is that they can induce I/R injury to the residual liver parenchyma [4, 12]. (123dok.net)
Repression of inflammatory pathways with Boswellia for alleviation of liver injury after renal ischemia reperfusion. (boswellia.org)
Renal ischemia-reperfusion injury (IRI) impaired renal and liver function significantly, but Boswellia attenuated this impairment in a dose-dependent fashion. (boswellia.org)

Our findings provide evidence that the NLRP1 and NLRP3 inflammasomes have a major role in neuronal cell death and behavioral deficits in stroke. (scienceopen.com)
Tissue plasminogen activator (tPA) thrombolysis, remains to be the only United States Food and Drug Administration (FDA) approved treatment for acute ischemia stroke. (nih.gov)
A number of studies have actually suggested that cannabinoids minimize ischemic injury and also advertise neuroprotection after a stroke. (jangadasea.com)
It is a typical problem of stroke as well as mind injury, and it is thought that cannabis might be useful to patients recuperating from these injuries. (jangadasea.com)

Multi-protein complexes called inflammasomes have recently been identified and shown to contribute to cell death in tissue injury. (scienceopen.com)
In conclusion, these findings direct toward an active involvement of tissue-resting leukocytes which may become therapeutic targets for concomitant medication in flap surgery to improve wound healing. (intechopen.com)

Vascular endothelial cell (EC)-derived factors play an important role in endothelial-cardiomyocyte crosstalk and could save cardiomyocytes (CMs) from injury. (mdpi.com)
In vitro, HL-1 cells (mouse cardiomyocytes) received chamber hypoxia-oxygenation reperfusion (H/R) for 24H4R with/without DLC1β plasmid, before collection for protein/mRNA analyses. (uwo.ca)

We first demonstrated the presence of IL-36(α/β) and its receptor (IL-36R) in ischemia/reperfusion-injured (IR-injured) mouse hearts and, interestingly, noted that expression of both increased with aging. (jci.org)
In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. (hindawi.com)

In the oncological setting, there are growing concerns regarding the deleterious impact of I/R injury on the risk of post-surgical tumor recurrence. (123dok.net)

RATIONALE AND OBJECTIVE: Vascular cell adhesion molecule-1 (VCAM-1) is upregulated in ischemia reperfusion injury (IRI), persisting after restoration of blood flow. (ox.ac.uk)

The rats in the IR group underwent 45 min partial kidney ischemia, and the animals in the IPC + IR group underwent two 5 min cycles of partial kidney ischemia followed by 10 min reperfusion and partial kidney ischemia for 45 min. (hindawi.com)
Kidney partial ischemia-reperfusion (IR) injury is defined as a reduction of the renal blood flow (RBF) followed by the recovery of RBF and reoxygenation [ 1 ]. (hindawi.com)
In view of the definition for AKI using conventional tests such as the blood urea nitrogen, serum creatinine levels, urine output quantity and creatinine clearance rate, it may result in delay in the timely detection of kidney injury and can lead to false-negative results, and dexmedetomidine for the prevention of AKI may be more effective than the current results. (medscape.com)

Scavenging peroxynitrite using seleno-organic compounds like ebselen provides renoprotection against ischemic injury. (scienceopen.com)

[ 27 ] Dexmedetomidine pretreatment attenuated the I/R injury by reducing inflammatory response mediated by toll-like receptor4 expression. (medscape.com)

The blood biochemical findings matched the HE staining result. (molecularhydrogenstudies.com)

The renin-angiotensin system (RAS) and hypertension also may be influenced by renal IR injury. (hindawi.com)

Therefore, developing effective preventive and therapeutic strategies for I/R-induced hepatic injury is required. (spandidos-publications.com)
Therapeutic strategies tackling I/R injury could not only improve post-surgical organ function, but also allow a reduction in the risk of cancer recurrence. (123dok.net)

Although these findings are preliminary, they are consistent with previous research study showing the advantages of cannabinoids. (jangadasea.com)

Renal ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon in clinical settings. (frontiersin.org)

Anatomy30

Organisms13

Diseases61

Chemicals and Drugs84

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes34

Disciplines and Occupations1

Information Science2

Health Care5

Middle cerebral artery6

Heart against ischemia-reperfusion injury2

Cerebral15

Myocardial4

Bilateral renal ischemia2

Vivo5

Transient2

Subsequent2

Hypoxia ischemia4

Atherosclerosis2

Mice7

Cardiac7

Abstract1

Inhibition3

Intestinal5

Anti-inflammatory4

Cause of acute kidney3

Morbidity2

Neuroprotective1

Dysfunction6

Tubular3

Deprivation2

Coagulation2

Damage14

Acute kidney3

Cellular1

Occurs1

Embryogenesis1

Protects1

Pancreatitis1

Transplantation9

Oxidative4

Inflammation2

Effects5

Model3

Primarily1

Liver9

Stroke4

Tissue2

Cardiomyocytes2

Receptor2

Deleterious1

Vascular1

Kidney3

Ischemic injury1

Inflammatory response1

Biochemical1

Hypertension1

Therapeutic2

Consistent1

Phenomenon1