Findings establish administration intranasal. Medical search. Frequent questions

Previous studies have demonstrated that intravenous (IV) administration of BCG is well-tolerated and effective in preventing tuberculosis infection in animals. (bvsalud.org)

We believe the results from this rabbit toxicology study will support our development strategy for our intranasal COVID-19 vaccine candidate, NT-CoV2-1. (biospace.com)
Its lead product is NT-CoV2-1, an intranasal vaccine candidate to prevent COVID-19 and variants of the SARS-CoV-2 virus. (biospace.com)
Early in the SARS-CoV-2 pandemic Estep founded the Rapid Deployment Vaccine Collaborative (RaDVaC), an open source vaccine project that controversially featured vaccine self administration. (wikipedia.org)
An intranasal Covid19 vaccine developed by researchers at the University of Hong Kong (HKU) in collaboration with Xiamen University and Wantai pharmaceutical has gained approval from the Chinese authorities for emergency use in the Mainland. (cvvt.hk)
Wantai BioPharm announced today (Dec 5) that the nasal vaccine has obtained the critical green light from the Chinese National Medical Products Administration. (cvvt.hk)
2. Prior chemotherapy, immunotherapy (tumour vaccine, cytokine or growth factor given to control the cancer) or other anti-cancer therapy within less than 2 weeks before study drug administration, or any persistent unresolved toxicity from such previous therapy that, according to the judgement of the investigator, may pose a risk for the subject if taking part in the study. (who.int)

For intranasal use only, the recommended dose is 1 spray per nostril twice daily in adults and adolescents 12 years of age and older. (rxlist.com)
This compares with a C max of 5 and 16 ng/mL following dosing with a 5 and 20 mg intranasal dose, respectively. (nih.gov)
useInNursing=* Based on determinations of levocabastine in breast milk after ophthalmic administration of the drug to one nursing woman, it was calculated that the daily dose of levocabastine in the infant was about 0.5 µg. (wikidoc.org)
On day 10, they received an intranasal dose of TDI (0.1%) mation, and nonspecific airway hyperresponsiveness in or vehicle. (cdc.gov)

A preclinical efficacy service provide with proven track record of intranasal delivery is needed to support the program. (scanbalt.org)
The findings from this preclinical toxicology study will be a part of our Investigational New Drug filing to the U.S. Food and Drug Administration," said Frederick W. Telling, Ph.D., Executive Chairman of Oragenics. (biospace.com)
Preclinical research in 6-hydroxydopamine (6-OHDA) and/or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned animals established persistent improvements of motor behavior after ASC-treatment. (biomedcentral.com)

Overall, our study demonstrates the potential of systemic IV BCG administration in the treatment of lung tumors, highlighting its ability to enhance immune responses and augment immune checkpoint blockade efficacy. (bvsalud.org)
Prospective cohort studies are needed to confirm these findings and validate the efficacy of this novel therapeutic strategy. (surgicalneurologyint.com)
Even before its clinical efficacy was established, our scientists found Draxxin is rapidly released from an intramuscular injection site, that it's readily distributed throughout the body and that it persists in the lungs," said Ashley Johnson, DVM, Zoetis. (thepigsite.com)

After priming [see DOSAGE AND ADMINISTRATION ], each metered spray delivers a 0.137 mL mean volume of suspension containing 137 mcg of azelastine hydrochloride (equivalent to 125 mcg of azelastine base) and 50 mcg of fluticasone propionate. (rxlist.com)

In a second pharmacokinetic study, Zoetis scientists evaluated drug concentrations in plasma and lungs after IM administration to healthy pigs. (thepigsite.com)

To investigate LCD's effect on GB therapy, we have begun a clinical trial using LCD as an addition to intranasal perillyl alcohol (POH) for recurrent GB (rGB) patients. (surgicalneurologyint.com)
The clinical relevance of the early pharmacokinetic research is well established, Johnson continued. (thepigsite.com)
However, long-term side effects of ketamine in the clinical setting have not been established. (wellwithalchemy.com)
These can be directly correlated to MRI morphometric traits and clinical findings of neuropathic pain. (surrey.ac.uk)
While no clinical data establishes causal link between HIV acquisition and use of this injectable progestin, prior work from our laboratory showed that DMPA comparably lowers genital levels of the cell-cell adhesion molecule desmoglein-1 (DSG1) and weakens genital epithelial barrier function in female mice and humans. (stanford.edu)
It also summarizes results from basic and translational research that establish biological plausibility for earlier clinical studies that identified enhanced HIV susceptibility in women using DMPA. (stanford.edu)

However, study on the effects of IL-27/anti-IL-27 antibody (anti-IL-27p28-Ab) administration to atherosclerosis model in ApoE -/- mice has not been reported. (hindawi.com)
In this study, we show that compared with mice in estrus, treatment of mice with DMPA or NET-EN significantly decreased genital levels of the cell-cell adhesion molecule desmoglein-1 and increased genital mucosal permeability. (stanford.edu)
These effects, however, were more pronounced in DMPA- versus NET-EN-treated mice. (stanford.edu)
Likewise, we detected comparable mortality rates in DMPA- and NET-EN-treated wild-type and humanized mice after intravaginal infection with HSV type 2 or cell-associated HIV type 1, respectively, but NET-EN treatment was associated with slower onset of HSV-induced genital pathology and lower burden of systemic HIV disease. (stanford.edu)
In contrast, mice that had received prior application(s) using protocols involving dermal application and subsequent of TDI, even if only on day 7, exhibited the following: ventilatory intranasal administration of TDI. (cdc.gov)
These in creating a mouse model for occupational asthma using HDI findings suggest that respiratory response to TDI depends on (hexamethylene diisocyanate), in which the sensitized mice prior frequency and concentration of dermal sensitization in mice. (cdc.gov)

These findings suggest that APOBEC3 editing may be a recurrent and a dominant driver of MPXV evolution within the current outbreak. (cdc.gov)

1999). Animal models are needed not only to understand how prior to intranasal challenge influences the respiratory response chemicals may induce asthma, but also to improve our ability to using toluene diisocyanate (TDI), a known respiratory sensitizer. (cdc.gov)

Herein, we sought to confirm and extend these findings by comparing genital epithelial barrier function in untreated rhesus macaques (RM) vs. RM treated with DMPA or DMPA and estrogen (E). Compared to controls, genital tissue from RM with pharmacologically relevant serum levels of medroxyprogesterone acetate displayed significantly lower DSG1 levels and greater permeability to low molecular mass molecules. (stanford.edu)

Our findings demonstrate that BCG inoculation reduced tumor growth and prolonged mouse survival in models of lung melanoma metastasis and orthotopic lung adenocarcinoma. (bvsalud.org)
These findings are consistent with research in younger adults and demonstrate that twice-weekly infusions yield a more sustained antidepressant response than once-weekly infusions, the authors note. (medscape.com)
These findings demonstrate that BP regulatory gene(s) exist within the differential chromosome segment trapped in the SHR-Lx congenic strain and that this region of chromosome 8 plays a major role in the hypertension of SHR vs. BN-Lx rats. (jci.org)

Each sumatriptan succinate tablet for oral administration contains 35, 70, or 140 mg of sumatriptan succinate equivalent to 25, 50, or 100 mg of sumatriptan, respectively. (nih.gov)
A food effect study involving administration of sumatriptan succinate tablets 100 mg to healthy volunteers under fasting conditions and with a high-fat meal indicated that the C max and AUC were increased by 15% and 12 %, respectively, when administered in the fed state. (nih.gov)

In the second part of this review, we provide evidence that frequent exercise enhances-rather than suppresses-immune competency, and highlight key findings from human vaccination studies which show heightened responses to bacterial and viral antigens following bouts of exercise. (frontiersin.org)

Additional studies are therefore warranted to establish further treatment guidelines in this area," Kim said. (medscape.com)
Included in the report are the findings of a review on heroin-assisted treatment by the Cochrane Drugs and Alcohol Group, along with the results of a meta-analysis of key studies undertaken. (druglawreform.info)
have now tested the replicability of experiments published in top-tier economics journals, finding that two-thirds of the 18 studies examined yielded replicable estimates of effect size and direction. (dericbownds.net)
Self-Directed Passive-Aggressive Behaviour as an Essential Component of Depression: Findings from Two Cross-Sectional Observational Studies. (uni-saarland.de)
Prof Clare Rusbridge and Dr Penny Knowler have had a collaboration with Dr Kibar's group of the University of Montreal since 2005 with an aim of identifying genetic markers for canine CMSM and to translate the findings into genomic studies on humans. (surrey.ac.uk)
In collaboration with the Medical Imaging Group at the University of Surrey (HeadSpace project) we are applying a machine learning approach to the significant MRI morphometric traits to establish a simple objective measure that could be applied to future genetic and other studies and develop a medical image analysis software that can be used to screen susceptible breeding dogs and be translated into human studies. (surrey.ac.uk)
Defining the parameters of the study as well as the timetable for deliverables was first addressed and in the light of the extensive scope of the studies, a phased approach was agreed to allow preliminary findings to be shared in time for the December 2010 OEWG and the full study to be completed before the Sixty- fourth World Health Assembly. (who.int)

The results presented in this study show that the LCD associated with intranasal POH therapy may represent a viable option as adjunctive therapy for rGB to improve survival without compromising patients' quality of life. (surgicalneurologyint.com)
The Long-Term Buffering Effect of Sense of Coherence on Psychopathological Symptoms During the COVID-19 Pandemic: Findings from a Prospective Observational Study. (uni-saarland.de)
Although the findings of this study indicate that PF-04886847 possesses limited anti-thrombotic and anti-inflammatory effects, PF-04886847 may have therapeutic potential in other kallikrein-kinin mediated diseases. (healthyconnectionsinc.com)
This document provides the Preliminary Findings of the study, notably the current state for each technical area, several possible targets, options and costs, as well as possible funding scenarios. (who.int)
3. Prior definitive radiation therapy within less than 4 weeks and prior palliative radiotherapy within less than 2 weeks before study drug administration. (who.int)
Radiopharmaceuticals (strontium, samarium) within less than 8 weeks before study drug administration. (who.int)
8. Immunosuppressive doses of systemic medications, such as steroids or absorbed topical steroids (doses >10 mg/day prednisone or equivalent) within 2 weeks before study drug administration. (who.int)

La présente note d'orientation a pour objectif de passer en revue les interventions disponibles pour la prise en charge des troubles liés à la consommation de substances psychoactives, d'examiner les bases factuelles pour ces interventions dont le guide d'intervention du Programme d'action de l'OMS : Combler les lacunes en santé mentale (mhGAP), et d'effectuer des recommandations concernant le traitement de ces troubles. (who.int)

Since lung damage following we.v. LPS only can be associated with just gentle intra-alveolar neutrophilic infiltrates, a combined mix of intranasal (i.n.) and we.v. administration was utilized to augment the lung damage[35]. (healthyconnectionsinc.com)

The NT-CoV2-1 program leverages coronavirus spike protein research licensed from the NIH and the NRC with a focus on reducing viral transmission and offering a more patient-friendly intranasal administration. (biospace.com)
With the support of the Miniature Wirehaired Dachshund club she established a nationwide program of DNA collection from affected dogs and their relatives to conduct a genome scan and characterization of the mutation. (surrey.ac.uk)
In addition, a test for detection of affected and carrier dogs was established to enable a controlled breeding program in affected dog breeds. (surrey.ac.uk)
Soon we hope to establish a preventative treatment program that will be translated for human patients. (surrey.ac.uk)

The toxicity of DMSO is usually well established in the books for years[29, 30]. (healthyconnectionsinc.com)

The findings are important because research on the effects of IV ketamine have not been well documented in geriatric patients, who have high rates of depression and TRD. (medscape.com)
In multiple system atrophy (MSA) or progressive supranuclear palsy (PSP) patients, though, only marginal reduced progression of natural progression could be established after subventricular or intravasal ASC implantations. (biomedcentral.com)
useInPed=* Safety and effectiveness in pediatric patients below the age of 12 have not been established. (wikidoc.org)
The findings have impact on understanding of the osseous changes in CM and why some patients are painful. (surrey.ac.uk)

Findings from international trials now suggest that the supervised use of medicinal heroin can be an effective second-line treatment for this small, and previously unresponsive, group. (druglawreform.info)

For a review of the putative mechanisms by which diabetes may influence AD risk and detailed commentary on interpreting the findings below in a broader context, please view the Discussion . (alzrisk.org)
Then, using findings from social and personality psychology, we make a case that different results almost certainly would have been found had the research been conducted in a different relational context. (frontiersin.org)
We neither attempt to review all evidence that relational context shapes neuroscience findings nor to put forward a theoretical analysis of all the ways relational context ought to shape neuroscience findings. (frontiersin.org)

The purpose of this article is to provide an up-to-date source of information about medication use in pregnancy, to review the US Food and Drug Administration (FDA) pregnancy and lactation categories, and to further describe FDA changes in drug labeling. (medscape.com)

Intravesical administration of Bacillus Calmette-Guérin (BCG) was one of the first FDA-approved immunotherapies and remains a standard treatment for bladder cancer. (bvsalud.org)
What to do once treatment-resistant depression is established based on risk factors and exclusion of other conditions? (psychiatrictimes.com)
However, analogous effects of NET-EN treatment on antivirus immunity and host susceptibility to genital infection are much less explored. (stanford.edu)
This finding suggests that a new treatment strategy at MMP inhibition should be explored to effectively combat Omicron BA.1 and other Omicron sublineages. (cvvt.hk)

These findings establish the promise of this prime-boost strategy involving rMVA. (nature.com)

In our research, we examined the influence of the administration of IL-27 and an anti-IL-27p28 antibody (anti-IL-27p28-Ab) on both the initiation and the progression of atherosclerosis. (hindawi.com)
In the groups (both the initiation and the progression) receiving recombinant IL-27 administration, the formation of atherosclerotic plaques was suspended, and the percentage of regulatory T cells (LAP + or Foxp3 + ) in the spleen and peripheral blood was increased. (hindawi.com)
Given the established link between vascular disease and the pathogenesis and/or progression of dementia and AD [1, 2], the co-occurrence of diabetes with these factors likely contributes to a relationship between diabetes and dementia risk. (alzrisk.org)

Once TRD is established on the basis of one or more of the risk factors and the exclusion of other conditions, the question arises: what to do next? (psychiatrictimes.com)

The intranasal delivery route is particularly relevant as it may further reduce transmission of the virus and provide a needle-free delivery option. (biospace.com)

A tenable hypothesis is presented which explains disparities between older oral dl-MPH bioavailability data generated using chiral derivatization-gas chromatography versus more recent findings using chiral liquid chromatography. (aspetjournals.org)

A more recent intranasal formulation of ketamine, esketamine, was approved by the US Food and Drug Administration for TRD in 2019, and some experts questioned its path to approval . (medscape.com)

The SENS Challenge panel of judges selected this submission as the best but concluded that it failed to meet the burden of proof established by the challenge: to show that "SENS is not worthy of learned debate. (wikipedia.org)

The findings contained in this document are preliminary in nature. (who.int)

Medication and LPS administration Pets had been anesthetized using intraperitoneal (i.p.) shot of sodium pentobarbital 50 mg/kg and positioned on a Significantly Infrared warming pad (Kent Scientific Company, Torrington, CT) to keep up normal body's temperature (37 1C). (healthyconnectionsinc.com)

Validated intranasal administration method in rats should be in place. (scanbalt.org)

FDA U.S. Food and Drug Administration. (cdc.gov)

Considering the fact that majority of the world's population is vaccinated with BCG and this will continue in the foreseeable future, finding individuals who have not been immunized with BCG will be a difficult task for testing any new vaccines. (nature.com)
Administration of anti-SARS-CoV-2 mRNA-based vaccines leads to the production of extraordinarily high levels of anti-Spike antibodies in serum 1 , 2 . (nature.com)
As stated in the working outline, in these preliminary findings, the focus of the access, affordability and effective deployment section is access to vaccines. (who.int)

4 MA is the most widely used illicit drug in the world after cannabis, 5 and it has become established as the most dominant drug problem in many western and midwestern states, severely impacting rural and suburban areas, as well as small to mid-sized cities. (psychiatrictimes.com)

Additionally, it is well-established that OXTRs are found in the VTA of rodents , and given the high similarity between the rodent and human brain, it is not unreasonable to assume that OXTRs exist in the human VTA. (casadopovosantana.com)

Ventilatory support by itself may result in patient recovery as the accumulated carbon dioxide is expelled, and thus naloxone administration is not necessary [8]. (capnoacademy.com)
The scholarships support the most innovative young researchers at a critical stage of their careers-their postdoctoral research-as they develop the new ideas and directions that will help establish them as independent neuroscientists. (nyas.org)

Research teams from Faculty of Architecture, Faculty of Engineering, Faculty of Science, LKS Faculty of Medicine, and two HKU Inno Laboratories, established under the Hong Kong Government's InnoHK programme, garnered two special grand prizes, one Gold Medal with the Congratulations of the Jury, six Gold Medals, six Silver Medals and four Bronze Medals with their innovations in the event. (cvvt.hk)

Another factor to consider is the ramifications of OXT administration on the peripheral system, specifically on the reproductive system, where it has a substantial role. (casadopovosantana.com)
To provide more reliable information in the United States, the Centers for Disease Control and Prevention (CDC) established a state-based system called the National Violent Death Reporting System (NVDRS), which collects facts about each violent incident from various sources to provide a clearer understanding of the causes of violent deaths (homicides and suicides). (msdmanuals.com)

The replicability of some scientific findings has recently been called into question. (dericbownds.net)

There are conflicting findings about the potential benefit or harm of taking folic acid plus vitamin B6 and vitamin B12 following angioplasty. (naturalmedicinejournal.com)

A key finding of the book that is at odds with current dietary recommendations regards certain refined carbohydrate (carbs) foods. (wikipedia.org)

Anatomy29

Organisms29

Diseases28

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment62

Psychiatry and Psychology3

Phenomena and Processes35

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Health Care9

Intravenous1

Vaccine6

Dose4

Preclinical3

Efficacy3

DOSAGE AND ADMINISTRATION1

Concentrations1

Clinical6

Mice6

Recurrent1

19991

Epithelial1

Demonstrate3

Sumatriptan2

Responses1

Studies7

Study7

Interventions1

Lung1

Program4

Toxicity1

Patients4

Trials1

Context3

Pregnancy1

Treatment4

Strategy1

Progression3

Risk1

Route1

Data1

Recent1

Challenge1

Nature1

Medication1

Method1

Food1

Vaccines3

Drug1

Human1

Support2

Research1

System2

Scientific1

Potential1

Current1